Coming soon: Matsy in StarDrop

For the last few months, we have been working together with Optibrium to integrate Matsy into their StarDrop platform for lead optimisation, the result of which will be released later this year:

Optibrium™ and NextMove Software, developers of software and chemoinformatics solutions for drug discovery, today announced an agreement to collaborate on the integration of NextMove Software’s Matsy technology with Optibrium’s StarDrop software suite. This combination will help to guide scientists’ optimisation strategies to quickly identify compounds with a high chance of success for their drug discovery projects.

The Matsy algorithm has been developed by NextMove Software to generate and search databases of matched molecular series to identify chemical substitutions that are most likely to improve target activity (J. Med. Chem., 2014, 57(6), pp 2704–2713). This goes beyond conventional ‘matched molecular pair analysis’ by using data from longer series of matched compounds (and not just pairs) to make more relevant predictions for a particular chemical series of interest. As part of the collaboration with Optibrium, Matsy will be applied in StarDrop’s Nova™ module, which automatically generates new compound structures to stimulate the search for optimisation strategies related to initial hit or lead compounds. StarDrop’s unique capabilities for multi-parameter optimisation and predictive modelling will enable efficient prioritisation of the resulting ideas to identify high quality compounds with the best chance of success.

For further information, see the full press release.