“Patents you wouldn’t want to work with”
Readers of Derek Lowe’s In The Pipeline may be familiar with a series of posts titled “Things I won’t work with”. In the spirit of those posts, we recently ran Casandra on one million reactions extracted from US Patents. One patent highlighted in this preliminary analysis contained an extremely energetic compound.
It turns out the above patent is actually from a defence agency and they were intending to make explosives. A more subtle reactive hazard was found in
Here the amide (DMF) and metal hydride (NaH) can react exothermically in a self-accelerating reaction[1,2].
 J. Buckley et al., Chemical & Engineering News, Jul. 12, 1982, page 5
 G. DeWail, Chemical & Engineering News, Sep. 13, 1982