A recent posting to the CHMINF-L mailing list at the University of Indiana reiterates a point made by Steve Heller in his recent keynote address to the 2014 ICCS/GCC meeting in Noordwijkerhout. In that presentation, Steve argues for the need for chemical structure canonicalization by showing 172 possible valid SMILES strings for the molecule Caffeine.
The representational degeneracy of line notations, connection tables and even structure diagrams is one of the main challenges of cheminformatics. A chemist’s concept of sameness doesn’t always match the classical “bond order” representation/model of organic chemistry. I’ll save a discussion of pros and cons of InChI vs SMILES for a future post, but for now we’ll investigate the core property that multiple SMILES map to a single InChI.
The original 172 SMILES for Caffeine were automatically generated by Ian Watson at Eli Lilly as described in his September 2010 CHMINF-L posting, but no claims were made as to whether this list is, or was intended to be, exhaustive.
A quick back-of-the-envelope calculation reveals that 172 is too low a bound for the number of possible SMILES permutations for Caffeine. SMILES generation resembles the depth-first traversal of an un-rooted undirected graph, potentially starting from any atom and making an arbitrary ordering decision at each branch point, i.e. each atom with more than two atom neighbours. Caffeine has 14 heavy atoms, two rings, 7 atoms with heavy atom degree three, and no symmetries. This means that Caffeine should have at least 14*2^(7-2)=448 SMILES. This calculation assumes that the SMILES string can start at any atom, and underestimates the branch points by subtracting the number of ring closures.
In fact, with a little programming magic (exercise left to the reader), it’s possible to come up with the following list of 4160 SMILES, all of which should canonicalize to the exact same form:
Cn1cnc2c1c(=O)n(c(=O)n2C)C Cn1cnc2c1c(=O)n(c(n2C)=O)C Cn1cnc2c1c(=O)n(C)c(=O)n2C Cn1cnc2c1c(=O)n(C)c(n2C)=O Cn1cnc2c1c(n(c(=O)n2C)C)=O Cn1cnc2c1c(n(c(n2C)=O)C)=O Cn1cnc2c1c(n(C)c(=O)n2C)=O Cn1cnc2c1c(n(C)c(n2C)=O)=O Cn1cnc2n(c(n(c(c12)=O)C)=O)C Cn1cnc2n(c(n(c(c21)=O)C)=O)C Cn1cnc2n(c(n(c(=O)c12)C)=O)C Cn1cnc2n(c(n(c(=O)c21)C)=O)C Cn1cnc2n(c(n(C)c(c12)=O)=O)C Cn1cnc2n(c(n(C)c(c21)=O)=O)C Cn1cnc2n(c(n(C)c(=O)c12)=O)C Cn1cnc2n(c(n(C)c(=O)c21)=O)C Cn1cnc2n(c(=O)n(c(c12)=O)C)C Cn1cnc2n(c(=O)n(c(c21)=O)C)C Cn1cnc2n(c(=O)n(c(=O)c12)C)C Cn1cnc2n(c(=O)n(c(=O)c21)C)C Cn1cnc2n(c(=O)n(C)c(c12)=O)C Cn1cnc2n(c(=O)n(C)c(c21)=O)C Cn1cnc2n(c(=O)n(C)c(=O)c12)C Cn1cnc2n(c(=O)n(C)c(=O)c21)C Cn1cnc2n(C)c(n(c(c12)=O)C)=O Cn1cnc2n(C)c(n(c(c21)=O)C)=O Cn1cnc2n(C)c(n(c(=O)c12)C)=O Cn1cnc2n(C)c(n(c(=O)c21)C)=O Cn1cnc2n(C)c(n(C)c(c12)=O)=O Cn1cnc2n(C)c(n(C)c(c21)=O)=O Cn1cnc2n(C)c(n(C)c(=O)c12)=O Cn1cnc2n(C)c(n(C)c(=O)c21)=O Cn1cnc2n(C)c(=O)n(c(c12)=O)C Cn1cnc2n(C)c(=O)n(c(c21)=O)C Cn1cnc2n(C)c(=O)n(c(=O)c12)C Cn1cnc2n(C)c(=O)n(c(=O)c21)C Cn1cnc2n(C)c(=O)n(C)c(c12)=O Cn1cnc2n(C)c(=O)n(C)c(c21)=O Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Cn1cnc2n(C)c(=O)n(C)c(=O)c21 Cn1cnc(n2C)c1c(=O)n(c2=O)C Cn1cnc(n2C)c1c(=O)n(C)c2=O Cn1cnc(n2C)c1c(n(c2=O)C)=O Cn1cnc(n2C)c1c(n(C)c2=O)=O Cn1cnc(n(c2=O)C)c1c(=O)n2C Cn1cnc(n(c2=O)C)c1c(n2C)=O Cn1cnc(n(c(n2C)=O)C)c1c2=O Cn1cnc(n(c(n(c2=O)C)=O)C)c12 Cn1cnc(n(c(n(c2=O)C)=O)C)c21 Cn1cnc(n(c(n(C)c2=O)=O)C)c12 Cn1cnc(n(c(n(C)c2=O)=O)C)c21 Cn1cnc(n(c(=O)n2C)C)c1c2=O Cn1cnc(n(c(=O)n(c2=O)C)C)c12 Cn1cnc(n(c(=O)n(c2=O)C)C)c21 Cn1cnc(n(c(=O)n(C)c2=O)C)c12 Cn1cnc(n(c(=O)n(C)c2=O)C)c21 Cn1cnc(n(C)c2=O)c1c(=O)n2C Cn1cnc(n(C)c2=O)c1c(n2C)=O Cn1cnc(n(C)c(n2C)=O)c1c2=O Cn1cnc(n(C)c(n(c2=O)C)=O)c12 Cn1cnc(n(C)c(n(c2=O)C)=O)c21 Cn1cnc(n(C)c(n(C)c2=O)=O)c12 Cn1cnc(n(C)c(n(C)c2=O)=O)c21 Cn1cnc(n(C)c(=O)n2C)c1c2=O Cn1cnc(n(C)c(=O)n(c2=O)C)c12 Cn1cnc(n(C)c(=O)n(c2=O)C)c21 Cn1cnc(n(C)c(=O)n(C)c2=O)c12 Cn1cnc(n(C)c(=O)n(C)c2=O)c21 Cn1cnc(c1c2=O)n(c(n2C)=O)C Cn1cnc(c1c2=O)n(c(=O)n2C)C Cn1cnc(c1c2=O)n(C)c(n2C)=O Cn1cnc(c1c2=O)n(C)c(=O)n2C Cn1cnc(c1c(=O)n2C)n(c2=O)C Cn1cnc(c1c(=O)n2C)n(C)c2=O Cn1cnc(c1c(=O)n(c2=O)C)n2C Cn1cnc(c1c(=O)n(C)c2=O)n2C Cn1cnc(c1c(n2C)=O)n(c2=O)C Cn1cnc(c1c(n2C)=O)n(C)c2=O Cn1cnc(c1c(n(c2=O)C)=O)n2C Cn1cnc(c1c(n(C)c2=O)=O)n2C Cn1c2c(=O)n(c(=O)n(c2nc1)C)C Cn1c2c(=O)n(c(=O)n(C)c2nc1)C Cn1c2c(=O)n(c(n(c2nc1)C)=O)C Cn1c2c(=O)n(c(n(C)c2nc1)=O)C Cn1c2c(=O)n(C)c(=O)n(c2nc1)C Cn1c2c(=O)n(C)c(=O)n(C)c2nc1 Cn1c2c(=O)n(C)c(n(c2nc1)C)=O Cn1c2c(=O)n(C)c(n(C)c2nc1)=O Cn1c2c(n(c(=O)n(c2nc1)C)C)=O Cn1c2c(n(c(=O)n(C)c2nc1)C)=O Cn1c2c(n(c(n(c2nc1)C)=O)C)=O Cn1c2c(n(c(n(C)c2nc1)=O)C)=O Cn1c2c(n(C)c(=O)n(c2nc1)C)=O Cn1c2c(n(C)c(=O)n(C)c2nc1)=O Cn1c2c(n(C)c(n(c2nc1)C)=O)=O Cn1c2c(n(C)c(n(C)c2nc1)=O)=O Cn1c2c(nc1)n(c(n(c2=O)C)=O)C Cn1c2c(nc1)n(c(n(C)c2=O)=O)C Cn1c2c(nc1)n(c(=O)n(c2=O)C)C Cn1c2c(nc1)n(c(=O)n(C)c2=O)C Cn1c2c(nc1)n(C)c(n(c2=O)C)=O Cn1c2c(nc1)n(C)c(n(C)c2=O)=O Cn1c2c(nc1)n(C)c(=O)n(c2=O)C Cn1c2c(nc1)n(C)c(=O)n(C)c2=O Cn1c2c(n(c(n(c2=O)C)=O)C)nc1 Cn1c2c(n(c(n(C)c2=O)=O)C)nc1 Cn1c2c(n(c(=O)n(c2=O)C)C)nc1 Cn1c2c(n(c(=O)n(C)c2=O)C)nc1 Cn1c2c(n(C)c(n(c2=O)C)=O)nc1 Cn1c2c(n(C)c(n(C)c2=O)=O)nc1 Cn1c2c(n(C)c(=O)n(c2=O)C)nc1 Cn1c2c(n(C)c(=O)n(C)c2=O)nc1 Cn1c(c2nc1)c(=O)n(c(=O)n2C)C Cn1c(c2nc1)c(=O)n(c(n2C)=O)C Cn1c(c2nc1)c(=O)n(C)c(=O)n2C Cn1c(c2nc1)c(=O)n(C)c(n2C)=O Cn1c(c2nc1)c(n(c(=O)n2C)C)=O Cn1c(c2nc1)c(n(c(n2C)=O)C)=O Cn1c(c2nc1)c(n(C)c(=O)n2C)=O Cn1c(c2nc1)c(n(C)c(n2C)=O)=O Cn1c(c(nc1)n2C)c(=O)n(c2=O)C Cn1c(c(nc1)n2C)c(=O)n(C)c2=O Cn1c(c(nc1)n2C)c(n(c2=O)C)=O Cn1c(c(nc1)n2C)c(n(C)c2=O)=O Cn1c(c(nc1)n(c2=O)C)c(=O)n2C Cn1c(c(nc1)n(c2=O)C)c(n2C)=O Cn1c(c(nc1)n(c(n2C)=O)C)c2=O Cn1c(c(nc1)n(c(=O)n2C)C)c2=O Cn1c(c(nc1)n(C)c2=O)c(=O)n2C Cn1c(c(nc1)n(C)c2=O)c(n2C)=O Cn1c(c(nc1)n(C)c(n2C)=O)c2=O Cn1c(c(nc1)n(C)c(=O)n2C)c2=O Cn1c(c(n2C)nc1)c(=O)n(c2=O)C Cn1c(c(n2C)nc1)c(=O)n(C)c2=O Cn1c(c(n2C)nc1)c(n(c2=O)C)=O Cn1c(c(n2C)nc1)c(n(C)c2=O)=O Cn1c(c(n(c2=O)C)nc1)c(=O)n2C Cn1c(c(n(c2=O)C)nc1)c(n2C)=O Cn1c(c(n(c(n2C)=O)C)nc1)c2=O Cn1c(c(n(c(=O)n2C)C)nc1)c2=O Cn1c(c(n(C)c2=O)nc1)c(=O)n2C Cn1c(c(n(C)c2=O)nc1)c(n2C)=O Cn1c(c(n(C)c(n2C)=O)nc1)c2=O Cn1c(c(n(C)c(=O)n2C)nc1)c2=O Cn1c(c2=O)c(nc1)n(c(n2C)=O)C Cn1c(c2=O)c(nc1)n(c(=O)n2C)C Cn1c(c2=O)c(nc1)n(C)c(n2C)=O Cn1c(c2=O)c(nc1)n(C)c(=O)n2C Cn1c(c2=O)c(n(c(n2C)=O)C)nc1 Cn1c(c2=O)c(n(c(=O)n2C)C)nc1 Cn1c(c2=O)c(n(C)c(n2C)=O)nc1 Cn1c(c2=O)c(n(C)c(=O)n2C)nc1 Cn1c(c(=O)n2C)c(nc1)n(c2=O)C Cn1c(c(=O)n2C)c(nc1)n(C)c2=O Cn1c(c(=O)n2C)c(n(c2=O)C)nc1 Cn1c(c(=O)n2C)c(n(C)c2=O)nc1 Cn1c(c(=O)n(c2=O)C)c(nc1)n2C Cn1c(c(=O)n(c2=O)C)c(n2C)nc1 Cn1c(c(=O)n(c(=O)n2C)C)c2nc1 Cn1c(c(=O)n(c(n2C)=O)C)c2nc1 Cn1c(c(=O)n(C)c2=O)c(nc1)n2C Cn1c(c(=O)n(C)c2=O)c(n2C)nc1 Cn1c(c(=O)n(C)c(=O)n2C)c2nc1 Cn1c(c(=O)n(C)c(n2C)=O)c2nc1 Cn1c(c(n2C)=O)c(nc1)n(c2=O)C Cn1c(c(n2C)=O)c(nc1)n(C)c2=O Cn1c(c(n2C)=O)c(n(c2=O)C)nc1 Cn1c(c(n2C)=O)c(n(C)c2=O)nc1 Cn1c(c(n(c2=O)C)=O)c(nc1)n2C Cn1c(c(n(c2=O)C)=O)c(n2C)nc1 Cn1c(c(n(c(=O)n2C)C)=O)c2nc1 Cn1c(c(n(c(n2C)=O)C)=O)c2nc1 Cn1c(c(n(C)c2=O)=O)c(nc1)n2C Cn1c(c(n(C)c2=O)=O)c(n2C)nc1 Cn1c(c(n(C)c(=O)n2C)=O)c2nc1 Cn1c(c(n(C)c(n2C)=O)=O)c2nc1 Cn(c1c2=O)cnc1n(c(n2C)=O)C Cn(c1c2=O)cnc1n(c(=O)n2C)C Cn(c1c2=O)cnc1n(C)c(n2C)=O Cn(c1c2=O)cnc1n(C)c(=O)n2C Cn(c1c(=O)n2C)cnc1n(c2=O)C Cn(c1c(=O)n2C)cnc1n(C)c2=O Cn(c1c(=O)n(c2=O)C)cnc1n2C Cn(c1c(=O)n(c(=O)n2C)C)cnc21 Cn(c1c(=O)n(c(=O)n2C)C)cnc12 Cn(c1c(=O)n(c(n2C)=O)C)cnc21 Cn(c1c(=O)n(c(n2C)=O)C)cnc12 Cn(c1c(=O)n(C)c2=O)cnc1n2C Cn(c1c(=O)n(C)c(=O)n2C)cnc21 Cn(c1c(=O)n(C)c(=O)n2C)cnc12 Cn(c1c(=O)n(C)c(n2C)=O)cnc21 Cn(c1c(=O)n(C)c(n2C)=O)cnc12 Cn(c1c(n2C)=O)cnc1n(c2=O)C Cn(c1c(n2C)=O)cnc1n(C)c2=O Cn(c1c(n(c2=O)C)=O)cnc1n2C Cn(c1c(n(c(=O)n2C)C)=O)cnc21 Cn(c1c(n(c(=O)n2C)C)=O)cnc12 Cn(c1c(n(c(n2C)=O)C)=O)cnc21 Cn(c1c(n(c(n2C)=O)C)=O)cnc12 Cn(c1c(n(C)c2=O)=O)cnc1n2C Cn(c1c(n(C)c(=O)n2C)=O)cnc21 Cn(c1c(n(C)c(=O)n2C)=O)cnc12 Cn(c1c(n(C)c(n2C)=O)=O)cnc21 Cn(c1c(n(C)c(n2C)=O)=O)cnc12 Cn(c1c2n(c(n(c1=O)C)=O)C)cn2 Cn(c1c2n(c(n(C)c1=O)=O)C)cn2 Cn(c1c2n(c(=O)n(c1=O)C)C)cn2 Cn(c1c2n(c(=O)n(C)c1=O)C)cn2 Cn(c1c2n(C)c(n(c1=O)C)=O)cn2 Cn(c1c2n(C)c(n(C)c1=O)=O)cn2 Cn(c1c2n(C)c(=O)n(c1=O)C)cn2 Cn(c1c2n(C)c(=O)n(C)c1=O)cn2 Cn(c(c1n2C)c(=O)n(c2=O)C)cn1 Cn(c(c1n2C)c(=O)n(C)c2=O)cn1 Cn(c(c1n2C)c(n(c2=O)C)=O)cn1 Cn(c(c1n2C)c(n(C)c2=O)=O)cn1 Cn(c(c1n(c2=O)C)c(=O)n2C)cn1 Cn(c(c1n(c2=O)C)c(n2C)=O)cn1 Cn(c(c1n(c(n2C)=O)C)c2=O)cn1 Cn(c(c1n(c(=O)n2C)C)c2=O)cn1 Cn(c(c1n(C)c2=O)c(=O)n2C)cn1 Cn(c(c1n(C)c2=O)c(n2C)=O)cn1 Cn(c(c1n(C)c(n2C)=O)c2=O)cn1 Cn(c(c1n(C)c(=O)n2C)c2=O)cn1 Cn(c(c1=O)c2n(c(n1C)=O)C)cn2 Cn(c(c1=O)c2n(c(=O)n1C)C)cn2 Cn(c(c1=O)c2n(C)c(n1C)=O)cn2 Cn(c(c1=O)c2n(C)c(=O)n1C)cn2 Cn(c(c(=O)n1C)c2n(c1=O)C)cn2 Cn(c(c(=O)n1C)c2n(C)c1=O)cn2 Cn(c(c(=O)n(c1=O)C)c2n1C)cn2 Cn(c(c(=O)n(C)c1=O)c2n1C)cn2 Cn(c(c(n1C)=O)c2n(c1=O)C)cn2 Cn(c(c(n1C)=O)c2n(C)c1=O)cn2 Cn(c(c(n(c1=O)C)=O)c2n1C)cn2 Cn(c(c(n(C)c1=O)=O)c2n1C)cn2 Cn(cnc1n2C)c1c(=O)n(c2=O)C Cn(cnc1n2C)c1c(=O)n(C)c2=O Cn(cnc1n2C)c1c(n(c2=O)C)=O Cn(cnc1n2C)c1c(n(C)c2=O)=O Cn(cnc1n(c2=O)C)c1c(=O)n2C Cn(cnc1n(c2=O)C)c1c(n2C)=O Cn(cnc1n(c(n2C)=O)C)c1c2=O Cn(cnc1n(c(n(c2=O)C)=O)C)c12 Cn(cnc1n(c(n(c2=O)C)=O)C)c21 Cn(cnc1n(c(n(C)c2=O)=O)C)c12 Cn(cnc1n(c(n(C)c2=O)=O)C)c21 Cn(cnc1n(c(=O)n2C)C)c1c2=O Cn(cnc1n(c(=O)n(c2=O)C)C)c12 Cn(cnc1n(c(=O)n(c2=O)C)C)c21 Cn(cnc1n(c(=O)n(C)c2=O)C)c12 Cn(cnc1n(c(=O)n(C)c2=O)C)c21 Cn(cnc1n(C)c2=O)c1c(=O)n2C Cn(cnc1n(C)c2=O)c1c(n2C)=O Cn(cnc1n(C)c(n2C)=O)c1c2=O Cn(cnc1n(C)c(n(c2=O)C)=O)c12 Cn(cnc1n(C)c(n(c2=O)C)=O)c21 Cn(cnc1n(C)c(n(C)c2=O)=O)c12 Cn(cnc1n(C)c(n(C)c2=O)=O)c21 Cn(cnc1n(C)c(=O)n2C)c1c2=O Cn(cnc1n(C)c(=O)n(c2=O)C)c12 Cn(cnc1n(C)c(=O)n(c2=O)C)c21 Cn(cnc1n(C)c(=O)n(C)c2=O)c12 Cn(cnc1n(C)c(=O)n(C)c2=O)c21 n1(C)cnc2c1c(=O)n(c(=O)n2C)C n1(C)cnc2c1c(=O)n(c(n2C)=O)C n1(C)cnc2c1c(=O)n(C)c(=O)n2C n1(C)cnc2c1c(=O)n(C)c(n2C)=O n1(C)cnc2c1c(n(c(=O)n2C)C)=O n1(C)cnc2c1c(n(c(n2C)=O)C)=O n1(C)cnc2c1c(n(C)c(=O)n2C)=O n1(C)cnc2c1c(n(C)c(n2C)=O)=O n1(C)cnc2n(c(n(c(c12)=O)C)=O)C n1(C)cnc2n(c(n(c(c21)=O)C)=O)C n1(C)cnc2n(c(n(c(=O)c12)C)=O)C n1(C)cnc2n(c(n(c(=O)c21)C)=O)C n1(C)cnc2n(c(n(C)c(c12)=O)=O)C n1(C)cnc2n(c(n(C)c(c21)=O)=O)C n1(C)cnc2n(c(n(C)c(=O)c12)=O)C n1(C)cnc2n(c(n(C)c(=O)c21)=O)C n1(C)cnc2n(c(=O)n(c(c12)=O)C)C n1(C)cnc2n(c(=O)n(c(c21)=O)C)C n1(C)cnc2n(c(=O)n(c(=O)c12)C)C n1(C)cnc2n(c(=O)n(c(=O)c21)C)C n1(C)cnc2n(c(=O)n(C)c(c12)=O)C n1(C)cnc2n(c(=O)n(C)c(c21)=O)C n1(C)cnc2n(c(=O)n(C)c(=O)c12)C n1(C)cnc2n(c(=O)n(C)c(=O)c21)C n1(C)cnc2n(C)c(n(c(c12)=O)C)=O n1(C)cnc2n(C)c(n(c(c21)=O)C)=O n1(C)cnc2n(C)c(n(c(=O)c12)C)=O n1(C)cnc2n(C)c(n(c(=O)c21)C)=O n1(C)cnc2n(C)c(n(C)c(c12)=O)=O n1(C)cnc2n(C)c(n(C)c(c21)=O)=O n1(C)cnc2n(C)c(n(C)c(=O)c12)=O n1(C)cnc2n(C)c(n(C)c(=O)c21)=O n1(C)cnc2n(C)c(=O)n(c(c12)=O)C n1(C)cnc2n(C)c(=O)n(c(c21)=O)C n1(C)cnc2n(C)c(=O)n(c(=O)c12)C n1(C)cnc2n(C)c(=O)n(c(=O)c21)C n1(C)cnc2n(C)c(=O)n(C)c(c12)=O n1(C)cnc2n(C)c(=O)n(C)c(c21)=O n1(C)cnc2n(C)c(=O)n(C)c(=O)c12 n1(C)cnc2n(C)c(=O)n(C)c(=O)c21 n1(C)cnc(n2C)c1c(=O)n(c2=O)C n1(C)cnc(n2C)c1c(=O)n(C)c2=O n1(C)cnc(n2C)c1c(n(c2=O)C)=O n1(C)cnc(n2C)c1c(n(C)c2=O)=O n1(C)cnc(n(c2=O)C)c1c(=O)n2C n1(C)cnc(n(c2=O)C)c1c(n2C)=O n1(C)cnc(n(c(n2C)=O)C)c1c2=O n1(C)cnc(n(c(n(c2=O)C)=O)C)c12 n1(C)cnc(n(c(n(c2=O)C)=O)C)c21 n1(C)cnc(n(c(n(C)c2=O)=O)C)c12 n1(C)cnc(n(c(n(C)c2=O)=O)C)c21 n1(C)cnc(n(c(=O)n2C)C)c1c2=O n1(C)cnc(n(c(=O)n(c2=O)C)C)c12 n1(C)cnc(n(c(=O)n(c2=O)C)C)c21 n1(C)cnc(n(c(=O)n(C)c2=O)C)c12 n1(C)cnc(n(c(=O)n(C)c2=O)C)c21 n1(C)cnc(n(C)c2=O)c1c(=O)n2C n1(C)cnc(n(C)c2=O)c1c(n2C)=O n1(C)cnc(n(C)c(n2C)=O)c1c2=O n1(C)cnc(n(C)c(n(c2=O)C)=O)c12 n1(C)cnc(n(C)c(n(c2=O)C)=O)c21 n1(C)cnc(n(C)c(n(C)c2=O)=O)c12 n1(C)cnc(n(C)c(n(C)c2=O)=O)c21 n1(C)cnc(n(C)c(=O)n2C)c1c2=O n1(C)cnc(n(C)c(=O)n(c2=O)C)c12 n1(C)cnc(n(C)c(=O)n(c2=O)C)c21 n1(C)cnc(n(C)c(=O)n(C)c2=O)c12 n1(C)cnc(n(C)c(=O)n(C)c2=O)c21 n1(C)cnc(c1c2=O)n(c(n2C)=O)C n1(C)cnc(c1c2=O)n(c(=O)n2C)C n1(C)cnc(c1c2=O)n(C)c(n2C)=O n1(C)cnc(c1c2=O)n(C)c(=O)n2C n1(C)cnc(c1c(=O)n2C)n(c2=O)C n1(C)cnc(c1c(=O)n2C)n(C)c2=O n1(C)cnc(c1c(=O)n(c2=O)C)n2C n1(C)cnc(c1c(=O)n(C)c2=O)n2C n1(C)cnc(c1c(n2C)=O)n(c2=O)C n1(C)cnc(c1c(n2C)=O)n(C)c2=O n1(C)cnc(c1c(n(c2=O)C)=O)n2C n1(C)cnc(c1c(n(C)c2=O)=O)n2C n1(cnc2c1c(=O)n(c(=O)n2C)C)C n1(cnc2c1c(=O)n(c(n2C)=O)C)C n1(cnc2c1c(=O)n(C)c(=O)n2C)C n1(cnc2c1c(=O)n(C)c(n2C)=O)C n1(cnc2c1c(n(c(=O)n2C)C)=O)C n1(cnc2c1c(n(c(n2C)=O)C)=O)C n1(cnc2c1c(n(C)c(=O)n2C)=O)C n1(cnc2c1c(n(C)c(n2C)=O)=O)C n1(cnc2n(c(n(c(c12)=O)C)=O)C)C n1(cnc2n(c(n(c(c21)=O)C)=O)C)C n1(cnc2n(c(n(c(=O)c12)C)=O)C)C n1(cnc2n(c(n(c(=O)c21)C)=O)C)C n1(cnc2n(c(n(C)c(c12)=O)=O)C)C n1(cnc2n(c(n(C)c(c21)=O)=O)C)C n1(cnc2n(c(n(C)c(=O)c12)=O)C)C n1(cnc2n(c(n(C)c(=O)c21)=O)C)C n1(cnc2n(c(=O)n(c(c12)=O)C)C)C n1(cnc2n(c(=O)n(c(c21)=O)C)C)C n1(cnc2n(c(=O)n(c(=O)c12)C)C)C n1(cnc2n(c(=O)n(c(=O)c21)C)C)C n1(cnc2n(c(=O)n(C)c(c12)=O)C)C n1(cnc2n(c(=O)n(C)c(c21)=O)C)C n1(cnc2n(c(=O)n(C)c(=O)c12)C)C n1(cnc2n(c(=O)n(C)c(=O)c21)C)C n1(cnc2n(C)c(n(c(c12)=O)C)=O)C n1(cnc2n(C)c(n(c(c21)=O)C)=O)C n1(cnc2n(C)c(n(c(=O)c12)C)=O)C n1(cnc2n(C)c(n(c(=O)c21)C)=O)C n1(cnc2n(C)c(n(C)c(c12)=O)=O)C n1(cnc2n(C)c(n(C)c(c21)=O)=O)C n1(cnc2n(C)c(n(C)c(=O)c12)=O)C n1(cnc2n(C)c(n(C)c(=O)c21)=O)C n1(cnc2n(C)c(=O)n(c(c12)=O)C)C n1(cnc2n(C)c(=O)n(c(c21)=O)C)C n1(cnc2n(C)c(=O)n(c(=O)c12)C)C n1(cnc2n(C)c(=O)n(c(=O)c21)C)C n1(cnc2n(C)c(=O)n(C)c(c12)=O)C n1(cnc2n(C)c(=O)n(C)c(c21)=O)C n1(cnc2n(C)c(=O)n(C)c(=O)c12)C n1(cnc2n(C)c(=O)n(C)c(=O)c21)C n1(cnc(n2C)c1c(=O)n(c2=O)C)C n1(cnc(n2C)c1c(=O)n(C)c2=O)C n1(cnc(n2C)c1c(n(c2=O)C)=O)C n1(cnc(n2C)c1c(n(C)c2=O)=O)C n1(cnc(n(c2=O)C)c1c(=O)n2C)C n1(cnc(n(c2=O)C)c1c(n2C)=O)C n1(cnc(n(c(n2C)=O)C)c1c2=O)C n1(cnc(n(c(n(c2=O)C)=O)C)c12)C n1(cnc(n(c(n(c2=O)C)=O)C)c21)C n1(cnc(n(c(n(C)c2=O)=O)C)c12)C n1(cnc(n(c(n(C)c2=O)=O)C)c21)C n1(cnc(n(c(=O)n2C)C)c1c2=O)C n1(cnc(n(c(=O)n(c2=O)C)C)c12)C n1(cnc(n(c(=O)n(c2=O)C)C)c21)C n1(cnc(n(c(=O)n(C)c2=O)C)c12)C n1(cnc(n(c(=O)n(C)c2=O)C)c21)C n1(cnc(n(C)c2=O)c1c(=O)n2C)C n1(cnc(n(C)c2=O)c1c(n2C)=O)C n1(cnc(n(C)c(n2C)=O)c1c2=O)C n1(cnc(n(C)c(n(c2=O)C)=O)c12)C n1(cnc(n(C)c(n(c2=O)C)=O)c21)C n1(cnc(n(C)c(n(C)c2=O)=O)c12)C n1(cnc(n(C)c(n(C)c2=O)=O)c21)C n1(cnc(n(C)c(=O)n2C)c1c2=O)C n1(cnc(n(C)c(=O)n(c2=O)C)c12)C n1(cnc(n(C)c(=O)n(c2=O)C)c21)C n1(cnc(n(C)c(=O)n(C)c2=O)c12)C n1(cnc(n(C)c(=O)n(C)c2=O)c21)C n1(cnc(c1c2=O)n(c(n2C)=O)C)C n1(cnc(c1c2=O)n(c(=O)n2C)C)C n1(cnc(c1c2=O)n(C)c(n2C)=O)C n1(cnc(c1c2=O)n(C)c(=O)n2C)C n1(cnc(c1c(=O)n2C)n(c2=O)C)C n1(cnc(c1c(=O)n2C)n(C)c2=O)C n1(cnc(c1c(=O)n(c2=O)C)n2C)C n1(cnc(c1c(=O)n(C)c2=O)n2C)C n1(cnc(c1c(n2C)=O)n(c2=O)C)C n1(cnc(c1c(n2C)=O)n(C)c2=O)C n1(cnc(c1c(n(c2=O)C)=O)n2C)C n1(cnc(c1c(n(C)c2=O)=O)n2C)C n1(C)c2c(=O)n(c(=O)n(c2nc1)C)C n1(C)c2c(=O)n(c(=O)n(C)c2nc1)C n1(C)c2c(=O)n(c(n(c2nc1)C)=O)C n1(C)c2c(=O)n(c(n(C)c2nc1)=O)C n1(C)c2c(=O)n(C)c(=O)n(c2nc1)C n1(C)c2c(=O)n(C)c(=O)n(C)c2nc1 n1(C)c2c(=O)n(C)c(n(c2nc1)C)=O n1(C)c2c(=O)n(C)c(n(C)c2nc1)=O n1(C)c2c(n(c(=O)n(c2nc1)C)C)=O n1(C)c2c(n(c(=O)n(C)c2nc1)C)=O n1(C)c2c(n(c(n(c2nc1)C)=O)C)=O n1(C)c2c(n(c(n(C)c2nc1)=O)C)=O n1(C)c2c(n(C)c(=O)n(c2nc1)C)=O n1(C)c2c(n(C)c(=O)n(C)c2nc1)=O n1(C)c2c(n(C)c(n(c2nc1)C)=O)=O n1(C)c2c(n(C)c(n(C)c2nc1)=O)=O n1(C)c2c(nc1)n(c(n(c2=O)C)=O)C n1(C)c2c(nc1)n(c(n(C)c2=O)=O)C n1(C)c2c(nc1)n(c(=O)n(c2=O)C)C n1(C)c2c(nc1)n(c(=O)n(C)c2=O)C n1(C)c2c(nc1)n(C)c(n(c2=O)C)=O n1(C)c2c(nc1)n(C)c(n(C)c2=O)=O n1(C)c2c(nc1)n(C)c(=O)n(c2=O)C n1(C)c2c(nc1)n(C)c(=O)n(C)c2=O n1(C)c2c(n(c(n(c2=O)C)=O)C)nc1 n1(C)c2c(n(c(n(C)c2=O)=O)C)nc1 n1(C)c2c(n(c(=O)n(c2=O)C)C)nc1 n1(C)c2c(n(c(=O)n(C)c2=O)C)nc1 n1(C)c2c(n(C)c(n(c2=O)C)=O)nc1 n1(C)c2c(n(C)c(n(C)c2=O)=O)nc1 n1(C)c2c(n(C)c(=O)n(c2=O)C)nc1 n1(C)c2c(n(C)c(=O)n(C)c2=O)nc1 n1(C)c(c2nc1)c(=O)n(c(=O)n2C)C n1(C)c(c2nc1)c(=O)n(c(n2C)=O)C n1(C)c(c2nc1)c(=O)n(C)c(=O)n2C n1(C)c(c2nc1)c(=O)n(C)c(n2C)=O n1(C)c(c2nc1)c(n(c(=O)n2C)C)=O n1(C)c(c2nc1)c(n(c(n2C)=O)C)=O n1(C)c(c2nc1)c(n(C)c(=O)n2C)=O n1(C)c(c2nc1)c(n(C)c(n2C)=O)=O n1(C)c(c(nc1)n2C)c(=O)n(c2=O)C n1(C)c(c(nc1)n2C)c(=O)n(C)c2=O n1(C)c(c(nc1)n2C)c(n(c2=O)C)=O n1(C)c(c(nc1)n2C)c(n(C)c2=O)=O n1(C)c(c(nc1)n(c2=O)C)c(=O)n2C n1(C)c(c(nc1)n(c2=O)C)c(n2C)=O n1(C)c(c(nc1)n(c(n2C)=O)C)c2=O n1(C)c(c(nc1)n(c(=O)n2C)C)c2=O n1(C)c(c(nc1)n(C)c2=O)c(=O)n2C n1(C)c(c(nc1)n(C)c2=O)c(n2C)=O n1(C)c(c(nc1)n(C)c(n2C)=O)c2=O n1(C)c(c(nc1)n(C)c(=O)n2C)c2=O n1(C)c(c(n2C)nc1)c(=O)n(c2=O)C n1(C)c(c(n2C)nc1)c(=O)n(C)c2=O n1(C)c(c(n2C)nc1)c(n(c2=O)C)=O n1(C)c(c(n2C)nc1)c(n(C)c2=O)=O n1(C)c(c(n(c2=O)C)nc1)c(=O)n2C n1(C)c(c(n(c2=O)C)nc1)c(n2C)=O n1(C)c(c(n(c(n2C)=O)C)nc1)c2=O n1(C)c(c(n(c(=O)n2C)C)nc1)c2=O n1(C)c(c(n(C)c2=O)nc1)c(=O)n2C n1(C)c(c(n(C)c2=O)nc1)c(n2C)=O n1(C)c(c(n(C)c(n2C)=O)nc1)c2=O n1(C)c(c(n(C)c(=O)n2C)nc1)c2=O n1(C)c(c2=O)c(nc1)n(c(n2C)=O)C n1(C)c(c2=O)c(nc1)n(c(=O)n2C)C n1(C)c(c2=O)c(nc1)n(C)c(n2C)=O n1(C)c(c2=O)c(nc1)n(C)c(=O)n2C n1(C)c(c2=O)c(n(c(n2C)=O)C)nc1 n1(C)c(c2=O)c(n(c(=O)n2C)C)nc1 n1(C)c(c2=O)c(n(C)c(n2C)=O)nc1 n1(C)c(c2=O)c(n(C)c(=O)n2C)nc1 n1(C)c(c(=O)n2C)c(nc1)n(c2=O)C n1(C)c(c(=O)n2C)c(nc1)n(C)c2=O n1(C)c(c(=O)n2C)c(n(c2=O)C)nc1 n1(C)c(c(=O)n2C)c(n(C)c2=O)nc1 n1(C)c(c(=O)n(c2=O)C)c(nc1)n2C n1(C)c(c(=O)n(c2=O)C)c(n2C)nc1 n1(C)c(c(=O)n(c(=O)n2C)C)c2nc1 n1(C)c(c(=O)n(c(n2C)=O)C)c2nc1 n1(C)c(c(=O)n(C)c2=O)c(nc1)n2C n1(C)c(c(=O)n(C)c2=O)c(n2C)nc1 n1(C)c(c(=O)n(C)c(=O)n2C)c2nc1 n1(C)c(c(=O)n(C)c(n2C)=O)c2nc1 n1(C)c(c(n2C)=O)c(nc1)n(c2=O)C n1(C)c(c(n2C)=O)c(nc1)n(C)c2=O n1(C)c(c(n2C)=O)c(n(c2=O)C)nc1 n1(C)c(c(n2C)=O)c(n(C)c2=O)nc1 n1(C)c(c(n(c2=O)C)=O)c(nc1)n2C n1(C)c(c(n(c2=O)C)=O)c(n2C)nc1 n1(C)c(c(n(c(=O)n2C)C)=O)c2nc1 n1(C)c(c(n(c(n2C)=O)C)=O)c2nc1 n1(C)c(c(n(C)c2=O)=O)c(nc1)n2C n1(C)c(c(n(C)c2=O)=O)c(n2C)nc1 n1(C)c(c(n(C)c(=O)n2C)=O)c2nc1 n1(C)c(c(n(C)c(n2C)=O)=O)c2nc1 n1(c2c(=O)n(c(=O)n(c2nc1)C)C)C n1(c2c(=O)n(c(=O)n(C)c2nc1)C)C n1(c2c(=O)n(c(n(c2nc1)C)=O)C)C n1(c2c(=O)n(c(n(C)c2nc1)=O)C)C n1(c2c(=O)n(C)c(=O)n(c2nc1)C)C n1(c2c(=O)n(C)c(=O)n(C)c2nc1)C n1(c2c(=O)n(C)c(n(c2nc1)C)=O)C n1(c2c(=O)n(C)c(n(C)c2nc1)=O)C n1(c2c(n(c(=O)n(c2nc1)C)C)=O)C n1(c2c(n(c(=O)n(C)c2nc1)C)=O)C n1(c2c(n(c(n(c2nc1)C)=O)C)=O)C n1(c2c(n(c(n(C)c2nc1)=O)C)=O)C n1(c2c(n(C)c(=O)n(c2nc1)C)=O)C n1(c2c(n(C)c(=O)n(C)c2nc1)=O)C n1(c2c(n(C)c(n(c2nc1)C)=O)=O)C n1(c2c(n(C)c(n(C)c2nc1)=O)=O)C n1(c2c(nc1)n(c(n(c2=O)C)=O)C)C n1(c2c(nc1)n(c(n(C)c2=O)=O)C)C n1(c2c(nc1)n(c(=O)n(c2=O)C)C)C n1(c2c(nc1)n(c(=O)n(C)c2=O)C)C n1(c2c(nc1)n(C)c(n(c2=O)C)=O)C n1(c2c(nc1)n(C)c(n(C)c2=O)=O)C n1(c2c(nc1)n(C)c(=O)n(c2=O)C)C n1(c2c(nc1)n(C)c(=O)n(C)c2=O)C n1(c2c(n(c(n(c2=O)C)=O)C)nc1)C n1(c2c(n(c(n(C)c2=O)=O)C)nc1)C n1(c2c(n(c(=O)n(c2=O)C)C)nc1)C n1(c2c(n(c(=O)n(C)c2=O)C)nc1)C n1(c2c(n(C)c(n(c2=O)C)=O)nc1)C n1(c2c(n(C)c(n(C)c2=O)=O)nc1)C n1(c2c(n(C)c(=O)n(c2=O)C)nc1)C n1(c2c(n(C)c(=O)n(C)c2=O)nc1)C n1(c(c2nc1)c(=O)n(c(=O)n2C)C)C n1(c(c2nc1)c(=O)n(c(n2C)=O)C)C n1(c(c2nc1)c(=O)n(C)c(=O)n2C)C n1(c(c2nc1)c(=O)n(C)c(n2C)=O)C n1(c(c2nc1)c(n(c(=O)n2C)C)=O)C n1(c(c2nc1)c(n(c(n2C)=O)C)=O)C n1(c(c2nc1)c(n(C)c(=O)n2C)=O)C n1(c(c2nc1)c(n(C)c(n2C)=O)=O)C n1(c(c(nc1)n2C)c(=O)n(c2=O)C)C n1(c(c(nc1)n2C)c(=O)n(C)c2=O)C n1(c(c(nc1)n2C)c(n(c2=O)C)=O)C n1(c(c(nc1)n2C)c(n(C)c2=O)=O)C n1(c(c(nc1)n(c2=O)C)c(=O)n2C)C n1(c(c(nc1)n(c2=O)C)c(n2C)=O)C n1(c(c(nc1)n(c(n2C)=O)C)c2=O)C n1(c(c(nc1)n(c(=O)n2C)C)c2=O)C n1(c(c(nc1)n(C)c2=O)c(=O)n2C)C n1(c(c(nc1)n(C)c2=O)c(n2C)=O)C n1(c(c(nc1)n(C)c(n2C)=O)c2=O)C n1(c(c(nc1)n(C)c(=O)n2C)c2=O)C n1(c(c(n2C)nc1)c(=O)n(c2=O)C)C n1(c(c(n2C)nc1)c(=O)n(C)c2=O)C n1(c(c(n2C)nc1)c(n(c2=O)C)=O)C n1(c(c(n2C)nc1)c(n(C)c2=O)=O)C n1(c(c(n(c2=O)C)nc1)c(=O)n2C)C n1(c(c(n(c2=O)C)nc1)c(n2C)=O)C n1(c(c(n(c(n2C)=O)C)nc1)c2=O)C n1(c(c(n(c(=O)n2C)C)nc1)c2=O)C n1(c(c(n(C)c2=O)nc1)c(=O)n2C)C n1(c(c(n(C)c2=O)nc1)c(n2C)=O)C n1(c(c(n(C)c(n2C)=O)nc1)c2=O)C n1(c(c(n(C)c(=O)n2C)nc1)c2=O)C n1(c(c2=O)c(nc1)n(c(n2C)=O)C)C n1(c(c2=O)c(nc1)n(c(=O)n2C)C)C n1(c(c2=O)c(nc1)n(C)c(n2C)=O)C n1(c(c2=O)c(nc1)n(C)c(=O)n2C)C n1(c(c2=O)c(n(c(n2C)=O)C)nc1)C n1(c(c2=O)c(n(c(=O)n2C)C)nc1)C n1(c(c2=O)c(n(C)c(n2C)=O)nc1)C n1(c(c2=O)c(n(C)c(=O)n2C)nc1)C n1(c(c(=O)n2C)c(nc1)n(c2=O)C)C n1(c(c(=O)n2C)c(nc1)n(C)c2=O)C n1(c(c(=O)n2C)c(n(c2=O)C)nc1)C n1(c(c(=O)n2C)c(n(C)c2=O)nc1)C n1(c(c(=O)n(c2=O)C)c(nc1)n2C)C n1(c(c(=O)n(c2=O)C)c(n2C)nc1)C n1(c(c(=O)n(c(=O)n2C)C)c2nc1)C n1(c(c(=O)n(c(n2C)=O)C)c2nc1)C n1(c(c(=O)n(C)c2=O)c(nc1)n2C)C n1(c(c(=O)n(C)c2=O)c(n2C)nc1)C n1(c(c(=O)n(C)c(=O)n2C)c2nc1)C n1(c(c(=O)n(C)c(n2C)=O)c2nc1)C n1(c(c(n2C)=O)c(nc1)n(c2=O)C)C n1(c(c(n2C)=O)c(nc1)n(C)c2=O)C n1(c(c(n2C)=O)c(n(c2=O)C)nc1)C n1(c(c(n2C)=O)c(n(C)c2=O)nc1)C n1(c(c(n(c2=O)C)=O)c(nc1)n2C)C n1(c(c(n(c2=O)C)=O)c(n2C)nc1)C n1(c(c(n(c(=O)n2C)C)=O)c2nc1)C n1(c(c(n(c(n2C)=O)C)=O)c2nc1)C n1(c(c(n(C)c2=O)=O)c(nc1)n2C)C n1(c(c(n(C)c2=O)=O)c(n2C)nc1)C n1(c(c(n(C)c(=O)n2C)=O)c2nc1)C n1(c(c(n(C)c(n2C)=O)=O)c2nc1)C c1nc2c(n1C)c(=O)n(c(=O)n2C)C c1nc2c(n1C)c(=O)n(c(n2C)=O)C c1nc2c(n1C)c(=O)n(C)c(=O)n2C c1nc2c(n1C)c(=O)n(C)c(n2C)=O c1nc2c(n1C)c(n(c(=O)n2C)C)=O c1nc2c(n1C)c(n(c(n2C)=O)C)=O c1nc2c(n1C)c(n(C)c(=O)n2C)=O c1nc2c(n1C)c(n(C)c(n2C)=O)=O c1nc2c(c(=O)n(c(=O)n2C)C)n1C c1nc2c(c(=O)n(c(n2C)=O)C)n1C c1nc2c(c(=O)n(C)c(=O)n2C)n1C c1nc2c(c(=O)n(C)c(n2C)=O)n1C c1nc2c(c(n(c(=O)n2C)C)=O)n1C c1nc2c(c(n(c(n2C)=O)C)=O)n1C c1nc2c(c(n(C)c(=O)n2C)=O)n1C c1nc2c(c(n(C)c(n2C)=O)=O)n1C c1nc2n(c(n(c(c2n1C)=O)C)=O)C c1nc2n(c(n(c(=O)c2n1C)C)=O)C c1nc2n(c(n(C)c(c2n1C)=O)=O)C c1nc2n(c(n(C)c(=O)c2n1C)=O)C c1nc2n(c(=O)n(c(c2n1C)=O)C)C c1nc2n(c(=O)n(c(=O)c2n1C)C)C c1nc2n(c(=O)n(C)c(c2n1C)=O)C c1nc2n(c(=O)n(C)c(=O)c2n1C)C c1nc2n(C)c(n(c(c2n1C)=O)C)=O c1nc2n(C)c(n(c(=O)c2n1C)C)=O c1nc2n(C)c(n(C)c(c2n1C)=O)=O c1nc2n(C)c(n(C)c(=O)c2n1C)=O c1nc2n(C)c(=O)n(c(c2n1C)=O)C c1nc2n(C)c(=O)n(c(=O)c2n1C)C c1nc2n(C)c(=O)n(C)c(c2n1C)=O c1nc2n(C)c(=O)n(C)c(=O)c2n1C c1nc(n2C)c(n1C)c(=O)n(c2=O)C c1nc(n2C)c(n1C)c(=O)n(C)c2=O c1nc(n2C)c(n1C)c(n(c2=O)C)=O c1nc(n2C)c(n1C)c(n(C)c2=O)=O c1nc(n2C)c(c(=O)n(c2=O)C)n1C c1nc(n2C)c(c(=O)n(C)c2=O)n1C c1nc(n2C)c(c(n(c2=O)C)=O)n1C c1nc(n2C)c(c(n(C)c2=O)=O)n1C c1nc(n(c2=O)C)c(n1C)c(=O)n2C c1nc(n(c2=O)C)c(n1C)c(n2C)=O c1nc(n(c2=O)C)c(c(=O)n2C)n1C c1nc(n(c2=O)C)c(c(n2C)=O)n1C c1nc(n(c(n2C)=O)C)c(n1C)c2=O c1nc(n(c(n2C)=O)C)c(c2=O)n1C c1nc(n(c(n(c2=O)C)=O)C)c2n1C c1nc(n(c(n(C)c2=O)=O)C)c2n1C c1nc(n(c(=O)n2C)C)c(n1C)c2=O c1nc(n(c(=O)n2C)C)c(c2=O)n1C c1nc(n(c(=O)n(c2=O)C)C)c2n1C c1nc(n(c(=O)n(C)c2=O)C)c2n1C c1nc(n(C)c2=O)c(n1C)c(=O)n2C c1nc(n(C)c2=O)c(n1C)c(n2C)=O c1nc(n(C)c2=O)c(c(=O)n2C)n1C c1nc(n(C)c2=O)c(c(n2C)=O)n1C c1nc(n(C)c(n2C)=O)c(n1C)c2=O c1nc(n(C)c(n2C)=O)c(c2=O)n1C c1nc(n(C)c(n(c2=O)C)=O)c2n1C c1nc(n(C)c(n(C)c2=O)=O)c2n1C c1nc(n(C)c(=O)n2C)c(n1C)c2=O c1nc(n(C)c(=O)n2C)c(c2=O)n1C c1nc(n(C)c(=O)n(c2=O)C)c2n1C c1nc(n(C)c(=O)n(C)c2=O)c2n1C c1nc(c2n1C)n(c(n(c2=O)C)=O)C c1nc(c2n1C)n(c(n(C)c2=O)=O)C c1nc(c2n1C)n(c(=O)n(c2=O)C)C c1nc(c2n1C)n(c(=O)n(C)c2=O)C c1nc(c2n1C)n(C)c(n(c2=O)C)=O c1nc(c2n1C)n(C)c(n(C)c2=O)=O c1nc(c2n1C)n(C)c(=O)n(c2=O)C c1nc(c2n1C)n(C)c(=O)n(C)c2=O c1nc(c(n1C)c2=O)n(c(n2C)=O)C c1nc(c(n1C)c2=O)n(c(=O)n2C)C c1nc(c(n1C)c2=O)n(C)c(n2C)=O c1nc(c(n1C)c2=O)n(C)c(=O)n2C c1nc(c(n1C)c(=O)n2C)n(c2=O)C c1nc(c(n1C)c(=O)n2C)n(C)c2=O c1nc(c(n1C)c(=O)n(c2=O)C)n2C c1nc(c(n1C)c(=O)n(C)c2=O)n2C c1nc(c(n1C)c(n2C)=O)n(c2=O)C c1nc(c(n1C)c(n2C)=O)n(C)c2=O c1nc(c(n1C)c(n(c2=O)C)=O)n2C c1nc(c(n1C)c(n(C)c2=O)=O)n2C c1nc(c(c2=O)n1C)n(c(n2C)=O)C c1nc(c(c2=O)n1C)n(c(=O)n2C)C c1nc(c(c2=O)n1C)n(C)c(n2C)=O c1nc(c(c2=O)n1C)n(C)c(=O)n2C c1nc(c(c(=O)n2C)n1C)n(c2=O)C c1nc(c(c(=O)n2C)n1C)n(C)c2=O c1nc(c(c(=O)n(c2=O)C)n1C)n2C c1nc(c(c(=O)n(C)c2=O)n1C)n2C c1nc(c(c(n2C)=O)n1C)n(c2=O)C c1nc(c(c(n2C)=O)n1C)n(C)c2=O c1nc(c(c(n(c2=O)C)=O)n1C)n2C c1nc(c(c(n(C)c2=O)=O)n1C)n2C c1n(C)c2c(=O)n(c(=O)n(c2n1)C)C c1n(C)c2c(=O)n(c(=O)n(C)c2n1)C c1n(C)c2c(=O)n(c(n(c2n1)C)=O)C c1n(C)c2c(=O)n(c(n(C)c2n1)=O)C c1n(C)c2c(=O)n(C)c(=O)n(c2n1)C c1n(C)c2c(=O)n(C)c(=O)n(C)c2n1 c1n(C)c2c(=O)n(C)c(n(c2n1)C)=O c1n(C)c2c(=O)n(C)c(n(C)c2n1)=O c1n(C)c2c(n(c(=O)n(c2n1)C)C)=O c1n(C)c2c(n(c(=O)n(C)c2n1)C)=O c1n(C)c2c(n(c(n(c2n1)C)=O)C)=O c1n(C)c2c(n(c(n(C)c2n1)=O)C)=O c1n(C)c2c(n(C)c(=O)n(c2n1)C)=O c1n(C)c2c(n(C)c(=O)n(C)c2n1)=O c1n(C)c2c(n(C)c(n(c2n1)C)=O)=O c1n(C)c2c(n(C)c(n(C)c2n1)=O)=O c1n(C)c2c(n1)n(c(n(c2=O)C)=O)C c1n(C)c2c(n1)n(c(n(C)c2=O)=O)C c1n(C)c2c(n1)n(c(=O)n(c2=O)C)C c1n(C)c2c(n1)n(c(=O)n(C)c2=O)C c1n(C)c2c(n1)n(C)c(n(c2=O)C)=O c1n(C)c2c(n1)n(C)c(n(C)c2=O)=O c1n(C)c2c(n1)n(C)c(=O)n(c2=O)C c1n(C)c2c(n1)n(C)c(=O)n(C)c2=O c1n(C)c2c(n(c(n(c2=O)C)=O)C)n1 c1n(C)c2c(n(c(n(C)c2=O)=O)C)n1 c1n(C)c2c(n(c(=O)n(c2=O)C)C)n1 c1n(C)c2c(n(c(=O)n(C)c2=O)C)n1 c1n(C)c2c(n(C)c(n(c2=O)C)=O)n1 c1n(C)c2c(n(C)c(n(C)c2=O)=O)n1 c1n(C)c2c(n(C)c(=O)n(c2=O)C)n1 c1n(C)c2c(n(C)c(=O)n(C)c2=O)n1 c1n(C)c(c2n1)c(=O)n(c(=O)n2C)C c1n(C)c(c2n1)c(=O)n(c(n2C)=O)C c1n(C)c(c2n1)c(=O)n(C)c(=O)n2C c1n(C)c(c2n1)c(=O)n(C)c(n2C)=O c1n(C)c(c2n1)c(n(c(=O)n2C)C)=O c1n(C)c(c2n1)c(n(c(n2C)=O)C)=O c1n(C)c(c2n1)c(n(C)c(=O)n2C)=O c1n(C)c(c2n1)c(n(C)c(n2C)=O)=O c1n(C)c(c(n1)n2C)c(=O)n(c2=O)C c1n(C)c(c(n1)n2C)c(=O)n(C)c2=O c1n(C)c(c(n1)n2C)c(n(c2=O)C)=O c1n(C)c(c(n1)n2C)c(n(C)c2=O)=O c1n(C)c(c(n1)n(c2=O)C)c(=O)n2C c1n(C)c(c(n1)n(c2=O)C)c(n2C)=O c1n(C)c(c(n1)n(c(n2C)=O)C)c2=O c1n(C)c(c(n1)n(c(=O)n2C)C)c2=O c1n(C)c(c(n1)n(C)c2=O)c(=O)n2C c1n(C)c(c(n1)n(C)c2=O)c(n2C)=O c1n(C)c(c(n1)n(C)c(n2C)=O)c2=O c1n(C)c(c(n1)n(C)c(=O)n2C)c2=O c1n(C)c(c(n2C)n1)c(=O)n(c2=O)C c1n(C)c(c(n2C)n1)c(=O)n(C)c2=O c1n(C)c(c(n2C)n1)c(n(c2=O)C)=O c1n(C)c(c(n2C)n1)c(n(C)c2=O)=O c1n(C)c(c(n(c2=O)C)n1)c(=O)n2C c1n(C)c(c(n(c2=O)C)n1)c(n2C)=O c1n(C)c(c(n(c(n2C)=O)C)n1)c2=O c1n(C)c(c(n(c(=O)n2C)C)n1)c2=O c1n(C)c(c(n(C)c2=O)n1)c(=O)n2C c1n(C)c(c(n(C)c2=O)n1)c(n2C)=O c1n(C)c(c(n(C)c(n2C)=O)n1)c2=O c1n(C)c(c(n(C)c(=O)n2C)n1)c2=O c1n(C)c(c2=O)c(n1)n(c(n2C)=O)C c1n(C)c(c2=O)c(n1)n(c(=O)n2C)C c1n(C)c(c2=O)c(n1)n(C)c(n2C)=O c1n(C)c(c2=O)c(n1)n(C)c(=O)n2C c1n(C)c(c2=O)c(n(c(n2C)=O)C)n1 c1n(C)c(c2=O)c(n(c(=O)n2C)C)n1 c1n(C)c(c2=O)c(n(C)c(n2C)=O)n1 c1n(C)c(c2=O)c(n(C)c(=O)n2C)n1 c1n(C)c(c(=O)n2C)c(n1)n(c2=O)C c1n(C)c(c(=O)n2C)c(n1)n(C)c2=O c1n(C)c(c(=O)n2C)c(n(c2=O)C)n1 c1n(C)c(c(=O)n2C)c(n(C)c2=O)n1 c1n(C)c(c(=O)n(c2=O)C)c(n1)n2C c1n(C)c(c(=O)n(c2=O)C)c(n2C)n1 c1n(C)c(c(=O)n(c(=O)n2C)C)c2n1 c1n(C)c(c(=O)n(c(n2C)=O)C)c2n1 c1n(C)c(c(=O)n(C)c2=O)c(n1)n2C c1n(C)c(c(=O)n(C)c2=O)c(n2C)n1 c1n(C)c(c(=O)n(C)c(=O)n2C)c2n1 c1n(C)c(c(=O)n(C)c(n2C)=O)c2n1 c1n(C)c(c(n2C)=O)c(n1)n(c2=O)C c1n(C)c(c(n2C)=O)c(n1)n(C)c2=O c1n(C)c(c(n2C)=O)c(n(c2=O)C)n1 c1n(C)c(c(n2C)=O)c(n(C)c2=O)n1 c1n(C)c(c(n(c2=O)C)=O)c(n1)n2C c1n(C)c(c(n(c2=O)C)=O)c(n2C)n1 c1n(C)c(c(n(c(=O)n2C)C)=O)c2n1 c1n(C)c(c(n(c(n2C)=O)C)=O)c2n1 c1n(C)c(c(n(C)c2=O)=O)c(n1)n2C c1n(C)c(c(n(C)c2=O)=O)c(n2C)n1 c1n(C)c(c(n(C)c(=O)n2C)=O)c2n1 c1n(C)c(c(n(C)c(n2C)=O)=O)c2n1 c1n(c2c(=O)n(c(=O)n(c2n1)C)C)C c1n(c2c(=O)n(c(=O)n(C)c2n1)C)C c1n(c2c(=O)n(c(n(c2n1)C)=O)C)C c1n(c2c(=O)n(c(n(C)c2n1)=O)C)C c1n(c2c(=O)n(C)c(=O)n(c2n1)C)C c1n(c2c(=O)n(C)c(=O)n(C)c2n1)C c1n(c2c(=O)n(C)c(n(c2n1)C)=O)C c1n(c2c(=O)n(C)c(n(C)c2n1)=O)C c1n(c2c(n(c(=O)n(c2n1)C)C)=O)C c1n(c2c(n(c(=O)n(C)c2n1)C)=O)C c1n(c2c(n(c(n(c2n1)C)=O)C)=O)C c1n(c2c(n(c(n(C)c2n1)=O)C)=O)C c1n(c2c(n(C)c(=O)n(c2n1)C)=O)C c1n(c2c(n(C)c(=O)n(C)c2n1)=O)C c1n(c2c(n(C)c(n(c2n1)C)=O)=O)C c1n(c2c(n(C)c(n(C)c2n1)=O)=O)C c1n(c2c(n1)n(c(n(c2=O)C)=O)C)C c1n(c2c(n1)n(c(n(C)c2=O)=O)C)C c1n(c2c(n1)n(c(=O)n(c2=O)C)C)C c1n(c2c(n1)n(c(=O)n(C)c2=O)C)C c1n(c2c(n1)n(C)c(n(c2=O)C)=O)C c1n(c2c(n1)n(C)c(n(C)c2=O)=O)C c1n(c2c(n1)n(C)c(=O)n(c2=O)C)C c1n(c2c(n1)n(C)c(=O)n(C)c2=O)C c1n(c2c(n(c(n(c2=O)C)=O)C)n1)C c1n(c2c(n(c(n(C)c2=O)=O)C)n1)C c1n(c2c(n(c(=O)n(c2=O)C)C)n1)C c1n(c2c(n(c(=O)n(C)c2=O)C)n1)C c1n(c2c(n(C)c(n(c2=O)C)=O)n1)C c1n(c2c(n(C)c(n(C)c2=O)=O)n1)C c1n(c2c(n(C)c(=O)n(c2=O)C)n1)C c1n(c2c(n(C)c(=O)n(C)c2=O)n1)C c1n(c(c2n1)c(=O)n(c(=O)n2C)C)C c1n(c(c2n1)c(=O)n(c(n2C)=O)C)C c1n(c(c2n1)c(=O)n(C)c(=O)n2C)C c1n(c(c2n1)c(=O)n(C)c(n2C)=O)C c1n(c(c2n1)c(n(c(=O)n2C)C)=O)C c1n(c(c2n1)c(n(c(n2C)=O)C)=O)C c1n(c(c2n1)c(n(C)c(=O)n2C)=O)C c1n(c(c2n1)c(n(C)c(n2C)=O)=O)C c1n(c(c(n1)n2C)c(=O)n(c2=O)C)C c1n(c(c(n1)n2C)c(=O)n(C)c2=O)C c1n(c(c(n1)n2C)c(n(c2=O)C)=O)C c1n(c(c(n1)n2C)c(n(C)c2=O)=O)C c1n(c(c(n1)n(c2=O)C)c(=O)n2C)C c1n(c(c(n1)n(c2=O)C)c(n2C)=O)C c1n(c(c(n1)n(c(n2C)=O)C)c2=O)C c1n(c(c(n1)n(c(=O)n2C)C)c2=O)C c1n(c(c(n1)n(C)c2=O)c(=O)n2C)C c1n(c(c(n1)n(C)c2=O)c(n2C)=O)C c1n(c(c(n1)n(C)c(n2C)=O)c2=O)C c1n(c(c(n1)n(C)c(=O)n2C)c2=O)C c1n(c(c(n2C)n1)c(=O)n(c2=O)C)C c1n(c(c(n2C)n1)c(=O)n(C)c2=O)C c1n(c(c(n2C)n1)c(n(c2=O)C)=O)C c1n(c(c(n2C)n1)c(n(C)c2=O)=O)C c1n(c(c(n(c2=O)C)n1)c(=O)n2C)C c1n(c(c(n(c2=O)C)n1)c(n2C)=O)C c1n(c(c(n(c(n2C)=O)C)n1)c2=O)C c1n(c(c(n(c(=O)n2C)C)n1)c2=O)C c1n(c(c(n(C)c2=O)n1)c(=O)n2C)C c1n(c(c(n(C)c2=O)n1)c(n2C)=O)C c1n(c(c(n(C)c(n2C)=O)n1)c2=O)C c1n(c(c(n(C)c(=O)n2C)n1)c2=O)C c1n(c(c2=O)c(n1)n(c(n2C)=O)C)C c1n(c(c2=O)c(n1)n(c(=O)n2C)C)C c1n(c(c2=O)c(n1)n(C)c(n2C)=O)C c1n(c(c2=O)c(n1)n(C)c(=O)n2C)C c1n(c(c2=O)c(n(c(n2C)=O)C)n1)C c1n(c(c2=O)c(n(c(=O)n2C)C)n1)C c1n(c(c2=O)c(n(C)c(n2C)=O)n1)C c1n(c(c2=O)c(n(C)c(=O)n2C)n1)C c1n(c(c(=O)n2C)c(n1)n(c2=O)C)C c1n(c(c(=O)n2C)c(n1)n(C)c2=O)C c1n(c(c(=O)n2C)c(n(c2=O)C)n1)C c1n(c(c(=O)n2C)c(n(C)c2=O)n1)C c1n(c(c(=O)n(c2=O)C)c(n1)n2C)C c1n(c(c(=O)n(c2=O)C)c(n2C)n1)C c1n(c(c(=O)n(c(=O)n2C)C)c2n1)C c1n(c(c(=O)n(c(n2C)=O)C)c2n1)C c1n(c(c(=O)n(C)c2=O)c(n1)n2C)C c1n(c(c(=O)n(C)c2=O)c(n2C)n1)C c1n(c(c(=O)n(C)c(=O)n2C)c2n1)C c1n(c(c(=O)n(C)c(n2C)=O)c2n1)C c1n(c(c(n2C)=O)c(n1)n(c2=O)C)C c1n(c(c(n2C)=O)c(n1)n(C)c2=O)C c1n(c(c(n2C)=O)c(n(c2=O)C)n1)C c1n(c(c(n2C)=O)c(n(C)c2=O)n1)C c1n(c(c(n(c2=O)C)=O)c(n1)n2C)C c1n(c(c(n(c2=O)C)=O)c(n2C)n1)C c1n(c(c(n(c(=O)n2C)C)=O)c2n1)C c1n(c(c(n(c(n2C)=O)C)=O)c2n1)C c1n(c(c(n(C)c2=O)=O)c(n1)n2C)C c1n(c(c(n(C)c2=O)=O)c(n2C)n1)C c1n(c(c(n(C)c(=O)n2C)=O)c2n1)C c1n(c(c(n(C)c(n2C)=O)=O)c2n1)C c(n1C)nc2c1c(=O)n(c(=O)n2C)C c(n1C)nc2c1c(=O)n(c(n2C)=O)C c(n1C)nc2c1c(=O)n(C)c(=O)n2C c(n1C)nc2c1c(=O)n(C)c(n2C)=O c(n1C)nc2c1c(n(c(=O)n2C)C)=O c(n1C)nc2c1c(n(c(n2C)=O)C)=O c(n1C)nc2c1c(n(C)c(=O)n2C)=O c(n1C)nc2c1c(n(C)c(n2C)=O)=O c(n1C)nc2n(c(n(c(c12)=O)C)=O)C c(n1C)nc2n(c(n(c(c21)=O)C)=O)C c(n1C)nc2n(c(n(c(=O)c12)C)=O)C c(n1C)nc2n(c(n(c(=O)c21)C)=O)C c(n1C)nc2n(c(n(C)c(c12)=O)=O)C c(n1C)nc2n(c(n(C)c(c21)=O)=O)C c(n1C)nc2n(c(n(C)c(=O)c12)=O)C c(n1C)nc2n(c(n(C)c(=O)c21)=O)C c(n1C)nc2n(c(=O)n(c(c12)=O)C)C c(n1C)nc2n(c(=O)n(c(c21)=O)C)C c(n1C)nc2n(c(=O)n(c(=O)c12)C)C c(n1C)nc2n(c(=O)n(c(=O)c21)C)C c(n1C)nc2n(c(=O)n(C)c(c12)=O)C c(n1C)nc2n(c(=O)n(C)c(c21)=O)C c(n1C)nc2n(c(=O)n(C)c(=O)c12)C c(n1C)nc2n(c(=O)n(C)c(=O)c21)C c(n1C)nc2n(C)c(n(c(c12)=O)C)=O c(n1C)nc2n(C)c(n(c(c21)=O)C)=O c(n1C)nc2n(C)c(n(c(=O)c12)C)=O c(n1C)nc2n(C)c(n(c(=O)c21)C)=O c(n1C)nc2n(C)c(n(C)c(c12)=O)=O c(n1C)nc2n(C)c(n(C)c(c21)=O)=O c(n1C)nc2n(C)c(n(C)c(=O)c12)=O c(n1C)nc2n(C)c(n(C)c(=O)c21)=O c(n1C)nc2n(C)c(=O)n(c(c12)=O)C c(n1C)nc2n(C)c(=O)n(c(c21)=O)C c(n1C)nc2n(C)c(=O)n(c(=O)c12)C c(n1C)nc2n(C)c(=O)n(c(=O)c21)C c(n1C)nc2n(C)c(=O)n(C)c(c12)=O c(n1C)nc2n(C)c(=O)n(C)c(c21)=O c(n1C)nc2n(C)c(=O)n(C)c(=O)c12 c(n1C)nc2n(C)c(=O)n(C)c(=O)c21 c(n1C)nc(n2C)c1c(=O)n(c2=O)C c(n1C)nc(n2C)c1c(=O)n(C)c2=O c(n1C)nc(n2C)c1c(n(c2=O)C)=O c(n1C)nc(n2C)c1c(n(C)c2=O)=O c(n1C)nc(n(c2=O)C)c1c(=O)n2C c(n1C)nc(n(c2=O)C)c1c(n2C)=O c(n1C)nc(n(c(n2C)=O)C)c1c2=O c(n1C)nc(n(c(n(c2=O)C)=O)C)c12 c(n1C)nc(n(c(n(c2=O)C)=O)C)c21 c(n1C)nc(n(c(n(C)c2=O)=O)C)c12 c(n1C)nc(n(c(n(C)c2=O)=O)C)c21 c(n1C)nc(n(c(=O)n2C)C)c1c2=O c(n1C)nc(n(c(=O)n(c2=O)C)C)c12 c(n1C)nc(n(c(=O)n(c2=O)C)C)c21 c(n1C)nc(n(c(=O)n(C)c2=O)C)c12 c(n1C)nc(n(c(=O)n(C)c2=O)C)c21 c(n1C)nc(n(C)c2=O)c1c(=O)n2C c(n1C)nc(n(C)c2=O)c1c(n2C)=O c(n1C)nc(n(C)c(n2C)=O)c1c2=O c(n1C)nc(n(C)c(n(c2=O)C)=O)c12 c(n1C)nc(n(C)c(n(c2=O)C)=O)c21 c(n1C)nc(n(C)c(n(C)c2=O)=O)c12 c(n1C)nc(n(C)c(n(C)c2=O)=O)c21 c(n1C)nc(n(C)c(=O)n2C)c1c2=O c(n1C)nc(n(C)c(=O)n(c2=O)C)c12 c(n1C)nc(n(C)c(=O)n(c2=O)C)c21 c(n1C)nc(n(C)c(=O)n(C)c2=O)c12 c(n1C)nc(n(C)c(=O)n(C)c2=O)c21 c(n1C)nc(c1c2=O)n(c(n2C)=O)C c(n1C)nc(c1c2=O)n(c(=O)n2C)C c(n1C)nc(c1c2=O)n(C)c(n2C)=O c(n1C)nc(c1c2=O)n(C)c(=O)n2C c(n1C)nc(c1c(=O)n2C)n(c2=O)C c(n1C)nc(c1c(=O)n2C)n(C)c2=O c(n1C)nc(c1c(=O)n(c2=O)C)n2C c(n1C)nc(c1c(=O)n(C)c2=O)n2C c(n1C)nc(c1c(n2C)=O)n(c2=O)C c(n1C)nc(c1c(n2C)=O)n(C)c2=O c(n1C)nc(c1c(n(c2=O)C)=O)n2C c(n1C)nc(c1c(n(C)c2=O)=O)n2C c(n(C)c1c2=O)nc1n(c(n2C)=O)C c(n(C)c1c2=O)nc1n(c(=O)n2C)C c(n(C)c1c2=O)nc1n(C)c(n2C)=O c(n(C)c1c2=O)nc1n(C)c(=O)n2C c(n(C)c1c(=O)n2C)nc1n(c2=O)C c(n(C)c1c(=O)n2C)nc1n(C)c2=O c(n(C)c1c(=O)n(c2=O)C)nc1n2C c(n(C)c1c(=O)n(c(=O)n2C)C)nc21 c(n(C)c1c(=O)n(c(=O)n2C)C)nc12 c(n(C)c1c(=O)n(c(n2C)=O)C)nc21 c(n(C)c1c(=O)n(c(n2C)=O)C)nc12 c(n(C)c1c(=O)n(C)c2=O)nc1n2C c(n(C)c1c(=O)n(C)c(=O)n2C)nc21 c(n(C)c1c(=O)n(C)c(=O)n2C)nc12 c(n(C)c1c(=O)n(C)c(n2C)=O)nc21 c(n(C)c1c(=O)n(C)c(n2C)=O)nc12 c(n(C)c1c(n2C)=O)nc1n(c2=O)C c(n(C)c1c(n2C)=O)nc1n(C)c2=O c(n(C)c1c(n(c2=O)C)=O)nc1n2C c(n(C)c1c(n(c(=O)n2C)C)=O)nc21 c(n(C)c1c(n(c(=O)n2C)C)=O)nc12 c(n(C)c1c(n(c(n2C)=O)C)=O)nc21 c(n(C)c1c(n(c(n2C)=O)C)=O)nc12 c(n(C)c1c(n(C)c2=O)=O)nc1n2C c(n(C)c1c(n(C)c(=O)n2C)=O)nc21 c(n(C)c1c(n(C)c(=O)n2C)=O)nc12 c(n(C)c1c(n(C)c(n2C)=O)=O)nc21 c(n(C)c1c(n(C)c(n2C)=O)=O)nc12 c(n(C)c1c2n(c(n(c1=O)C)=O)C)n2 c(n(C)c1c2n(c(n(C)c1=O)=O)C)n2 c(n(C)c1c2n(c(=O)n(c1=O)C)C)n2 c(n(C)c1c2n(c(=O)n(C)c1=O)C)n2 c(n(C)c1c2n(C)c(n(c1=O)C)=O)n2 c(n(C)c1c2n(C)c(n(C)c1=O)=O)n2 c(n(C)c1c2n(C)c(=O)n(c1=O)C)n2 c(n(C)c1c2n(C)c(=O)n(C)c1=O)n2 c(n(C)c(c1n2C)c(=O)n(c2=O)C)n1 c(n(C)c(c1n2C)c(=O)n(C)c2=O)n1 c(n(C)c(c1n2C)c(n(c2=O)C)=O)n1 c(n(C)c(c1n2C)c(n(C)c2=O)=O)n1 c(n(C)c(c1n(c2=O)C)c(=O)n2C)n1 c(n(C)c(c1n(c2=O)C)c(n2C)=O)n1 c(n(C)c(c1n(c(n2C)=O)C)c2=O)n1 c(n(C)c(c1n(c(=O)n2C)C)c2=O)n1 c(n(C)c(c1n(C)c2=O)c(=O)n2C)n1 c(n(C)c(c1n(C)c2=O)c(n2C)=O)n1 c(n(C)c(c1n(C)c(n2C)=O)c2=O)n1 c(n(C)c(c1n(C)c(=O)n2C)c2=O)n1 c(n(C)c(c1=O)c2n(c(n1C)=O)C)n2 c(n(C)c(c1=O)c2n(c(=O)n1C)C)n2 c(n(C)c(c1=O)c2n(C)c(n1C)=O)n2 c(n(C)c(c1=O)c2n(C)c(=O)n1C)n2 c(n(C)c(c(=O)n1C)c2n(c1=O)C)n2 c(n(C)c(c(=O)n1C)c2n(C)c1=O)n2 c(n(C)c(c(=O)n(c1=O)C)c2n1C)n2 c(n(C)c(c(=O)n(C)c1=O)c2n1C)n2 c(n(C)c(c(n1C)=O)c2n(c1=O)C)n2 c(n(C)c(c(n1C)=O)c2n(C)c1=O)n2 c(n(C)c(c(n(c1=O)C)=O)c2n1C)n2 c(n(C)c(c(n(C)c1=O)=O)c2n1C)n2 c(n(c1c2=O)C)nc1n(c(n2C)=O)C c(n(c1c2=O)C)nc1n(c(=O)n2C)C c(n(c1c2=O)C)nc1n(C)c(n2C)=O c(n(c1c2=O)C)nc1n(C)c(=O)n2C c(n(c1c(=O)n2C)C)nc1n(c2=O)C c(n(c1c(=O)n2C)C)nc1n(C)c2=O c(n(c1c(=O)n(c2=O)C)C)nc1n2C c(n(c1c(=O)n(c(=O)n2C)C)C)nc21 c(n(c1c(=O)n(c(=O)n2C)C)C)nc12 c(n(c1c(=O)n(c(n2C)=O)C)C)nc21 c(n(c1c(=O)n(c(n2C)=O)C)C)nc12 c(n(c1c(=O)n(C)c2=O)C)nc1n2C c(n(c1c(=O)n(C)c(=O)n2C)C)nc21 c(n(c1c(=O)n(C)c(=O)n2C)C)nc12 c(n(c1c(=O)n(C)c(n2C)=O)C)nc21 c(n(c1c(=O)n(C)c(n2C)=O)C)nc12 c(n(c1c(n2C)=O)C)nc1n(c2=O)C c(n(c1c(n2C)=O)C)nc1n(C)c2=O c(n(c1c(n(c2=O)C)=O)C)nc1n2C c(n(c1c(n(c(=O)n2C)C)=O)C)nc21 c(n(c1c(n(c(=O)n2C)C)=O)C)nc12 c(n(c1c(n(c(n2C)=O)C)=O)C)nc21 c(n(c1c(n(c(n2C)=O)C)=O)C)nc12 c(n(c1c(n(C)c2=O)=O)C)nc1n2C c(n(c1c(n(C)c(=O)n2C)=O)C)nc21 c(n(c1c(n(C)c(=O)n2C)=O)C)nc12 c(n(c1c(n(C)c(n2C)=O)=O)C)nc21 c(n(c1c(n(C)c(n2C)=O)=O)C)nc12 c(n(c1c2n(c(n(c1=O)C)=O)C)C)n2 c(n(c1c2n(c(n(C)c1=O)=O)C)C)n2 c(n(c1c2n(c(=O)n(c1=O)C)C)C)n2 c(n(c1c2n(c(=O)n(C)c1=O)C)C)n2 c(n(c1c2n(C)c(n(c1=O)C)=O)C)n2 c(n(c1c2n(C)c(n(C)c1=O)=O)C)n2 c(n(c1c2n(C)c(=O)n(c1=O)C)C)n2 c(n(c1c2n(C)c(=O)n(C)c1=O)C)n2 c(n(c(c1n2C)c(=O)n(c2=O)C)C)n1 c(n(c(c1n2C)c(=O)n(C)c2=O)C)n1 c(n(c(c1n2C)c(n(c2=O)C)=O)C)n1 c(n(c(c1n2C)c(n(C)c2=O)=O)C)n1 c(n(c(c1n(c2=O)C)c(=O)n2C)C)n1 c(n(c(c1n(c2=O)C)c(n2C)=O)C)n1 c(n(c(c1n(c(n2C)=O)C)c2=O)C)n1 c(n(c(c1n(c(=O)n2C)C)c2=O)C)n1 c(n(c(c1n(C)c2=O)c(=O)n2C)C)n1 c(n(c(c1n(C)c2=O)c(n2C)=O)C)n1 c(n(c(c1n(C)c(n2C)=O)c2=O)C)n1 c(n(c(c1n(C)c(=O)n2C)c2=O)C)n1 c(n(c(c1=O)c2n(c(n1C)=O)C)C)n2 c(n(c(c1=O)c2n(c(=O)n1C)C)C)n2 c(n(c(c1=O)c2n(C)c(n1C)=O)C)n2 c(n(c(c1=O)c2n(C)c(=O)n1C)C)n2 c(n(c(c(=O)n1C)c2n(c1=O)C)C)n2 c(n(c(c(=O)n1C)c2n(C)c1=O)C)n2 c(n(c(c(=O)n(c1=O)C)c2n1C)C)n2 c(n(c(c(=O)n(C)c1=O)c2n1C)C)n2 c(n(c(c(n1C)=O)c2n(c1=O)C)C)n2 c(n(c(c(n1C)=O)c2n(C)c1=O)C)n2 c(n(c(c(n(c1=O)C)=O)c2n1C)C)n2 c(n(c(c(n(C)c1=O)=O)c2n1C)C)n2 c(nc1c2c(=O)n(c(=O)n1C)C)n2C c(nc1c2c(=O)n(c(n1C)=O)C)n2C c(nc1c2c(=O)n(C)c(=O)n1C)n2C c(nc1c2c(=O)n(C)c(n1C)=O)n2C c(nc1c2c(n(c(=O)n1C)C)=O)n2C c(nc1c2c(n(c(n1C)=O)C)=O)n2C c(nc1c2c(n(C)c(=O)n1C)=O)n2C c(nc1c2c(n(C)c(n1C)=O)=O)n2C c(nc1n2C)n(C)c1c(=O)n(c2=O)C c(nc1n2C)n(C)c1c(=O)n(C)c2=O c(nc1n2C)n(C)c1c(n(c2=O)C)=O c(nc1n2C)n(C)c1c(n(C)c2=O)=O c(nc1n2C)n(c1c(=O)n(c2=O)C)C c(nc1n2C)n(c1c(=O)n(C)c2=O)C c(nc1n2C)n(c1c(n(c2=O)C)=O)C c(nc1n2C)n(c1c(n(C)c2=O)=O)C c(nc1n(c2=O)C)n(C)c1c(=O)n2C c(nc1n(c2=O)C)n(C)c1c(n2C)=O c(nc1n(c2=O)C)n(c1c(=O)n2C)C c(nc1n(c2=O)C)n(c1c(n2C)=O)C c(nc1n(c(n2C)=O)C)n(C)c1c2=O c(nc1n(c(n2C)=O)C)n(c1c2=O)C c(nc1n(c(n(c2=O)C)=O)C)n(C)c12 c(nc1n(c(n(c2=O)C)=O)C)n(C)c21 c(nc1n(c(n(c2=O)C)=O)C)n(c12)C c(nc1n(c(n(c2=O)C)=O)C)n(c21)C c(nc1n(c(n(C)c2=O)=O)C)n(C)c12 c(nc1n(c(n(C)c2=O)=O)C)n(C)c21 c(nc1n(c(n(C)c2=O)=O)C)n(c12)C c(nc1n(c(n(C)c2=O)=O)C)n(c21)C c(nc1n(c(=O)n2C)C)n(C)c1c2=O c(nc1n(c(=O)n2C)C)n(c1c2=O)C c(nc1n(c(=O)n(c2=O)C)C)n(C)c12 c(nc1n(c(=O)n(c2=O)C)C)n(C)c21 c(nc1n(c(=O)n(c2=O)C)C)n(c12)C c(nc1n(c(=O)n(c2=O)C)C)n(c21)C c(nc1n(c(=O)n(C)c2=O)C)n(C)c12 c(nc1n(c(=O)n(C)c2=O)C)n(C)c21 c(nc1n(c(=O)n(C)c2=O)C)n(c12)C c(nc1n(c(=O)n(C)c2=O)C)n(c21)C c(nc1n(C)c2=O)n(C)c1c(=O)n2C c(nc1n(C)c2=O)n(C)c1c(n2C)=O c(nc1n(C)c2=O)n(c1c(=O)n2C)C c(nc1n(C)c2=O)n(c1c(n2C)=O)C c(nc1n(C)c(n2C)=O)n(C)c1c2=O c(nc1n(C)c(n2C)=O)n(c1c2=O)C c(nc1n(C)c(n(c2=O)C)=O)n(C)c12 c(nc1n(C)c(n(c2=O)C)=O)n(C)c21 c(nc1n(C)c(n(c2=O)C)=O)n(c12)C c(nc1n(C)c(n(c2=O)C)=O)n(c21)C c(nc1n(C)c(n(C)c2=O)=O)n(C)c12 c(nc1n(C)c(n(C)c2=O)=O)n(C)c21 c(nc1n(C)c(n(C)c2=O)=O)n(c12)C c(nc1n(C)c(n(C)c2=O)=O)n(c21)C c(nc1n(C)c(=O)n2C)n(C)c1c2=O c(nc1n(C)c(=O)n2C)n(c1c2=O)C c(nc1n(C)c(=O)n(c2=O)C)n(C)c12 c(nc1n(C)c(=O)n(c2=O)C)n(C)c21 c(nc1n(C)c(=O)n(c2=O)C)n(c12)C c(nc1n(C)c(=O)n(c2=O)C)n(c21)C c(nc1n(C)c(=O)n(C)c2=O)n(C)c12 c(nc1n(C)c(=O)n(C)c2=O)n(C)c21 c(nc1n(C)c(=O)n(C)c2=O)n(c12)C c(nc1n(C)c(=O)n(C)c2=O)n(c21)C c(nc(n1C)c2c(=O)n(c1=O)C)n2C c(nc(n1C)c2c(=O)n(C)c1=O)n2C c(nc(n1C)c2c(n(c1=O)C)=O)n2C c(nc(n1C)c2c(n(C)c1=O)=O)n2C c(nc(n(c1=O)C)c2c(=O)n1C)n2C c(nc(n(c1=O)C)c2c(n1C)=O)n2C c(nc(n(c(n1C)=O)C)c2c1=O)n2C c(nc(n(c(=O)n1C)C)c2c1=O)n2C c(nc(n(C)c1=O)c2c(=O)n1C)n2C c(nc(n(C)c1=O)c2c(n1C)=O)n2C c(nc(n(C)c(n1C)=O)c2c1=O)n2C c(nc(n(C)c(=O)n1C)c2c1=O)n2C c(nc(c1c2=O)n(c(n2C)=O)C)n1C c(nc(c1c2=O)n(c(=O)n2C)C)n1C c(nc(c1c2=O)n(C)c(n2C)=O)n1C c(nc(c1c2=O)n(C)c(=O)n2C)n1C c(nc(c1c(=O)n2C)n(c2=O)C)n1C c(nc(c1c(=O)n2C)n(C)c2=O)n1C c(nc(c1c(=O)n(c2=O)C)n2C)n1C c(nc(c1c(=O)n(C)c2=O)n2C)n1C c(nc(c1c(n2C)=O)n(c2=O)C)n1C c(nc(c1c(n2C)=O)n(C)c2=O)n1C c(nc(c1c(n(c2=O)C)=O)n2C)n1C c(nc(c1c(n(C)c2=O)=O)n2C)n1C n1c2c(n(C)c1)c(=O)n(c(=O)n2C)C n1c2c(n(C)c1)c(=O)n(c(n2C)=O)C n1c2c(n(C)c1)c(=O)n(C)c(=O)n2C n1c2c(n(C)c1)c(=O)n(C)c(n2C)=O n1c2c(n(C)c1)c(n(c(=O)n2C)C)=O n1c2c(n(C)c1)c(n(c(n2C)=O)C)=O n1c2c(n(C)c1)c(n(C)c(=O)n2C)=O n1c2c(n(C)c1)c(n(C)c(n2C)=O)=O n1c2c(n(c1)C)c(=O)n(c(=O)n2C)C n1c2c(n(c1)C)c(=O)n(c(n2C)=O)C n1c2c(n(c1)C)c(=O)n(C)c(=O)n2C n1c2c(n(c1)C)c(=O)n(C)c(n2C)=O n1c2c(n(c1)C)c(n(c(=O)n2C)C)=O n1c2c(n(c1)C)c(n(c(n2C)=O)C)=O n1c2c(n(c1)C)c(n(C)c(=O)n2C)=O n1c2c(n(c1)C)c(n(C)c(n2C)=O)=O n1c2c(c(=O)n(c(=O)n2C)C)n(C)c1 n1c2c(c(=O)n(c(=O)n2C)C)n(c1)C n1c2c(c(=O)n(c(n2C)=O)C)n(C)c1 n1c2c(c(=O)n(c(n2C)=O)C)n(c1)C n1c2c(c(=O)n(C)c(=O)n2C)n(C)c1 n1c2c(c(=O)n(C)c(=O)n2C)n(c1)C n1c2c(c(=O)n(C)c(n2C)=O)n(C)c1 n1c2c(c(=O)n(C)c(n2C)=O)n(c1)C n1c2c(c(n(c(=O)n2C)C)=O)n(C)c1 n1c2c(c(n(c(=O)n2C)C)=O)n(c1)C n1c2c(c(n(c(n2C)=O)C)=O)n(C)c1 n1c2c(c(n(c(n2C)=O)C)=O)n(c1)C n1c2c(c(n(C)c(=O)n2C)=O)n(C)c1 n1c2c(c(n(C)c(=O)n2C)=O)n(c1)C n1c2c(c(n(C)c(n2C)=O)=O)n(C)c1 n1c2c(c(n(C)c(n2C)=O)=O)n(c1)C n1c2n(c(n(c(c2n(C)c1)=O)C)=O)C n1c2n(c(n(c(c2n(c1)C)=O)C)=O)C n1c2n(c(n(c(=O)c2n(C)c1)C)=O)C n1c2n(c(n(c(=O)c2n(c1)C)C)=O)C n1c2n(c(n(C)c(c2n(C)c1)=O)=O)C n1c2n(c(n(C)c(c2n(c1)C)=O)=O)C n1c2n(c(n(C)c(=O)c2n(C)c1)=O)C n1c2n(c(n(C)c(=O)c2n(c1)C)=O)C n1c2n(c(=O)n(c(c2n(C)c1)=O)C)C n1c2n(c(=O)n(c(c2n(c1)C)=O)C)C n1c2n(c(=O)n(c(=O)c2n(C)c1)C)C n1c2n(c(=O)n(c(=O)c2n(c1)C)C)C n1c2n(c(=O)n(C)c(c2n(C)c1)=O)C n1c2n(c(=O)n(C)c(c2n(c1)C)=O)C n1c2n(c(=O)n(C)c(=O)c2n(C)c1)C n1c2n(c(=O)n(C)c(=O)c2n(c1)C)C n1c2n(C)c(n(c(c2n(C)c1)=O)C)=O n1c2n(C)c(n(c(c2n(c1)C)=O)C)=O n1c2n(C)c(n(c(=O)c2n(C)c1)C)=O n1c2n(C)c(n(c(=O)c2n(c1)C)C)=O n1c2n(C)c(n(C)c(c2n(C)c1)=O)=O n1c2n(C)c(n(C)c(c2n(c1)C)=O)=O n1c2n(C)c(n(C)c(=O)c2n(C)c1)=O n1c2n(C)c(n(C)c(=O)c2n(c1)C)=O n1c2n(C)c(=O)n(c(c2n(C)c1)=O)C n1c2n(C)c(=O)n(c(c2n(c1)C)=O)C n1c2n(C)c(=O)n(c(=O)c2n(C)c1)C n1c2n(C)c(=O)n(c(=O)c2n(c1)C)C n1c2n(C)c(=O)n(C)c(c2n(C)c1)=O n1c2n(C)c(=O)n(C)c(c2n(c1)C)=O n1c2n(C)c(=O)n(C)c(=O)c2n(C)c1 n1c2n(C)c(=O)n(C)c(=O)c2n(c1)C n1c(n2C)c(n(C)c1)c(=O)n(c2=O)C n1c(n2C)c(n(C)c1)c(=O)n(C)c2=O n1c(n2C)c(n(C)c1)c(n(c2=O)C)=O n1c(n2C)c(n(C)c1)c(n(C)c2=O)=O n1c(n2C)c(n(c1)C)c(=O)n(c2=O)C n1c(n2C)c(n(c1)C)c(=O)n(C)c2=O n1c(n2C)c(n(c1)C)c(n(c2=O)C)=O n1c(n2C)c(n(c1)C)c(n(C)c2=O)=O n1c(n2C)c(c(=O)n(c2=O)C)n(C)c1 n1c(n2C)c(c(=O)n(c2=O)C)n(c1)C n1c(n2C)c(c(=O)n(C)c2=O)n(C)c1 n1c(n2C)c(c(=O)n(C)c2=O)n(c1)C n1c(n2C)c(c(n(c2=O)C)=O)n(C)c1 n1c(n2C)c(c(n(c2=O)C)=O)n(c1)C n1c(n2C)c(c(n(C)c2=O)=O)n(C)c1 n1c(n2C)c(c(n(C)c2=O)=O)n(c1)C n1c(n(c2=O)C)c(n(C)c1)c(=O)n2C n1c(n(c2=O)C)c(n(C)c1)c(n2C)=O n1c(n(c2=O)C)c(n(c1)C)c(=O)n2C n1c(n(c2=O)C)c(n(c1)C)c(n2C)=O n1c(n(c2=O)C)c(c(=O)n2C)n(C)c1 n1c(n(c2=O)C)c(c(=O)n2C)n(c1)C n1c(n(c2=O)C)c(c(n2C)=O)n(C)c1 n1c(n(c2=O)C)c(c(n2C)=O)n(c1)C n1c(n(c(n2C)=O)C)c(n(C)c1)c2=O n1c(n(c(n2C)=O)C)c(n(c1)C)c2=O n1c(n(c(n2C)=O)C)c(c2=O)n(C)c1 n1c(n(c(n2C)=O)C)c(c2=O)n(c1)C n1c(n(c(n(c2=O)C)=O)C)c2n(C)c1 n1c(n(c(n(c2=O)C)=O)C)c2n(c1)C n1c(n(c(n(C)c2=O)=O)C)c2n(C)c1 n1c(n(c(n(C)c2=O)=O)C)c2n(c1)C n1c(n(c(=O)n2C)C)c(n(C)c1)c2=O n1c(n(c(=O)n2C)C)c(n(c1)C)c2=O n1c(n(c(=O)n2C)C)c(c2=O)n(C)c1 n1c(n(c(=O)n2C)C)c(c2=O)n(c1)C n1c(n(c(=O)n(c2=O)C)C)c2n(C)c1 n1c(n(c(=O)n(c2=O)C)C)c2n(c1)C n1c(n(c(=O)n(C)c2=O)C)c2n(C)c1 n1c(n(c(=O)n(C)c2=O)C)c2n(c1)C n1c(n(C)c2=O)c(n(C)c1)c(=O)n2C n1c(n(C)c2=O)c(n(C)c1)c(n2C)=O n1c(n(C)c2=O)c(n(c1)C)c(=O)n2C n1c(n(C)c2=O)c(n(c1)C)c(n2C)=O n1c(n(C)c2=O)c(c(=O)n2C)n(C)c1 n1c(n(C)c2=O)c(c(=O)n2C)n(c1)C n1c(n(C)c2=O)c(c(n2C)=O)n(C)c1 n1c(n(C)c2=O)c(c(n2C)=O)n(c1)C n1c(n(C)c(n2C)=O)c(n(C)c1)c2=O n1c(n(C)c(n2C)=O)c(n(c1)C)c2=O n1c(n(C)c(n2C)=O)c(c2=O)n(C)c1 n1c(n(C)c(n2C)=O)c(c2=O)n(c1)C n1c(n(C)c(n(c2=O)C)=O)c2n(C)c1 n1c(n(C)c(n(c2=O)C)=O)c2n(c1)C n1c(n(C)c(n(C)c2=O)=O)c2n(C)c1 n1c(n(C)c(n(C)c2=O)=O)c2n(c1)C n1c(n(C)c(=O)n2C)c(n(C)c1)c2=O n1c(n(C)c(=O)n2C)c(n(c1)C)c2=O n1c(n(C)c(=O)n2C)c(c2=O)n(C)c1 n1c(n(C)c(=O)n2C)c(c2=O)n(c1)C n1c(n(C)c(=O)n(c2=O)C)c2n(C)c1 n1c(n(C)c(=O)n(c2=O)C)c2n(c1)C n1c(n(C)c(=O)n(C)c2=O)c2n(C)c1 n1c(n(C)c(=O)n(C)c2=O)c2n(c1)C n1c(c2n(C)c1)n(c(n(c2=O)C)=O)C n1c(c2n(C)c1)n(c(n(C)c2=O)=O)C n1c(c2n(C)c1)n(c(=O)n(c2=O)C)C n1c(c2n(C)c1)n(c(=O)n(C)c2=O)C n1c(c2n(C)c1)n(C)c(n(c2=O)C)=O n1c(c2n(C)c1)n(C)c(n(C)c2=O)=O n1c(c2n(C)c1)n(C)c(=O)n(c2=O)C n1c(c2n(C)c1)n(C)c(=O)n(C)c2=O n1c(c2n(c1)C)n(c(n(c2=O)C)=O)C n1c(c2n(c1)C)n(c(n(C)c2=O)=O)C n1c(c2n(c1)C)n(c(=O)n(c2=O)C)C n1c(c2n(c1)C)n(c(=O)n(C)c2=O)C n1c(c2n(c1)C)n(C)c(n(c2=O)C)=O n1c(c2n(c1)C)n(C)c(n(C)c2=O)=O n1c(c2n(c1)C)n(C)c(=O)n(c2=O)C n1c(c2n(c1)C)n(C)c(=O)n(C)c2=O n1c(c(n(C)c1)c2=O)n(c(n2C)=O)C n1c(c(n(C)c1)c2=O)n(c(=O)n2C)C n1c(c(n(C)c1)c2=O)n(C)c(n2C)=O n1c(c(n(C)c1)c2=O)n(C)c(=O)n2C n1c(c(n(C)c1)c(=O)n2C)n(c2=O)C n1c(c(n(C)c1)c(=O)n2C)n(C)c2=O n1c(c(n(C)c1)c(=O)n(c2=O)C)n2C n1c(c(n(C)c1)c(=O)n(C)c2=O)n2C n1c(c(n(C)c1)c(n2C)=O)n(c2=O)C n1c(c(n(C)c1)c(n2C)=O)n(C)c2=O n1c(c(n(C)c1)c(n(c2=O)C)=O)n2C n1c(c(n(C)c1)c(n(C)c2=O)=O)n2C n1c(c(n(c1)C)c2=O)n(c(n2C)=O)C n1c(c(n(c1)C)c2=O)n(c(=O)n2C)C n1c(c(n(c1)C)c2=O)n(C)c(n2C)=O n1c(c(n(c1)C)c2=O)n(C)c(=O)n2C n1c(c(n(c1)C)c(=O)n2C)n(c2=O)C n1c(c(n(c1)C)c(=O)n2C)n(C)c2=O n1c(c(n(c1)C)c(=O)n(c2=O)C)n2C n1c(c(n(c1)C)c(=O)n(C)c2=O)n2C n1c(c(n(c1)C)c(n2C)=O)n(c2=O)C n1c(c(n(c1)C)c(n2C)=O)n(C)c2=O n1c(c(n(c1)C)c(n(c2=O)C)=O)n2C n1c(c(n(c1)C)c(n(C)c2=O)=O)n2C n1c(c(c2=O)n(C)c1)n(c(n2C)=O)C n1c(c(c2=O)n(C)c1)n(c(=O)n2C)C n1c(c(c2=O)n(C)c1)n(C)c(n2C)=O n1c(c(c2=O)n(C)c1)n(C)c(=O)n2C n1c(c(c2=O)n(c1)C)n(c(n2C)=O)C n1c(c(c2=O)n(c1)C)n(c(=O)n2C)C n1c(c(c2=O)n(c1)C)n(C)c(n2C)=O n1c(c(c2=O)n(c1)C)n(C)c(=O)n2C n1c(c(c(=O)n2C)n(C)c1)n(c2=O)C n1c(c(c(=O)n2C)n(C)c1)n(C)c2=O n1c(c(c(=O)n2C)n(c1)C)n(c2=O)C n1c(c(c(=O)n2C)n(c1)C)n(C)c2=O n1c(c(c(=O)n(c2=O)C)n(C)c1)n2C n1c(c(c(=O)n(c2=O)C)n(c1)C)n2C n1c(c(c(=O)n(C)c2=O)n(C)c1)n2C n1c(c(c(=O)n(C)c2=O)n(c1)C)n2C n1c(c(c(n2C)=O)n(C)c1)n(c2=O)C n1c(c(c(n2C)=O)n(C)c1)n(C)c2=O n1c(c(c(n2C)=O)n(c1)C)n(c2=O)C n1c(c(c(n2C)=O)n(c1)C)n(C)c2=O n1c(c(c(n(c2=O)C)=O)n(C)c1)n2C n1c(c(c(n(c2=O)C)=O)n(c1)C)n2C n1c(c(c(n(C)c2=O)=O)n(C)c1)n2C n1c(c(c(n(C)c2=O)=O)n(c1)C)n2C n1cn(C)c2c(=O)n(c(=O)n(c12)C)C n1cn(C)c2c(=O)n(c(=O)n(c21)C)C n1cn(C)c2c(=O)n(c(=O)n(C)c12)C n1cn(C)c2c(=O)n(c(=O)n(C)c21)C n1cn(C)c2c(=O)n(c(n(c12)C)=O)C n1cn(C)c2c(=O)n(c(n(c21)C)=O)C n1cn(C)c2c(=O)n(c(n(C)c12)=O)C n1cn(C)c2c(=O)n(c(n(C)c21)=O)C n1cn(C)c2c(=O)n(C)c(=O)n(c12)C n1cn(C)c2c(=O)n(C)c(=O)n(c21)C n1cn(C)c2c(=O)n(C)c(=O)n(C)c12 n1cn(C)c2c(=O)n(C)c(=O)n(C)c21 n1cn(C)c2c(=O)n(C)c(n(c12)C)=O n1cn(C)c2c(=O)n(C)c(n(c21)C)=O n1cn(C)c2c(=O)n(C)c(n(C)c12)=O n1cn(C)c2c(=O)n(C)c(n(C)c21)=O n1cn(C)c2c(n(c(=O)n(c12)C)C)=O n1cn(C)c2c(n(c(=O)n(c21)C)C)=O n1cn(C)c2c(n(c(=O)n(C)c12)C)=O n1cn(C)c2c(n(c(=O)n(C)c21)C)=O n1cn(C)c2c(n(c(n(c12)C)=O)C)=O n1cn(C)c2c(n(c(n(c21)C)=O)C)=O n1cn(C)c2c(n(c(n(C)c12)=O)C)=O n1cn(C)c2c(n(c(n(C)c21)=O)C)=O n1cn(C)c2c(n(C)c(=O)n(c12)C)=O n1cn(C)c2c(n(C)c(=O)n(c21)C)=O n1cn(C)c2c(n(C)c(=O)n(C)c12)=O n1cn(C)c2c(n(C)c(=O)n(C)c21)=O n1cn(C)c2c(n(C)c(n(c12)C)=O)=O n1cn(C)c2c(n(C)c(n(c21)C)=O)=O n1cn(C)c2c(n(C)c(n(C)c12)=O)=O n1cn(C)c2c(n(C)c(n(C)c21)=O)=O n1cn(C)c2c1n(c(n(c2=O)C)=O)C n1cn(C)c2c1n(c(n(C)c2=O)=O)C n1cn(C)c2c1n(c(=O)n(c2=O)C)C n1cn(C)c2c1n(c(=O)n(C)c2=O)C n1cn(C)c2c1n(C)c(n(c2=O)C)=O n1cn(C)c2c1n(C)c(n(C)c2=O)=O n1cn(C)c2c1n(C)c(=O)n(c2=O)C n1cn(C)c2c1n(C)c(=O)n(C)c2=O n1cn(C)c(c1n2C)c(=O)n(c2=O)C n1cn(C)c(c1n2C)c(=O)n(C)c2=O n1cn(C)c(c1n2C)c(n(c2=O)C)=O n1cn(C)c(c1n2C)c(n(C)c2=O)=O n1cn(C)c(c1n(c2=O)C)c(=O)n2C n1cn(C)c(c1n(c2=O)C)c(n2C)=O n1cn(C)c(c1n(c(n2C)=O)C)c2=O n1cn(C)c(c1n(c(=O)n2C)C)c2=O n1cn(C)c(c1n(C)c2=O)c(=O)n2C n1cn(C)c(c1n(C)c2=O)c(n2C)=O n1cn(C)c(c1n(C)c(n2C)=O)c2=O n1cn(C)c(c1n(C)c(=O)n2C)c2=O n1cn(C)c(c2=O)c1n(c(n2C)=O)C n1cn(C)c(c2=O)c1n(c(=O)n2C)C n1cn(C)c(c2=O)c1n(C)c(n2C)=O n1cn(C)c(c2=O)c1n(C)c(=O)n2C n1cn(C)c(c(=O)n2C)c1n(c2=O)C n1cn(C)c(c(=O)n2C)c1n(C)c2=O n1cn(C)c(c(=O)n(c2=O)C)c1n2C n1cn(C)c(c(=O)n(c(=O)n2C)C)c12 n1cn(C)c(c(=O)n(c(=O)n2C)C)c21 n1cn(C)c(c(=O)n(c(n2C)=O)C)c12 n1cn(C)c(c(=O)n(c(n2C)=O)C)c21 n1cn(C)c(c(=O)n(C)c2=O)c1n2C n1cn(C)c(c(=O)n(C)c(=O)n2C)c12 n1cn(C)c(c(=O)n(C)c(=O)n2C)c21 n1cn(C)c(c(=O)n(C)c(n2C)=O)c12 n1cn(C)c(c(=O)n(C)c(n2C)=O)c21 n1cn(C)c(c(n2C)=O)c1n(c2=O)C n1cn(C)c(c(n2C)=O)c1n(C)c2=O n1cn(C)c(c(n(c2=O)C)=O)c1n2C n1cn(C)c(c(n(c(=O)n2C)C)=O)c12 n1cn(C)c(c(n(c(=O)n2C)C)=O)c21 n1cn(C)c(c(n(c(n2C)=O)C)=O)c12 n1cn(C)c(c(n(c(n2C)=O)C)=O)c21 n1cn(C)c(c(n(C)c2=O)=O)c1n2C n1cn(C)c(c(n(C)c(=O)n2C)=O)c12 n1cn(C)c(c(n(C)c(=O)n2C)=O)c21 n1cn(C)c(c(n(C)c(n2C)=O)=O)c12 n1cn(C)c(c(n(C)c(n2C)=O)=O)c21 n1cn(c2c(=O)n(c(=O)n(c12)C)C)C n1cn(c2c(=O)n(c(=O)n(c21)C)C)C n1cn(c2c(=O)n(c(=O)n(C)c12)C)C n1cn(c2c(=O)n(c(=O)n(C)c21)C)C n1cn(c2c(=O)n(c(n(c12)C)=O)C)C n1cn(c2c(=O)n(c(n(c21)C)=O)C)C n1cn(c2c(=O)n(c(n(C)c12)=O)C)C n1cn(c2c(=O)n(c(n(C)c21)=O)C)C n1cn(c2c(=O)n(C)c(=O)n(c12)C)C n1cn(c2c(=O)n(C)c(=O)n(c21)C)C n1cn(c2c(=O)n(C)c(=O)n(C)c12)C n1cn(c2c(=O)n(C)c(=O)n(C)c21)C n1cn(c2c(=O)n(C)c(n(c12)C)=O)C n1cn(c2c(=O)n(C)c(n(c21)C)=O)C n1cn(c2c(=O)n(C)c(n(C)c12)=O)C n1cn(c2c(=O)n(C)c(n(C)c21)=O)C n1cn(c2c(n(c(=O)n(c12)C)C)=O)C n1cn(c2c(n(c(=O)n(c21)C)C)=O)C n1cn(c2c(n(c(=O)n(C)c12)C)=O)C n1cn(c2c(n(c(=O)n(C)c21)C)=O)C n1cn(c2c(n(c(n(c12)C)=O)C)=O)C n1cn(c2c(n(c(n(c21)C)=O)C)=O)C n1cn(c2c(n(c(n(C)c12)=O)C)=O)C n1cn(c2c(n(c(n(C)c21)=O)C)=O)C n1cn(c2c(n(C)c(=O)n(c12)C)=O)C n1cn(c2c(n(C)c(=O)n(c21)C)=O)C n1cn(c2c(n(C)c(=O)n(C)c12)=O)C n1cn(c2c(n(C)c(=O)n(C)c21)=O)C n1cn(c2c(n(C)c(n(c12)C)=O)=O)C n1cn(c2c(n(C)c(n(c21)C)=O)=O)C n1cn(c2c(n(C)c(n(C)c12)=O)=O)C n1cn(c2c(n(C)c(n(C)c21)=O)=O)C n1cn(c2c1n(c(n(c2=O)C)=O)C)C n1cn(c2c1n(c(n(C)c2=O)=O)C)C n1cn(c2c1n(c(=O)n(c2=O)C)C)C n1cn(c2c1n(c(=O)n(C)c2=O)C)C n1cn(c2c1n(C)c(n(c2=O)C)=O)C n1cn(c2c1n(C)c(n(C)c2=O)=O)C n1cn(c2c1n(C)c(=O)n(c2=O)C)C n1cn(c2c1n(C)c(=O)n(C)c2=O)C n1cn(c(c1n2C)c(=O)n(c2=O)C)C n1cn(c(c1n2C)c(=O)n(C)c2=O)C n1cn(c(c1n2C)c(n(c2=O)C)=O)C n1cn(c(c1n2C)c(n(C)c2=O)=O)C n1cn(c(c1n(c2=O)C)c(=O)n2C)C n1cn(c(c1n(c2=O)C)c(n2C)=O)C n1cn(c(c1n(c(n2C)=O)C)c2=O)C n1cn(c(c1n(c(=O)n2C)C)c2=O)C n1cn(c(c1n(C)c2=O)c(=O)n2C)C n1cn(c(c1n(C)c2=O)c(n2C)=O)C n1cn(c(c1n(C)c(n2C)=O)c2=O)C n1cn(c(c1n(C)c(=O)n2C)c2=O)C n1cn(c(c2=O)c1n(c(n2C)=O)C)C n1cn(c(c2=O)c1n(c(=O)n2C)C)C n1cn(c(c2=O)c1n(C)c(n2C)=O)C n1cn(c(c2=O)c1n(C)c(=O)n2C)C n1cn(c(c(=O)n2C)c1n(c2=O)C)C n1cn(c(c(=O)n2C)c1n(C)c2=O)C n1cn(c(c(=O)n(c2=O)C)c1n2C)C n1cn(c(c(=O)n(c(=O)n2C)C)c12)C n1cn(c(c(=O)n(c(=O)n2C)C)c21)C n1cn(c(c(=O)n(c(n2C)=O)C)c12)C n1cn(c(c(=O)n(c(n2C)=O)C)c21)C n1cn(c(c(=O)n(C)c2=O)c1n2C)C n1cn(c(c(=O)n(C)c(=O)n2C)c12)C n1cn(c(c(=O)n(C)c(=O)n2C)c21)C n1cn(c(c(=O)n(C)c(n2C)=O)c12)C n1cn(c(c(=O)n(C)c(n2C)=O)c21)C n1cn(c(c(n2C)=O)c1n(c2=O)C)C n1cn(c(c(n2C)=O)c1n(C)c2=O)C n1cn(c(c(n(c2=O)C)=O)c1n2C)C n1cn(c(c(n(c(=O)n2C)C)=O)c12)C n1cn(c(c(n(c(=O)n2C)C)=O)c21)C n1cn(c(c(n(c(n2C)=O)C)=O)c12)C n1cn(c(c(n(c(n2C)=O)C)=O)c21)C n1cn(c(c(n(C)c2=O)=O)c1n2C)C n1cn(c(c(n(C)c(=O)n2C)=O)c12)C n1cn(c(c(n(C)c(=O)n2C)=O)c21)C n1cn(c(c(n(C)c(n2C)=O)=O)c12)C n1cn(c(c(n(C)c(n2C)=O)=O)c21)C n(cn1C)c2c1c(=O)n(c(=O)n2C)C n(cn1C)c2c1c(=O)n(c(n2C)=O)C n(cn1C)c2c1c(=O)n(C)c(=O)n2C n(cn1C)c2c1c(=O)n(C)c(n2C)=O n(cn1C)c2c1c(n(c(=O)n2C)C)=O n(cn1C)c2c1c(n(c(n2C)=O)C)=O n(cn1C)c2c1c(n(C)c(=O)n2C)=O n(cn1C)c2c1c(n(C)c(n2C)=O)=O n(cn1C)c2n(c(n(c(c12)=O)C)=O)C n(cn1C)c2n(c(n(c(c21)=O)C)=O)C n(cn1C)c2n(c(n(c(=O)c12)C)=O)C n(cn1C)c2n(c(n(c(=O)c21)C)=O)C n(cn1C)c2n(c(n(C)c(c12)=O)=O)C n(cn1C)c2n(c(n(C)c(c21)=O)=O)C n(cn1C)c2n(c(n(C)c(=O)c12)=O)C n(cn1C)c2n(c(n(C)c(=O)c21)=O)C n(cn1C)c2n(c(=O)n(c(c12)=O)C)C n(cn1C)c2n(c(=O)n(c(c21)=O)C)C n(cn1C)c2n(c(=O)n(c(=O)c12)C)C n(cn1C)c2n(c(=O)n(c(=O)c21)C)C n(cn1C)c2n(c(=O)n(C)c(c12)=O)C n(cn1C)c2n(c(=O)n(C)c(c21)=O)C n(cn1C)c2n(c(=O)n(C)c(=O)c12)C n(cn1C)c2n(c(=O)n(C)c(=O)c21)C n(cn1C)c2n(C)c(n(c(c12)=O)C)=O n(cn1C)c2n(C)c(n(c(c21)=O)C)=O n(cn1C)c2n(C)c(n(c(=O)c12)C)=O n(cn1C)c2n(C)c(n(c(=O)c21)C)=O n(cn1C)c2n(C)c(n(C)c(c12)=O)=O n(cn1C)c2n(C)c(n(C)c(c21)=O)=O n(cn1C)c2n(C)c(n(C)c(=O)c12)=O n(cn1C)c2n(C)c(n(C)c(=O)c21)=O n(cn1C)c2n(C)c(=O)n(c(c12)=O)C n(cn1C)c2n(C)c(=O)n(c(c21)=O)C n(cn1C)c2n(C)c(=O)n(c(=O)c12)C n(cn1C)c2n(C)c(=O)n(c(=O)c21)C n(cn1C)c2n(C)c(=O)n(C)c(c12)=O n(cn1C)c2n(C)c(=O)n(C)c(c21)=O n(cn1C)c2n(C)c(=O)n(C)c(=O)c12 n(cn1C)c2n(C)c(=O)n(C)c(=O)c21 n(cn1C)c(n2C)c1c(=O)n(c2=O)C n(cn1C)c(n2C)c1c(=O)n(C)c2=O n(cn1C)c(n2C)c1c(n(c2=O)C)=O n(cn1C)c(n2C)c1c(n(C)c2=O)=O n(cn1C)c(n(c2=O)C)c1c(=O)n2C n(cn1C)c(n(c2=O)C)c1c(n2C)=O n(cn1C)c(n(c(n2C)=O)C)c1c2=O n(cn1C)c(n(c(n(c2=O)C)=O)C)c12 n(cn1C)c(n(c(n(c2=O)C)=O)C)c21 n(cn1C)c(n(c(n(C)c2=O)=O)C)c12 n(cn1C)c(n(c(n(C)c2=O)=O)C)c21 n(cn1C)c(n(c(=O)n2C)C)c1c2=O n(cn1C)c(n(c(=O)n(c2=O)C)C)c12 n(cn1C)c(n(c(=O)n(c2=O)C)C)c21 n(cn1C)c(n(c(=O)n(C)c2=O)C)c12 n(cn1C)c(n(c(=O)n(C)c2=O)C)c21 n(cn1C)c(n(C)c2=O)c1c(=O)n2C n(cn1C)c(n(C)c2=O)c1c(n2C)=O n(cn1C)c(n(C)c(n2C)=O)c1c2=O n(cn1C)c(n(C)c(n(c2=O)C)=O)c12 n(cn1C)c(n(C)c(n(c2=O)C)=O)c21 n(cn1C)c(n(C)c(n(C)c2=O)=O)c12 n(cn1C)c(n(C)c(n(C)c2=O)=O)c21 n(cn1C)c(n(C)c(=O)n2C)c1c2=O n(cn1C)c(n(C)c(=O)n(c2=O)C)c12 n(cn1C)c(n(C)c(=O)n(c2=O)C)c21 n(cn1C)c(n(C)c(=O)n(C)c2=O)c12 n(cn1C)c(n(C)c(=O)n(C)c2=O)c21 n(cn1C)c(c1c2=O)n(c(n2C)=O)C n(cn1C)c(c1c2=O)n(c(=O)n2C)C n(cn1C)c(c1c2=O)n(C)c(n2C)=O n(cn1C)c(c1c2=O)n(C)c(=O)n2C n(cn1C)c(c1c(=O)n2C)n(c2=O)C n(cn1C)c(c1c(=O)n2C)n(C)c2=O n(cn1C)c(c1c(=O)n(c2=O)C)n2C n(cn1C)c(c1c(=O)n(C)c2=O)n2C n(cn1C)c(c1c(n2C)=O)n(c2=O)C n(cn1C)c(c1c(n2C)=O)n(C)c2=O n(cn1C)c(c1c(n(c2=O)C)=O)n2C n(cn1C)c(c1c(n(C)c2=O)=O)n2C n(cn(C)c1c2=O)c1n(c(n2C)=O)C n(cn(C)c1c2=O)c1n(c(=O)n2C)C n(cn(C)c1c2=O)c1n(C)c(n2C)=O n(cn(C)c1c2=O)c1n(C)c(=O)n2C n(cn(C)c1c(=O)n2C)c1n(c2=O)C n(cn(C)c1c(=O)n2C)c1n(C)c2=O n(cn(C)c1c(=O)n(c2=O)C)c1n2C n(cn(C)c1c(=O)n(c(=O)n2C)C)c21 n(cn(C)c1c(=O)n(c(=O)n2C)C)c12 n(cn(C)c1c(=O)n(c(n2C)=O)C)c21 n(cn(C)c1c(=O)n(c(n2C)=O)C)c12 n(cn(C)c1c(=O)n(C)c2=O)c1n2C n(cn(C)c1c(=O)n(C)c(=O)n2C)c21 n(cn(C)c1c(=O)n(C)c(=O)n2C)c12 n(cn(C)c1c(=O)n(C)c(n2C)=O)c21 n(cn(C)c1c(=O)n(C)c(n2C)=O)c12 n(cn(C)c1c(n2C)=O)c1n(c2=O)C n(cn(C)c1c(n2C)=O)c1n(C)c2=O n(cn(C)c1c(n(c2=O)C)=O)c1n2C n(cn(C)c1c(n(c(=O)n2C)C)=O)c21 n(cn(C)c1c(n(c(=O)n2C)C)=O)c12 n(cn(C)c1c(n(c(n2C)=O)C)=O)c21 n(cn(C)c1c(n(c(n2C)=O)C)=O)c12 n(cn(C)c1c(n(C)c2=O)=O)c1n2C n(cn(C)c1c(n(C)c(=O)n2C)=O)c21 n(cn(C)c1c(n(C)c(=O)n2C)=O)c12 n(cn(C)c1c(n(C)c(n2C)=O)=O)c21 n(cn(C)c1c(n(C)c(n2C)=O)=O)c12 n(cn(c1c2=O)C)c1n(c(n2C)=O)C n(cn(c1c2=O)C)c1n(c(=O)n2C)C n(cn(c1c2=O)C)c1n(C)c(n2C)=O n(cn(c1c2=O)C)c1n(C)c(=O)n2C n(cn(c1c(=O)n2C)C)c1n(c2=O)C n(cn(c1c(=O)n2C)C)c1n(C)c2=O n(cn(c1c(=O)n(c2=O)C)C)c1n2C n(cn(c1c(=O)n(c(=O)n2C)C)C)c21 n(cn(c1c(=O)n(c(=O)n2C)C)C)c12 n(cn(c1c(=O)n(c(n2C)=O)C)C)c21 n(cn(c1c(=O)n(c(n2C)=O)C)C)c12 n(cn(c1c(=O)n(C)c2=O)C)c1n2C n(cn(c1c(=O)n(C)c(=O)n2C)C)c21 n(cn(c1c(=O)n(C)c(=O)n2C)C)c12 n(cn(c1c(=O)n(C)c(n2C)=O)C)c21 n(cn(c1c(=O)n(C)c(n2C)=O)C)c12 n(cn(c1c(n2C)=O)C)c1n(c2=O)C n(cn(c1c(n2C)=O)C)c1n(C)c2=O n(cn(c1c(n(c2=O)C)=O)C)c1n2C n(cn(c1c(n(c(=O)n2C)C)=O)C)c21 n(cn(c1c(n(c(=O)n2C)C)=O)C)c12 n(cn(c1c(n(c(n2C)=O)C)=O)C)c21 n(cn(c1c(n(c(n2C)=O)C)=O)C)c12 n(cn(c1c(n(C)c2=O)=O)C)c1n2C n(cn(c1c(n(C)c(=O)n2C)=O)C)c21 n(cn(c1c(n(C)c(=O)n2C)=O)C)c12 n(cn(c1c(n(C)c(n2C)=O)=O)C)c21 n(cn(c1c(n(C)c(n2C)=O)=O)C)c12 n(c1c2c(=O)n(c(=O)n1C)C)cn2C n(c1c2c(=O)n(c(n1C)=O)C)cn2C n(c1c2c(=O)n(C)c(=O)n1C)cn2C n(c1c2c(=O)n(C)c(n1C)=O)cn2C n(c1c2c(n(c(=O)n1C)C)=O)cn2C n(c1c2c(n(c(n1C)=O)C)=O)cn2C n(c1c2c(n(C)c(=O)n1C)=O)cn2C n(c1c2c(n(C)c(n1C)=O)=O)cn2C n(c1c(n2C)c(=O)n(c(=O)n1C)C)c2 n(c1c(n2C)c(=O)n(c(n1C)=O)C)c2 n(c1c(n2C)c(=O)n(C)c(=O)n1C)c2 n(c1c(n2C)c(=O)n(C)c(n1C)=O)c2 n(c1c(n2C)c(n(c(=O)n1C)C)=O)c2 n(c1c(n2C)c(n(c(n1C)=O)C)=O)c2 n(c1c(n2C)c(n(C)c(=O)n1C)=O)c2 n(c1c(n2C)c(n(C)c(n1C)=O)=O)c2 n(c1c(c(=O)n(c(=O)n1C)C)n2C)c2 n(c1c(c(=O)n(c(n1C)=O)C)n2C)c2 n(c1c(c(=O)n(C)c(=O)n1C)n2C)c2 n(c1c(c(=O)n(C)c(n1C)=O)n2C)c2 n(c1c(c(n(c(=O)n1C)C)=O)n2C)c2 n(c1c(c(n(c(n1C)=O)C)=O)n2C)c2 n(c1c(c(n(C)c(=O)n1C)=O)n2C)c2 n(c1c(c(n(C)c(n1C)=O)=O)n2C)c2 n(c1n2C)cn(C)c1c(=O)n(c2=O)C n(c1n2C)cn(C)c1c(=O)n(C)c2=O n(c1n2C)cn(C)c1c(n(c2=O)C)=O n(c1n2C)cn(C)c1c(n(C)c2=O)=O n(c1n2C)cn(c1c(=O)n(c2=O)C)C n(c1n2C)cn(c1c(=O)n(C)c2=O)C n(c1n2C)cn(c1c(n(c2=O)C)=O)C n(c1n2C)cn(c1c(n(C)c2=O)=O)C n(c1n(c2=O)C)cn(C)c1c(=O)n2C n(c1n(c2=O)C)cn(C)c1c(n2C)=O n(c1n(c2=O)C)cn(c1c(=O)n2C)C n(c1n(c2=O)C)cn(c1c(n2C)=O)C n(c1n(c(n2C)=O)C)cn(C)c1c2=O n(c1n(c(n2C)=O)C)cn(c1c2=O)C n(c1n(c(n(c2=O)C)=O)C)cn(C)c12 n(c1n(c(n(c2=O)C)=O)C)cn(C)c21 n(c1n(c(n(c2=O)C)=O)C)cn(c12)C n(c1n(c(n(c2=O)C)=O)C)cn(c21)C n(c1n(c(n(c(c1n2C)=O)C)=O)C)c2 n(c1n(c(n(c(=O)c1n2C)C)=O)C)c2 n(c1n(c(n(C)c2=O)=O)C)cn(C)c12 n(c1n(c(n(C)c2=O)=O)C)cn(C)c21 n(c1n(c(n(C)c2=O)=O)C)cn(c12)C n(c1n(c(n(C)c2=O)=O)C)cn(c21)C n(c1n(c(n(C)c(c1n2C)=O)=O)C)c2 n(c1n(c(n(C)c(=O)c1n2C)=O)C)c2 n(c1n(c(=O)n2C)C)cn(C)c1c2=O n(c1n(c(=O)n2C)C)cn(c1c2=O)C n(c1n(c(=O)n(c2=O)C)C)cn(C)c12 n(c1n(c(=O)n(c2=O)C)C)cn(C)c21 n(c1n(c(=O)n(c2=O)C)C)cn(c12)C n(c1n(c(=O)n(c2=O)C)C)cn(c21)C n(c1n(c(=O)n(c(c1n2C)=O)C)C)c2 n(c1n(c(=O)n(c(=O)c1n2C)C)C)c2 n(c1n(c(=O)n(C)c2=O)C)cn(C)c12 n(c1n(c(=O)n(C)c2=O)C)cn(C)c21 n(c1n(c(=O)n(C)c2=O)C)cn(c12)C n(c1n(c(=O)n(C)c2=O)C)cn(c21)C n(c1n(c(=O)n(C)c(c1n2C)=O)C)c2 n(c1n(c(=O)n(C)c(=O)c1n2C)C)c2 n(c1n(C)c2=O)cn(C)c1c(=O)n2C n(c1n(C)c2=O)cn(C)c1c(n2C)=O n(c1n(C)c2=O)cn(c1c(=O)n2C)C n(c1n(C)c2=O)cn(c1c(n2C)=O)C n(c1n(C)c(n2C)=O)cn(C)c1c2=O n(c1n(C)c(n2C)=O)cn(c1c2=O)C n(c1n(C)c(n(c2=O)C)=O)cn(C)c12 n(c1n(C)c(n(c2=O)C)=O)cn(C)c21 n(c1n(C)c(n(c2=O)C)=O)cn(c12)C n(c1n(C)c(n(c2=O)C)=O)cn(c21)C n(c1n(C)c(n(c(c1n2C)=O)C)=O)c2 n(c1n(C)c(n(c(=O)c1n2C)C)=O)c2 n(c1n(C)c(n(C)c2=O)=O)cn(C)c12 n(c1n(C)c(n(C)c2=O)=O)cn(C)c21 n(c1n(C)c(n(C)c2=O)=O)cn(c12)C n(c1n(C)c(n(C)c2=O)=O)cn(c21)C n(c1n(C)c(n(C)c(c1n2C)=O)=O)c2 n(c1n(C)c(n(C)c(=O)c1n2C)=O)c2 n(c1n(C)c(=O)n2C)cn(C)c1c2=O n(c1n(C)c(=O)n2C)cn(c1c2=O)C n(c1n(C)c(=O)n(c2=O)C)cn(C)c12 n(c1n(C)c(=O)n(c2=O)C)cn(C)c21 n(c1n(C)c(=O)n(c2=O)C)cn(c12)C n(c1n(C)c(=O)n(c2=O)C)cn(c21)C n(c1n(C)c(=O)n(c(c1n2C)=O)C)c2 n(c1n(C)c(=O)n(c(=O)c1n2C)C)c2 n(c1n(C)c(=O)n(C)c2=O)cn(C)c12 n(c1n(C)c(=O)n(C)c2=O)cn(C)c21 n(c1n(C)c(=O)n(C)c2=O)cn(c12)C n(c1n(C)c(=O)n(C)c2=O)cn(c21)C n(c1n(C)c(=O)n(C)c(c1n2C)=O)c2 n(c1n(C)c(=O)n(C)c(=O)c1n2C)c2 n(c(n1C)c2c(=O)n(c1=O)C)cn2C n(c(n1C)c2c(=O)n(C)c1=O)cn2C n(c(n1C)c2c(n(c1=O)C)=O)cn2C n(c(n1C)c2c(n(C)c1=O)=O)cn2C n(c(n1C)c(n2C)c(=O)n(c1=O)C)c2 n(c(n1C)c(n2C)c(=O)n(C)c1=O)c2 n(c(n1C)c(n2C)c(n(c1=O)C)=O)c2 n(c(n1C)c(n2C)c(n(C)c1=O)=O)c2 n(c(n1C)c(c(=O)n(c1=O)C)n2C)c2 n(c(n1C)c(c(=O)n(C)c1=O)n2C)c2 n(c(n1C)c(c(n(c1=O)C)=O)n2C)c2 n(c(n1C)c(c(n(C)c1=O)=O)n2C)c2 n(c(n(c1=O)C)c2c(=O)n1C)cn2C n(c(n(c1=O)C)c2c(n1C)=O)cn2C n(c(n(c1=O)C)c(n2C)c(=O)n1C)c2 n(c(n(c1=O)C)c(n2C)c(n1C)=O)c2 n(c(n(c1=O)C)c(c(=O)n1C)n2C)c2 n(c(n(c1=O)C)c(c(n1C)=O)n2C)c2 n(c(n(c(n1C)=O)C)c2c1=O)cn2C n(c(n(c(n1C)=O)C)c(n2C)c1=O)c2 n(c(n(c(n1C)=O)C)c(c1=O)n2C)c2 n(c(n(c(n(c1=O)C)=O)C)c1n2C)c2 n(c(n(c(n(C)c1=O)=O)C)c1n2C)c2 n(c(n(c(=O)n1C)C)c2c1=O)cn2C n(c(n(c(=O)n1C)C)c(n2C)c1=O)c2 n(c(n(c(=O)n1C)C)c(c1=O)n2C)c2 n(c(n(c(=O)n(c1=O)C)C)c1n2C)c2 n(c(n(c(=O)n(C)c1=O)C)c1n2C)c2 n(c(n(C)c1=O)c2c(=O)n1C)cn2C n(c(n(C)c1=O)c2c(n1C)=O)cn2C n(c(n(C)c1=O)c(n2C)c(=O)n1C)c2 n(c(n(C)c1=O)c(n2C)c(n1C)=O)c2 n(c(n(C)c1=O)c(c(=O)n1C)n2C)c2 n(c(n(C)c1=O)c(c(n1C)=O)n2C)c2 n(c(n(C)c(n1C)=O)c2c1=O)cn2C n(c(n(C)c(n1C)=O)c(n2C)c1=O)c2 n(c(n(C)c(n1C)=O)c(c1=O)n2C)c2 n(c(n(C)c(n(c1=O)C)=O)c1n2C)c2 n(c(n(C)c(n(C)c1=O)=O)c1n2C)c2 n(c(n(C)c(=O)n1C)c2c1=O)cn2C n(c(n(C)c(=O)n1C)c(n2C)c1=O)c2 n(c(n(C)c(=O)n1C)c(c1=O)n2C)c2 n(c(n(C)c(=O)n(c1=O)C)c1n2C)c2 n(c(n(C)c(=O)n(C)c1=O)c1n2C)c2 n(c(c1c2=O)n(c(n2C)=O)C)cn1C n(c(c1c2=O)n(c(=O)n2C)C)cn1C n(c(c1c2=O)n(C)c(n2C)=O)cn1C n(c(c1c2=O)n(C)c(=O)n2C)cn1C n(c(c1c(=O)n2C)n(c2=O)C)cn1C n(c(c1c(=O)n2C)n(C)c2=O)cn1C n(c(c1c(=O)n(c2=O)C)n2C)cn1C n(c(c1c(=O)n(C)c2=O)n2C)cn1C n(c(c1c(n2C)=O)n(c2=O)C)cn1C n(c(c1c(n2C)=O)n(C)c2=O)cn1C n(c(c1c(n(c2=O)C)=O)n2C)cn1C n(c(c1c(n(C)c2=O)=O)n2C)cn1C n(c(c1n2C)n(c(n(c1=O)C)=O)C)c2 n(c(c1n2C)n(c(n(C)c1=O)=O)C)c2 n(c(c1n2C)n(c(=O)n(c1=O)C)C)c2 n(c(c1n2C)n(c(=O)n(C)c1=O)C)c2 n(c(c1n2C)n(C)c(n(c1=O)C)=O)c2 n(c(c1n2C)n(C)c(n(C)c1=O)=O)c2 n(c(c1n2C)n(C)c(=O)n(c1=O)C)c2 n(c(c1n2C)n(C)c(=O)n(C)c1=O)c2 n(c(c(n1C)c2=O)n(c(n2C)=O)C)c1 n(c(c(n1C)c2=O)n(c(=O)n2C)C)c1 n(c(c(n1C)c2=O)n(C)c(n2C)=O)c1 n(c(c(n1C)c2=O)n(C)c(=O)n2C)c1 n(c(c(n1C)c(=O)n2C)n(c2=O)C)c1 n(c(c(n1C)c(=O)n2C)n(C)c2=O)c1 n(c(c(n1C)c(=O)n(c2=O)C)n2C)c1 n(c(c(n1C)c(=O)n(C)c2=O)n2C)c1 n(c(c(n1C)c(n2C)=O)n(c2=O)C)c1 n(c(c(n1C)c(n2C)=O)n(C)c2=O)c1 n(c(c(n1C)c(n(c2=O)C)=O)n2C)c1 n(c(c(n1C)c(n(C)c2=O)=O)n2C)c1 n(c(c(c1=O)n2C)n(c(n1C)=O)C)c2 n(c(c(c1=O)n2C)n(c(=O)n1C)C)c2 n(c(c(c1=O)n2C)n(C)c(n1C)=O)c2 n(c(c(c1=O)n2C)n(C)c(=O)n1C)c2 n(c(c(c(=O)n1C)n2C)n(c1=O)C)c2 n(c(c(c(=O)n1C)n2C)n(C)c1=O)c2 n(c(c(c(=O)n(c1=O)C)n2C)n1C)c2 n(c(c(c(=O)n(C)c1=O)n2C)n1C)c2 n(c(c(c(n1C)=O)n2C)n(c1=O)C)c2 n(c(c(c(n1C)=O)n2C)n(C)c1=O)c2 n(c(c(c(n(c1=O)C)=O)n2C)n1C)c2 n(c(c(c(n(C)c1=O)=O)n2C)n1C)c2 c12c(n(C)cn1)c(=O)n(c(=O)n2C)C c12c(n(C)cn1)c(=O)n(c(n2C)=O)C c12c(n(C)cn1)c(=O)n(C)c(=O)n2C c12c(n(C)cn1)c(=O)n(C)c(n2C)=O c12c(n(C)cn1)c(n(c(=O)n2C)C)=O c12c(n(C)cn1)c(n(c(n2C)=O)C)=O c12c(n(C)cn1)c(n(C)c(=O)n2C)=O c12c(n(C)cn1)c(n(C)c(n2C)=O)=O c12c(n(cn1)C)c(=O)n(c(=O)n2C)C c12c(n(cn1)C)c(=O)n(c(n2C)=O)C c12c(n(cn1)C)c(=O)n(C)c(=O)n2C c12c(n(cn1)C)c(=O)n(C)c(n2C)=O c12c(n(cn1)C)c(n(c(=O)n2C)C)=O c12c(n(cn1)C)c(n(c(n2C)=O)C)=O c12c(n(cn1)C)c(n(C)c(=O)n2C)=O c12c(n(cn1)C)c(n(C)c(n2C)=O)=O c12c(c(=O)n(c(=O)n2C)C)n(C)cn1 c12c(c(=O)n(c(=O)n2C)C)n(cn1)C c12c(c(=O)n(c(n2C)=O)C)n(C)cn1 c12c(c(=O)n(c(n2C)=O)C)n(cn1)C c12c(c(=O)n(C)c(=O)n2C)n(C)cn1 c12c(c(=O)n(C)c(=O)n2C)n(cn1)C c12c(c(=O)n(C)c(n2C)=O)n(C)cn1 c12c(c(=O)n(C)c(n2C)=O)n(cn1)C c12c(c(n(c(=O)n2C)C)=O)n(C)cn1 c12c(c(n(c(=O)n2C)C)=O)n(cn1)C c12c(c(n(c(n2C)=O)C)=O)n(C)cn1 c12c(c(n(c(n2C)=O)C)=O)n(cn1)C c12c(c(n(C)c(=O)n2C)=O)n(C)cn1 c12c(c(n(C)c(=O)n2C)=O)n(cn1)C c12c(c(n(C)c(n2C)=O)=O)n(C)cn1 c12c(c(n(C)c(n2C)=O)=O)n(cn1)C c12n(c(n(c(c2n(C)cn1)=O)C)=O)C c12n(c(n(c(c2n(cn1)C)=O)C)=O)C c12n(c(n(c(=O)c2n(C)cn1)C)=O)C c12n(c(n(c(=O)c2n(cn1)C)C)=O)C c12n(c(n(C)c(c2n(C)cn1)=O)=O)C c12n(c(n(C)c(c2n(cn1)C)=O)=O)C c12n(c(n(C)c(=O)c2n(C)cn1)=O)C c12n(c(n(C)c(=O)c2n(cn1)C)=O)C c12n(c(=O)n(c(c2n(C)cn1)=O)C)C c12n(c(=O)n(c(c2n(cn1)C)=O)C)C c12n(c(=O)n(c(=O)c2n(C)cn1)C)C c12n(c(=O)n(c(=O)c2n(cn1)C)C)C c12n(c(=O)n(C)c(c2n(C)cn1)=O)C c12n(c(=O)n(C)c(c2n(cn1)C)=O)C c12n(c(=O)n(C)c(=O)c2n(C)cn1)C c12n(c(=O)n(C)c(=O)c2n(cn1)C)C c12n(C)c(n(c(c2n(C)cn1)=O)C)=O c12n(C)c(n(c(c2n(cn1)C)=O)C)=O c12n(C)c(n(c(=O)c2n(C)cn1)C)=O c12n(C)c(n(c(=O)c2n(cn1)C)C)=O c12n(C)c(n(C)c(c2n(C)cn1)=O)=O c12n(C)c(n(C)c(c2n(cn1)C)=O)=O c12n(C)c(n(C)c(=O)c2n(C)cn1)=O c12n(C)c(n(C)c(=O)c2n(cn1)C)=O c12n(C)c(=O)n(c(c2n(C)cn1)=O)C c12n(C)c(=O)n(c(c2n(cn1)C)=O)C c12n(C)c(=O)n(c(=O)c2n(C)cn1)C c12n(C)c(=O)n(c(=O)c2n(cn1)C)C c12n(C)c(=O)n(C)c(c2n(C)cn1)=O c12n(C)c(=O)n(C)c(c2n(cn1)C)=O c12n(C)c(=O)n(C)c(=O)c2n(C)cn1 c12n(C)c(=O)n(C)c(=O)c2n(cn1)C c1(n2C)c(n(C)cn1)c(=O)n(c2=O)C c1(n2C)c(n(C)cn1)c(=O)n(C)c2=O c1(n2C)c(n(C)cn1)c(n(c2=O)C)=O c1(n2C)c(n(C)cn1)c(n(C)c2=O)=O c1(n2C)c(n(cn1)C)c(=O)n(c2=O)C c1(n2C)c(n(cn1)C)c(=O)n(C)c2=O c1(n2C)c(n(cn1)C)c(n(c2=O)C)=O c1(n2C)c(n(cn1)C)c(n(C)c2=O)=O c1(n2C)c(c(=O)n(c2=O)C)n(C)cn1 c1(n2C)c(c(=O)n(c2=O)C)n(cn1)C c1(n2C)c(c(=O)n(C)c2=O)n(C)cn1 c1(n2C)c(c(=O)n(C)c2=O)n(cn1)C c1(n2C)c(c(n(c2=O)C)=O)n(C)cn1 c1(n2C)c(c(n(c2=O)C)=O)n(cn1)C c1(n2C)c(c(n(C)c2=O)=O)n(C)cn1 c1(n2C)c(c(n(C)c2=O)=O)n(cn1)C c1(n(c2=O)C)c(n(C)cn1)c(=O)n2C c1(n(c2=O)C)c(n(C)cn1)c(n2C)=O c1(n(c2=O)C)c(n(cn1)C)c(=O)n2C c1(n(c2=O)C)c(n(cn1)C)c(n2C)=O c1(n(c2=O)C)c(c(=O)n2C)n(C)cn1 c1(n(c2=O)C)c(c(=O)n2C)n(cn1)C c1(n(c2=O)C)c(c(n2C)=O)n(C)cn1 c1(n(c2=O)C)c(c(n2C)=O)n(cn1)C c1(n(c(n2C)=O)C)c(n(C)cn1)c2=O c1(n(c(n2C)=O)C)c(n(cn1)C)c2=O c1(n(c(n2C)=O)C)c(c2=O)n(C)cn1 c1(n(c(n2C)=O)C)c(c2=O)n(cn1)C c1(n(c(n(c2=O)C)=O)C)c2n(C)cn1 c1(n(c(n(c2=O)C)=O)C)c2n(cn1)C c1(n(c(n(C)c2=O)=O)C)c2n(C)cn1 c1(n(c(n(C)c2=O)=O)C)c2n(cn1)C c1(n(c(=O)n2C)C)c(n(C)cn1)c2=O c1(n(c(=O)n2C)C)c(n(cn1)C)c2=O c1(n(c(=O)n2C)C)c(c2=O)n(C)cn1 c1(n(c(=O)n2C)C)c(c2=O)n(cn1)C c1(n(c(=O)n(c2=O)C)C)c2n(C)cn1 c1(n(c(=O)n(c2=O)C)C)c2n(cn1)C c1(n(c(=O)n(C)c2=O)C)c2n(C)cn1 c1(n(c(=O)n(C)c2=O)C)c2n(cn1)C c1(n(C)c2=O)c(n(C)cn1)c(=O)n2C c1(n(C)c2=O)c(n(C)cn1)c(n2C)=O c1(n(C)c2=O)c(n(cn1)C)c(=O)n2C c1(n(C)c2=O)c(n(cn1)C)c(n2C)=O c1(n(C)c2=O)c(c(=O)n2C)n(C)cn1 c1(n(C)c2=O)c(c(=O)n2C)n(cn1)C c1(n(C)c2=O)c(c(n2C)=O)n(C)cn1 c1(n(C)c2=O)c(c(n2C)=O)n(cn1)C c1(n(C)c(n2C)=O)c(n(C)cn1)c2=O c1(n(C)c(n2C)=O)c(n(cn1)C)c2=O c1(n(C)c(n2C)=O)c(c2=O)n(C)cn1 c1(n(C)c(n2C)=O)c(c2=O)n(cn1)C c1(n(C)c(n(c2=O)C)=O)c2n(C)cn1 c1(n(C)c(n(c2=O)C)=O)c2n(cn1)C c1(n(C)c(n(C)c2=O)=O)c2n(C)cn1 c1(n(C)c(n(C)c2=O)=O)c2n(cn1)C c1(n(C)c(=O)n2C)c(n(C)cn1)c2=O c1(n(C)c(=O)n2C)c(n(cn1)C)c2=O c1(n(C)c(=O)n2C)c(c2=O)n(C)cn1 c1(n(C)c(=O)n2C)c(c2=O)n(cn1)C c1(n(C)c(=O)n(c2=O)C)c2n(C)cn1 c1(n(C)c(=O)n(c2=O)C)c2n(cn1)C c1(n(C)c(=O)n(C)c2=O)c2n(C)cn1 c1(n(C)c(=O)n(C)c2=O)c2n(cn1)C c1(c2n(C)cn1)n(c(n(c2=O)C)=O)C c1(c2n(C)cn1)n(c(n(C)c2=O)=O)C c1(c2n(C)cn1)n(c(=O)n(c2=O)C)C c1(c2n(C)cn1)n(c(=O)n(C)c2=O)C c1(c2n(C)cn1)n(C)c(n(c2=O)C)=O c1(c2n(C)cn1)n(C)c(n(C)c2=O)=O c1(c2n(C)cn1)n(C)c(=O)n(c2=O)C c1(c2n(C)cn1)n(C)c(=O)n(C)c2=O c1(c2n(cn1)C)n(c(n(c2=O)C)=O)C c1(c2n(cn1)C)n(c(n(C)c2=O)=O)C c1(c2n(cn1)C)n(c(=O)n(c2=O)C)C c1(c2n(cn1)C)n(c(=O)n(C)c2=O)C c1(c2n(cn1)C)n(C)c(n(c2=O)C)=O c1(c2n(cn1)C)n(C)c(n(C)c2=O)=O c1(c2n(cn1)C)n(C)c(=O)n(c2=O)C c1(c2n(cn1)C)n(C)c(=O)n(C)c2=O c1(c(n(C)cn1)c2=O)n(c(n2C)=O)C c1(c(n(C)cn1)c2=O)n(c(=O)n2C)C c1(c(n(C)cn1)c2=O)n(C)c(n2C)=O c1(c(n(C)cn1)c2=O)n(C)c(=O)n2C c1(c(n(C)cn1)c(=O)n2C)n(c2=O)C c1(c(n(C)cn1)c(=O)n2C)n(C)c2=O c1(c(n(C)cn1)c(=O)n(c2=O)C)n2C c1(c(n(C)cn1)c(=O)n(C)c2=O)n2C c1(c(n(C)cn1)c(n2C)=O)n(c2=O)C c1(c(n(C)cn1)c(n2C)=O)n(C)c2=O c1(c(n(C)cn1)c(n(c2=O)C)=O)n2C c1(c(n(C)cn1)c(n(C)c2=O)=O)n2C c1(c(n(cn1)C)c2=O)n(c(n2C)=O)C c1(c(n(cn1)C)c2=O)n(c(=O)n2C)C c1(c(n(cn1)C)c2=O)n(C)c(n2C)=O c1(c(n(cn1)C)c2=O)n(C)c(=O)n2C c1(c(n(cn1)C)c(=O)n2C)n(c2=O)C c1(c(n(cn1)C)c(=O)n2C)n(C)c2=O c1(c(n(cn1)C)c(=O)n(c2=O)C)n2C c1(c(n(cn1)C)c(=O)n(C)c2=O)n2C c1(c(n(cn1)C)c(n2C)=O)n(c2=O)C c1(c(n(cn1)C)c(n2C)=O)n(C)c2=O c1(c(n(cn1)C)c(n(c2=O)C)=O)n2C c1(c(n(cn1)C)c(n(C)c2=O)=O)n2C c1(c(c2=O)n(C)cn1)n(c(n2C)=O)C c1(c(c2=O)n(C)cn1)n(c(=O)n2C)C c1(c(c2=O)n(C)cn1)n(C)c(n2C)=O c1(c(c2=O)n(C)cn1)n(C)c(=O)n2C c1(c(c2=O)n(cn1)C)n(c(n2C)=O)C c1(c(c2=O)n(cn1)C)n(c(=O)n2C)C c1(c(c2=O)n(cn1)C)n(C)c(n2C)=O c1(c(c2=O)n(cn1)C)n(C)c(=O)n2C c1(c(c(=O)n2C)n(C)cn1)n(c2=O)C c1(c(c(=O)n2C)n(C)cn1)n(C)c2=O c1(c(c(=O)n2C)n(cn1)C)n(c2=O)C c1(c(c(=O)n2C)n(cn1)C)n(C)c2=O c1(c(c(=O)n(c2=O)C)n(C)cn1)n2C c1(c(c(=O)n(c2=O)C)n(cn1)C)n2C c1(c(c(=O)n(C)c2=O)n(C)cn1)n2C c1(c(c(=O)n(C)c2=O)n(cn1)C)n2C c1(c(c(n2C)=O)n(C)cn1)n(c2=O)C c1(c(c(n2C)=O)n(C)cn1)n(C)c2=O c1(c(c(n2C)=O)n(cn1)C)n(c2=O)C c1(c(c(n2C)=O)n(cn1)C)n(C)c2=O c1(c(c(n(c2=O)C)=O)n(C)cn1)n2C c1(c(c(n(c2=O)C)=O)n(cn1)C)n2C c1(c(c(n(C)c2=O)=O)n(C)cn1)n2C c1(c(c(n(C)c2=O)=O)n(cn1)C)n2C c12c(n(C)cn2)c(=O)n(c(=O)n1C)C c12c(n(C)cn2)c(=O)n(c(n1C)=O)C c12c(n(C)cn2)c(=O)n(C)c(=O)n1C c12c(n(C)cn2)c(=O)n(C)c(n1C)=O c12c(n(C)cn2)c(n(c(=O)n1C)C)=O c12c(n(C)cn2)c(n(c(n1C)=O)C)=O c12c(n(C)cn2)c(n(C)c(=O)n1C)=O c12c(n(C)cn2)c(n(C)c(n1C)=O)=O c12c(n(cn2)C)c(=O)n(c(=O)n1C)C c12c(n(cn2)C)c(=O)n(c(n1C)=O)C c12c(n(cn2)C)c(=O)n(C)c(=O)n1C c12c(n(cn2)C)c(=O)n(C)c(n1C)=O c12c(n(cn2)C)c(n(c(=O)n1C)C)=O c12c(n(cn2)C)c(n(c(n1C)=O)C)=O c12c(n(cn2)C)c(n(C)c(=O)n1C)=O c12c(n(cn2)C)c(n(C)c(n1C)=O)=O c12c(c(=O)n(c(=O)n1C)C)n(C)cn2 c12c(c(=O)n(c(=O)n1C)C)n(cn2)C c12c(c(=O)n(c(n1C)=O)C)n(C)cn2 c12c(c(=O)n(c(n1C)=O)C)n(cn2)C c12c(c(=O)n(C)c(=O)n1C)n(C)cn2 c12c(c(=O)n(C)c(=O)n1C)n(cn2)C c12c(c(=O)n(C)c(n1C)=O)n(C)cn2 c12c(c(=O)n(C)c(n1C)=O)n(cn2)C c12c(c(n(c(=O)n1C)C)=O)n(C)cn2 c12c(c(n(c(=O)n1C)C)=O)n(cn2)C c12c(c(n(c(n1C)=O)C)=O)n(C)cn2 c12c(c(n(c(n1C)=O)C)=O)n(cn2)C c12c(c(n(C)c(=O)n1C)=O)n(C)cn2 c12c(c(n(C)c(=O)n1C)=O)n(cn2)C c12c(c(n(C)c(n1C)=O)=O)n(C)cn2 c12c(c(n(C)c(n1C)=O)=O)n(cn2)C c12ncn(C)c2c(=O)n(c(=O)n1C)C c12ncn(C)c2c(=O)n(c(n1C)=O)C c12ncn(C)c2c(=O)n(C)c(=O)n1C c12ncn(C)c2c(=O)n(C)c(n1C)=O c12ncn(C)c2c(n(c(=O)n1C)C)=O c12ncn(C)c2c(n(c(n1C)=O)C)=O c12ncn(C)c2c(n(C)c(=O)n1C)=O c12ncn(C)c2c(n(C)c(n1C)=O)=O c12ncn(c2c(=O)n(c(=O)n1C)C)C c12ncn(c2c(=O)n(c(n1C)=O)C)C c12ncn(c2c(=O)n(C)c(=O)n1C)C c12ncn(c2c(=O)n(C)c(n1C)=O)C c12ncn(c2c(n(c(=O)n1C)C)=O)C c12ncn(c2c(n(c(n1C)=O)C)=O)C c12ncn(c2c(n(C)c(=O)n1C)=O)C c12ncn(c2c(n(C)c(n1C)=O)=O)C c1(ncn2C)c2c(=O)n(c(=O)n1C)C c1(ncn2C)c2c(=O)n(c(n1C)=O)C c1(ncn2C)c2c(=O)n(C)c(=O)n1C c1(ncn2C)c2c(=O)n(C)c(n1C)=O c1(ncn2C)c2c(n(c(=O)n1C)C)=O c1(ncn2C)c2c(n(c(n1C)=O)C)=O c1(ncn2C)c2c(n(C)c(=O)n1C)=O c1(ncn2C)c2c(n(C)c(n1C)=O)=O c1(c2c(=O)n(c(=O)n1C)C)ncn2C c1(c2c(=O)n(c(n1C)=O)C)ncn2C c1(c2c(=O)n(C)c(=O)n1C)ncn2C c1(c2c(=O)n(C)c(n1C)=O)ncn2C c1(c2c(n(c(=O)n1C)C)=O)ncn2C c1(c2c(n(c(n1C)=O)C)=O)ncn2C c1(c2c(n(C)c(=O)n1C)=O)ncn2C c1(c2c(n(C)c(n1C)=O)=O)ncn2C c1(c(n2C)c(=O)n(c(=O)n1C)C)nc2 c1(c(n2C)c(=O)n(c(n1C)=O)C)nc2 c1(c(n2C)c(=O)n(C)c(=O)n1C)nc2 c1(c(n2C)c(=O)n(C)c(n1C)=O)nc2 c1(c(n2C)c(n(c(=O)n1C)C)=O)nc2 c1(c(n2C)c(n(c(n1C)=O)C)=O)nc2 c1(c(n2C)c(n(C)c(=O)n1C)=O)nc2 c1(c(n2C)c(n(C)c(n1C)=O)=O)nc2 c1(c(c(=O)n(c(=O)n1C)C)n2C)nc2 c1(c(c(=O)n(c(n1C)=O)C)n2C)nc2 c1(c(c(=O)n(C)c(=O)n1C)n2C)nc2 c1(c(c(=O)n(C)c(n1C)=O)n2C)nc2 c1(c(c(n(c(=O)n1C)C)=O)n2C)nc2 c1(c(c(n(c(n1C)=O)C)=O)n2C)nc2 c1(c(c(n(C)c(=O)n1C)=O)n2C)nc2 c1(c(c(n(C)c(n1C)=O)=O)n2C)nc2 c12n(c(n(c(c1n(C)cn2)=O)C)=O)C c12n(c(n(c(c1n(cn2)C)=O)C)=O)C c12n(c(n(c(=O)c1n(C)cn2)C)=O)C c12n(c(n(c(=O)c1n(cn2)C)C)=O)C c12n(c(n(C)c(c1n(C)cn2)=O)=O)C c12n(c(n(C)c(c1n(cn2)C)=O)=O)C c12n(c(n(C)c(=O)c1n(C)cn2)=O)C c12n(c(n(C)c(=O)c1n(cn2)C)=O)C c12n(c(=O)n(c(c1n(C)cn2)=O)C)C c12n(c(=O)n(c(c1n(cn2)C)=O)C)C c12n(c(=O)n(c(=O)c1n(C)cn2)C)C c12n(c(=O)n(c(=O)c1n(cn2)C)C)C c12n(c(=O)n(C)c(c1n(C)cn2)=O)C c12n(c(=O)n(C)c(c1n(cn2)C)=O)C c12n(c(=O)n(C)c(=O)c1n(C)cn2)C c12n(c(=O)n(C)c(=O)c1n(cn2)C)C c12n(C)c(n(c(c1n(C)cn2)=O)C)=O c12n(C)c(n(c(c1n(cn2)C)=O)C)=O c12n(C)c(n(c(=O)c1n(C)cn2)C)=O c12n(C)c(n(c(=O)c1n(cn2)C)C)=O c12n(C)c(n(C)c(c1n(C)cn2)=O)=O c12n(C)c(n(C)c(c1n(cn2)C)=O)=O c12n(C)c(n(C)c(=O)c1n(C)cn2)=O c12n(C)c(n(C)c(=O)c1n(cn2)C)=O c12n(C)c(=O)n(c(c1n(C)cn2)=O)C c12n(C)c(=O)n(c(c1n(cn2)C)=O)C c12n(C)c(=O)n(c(=O)c1n(C)cn2)C c12n(C)c(=O)n(c(=O)c1n(cn2)C)C c12n(C)c(=O)n(C)c(c1n(C)cn2)=O c12n(C)c(=O)n(C)c(c1n(cn2)C)=O c12n(C)c(=O)n(C)c(=O)c1n(C)cn2 c12n(C)c(=O)n(C)c(=O)c1n(cn2)C c12ncn(C)c1c(=O)n(c(=O)n2C)C c12ncn(C)c1c(=O)n(c(n2C)=O)C c12ncn(C)c1c(=O)n(C)c(=O)n2C c12ncn(C)c1c(=O)n(C)c(n2C)=O c12ncn(C)c1c(n(c(=O)n2C)C)=O c12ncn(C)c1c(n(c(n2C)=O)C)=O c12ncn(C)c1c(n(C)c(=O)n2C)=O c12ncn(C)c1c(n(C)c(n2C)=O)=O c12ncn(c1c(=O)n(c(=O)n2C)C)C c12ncn(c1c(=O)n(c(n2C)=O)C)C c12ncn(c1c(=O)n(C)c(=O)n2C)C c12ncn(c1c(=O)n(C)c(n2C)=O)C c12ncn(c1c(n(c(=O)n2C)C)=O)C c12ncn(c1c(n(c(n2C)=O)C)=O)C c12ncn(c1c(n(C)c(=O)n2C)=O)C c12ncn(c1c(n(C)c(n2C)=O)=O)C c1(ncn2C)n(c(n(c(c21)=O)C)=O)C c1(ncn2C)n(c(n(c(c12)=O)C)=O)C c1(ncn2C)n(c(n(c(=O)c21)C)=O)C c1(ncn2C)n(c(n(c(=O)c12)C)=O)C c1(ncn2C)n(c(n(C)c(c21)=O)=O)C c1(ncn2C)n(c(n(C)c(c12)=O)=O)C c1(ncn2C)n(c(n(C)c(=O)c21)=O)C c1(ncn2C)n(c(n(C)c(=O)c12)=O)C c1(ncn2C)n(c(=O)n(c(c21)=O)C)C c1(ncn2C)n(c(=O)n(c(c12)=O)C)C c1(ncn2C)n(c(=O)n(c(=O)c21)C)C c1(ncn2C)n(c(=O)n(c(=O)c12)C)C c1(ncn2C)n(c(=O)n(C)c(c21)=O)C c1(ncn2C)n(c(=O)n(C)c(c12)=O)C c1(ncn2C)n(c(=O)n(C)c(=O)c21)C c1(ncn2C)n(c(=O)n(C)c(=O)c12)C c1(ncn2C)n(C)c(n(c(c21)=O)C)=O c1(ncn2C)n(C)c(n(c(c12)=O)C)=O c1(ncn2C)n(C)c(n(c(=O)c21)C)=O c1(ncn2C)n(C)c(n(c(=O)c12)C)=O c1(ncn2C)n(C)c(n(C)c(c21)=O)=O c1(ncn2C)n(C)c(n(C)c(c12)=O)=O c1(ncn2C)n(C)c(n(C)c(=O)c21)=O c1(ncn2C)n(C)c(n(C)c(=O)c12)=O c1(ncn2C)n(C)c(=O)n(c(c21)=O)C c1(ncn2C)n(C)c(=O)n(c(c12)=O)C c1(ncn2C)n(C)c(=O)n(c(=O)c21)C c1(ncn2C)n(C)c(=O)n(c(=O)c12)C c1(ncn2C)n(C)c(=O)n(C)c(c21)=O c1(ncn2C)n(C)c(=O)n(C)c(c12)=O c1(ncn2C)n(C)c(=O)n(C)c(=O)c21 c1(ncn2C)n(C)c(=O)n(C)c(=O)c12 c1(ncn(C)c1c2=O)n(c(n2C)=O)C c1(ncn(C)c1c2=O)n(c(=O)n2C)C c1(ncn(C)c1c2=O)n(C)c(n2C)=O c1(ncn(C)c1c2=O)n(C)c(=O)n2C c1(ncn(C)c1c(=O)n2C)n(c2=O)C c1(ncn(C)c1c(=O)n2C)n(C)c2=O c1(ncn(C)c1c(=O)n(c2=O)C)n2C c1(ncn(C)c1c(=O)n(C)c2=O)n2C c1(ncn(C)c1c(n2C)=O)n(c2=O)C c1(ncn(C)c1c(n2C)=O)n(C)c2=O c1(ncn(C)c1c(n(c2=O)C)=O)n2C c1(ncn(C)c1c(n(C)c2=O)=O)n2C c1(ncn(c1c2=O)C)n(c(n2C)=O)C c1(ncn(c1c2=O)C)n(c(=O)n2C)C c1(ncn(c1c2=O)C)n(C)c(n2C)=O c1(ncn(c1c2=O)C)n(C)c(=O)n2C c1(ncn(c1c(=O)n2C)C)n(c2=O)C c1(ncn(c1c(=O)n2C)C)n(C)c2=O c1(ncn(c1c(=O)n(c2=O)C)C)n2C c1(ncn(c1c(=O)n(C)c2=O)C)n2C c1(ncn(c1c(n2C)=O)C)n(c2=O)C c1(ncn(c1c(n2C)=O)C)n(C)c2=O c1(ncn(c1c(n(c2=O)C)=O)C)n2C c1(ncn(c1c(n(C)c2=O)=O)C)n2C c1(n2C)ncn(C)c1c(=O)n(c2=O)C c1(n2C)ncn(C)c1c(=O)n(C)c2=O c1(n2C)ncn(C)c1c(n(c2=O)C)=O c1(n2C)ncn(C)c1c(n(C)c2=O)=O c1(n2C)ncn(c1c(=O)n(c2=O)C)C c1(n2C)ncn(c1c(=O)n(C)c2=O)C c1(n2C)ncn(c1c(n(c2=O)C)=O)C c1(n2C)ncn(c1c(n(C)c2=O)=O)C c1(n(c2=O)C)ncn(C)c1c(=O)n2C c1(n(c2=O)C)ncn(C)c1c(n2C)=O c1(n(c2=O)C)ncn(c1c(=O)n2C)C c1(n(c2=O)C)ncn(c1c(n2C)=O)C c1(n(c(n2C)=O)C)ncn(C)c1c2=O c1(n(c(n2C)=O)C)ncn(c1c2=O)C c1(n(c(n(c2=O)C)=O)C)ncn(C)c12 c1(n(c(n(c2=O)C)=O)C)ncn(C)c21 c1(n(c(n(c2=O)C)=O)C)ncn(c12)C c1(n(c(n(c2=O)C)=O)C)ncn(c21)C c1(n(c(n(c(c1n2C)=O)C)=O)C)nc2 c1(n(c(n(c(=O)c1n2C)C)=O)C)nc2 c1(n(c(n(C)c2=O)=O)C)ncn(C)c12 c1(n(c(n(C)c2=O)=O)C)ncn(C)c21 c1(n(c(n(C)c2=O)=O)C)ncn(c12)C c1(n(c(n(C)c2=O)=O)C)ncn(c21)C c1(n(c(n(C)c(c1n2C)=O)=O)C)nc2 c1(n(c(n(C)c(=O)c1n2C)=O)C)nc2 c1(n(c(=O)n2C)C)ncn(C)c1c2=O c1(n(c(=O)n2C)C)ncn(c1c2=O)C c1(n(c(=O)n(c2=O)C)C)ncn(C)c12 c1(n(c(=O)n(c2=O)C)C)ncn(C)c21 c1(n(c(=O)n(c2=O)C)C)ncn(c12)C c1(n(c(=O)n(c2=O)C)C)ncn(c21)C c1(n(c(=O)n(c(c1n2C)=O)C)C)nc2 c1(n(c(=O)n(c(=O)c1n2C)C)C)nc2 c1(n(c(=O)n(C)c2=O)C)ncn(C)c12 c1(n(c(=O)n(C)c2=O)C)ncn(C)c21 c1(n(c(=O)n(C)c2=O)C)ncn(c12)C c1(n(c(=O)n(C)c2=O)C)ncn(c21)C c1(n(c(=O)n(C)c(c1n2C)=O)C)nc2 c1(n(c(=O)n(C)c(=O)c1n2C)C)nc2 c1(n(C)c2=O)ncn(C)c1c(=O)n2C c1(n(C)c2=O)ncn(C)c1c(n2C)=O c1(n(C)c2=O)ncn(c1c(=O)n2C)C c1(n(C)c2=O)ncn(c1c(n2C)=O)C c1(n(C)c(n2C)=O)ncn(C)c1c2=O c1(n(C)c(n2C)=O)ncn(c1c2=O)C c1(n(C)c(n(c2=O)C)=O)ncn(C)c12 c1(n(C)c(n(c2=O)C)=O)ncn(C)c21 c1(n(C)c(n(c2=O)C)=O)ncn(c12)C c1(n(C)c(n(c2=O)C)=O)ncn(c21)C c1(n(C)c(n(c(c1n2C)=O)C)=O)nc2 c1(n(C)c(n(c(=O)c1n2C)C)=O)nc2 c1(n(C)c(n(C)c2=O)=O)ncn(C)c12 c1(n(C)c(n(C)c2=O)=O)ncn(C)c21 c1(n(C)c(n(C)c2=O)=O)ncn(c12)C c1(n(C)c(n(C)c2=O)=O)ncn(c21)C c1(n(C)c(n(C)c(c1n2C)=O)=O)nc2 c1(n(C)c(n(C)c(=O)c1n2C)=O)nc2 c1(n(C)c(=O)n2C)ncn(C)c1c2=O c1(n(C)c(=O)n2C)ncn(c1c2=O)C c1(n(C)c(=O)n(c2=O)C)ncn(C)c12 c1(n(C)c(=O)n(c2=O)C)ncn(C)c21 c1(n(C)c(=O)n(c2=O)C)ncn(c12)C c1(n(C)c(=O)n(c2=O)C)ncn(c21)C c1(n(C)c(=O)n(c(c1n2C)=O)C)nc2 c1(n(C)c(=O)n(c(=O)c1n2C)C)nc2 c1(n(C)c(=O)n(C)c2=O)ncn(C)c12 c1(n(C)c(=O)n(C)c2=O)ncn(C)c21 c1(n(C)c(=O)n(C)c2=O)ncn(c12)C c1(n(C)c(=O)n(C)c2=O)ncn(c21)C c1(n(C)c(=O)n(C)c(c1n2C)=O)nc2 c1(n(C)c(=O)n(C)c(=O)c1n2C)nc2 c12c(=O)n(c(=O)n(c2ncn1C)C)C c12c(=O)n(c(=O)n(C)c2ncn1C)C c12c(=O)n(c(n(c2ncn1C)C)=O)C c12c(=O)n(c(n(C)c2ncn1C)=O)C c12c(=O)n(C)c(=O)n(c2ncn1C)C c12c(=O)n(C)c(=O)n(C)c2ncn1C c12c(=O)n(C)c(n(c2ncn1C)C)=O c12c(=O)n(C)c(n(C)c2ncn1C)=O c12c(n(c(=O)n(c2ncn1C)C)C)=O c12c(n(c(=O)n(C)c2ncn1C)C)=O c12c(n(c(n(c2ncn1C)C)=O)C)=O c12c(n(c(n(C)c2ncn1C)=O)C)=O c12c(n(C)c(=O)n(c2ncn1C)C)=O c12c(n(C)c(=O)n(C)c2ncn1C)=O c12c(n(C)c(n(c2ncn1C)C)=O)=O c12c(n(C)c(n(C)c2ncn1C)=O)=O c12c(ncn1C)n(c(n(c2=O)C)=O)C c12c(ncn1C)n(c(n(C)c2=O)=O)C c12c(ncn1C)n(c(=O)n(c2=O)C)C c12c(ncn1C)n(c(=O)n(C)c2=O)C c12c(ncn1C)n(C)c(n(c2=O)C)=O c12c(ncn1C)n(C)c(n(C)c2=O)=O c12c(ncn1C)n(C)c(=O)n(c2=O)C c12c(ncn1C)n(C)c(=O)n(C)c2=O c12c(n(c(n(c2=O)C)=O)C)ncn1C c12c(n(c(n(C)c2=O)=O)C)ncn1C c12c(n(c(=O)n(c2=O)C)C)ncn1C c12c(n(c(=O)n(C)c2=O)C)ncn1C c12c(n(C)c(n(c2=O)C)=O)ncn1C c12c(n(C)c(n(C)c2=O)=O)ncn1C c12c(n(C)c(=O)n(c2=O)C)ncn1C c12c(n(C)c(=O)n(C)c2=O)ncn1C c1(c2ncn1C)c(=O)n(c(=O)n2C)C c1(c2ncn1C)c(=O)n(c(n2C)=O)C c1(c2ncn1C)c(=O)n(C)c(=O)n2C c1(c2ncn1C)c(=O)n(C)c(n2C)=O c1(c2ncn1C)c(n(c(=O)n2C)C)=O c1(c2ncn1C)c(n(c(n2C)=O)C)=O c1(c2ncn1C)c(n(C)c(=O)n2C)=O c1(c2ncn1C)c(n(C)c(n2C)=O)=O c1(c(ncn1C)n2C)c(=O)n(c2=O)C c1(c(ncn1C)n2C)c(=O)n(C)c2=O c1(c(ncn1C)n2C)c(n(c2=O)C)=O c1(c(ncn1C)n2C)c(n(C)c2=O)=O c1(c(ncn1C)n(c2=O)C)c(=O)n2C c1(c(ncn1C)n(c2=O)C)c(n2C)=O c1(c(ncn1C)n(c(n2C)=O)C)c2=O c1(c(ncn1C)n(c(=O)n2C)C)c2=O c1(c(ncn1C)n(C)c2=O)c(=O)n2C c1(c(ncn1C)n(C)c2=O)c(n2C)=O c1(c(ncn1C)n(C)c(n2C)=O)c2=O c1(c(ncn1C)n(C)c(=O)n2C)c2=O c1(c(n2C)ncn1C)c(=O)n(c2=O)C c1(c(n2C)ncn1C)c(=O)n(C)c2=O c1(c(n2C)ncn1C)c(n(c2=O)C)=O c1(c(n2C)ncn1C)c(n(C)c2=O)=O c1(c(n(c2=O)C)ncn1C)c(=O)n2C c1(c(n(c2=O)C)ncn1C)c(n2C)=O c1(c(n(c(n2C)=O)C)ncn1C)c2=O c1(c(n(c(=O)n2C)C)ncn1C)c2=O c1(c(n(C)c2=O)ncn1C)c(=O)n2C c1(c(n(C)c2=O)ncn1C)c(n2C)=O c1(c(n(C)c(n2C)=O)ncn1C)c2=O c1(c(n(C)c(=O)n2C)ncn1C)c2=O c1(c2=O)c(ncn1C)n(c(n2C)=O)C c1(c2=O)c(ncn1C)n(c(=O)n2C)C c1(c2=O)c(ncn1C)n(C)c(n2C)=O c1(c2=O)c(ncn1C)n(C)c(=O)n2C c1(c2=O)c(n(c(n2C)=O)C)ncn1C c1(c2=O)c(n(c(=O)n2C)C)ncn1C c1(c2=O)c(n(C)c(n2C)=O)ncn1C c1(c2=O)c(n(C)c(=O)n2C)ncn1C c1(c(=O)n2C)c(ncn1C)n(c2=O)C c1(c(=O)n2C)c(ncn1C)n(C)c2=O c1(c(=O)n2C)c(n(c2=O)C)ncn1C c1(c(=O)n2C)c(n(C)c2=O)ncn1C c1(c(=O)n(c2=O)C)c(ncn1C)n2C c1(c(=O)n(c2=O)C)c(n2C)ncn1C c1(c(=O)n(c(=O)n2C)C)c2ncn1C c1(c(=O)n(c(n2C)=O)C)c2ncn1C c1(c(=O)n(C)c2=O)c(ncn1C)n2C c1(c(=O)n(C)c2=O)c(n2C)ncn1C c1(c(=O)n(C)c(=O)n2C)c2ncn1C c1(c(=O)n(C)c(n2C)=O)c2ncn1C c1(c(n2C)=O)c(ncn1C)n(c2=O)C c1(c(n2C)=O)c(ncn1C)n(C)c2=O c1(c(n2C)=O)c(n(c2=O)C)ncn1C c1(c(n2C)=O)c(n(C)c2=O)ncn1C c1(c(n(c2=O)C)=O)c(ncn1C)n2C c1(c(n(c2=O)C)=O)c(n2C)ncn1C c1(c(n(c(=O)n2C)C)=O)c2ncn1C c1(c(n(c(n2C)=O)C)=O)c2ncn1C c1(c(n(C)c2=O)=O)c(ncn1C)n2C c1(c(n(C)c2=O)=O)c(n2C)ncn1C c1(c(n(C)c(=O)n2C)=O)c2ncn1C c1(c(n(C)c(n2C)=O)=O)c2ncn1C c12c(=O)n(c(=O)n(c1ncn2C)C)C c12c(=O)n(c(=O)n(C)c1ncn2C)C c12c(=O)n(c(n(c1ncn2C)C)=O)C c12c(=O)n(c(n(C)c1ncn2C)=O)C c12c(=O)n(C)c(=O)n(c1ncn2C)C c12c(=O)n(C)c(=O)n(C)c1ncn2C c12c(=O)n(C)c(n(c1ncn2C)C)=O c12c(=O)n(C)c(n(C)c1ncn2C)=O c12c(n(c(=O)n(c1ncn2C)C)C)=O c12c(n(c(=O)n(C)c1ncn2C)C)=O c12c(n(c(n(c1ncn2C)C)=O)C)=O c12c(n(c(n(C)c1ncn2C)=O)C)=O c12c(n(C)c(=O)n(c1ncn2C)C)=O c12c(n(C)c(=O)n(C)c1ncn2C)=O c12c(n(C)c(n(c1ncn2C)C)=O)=O c12c(n(C)c(n(C)c1ncn2C)=O)=O c12n(C)cnc1n(c(n(c2=O)C)=O)C c12n(C)cnc1n(c(n(C)c2=O)=O)C c12n(C)cnc1n(c(=O)n(c2=O)C)C c12n(C)cnc1n(c(=O)n(C)c2=O)C c12n(C)cnc1n(C)c(n(c2=O)C)=O c12n(C)cnc1n(C)c(n(C)c2=O)=O c12n(C)cnc1n(C)c(=O)n(c2=O)C c12n(C)cnc1n(C)c(=O)n(C)c2=O c12n(cnc1n(c(n(c2=O)C)=O)C)C c12n(cnc1n(c(n(C)c2=O)=O)C)C c12n(cnc1n(c(=O)n(c2=O)C)C)C c12n(cnc1n(c(=O)n(C)c2=O)C)C c12n(cnc1n(C)c(n(c2=O)C)=O)C c12n(cnc1n(C)c(n(C)c2=O)=O)C c12n(cnc1n(C)c(=O)n(c2=O)C)C c12n(cnc1n(C)c(=O)n(C)c2=O)C c1(n2C)c(=O)n(c(=O)n(c1nc2)C)C c1(n2C)c(=O)n(c(=O)n(C)c1nc2)C c1(n2C)c(=O)n(c(n(c1nc2)C)=O)C c1(n2C)c(=O)n(c(n(C)c1nc2)=O)C c1(n2C)c(=O)n(C)c(=O)n(c1nc2)C c1(n2C)c(=O)n(C)c(=O)n(C)c1nc2 c1(n2C)c(=O)n(C)c(n(c1nc2)C)=O c1(n2C)c(=O)n(C)c(n(C)c1nc2)=O c1(n2C)c(n(c(=O)n(c1nc2)C)C)=O c1(n2C)c(n(c(=O)n(C)c1nc2)C)=O c1(n2C)c(n(c(n(c1nc2)C)=O)C)=O c1(n2C)c(n(c(n(C)c1nc2)=O)C)=O c1(n2C)c(n(C)c(=O)n(c1nc2)C)=O c1(n2C)c(n(C)c(=O)n(C)c1nc2)=O c1(n2C)c(n(C)c(n(c1nc2)C)=O)=O c1(n2C)c(n(C)c(n(C)c1nc2)=O)=O c1(n(C)cnc1n2C)c(=O)n(c2=O)C c1(n(C)cnc1n2C)c(=O)n(C)c2=O c1(n(C)cnc1n2C)c(n(c2=O)C)=O c1(n(C)cnc1n2C)c(n(C)c2=O)=O c1(n(C)cnc1n(c2=O)C)c(=O)n2C c1(n(C)cnc1n(c2=O)C)c(n2C)=O c1(n(C)cnc1n(c(n2C)=O)C)c2=O c1(n(C)cnc1n(c(=O)n2C)C)c2=O c1(n(C)cnc1n(C)c2=O)c(=O)n2C c1(n(C)cnc1n(C)c2=O)c(n2C)=O c1(n(C)cnc1n(C)c(n2C)=O)c2=O c1(n(C)cnc1n(C)c(=O)n2C)c2=O c1(n(cnc1n2C)C)c(=O)n(c2=O)C c1(n(cnc1n2C)C)c(=O)n(C)c2=O c1(n(cnc1n2C)C)c(n(c2=O)C)=O c1(n(cnc1n2C)C)c(n(C)c2=O)=O c1(n(cnc1n(c2=O)C)C)c(=O)n2C c1(n(cnc1n(c2=O)C)C)c(n2C)=O c1(n(cnc1n(c(n2C)=O)C)C)c2=O c1(n(cnc1n(c(=O)n2C)C)C)c2=O c1(n(cnc1n(C)c2=O)C)c(=O)n2C c1(n(cnc1n(C)c2=O)C)c(n2C)=O c1(n(cnc1n(C)c(n2C)=O)C)c2=O c1(n(cnc1n(C)c(=O)n2C)C)c2=O c1(c2=O)n(C)cnc1n(c(n2C)=O)C c1(c2=O)n(C)cnc1n(c(=O)n2C)C c1(c2=O)n(C)cnc1n(C)c(n2C)=O c1(c2=O)n(C)cnc1n(C)c(=O)n2C c1(c2=O)n(cnc1n(c(n2C)=O)C)C c1(c2=O)n(cnc1n(c(=O)n2C)C)C c1(c2=O)n(cnc1n(C)c(n2C)=O)C c1(c2=O)n(cnc1n(C)c(=O)n2C)C c1(c(=O)n2C)n(C)cnc1n(c2=O)C c1(c(=O)n2C)n(C)cnc1n(C)c2=O c1(c(=O)n2C)n(cnc1n(c2=O)C)C c1(c(=O)n2C)n(cnc1n(C)c2=O)C c1(c(=O)n(c2=O)C)n(C)cnc1n2C c1(c(=O)n(c2=O)C)n(cnc1n2C)C c1(c(=O)n(c(=O)n2C)C)n(C)cnc21 c1(c(=O)n(c(=O)n2C)C)n(C)cnc12 c1(c(=O)n(c(=O)n2C)C)n(cnc21)C c1(c(=O)n(c(=O)n2C)C)n(cnc12)C c1(c(=O)n(c(n2C)=O)C)n(C)cnc21 c1(c(=O)n(c(n2C)=O)C)n(C)cnc12 c1(c(=O)n(c(n2C)=O)C)n(cnc21)C c1(c(=O)n(c(n2C)=O)C)n(cnc12)C c1(c(=O)n(C)c2=O)n(C)cnc1n2C c1(c(=O)n(C)c2=O)n(cnc1n2C)C c1(c(=O)n(C)c(=O)n2C)n(C)cnc21 c1(c(=O)n(C)c(=O)n2C)n(C)cnc12 c1(c(=O)n(C)c(=O)n2C)n(cnc21)C c1(c(=O)n(C)c(=O)n2C)n(cnc12)C c1(c(=O)n(C)c(n2C)=O)n(C)cnc21 c1(c(=O)n(C)c(n2C)=O)n(C)cnc12 c1(c(=O)n(C)c(n2C)=O)n(cnc21)C c1(c(=O)n(C)c(n2C)=O)n(cnc12)C c1(c(n2C)=O)n(C)cnc1n(c2=O)C c1(c(n2C)=O)n(C)cnc1n(C)c2=O c1(c(n2C)=O)n(cnc1n(c2=O)C)C c1(c(n2C)=O)n(cnc1n(C)c2=O)C c1(c(n(c2=O)C)=O)n(C)cnc1n2C c1(c(n(c2=O)C)=O)n(cnc1n2C)C c1(c(n(c(=O)n2C)C)=O)n(C)cnc21 c1(c(n(c(=O)n2C)C)=O)n(C)cnc12 c1(c(n(c(=O)n2C)C)=O)n(cnc21)C c1(c(n(c(=O)n2C)C)=O)n(cnc12)C c1(c(n(c(n2C)=O)C)=O)n(C)cnc21 c1(c(n(c(n2C)=O)C)=O)n(C)cnc12 c1(c(n(c(n2C)=O)C)=O)n(cnc21)C c1(c(n(c(n2C)=O)C)=O)n(cnc12)C c1(c(n(C)c2=O)=O)n(C)cnc1n2C c1(c(n(C)c2=O)=O)n(cnc1n2C)C c1(c(n(C)c(=O)n2C)=O)n(C)cnc21 c1(c(n(C)c(=O)n2C)=O)n(C)cnc12 c1(c(n(C)c(=O)n2C)=O)n(cnc21)C c1(c(n(C)c(=O)n2C)=O)n(cnc12)C c1(c(n(C)c(n2C)=O)=O)n(C)cnc21 c1(c(n(C)c(n2C)=O)=O)n(C)cnc12 c1(c(n(C)c(n2C)=O)=O)n(cnc21)C c1(c(n(C)c(n2C)=O)=O)n(cnc12)C c12c(ncn2C)n(c(n(c1=O)C)=O)C c12c(ncn2C)n(c(n(C)c1=O)=O)C c12c(ncn2C)n(c(=O)n(c1=O)C)C c12c(ncn2C)n(c(=O)n(C)c1=O)C c12c(ncn2C)n(C)c(n(c1=O)C)=O c12c(ncn2C)n(C)c(n(C)c1=O)=O c12c(ncn2C)n(C)c(=O)n(c1=O)C c12c(ncn2C)n(C)c(=O)n(C)c1=O c12c(n(c(n(c1=O)C)=O)C)ncn2C c12c(n(c(n(C)c1=O)=O)C)ncn2C c12c(n(c(=O)n(c1=O)C)C)ncn2C c12c(n(c(=O)n(C)c1=O)C)ncn2C c12c(n(C)c(n(c1=O)C)=O)ncn2C c12c(n(C)c(n(C)c1=O)=O)ncn2C c12c(n(C)c(=O)n(c1=O)C)ncn2C c12c(n(C)c(=O)n(C)c1=O)ncn2C c12n(C)cnc2n(c(n(c1=O)C)=O)C c12n(C)cnc2n(c(n(C)c1=O)=O)C c12n(C)cnc2n(c(=O)n(c1=O)C)C c12n(C)cnc2n(c(=O)n(C)c1=O)C c12n(C)cnc2n(C)c(n(c1=O)C)=O c12n(C)cnc2n(C)c(n(C)c1=O)=O c12n(C)cnc2n(C)c(=O)n(c1=O)C c12n(C)cnc2n(C)c(=O)n(C)c1=O c12n(cnc2n(c(n(c1=O)C)=O)C)C c12n(cnc2n(c(n(C)c1=O)=O)C)C c12n(cnc2n(c(=O)n(c1=O)C)C)C c12n(cnc2n(c(=O)n(C)c1=O)C)C c12n(cnc2n(C)c(n(c1=O)C)=O)C c12n(cnc2n(C)c(n(C)c1=O)=O)C c12n(cnc2n(C)c(=O)n(c1=O)C)C c12n(cnc2n(C)c(=O)n(C)c1=O)C c1(n2C)c(nc2)n(c(n(c1=O)C)=O)C c1(n2C)c(nc2)n(c(n(C)c1=O)=O)C c1(n2C)c(nc2)n(c(=O)n(c1=O)C)C c1(n2C)c(nc2)n(c(=O)n(C)c1=O)C c1(n2C)c(nc2)n(C)c(n(c1=O)C)=O c1(n2C)c(nc2)n(C)c(n(C)c1=O)=O c1(n2C)c(nc2)n(C)c(=O)n(c1=O)C c1(n2C)c(nc2)n(C)c(=O)n(C)c1=O c1(n2C)c(n(c(n(c1=O)C)=O)C)nc2 c1(n2C)c(n(c(n(C)c1=O)=O)C)nc2 c1(n2C)c(n(c(=O)n(c1=O)C)C)nc2 c1(n2C)c(n(c(=O)n(C)c1=O)C)nc2 c1(n2C)c(n(C)c(n(c1=O)C)=O)nc2 c1(n2C)c(n(C)c(n(C)c1=O)=O)nc2 c1(n2C)c(n(C)c(=O)n(c1=O)C)nc2 c1(n2C)c(n(C)c(=O)n(C)c1=O)nc2 c1(c2n(c(n(c1=O)C)=O)C)n(C)cn2 c1(c2n(c(n(c1=O)C)=O)C)n(cn2)C c1(c2n(c(n(C)c1=O)=O)C)n(C)cn2 c1(c2n(c(n(C)c1=O)=O)C)n(cn2)C c1(c2n(c(=O)n(c1=O)C)C)n(C)cn2 c1(c2n(c(=O)n(c1=O)C)C)n(cn2)C c1(c2n(c(=O)n(C)c1=O)C)n(C)cn2 c1(c2n(c(=O)n(C)c1=O)C)n(cn2)C c1(c2n(C)c(n(c1=O)C)=O)n(C)cn2 c1(c2n(C)c(n(c1=O)C)=O)n(cn2)C c1(c2n(C)c(n(C)c1=O)=O)n(C)cn2 c1(c2n(C)c(n(C)c1=O)=O)n(cn2)C c1(c2n(C)c(=O)n(c1=O)C)n(C)cn2 c1(c2n(C)c(=O)n(c1=O)C)n(cn2)C c1(c2n(C)c(=O)n(C)c1=O)n(C)cn2 c1(c2n(C)c(=O)n(C)c1=O)n(cn2)C c1(=O)n(c(=O)n(c2c1n(C)cn2)C)C c1(=O)n(c(=O)n(c2c1n(cn2)C)C)C c1(=O)n(c(=O)n(c2ncn(C)c21)C)C c1(=O)n(c(=O)n(c2ncn(C)c12)C)C c1(=O)n(c(=O)n(c2ncn(c21)C)C)C c1(=O)n(c(=O)n(c2ncn(c12)C)C)C c1(=O)n(c(=O)n(c(ncn2C)c21)C)C c1(=O)n(c(=O)n(c(ncn2C)c12)C)C c1(=O)n(c(=O)n(c(c1n2C)nc2)C)C c1(=O)n(c(=O)n(C)c2c1n(C)cn2)C c1(=O)n(c(=O)n(C)c2c1n(cn2)C)C c1(=O)n(c(=O)n(C)c2ncn(C)c21)C c1(=O)n(c(=O)n(C)c2ncn(C)c12)C c1(=O)n(c(=O)n(C)c2ncn(c21)C)C c1(=O)n(c(=O)n(C)c2ncn(c12)C)C c1(=O)n(c(=O)n(C)c(ncn2C)c21)C c1(=O)n(c(=O)n(C)c(ncn2C)c12)C c1(=O)n(c(=O)n(C)c(c1n2C)nc2)C c1(=O)n(c(n(c2c1n(C)cn2)C)=O)C c1(=O)n(c(n(c2c1n(cn2)C)C)=O)C c1(=O)n(c(n(c2ncn(C)c21)C)=O)C c1(=O)n(c(n(c2ncn(C)c12)C)=O)C c1(=O)n(c(n(c2ncn(c21)C)C)=O)C c1(=O)n(c(n(c2ncn(c12)C)C)=O)C c1(=O)n(c(n(c(ncn2C)c21)C)=O)C c1(=O)n(c(n(c(ncn2C)c12)C)=O)C c1(=O)n(c(n(c(c1n2C)nc2)C)=O)C c1(=O)n(c(n(C)c2c1n(C)cn2)=O)C c1(=O)n(c(n(C)c2c1n(cn2)C)=O)C c1(=O)n(c(n(C)c2ncn(C)c21)=O)C c1(=O)n(c(n(C)c2ncn(C)c12)=O)C c1(=O)n(c(n(C)c2ncn(c21)C)=O)C c1(=O)n(c(n(C)c2ncn(c12)C)=O)C c1(=O)n(c(n(C)c(ncn2C)c21)=O)C c1(=O)n(c(n(C)c(ncn2C)c12)=O)C c1(=O)n(c(n(C)c(c1n2C)nc2)=O)C c1(=O)n(C)c(=O)n(c2c1n(C)cn2)C c1(=O)n(C)c(=O)n(c2c1n(cn2)C)C c1(=O)n(C)c(=O)n(c2ncn(C)c21)C c1(=O)n(C)c(=O)n(c2ncn(C)c12)C c1(=O)n(C)c(=O)n(c2ncn(c21)C)C c1(=O)n(C)c(=O)n(c2ncn(c12)C)C c1(=O)n(C)c(=O)n(c(ncn2C)c21)C c1(=O)n(C)c(=O)n(c(ncn2C)c12)C c1(=O)n(C)c(=O)n(c(c1n2C)nc2)C c1(=O)n(C)c(=O)n(C)c2c1n(C)cn2 c1(=O)n(C)c(=O)n(C)c2c1n(cn2)C c1(=O)n(C)c(=O)n(C)c2ncn(C)c21 c1(=O)n(C)c(=O)n(C)c2ncn(C)c12 c1(=O)n(C)c(=O)n(C)c2ncn(c21)C c1(=O)n(C)c(=O)n(C)c2ncn(c12)C c1(=O)n(C)c(=O)n(C)c(ncn2C)c21 c1(=O)n(C)c(=O)n(C)c(ncn2C)c12 c1(=O)n(C)c(=O)n(C)c(c1n2C)nc2 c1(=O)n(C)c(n(c2c1n(C)cn2)C)=O c1(=O)n(C)c(n(c2c1n(cn2)C)C)=O c1(=O)n(C)c(n(c2ncn(C)c21)C)=O c1(=O)n(C)c(n(c2ncn(C)c12)C)=O c1(=O)n(C)c(n(c2ncn(c21)C)C)=O c1(=O)n(C)c(n(c2ncn(c12)C)C)=O c1(=O)n(C)c(n(c(ncn2C)c21)C)=O c1(=O)n(C)c(n(c(ncn2C)c12)C)=O c1(=O)n(C)c(n(c(c1n2C)nc2)C)=O c1(=O)n(C)c(n(C)c2c1n(C)cn2)=O c1(=O)n(C)c(n(C)c2c1n(cn2)C)=O c1(=O)n(C)c(n(C)c2ncn(C)c21)=O c1(=O)n(C)c(n(C)c2ncn(C)c12)=O c1(=O)n(C)c(n(C)c2ncn(c21)C)=O c1(=O)n(C)c(n(C)c2ncn(c12)C)=O c1(=O)n(C)c(n(C)c(ncn2C)c21)=O c1(=O)n(C)c(n(C)c(ncn2C)c12)=O c1(=O)n(C)c(n(C)c(c1n2C)nc2)=O c1(n(c(=O)n(c2c1n(C)cn2)C)C)=O c1(n(c(=O)n(c2c1n(cn2)C)C)C)=O c1(n(c(=O)n(c2ncn(C)c21)C)C)=O c1(n(c(=O)n(c2ncn(C)c12)C)C)=O c1(n(c(=O)n(c2ncn(c21)C)C)C)=O c1(n(c(=O)n(c2ncn(c12)C)C)C)=O c1(n(c(=O)n(c(ncn2C)c21)C)C)=O c1(n(c(=O)n(c(ncn2C)c12)C)C)=O c1(n(c(=O)n(c(c1n2C)nc2)C)C)=O c1(n(c(=O)n(C)c2c1n(C)cn2)C)=O c1(n(c(=O)n(C)c2c1n(cn2)C)C)=O c1(n(c(=O)n(C)c2ncn(C)c21)C)=O c1(n(c(=O)n(C)c2ncn(C)c12)C)=O c1(n(c(=O)n(C)c2ncn(c21)C)C)=O c1(n(c(=O)n(C)c2ncn(c12)C)C)=O c1(n(c(=O)n(C)c(ncn2C)c21)C)=O c1(n(c(=O)n(C)c(ncn2C)c12)C)=O c1(n(c(=O)n(C)c(c1n2C)nc2)C)=O c1(n(c(n(c2c1n(C)cn2)C)=O)C)=O c1(n(c(n(c2c1n(cn2)C)C)=O)C)=O c1(n(c(n(c2ncn(C)c21)C)=O)C)=O c1(n(c(n(c2ncn(C)c12)C)=O)C)=O c1(n(c(n(c2ncn(c21)C)C)=O)C)=O c1(n(c(n(c2ncn(c12)C)C)=O)C)=O c1(n(c(n(c(ncn2C)c21)C)=O)C)=O c1(n(c(n(c(ncn2C)c12)C)=O)C)=O c1(n(c(n(c(c1n2C)nc2)C)=O)C)=O c1(n(c(n(C)c2c1n(C)cn2)=O)C)=O c1(n(c(n(C)c2c1n(cn2)C)=O)C)=O c1(n(c(n(C)c2ncn(C)c21)=O)C)=O c1(n(c(n(C)c2ncn(C)c12)=O)C)=O c1(n(c(n(C)c2ncn(c21)C)=O)C)=O c1(n(c(n(C)c2ncn(c12)C)=O)C)=O c1(n(c(n(C)c(ncn2C)c21)=O)C)=O c1(n(c(n(C)c(ncn2C)c12)=O)C)=O c1(n(c(n(C)c(c1n2C)nc2)=O)C)=O c1(n(C)c(=O)n(c2c1n(C)cn2)C)=O c1(n(C)c(=O)n(c2c1n(cn2)C)C)=O c1(n(C)c(=O)n(c2ncn(C)c21)C)=O c1(n(C)c(=O)n(c2ncn(C)c12)C)=O c1(n(C)c(=O)n(c2ncn(c21)C)C)=O c1(n(C)c(=O)n(c2ncn(c12)C)C)=O c1(n(C)c(=O)n(c(ncn2C)c21)C)=O c1(n(C)c(=O)n(c(ncn2C)c12)C)=O c1(n(C)c(=O)n(c(c1n2C)nc2)C)=O c1(n(C)c(=O)n(C)c2c1n(C)cn2)=O c1(n(C)c(=O)n(C)c2c1n(cn2)C)=O c1(n(C)c(=O)n(C)c2ncn(C)c21)=O c1(n(C)c(=O)n(C)c2ncn(C)c12)=O c1(n(C)c(=O)n(C)c2ncn(c21)C)=O c1(n(C)c(=O)n(C)c2ncn(c12)C)=O c1(n(C)c(=O)n(C)c(ncn2C)c21)=O c1(n(C)c(=O)n(C)c(ncn2C)c12)=O c1(n(C)c(=O)n(C)c(c1n2C)nc2)=O c1(n(C)c(n(c2c1n(C)cn2)C)=O)=O c1(n(C)c(n(c2c1n(cn2)C)C)=O)=O c1(n(C)c(n(c2ncn(C)c21)C)=O)=O c1(n(C)c(n(c2ncn(C)c12)C)=O)=O c1(n(C)c(n(c2ncn(c21)C)C)=O)=O c1(n(C)c(n(c2ncn(c12)C)C)=O)=O c1(n(C)c(n(c(ncn2C)c21)C)=O)=O c1(n(C)c(n(c(ncn2C)c12)C)=O)=O c1(n(C)c(n(c(c1n2C)nc2)C)=O)=O c1(n(C)c(n(C)c2c1n(C)cn2)=O)=O c1(n(C)c(n(C)c2c1n(cn2)C)=O)=O c1(n(C)c(n(C)c2ncn(C)c21)=O)=O c1(n(C)c(n(C)c2ncn(C)c12)=O)=O c1(n(C)c(n(C)c2ncn(c21)C)=O)=O c1(n(C)c(n(C)c2ncn(c12)C)=O)=O c1(n(C)c(n(C)c(ncn2C)c21)=O)=O c1(n(C)c(n(C)c(ncn2C)c12)=O)=O c1(n(C)c(n(C)c(c1n2C)nc2)=O)=O c1(c2c(ncn2C)n(c(n1C)=O)C)=O c1(c2c(ncn2C)n(c(=O)n1C)C)=O c1(c2c(ncn2C)n(C)c(n1C)=O)=O c1(c2c(ncn2C)n(C)c(=O)n1C)=O c1(c2c(n(c(n1C)=O)C)ncn2C)=O c1(c2c(n(c(=O)n1C)C)ncn2C)=O c1(c2c(n(C)c(n1C)=O)ncn2C)=O c1(c2c(n(C)c(=O)n1C)ncn2C)=O c1(c2n(C)cnc2n(c(n1C)=O)C)=O c1(c2n(C)cnc2n(c(=O)n1C)C)=O c1(c2n(C)cnc2n(C)c(n1C)=O)=O c1(c2n(C)cnc2n(C)c(=O)n1C)=O c1(c2n(cnc2n(c(n1C)=O)C)C)=O c1(c2n(cnc2n(c(=O)n1C)C)C)=O c1(c2n(cnc2n(C)c(n1C)=O)C)=O c1(c2n(cnc2n(C)c(=O)n1C)C)=O c1(c(n2C)c(nc2)n(c(n1C)=O)C)=O c1(c(n2C)c(nc2)n(c(=O)n1C)C)=O c1(c(n2C)c(nc2)n(C)c(n1C)=O)=O c1(c(n2C)c(nc2)n(C)c(=O)n1C)=O c1(c(n2C)c(n(c(n1C)=O)C)nc2)=O c1(c(n2C)c(n(c(=O)n1C)C)nc2)=O c1(c(n2C)c(n(C)c(n1C)=O)nc2)=O c1(c(n2C)c(n(C)c(=O)n1C)nc2)=O c1(c(c2n(c(n1C)=O)C)n(C)cn2)=O c1(c(c2n(c(n1C)=O)C)n(cn2)C)=O c1(c(c2n(c(=O)n1C)C)n(C)cn2)=O c1(c(c2n(c(=O)n1C)C)n(cn2)C)=O c1(c(c2n(C)c(n1C)=O)n(C)cn2)=O c1(c(c2n(C)c(n1C)=O)n(cn2)C)=O c1(c(c2n(C)c(=O)n1C)n(C)cn2)=O c1(c(c2n(C)c(=O)n1C)n(cn2)C)=O c1(=O)c2c(ncn2C)n(c(n1C)=O)C c1(=O)c2c(ncn2C)n(c(=O)n1C)C c1(=O)c2c(ncn2C)n(C)c(n1C)=O c1(=O)c2c(ncn2C)n(C)c(=O)n1C c1(=O)c2c(n(c(n1C)=O)C)ncn2C c1(=O)c2c(n(c(=O)n1C)C)ncn2C c1(=O)c2c(n(C)c(n1C)=O)ncn2C c1(=O)c2c(n(C)c(=O)n1C)ncn2C c1(=O)c2n(C)cnc2n(c(n1C)=O)C c1(=O)c2n(C)cnc2n(c(=O)n1C)C c1(=O)c2n(C)cnc2n(C)c(n1C)=O c1(=O)c2n(C)cnc2n(C)c(=O)n1C c1(=O)c2n(cnc2n(c(n1C)=O)C)C c1(=O)c2n(cnc2n(c(=O)n1C)C)C c1(=O)c2n(cnc2n(C)c(n1C)=O)C c1(=O)c2n(cnc2n(C)c(=O)n1C)C c1(=O)c(n2C)c(nc2)n(c(n1C)=O)C c1(=O)c(n2C)c(nc2)n(c(=O)n1C)C c1(=O)c(n2C)c(nc2)n(C)c(n1C)=O c1(=O)c(n2C)c(nc2)n(C)c(=O)n1C c1(=O)c(n2C)c(n(c(n1C)=O)C)nc2 c1(=O)c(n2C)c(n(c(=O)n1C)C)nc2 c1(=O)c(n2C)c(n(C)c(n1C)=O)nc2 c1(=O)c(n2C)c(n(C)c(=O)n1C)nc2 c1(=O)c(c2n(c(n1C)=O)C)n(C)cn2 c1(=O)c(c2n(c(n1C)=O)C)n(cn2)C c1(=O)c(c2n(c(=O)n1C)C)n(C)cn2 c1(=O)c(c2n(c(=O)n1C)C)n(cn2)C c1(=O)c(c2n(C)c(n1C)=O)n(C)cn2 c1(=O)c(c2n(C)c(n1C)=O)n(cn2)C c1(=O)c(c2n(C)c(=O)n1C)n(C)cn2 c1(=O)c(c2n(C)c(=O)n1C)n(cn2)C O=c1n(c(=O)n(c2c1n(C)cn2)C)C O=c1n(c(=O)n(c2c1n(cn2)C)C)C O=c1n(c(=O)n(c2ncn(C)c21)C)C O=c1n(c(=O)n(c2ncn(C)c12)C)C O=c1n(c(=O)n(c2ncn(c21)C)C)C O=c1n(c(=O)n(c2ncn(c12)C)C)C O=c1n(c(=O)n(c(ncn2C)c21)C)C O=c1n(c(=O)n(c(ncn2C)c12)C)C O=c1n(c(=O)n(c(c1n2C)nc2)C)C O=c1n(c(=O)n(C)c2c1n(C)cn2)C O=c1n(c(=O)n(C)c2c1n(cn2)C)C O=c1n(c(=O)n(C)c2ncn(C)c21)C O=c1n(c(=O)n(C)c2ncn(C)c12)C O=c1n(c(=O)n(C)c2ncn(c21)C)C O=c1n(c(=O)n(C)c2ncn(c12)C)C O=c1n(c(=O)n(C)c(ncn2C)c21)C O=c1n(c(=O)n(C)c(ncn2C)c12)C O=c1n(c(=O)n(C)c(c1n2C)nc2)C O=c1n(c(n(c2c1n(C)cn2)C)=O)C O=c1n(c(n(c2c1n(cn2)C)C)=O)C O=c1n(c(n(c2ncn(C)c21)C)=O)C O=c1n(c(n(c2ncn(C)c12)C)=O)C O=c1n(c(n(c2ncn(c21)C)C)=O)C O=c1n(c(n(c2ncn(c12)C)C)=O)C O=c1n(c(n(c(ncn2C)c21)C)=O)C O=c1n(c(n(c(ncn2C)c12)C)=O)C O=c1n(c(n(c(c1n2C)nc2)C)=O)C O=c1n(c(n(C)c2c1n(C)cn2)=O)C O=c1n(c(n(C)c2c1n(cn2)C)=O)C O=c1n(c(n(C)c2ncn(C)c21)=O)C O=c1n(c(n(C)c2ncn(C)c12)=O)C O=c1n(c(n(C)c2ncn(c21)C)=O)C O=c1n(c(n(C)c2ncn(c12)C)=O)C O=c1n(c(n(C)c(ncn2C)c21)=O)C O=c1n(c(n(C)c(ncn2C)c12)=O)C O=c1n(c(n(C)c(c1n2C)nc2)=O)C O=c1n(C)c(=O)n(c2c1n(C)cn2)C O=c1n(C)c(=O)n(c2c1n(cn2)C)C O=c1n(C)c(=O)n(c2ncn(C)c21)C O=c1n(C)c(=O)n(c2ncn(C)c12)C O=c1n(C)c(=O)n(c2ncn(c21)C)C O=c1n(C)c(=O)n(c2ncn(c12)C)C O=c1n(C)c(=O)n(c(ncn2C)c21)C O=c1n(C)c(=O)n(c(ncn2C)c12)C O=c1n(C)c(=O)n(c(c1n2C)nc2)C O=c1n(C)c(=O)n(C)c2c1n(C)cn2 O=c1n(C)c(=O)n(C)c2c1n(cn2)C O=c1n(C)c(=O)n(C)c2ncn(C)c21 O=c1n(C)c(=O)n(C)c2ncn(C)c12 O=c1n(C)c(=O)n(C)c2ncn(c21)C O=c1n(C)c(=O)n(C)c2ncn(c12)C O=c1n(C)c(=O)n(C)c(ncn2C)c21 O=c1n(C)c(=O)n(C)c(ncn2C)c12 O=c1n(C)c(=O)n(C)c(c1n2C)nc2 O=c1n(C)c(n(c2c1n(C)cn2)C)=O O=c1n(C)c(n(c2c1n(cn2)C)C)=O O=c1n(C)c(n(c2ncn(C)c21)C)=O O=c1n(C)c(n(c2ncn(C)c12)C)=O O=c1n(C)c(n(c2ncn(c21)C)C)=O O=c1n(C)c(n(c2ncn(c12)C)C)=O O=c1n(C)c(n(c(ncn2C)c21)C)=O O=c1n(C)c(n(c(ncn2C)c12)C)=O O=c1n(C)c(n(c(c1n2C)nc2)C)=O O=c1n(C)c(n(C)c2c1n(C)cn2)=O O=c1n(C)c(n(C)c2c1n(cn2)C)=O O=c1n(C)c(n(C)c2ncn(C)c21)=O O=c1n(C)c(n(C)c2ncn(C)c12)=O O=c1n(C)c(n(C)c2ncn(c21)C)=O O=c1n(C)c(n(C)c2ncn(c12)C)=O O=c1n(C)c(n(C)c(ncn2C)c21)=O O=c1n(C)c(n(C)c(ncn2C)c12)=O O=c1n(C)c(n(C)c(c1n2C)nc2)=O O=c1c2c(ncn2C)n(c(n1C)=O)C O=c1c2c(ncn2C)n(c(=O)n1C)C O=c1c2c(ncn2C)n(C)c(n1C)=O O=c1c2c(ncn2C)n(C)c(=O)n1C O=c1c2c(n(c(n1C)=O)C)ncn2C O=c1c2c(n(c(=O)n1C)C)ncn2C O=c1c2c(n(C)c(n1C)=O)ncn2C O=c1c2c(n(C)c(=O)n1C)ncn2C O=c1c2n(C)cnc2n(c(n1C)=O)C O=c1c2n(C)cnc2n(c(=O)n1C)C O=c1c2n(C)cnc2n(C)c(n1C)=O O=c1c2n(C)cnc2n(C)c(=O)n1C O=c1c2n(cnc2n(c(n1C)=O)C)C O=c1c2n(cnc2n(c(=O)n1C)C)C O=c1c2n(cnc2n(C)c(n1C)=O)C O=c1c2n(cnc2n(C)c(=O)n1C)C O=c1c(n2C)c(nc2)n(c(n1C)=O)C O=c1c(n2C)c(nc2)n(c(=O)n1C)C O=c1c(n2C)c(nc2)n(C)c(n1C)=O O=c1c(n2C)c(nc2)n(C)c(=O)n1C O=c1c(n2C)c(n(c(n1C)=O)C)nc2 O=c1c(n2C)c(n(c(=O)n1C)C)nc2 O=c1c(n2C)c(n(C)c(n1C)=O)nc2 O=c1c(n2C)c(n(C)c(=O)n1C)nc2 O=c1c(c2n(c(n1C)=O)C)n(C)cn2 O=c1c(c2n(c(n1C)=O)C)n(cn2)C O=c1c(c2n(c(=O)n1C)C)n(C)cn2 O=c1c(c2n(c(=O)n1C)C)n(cn2)C O=c1c(c2n(C)c(n1C)=O)n(C)cn2 O=c1c(c2n(C)c(n1C)=O)n(cn2)C O=c1c(c2n(C)c(=O)n1C)n(C)cn2 O=c1c(c2n(C)c(=O)n1C)n(cn2)C O=c(c1c2ncn1C)n(c(=O)n2C)C O=c(c1c2ncn1C)n(c(n2C)=O)C O=c(c1c2ncn1C)n(C)c(=O)n2C O=c(c1c2ncn1C)n(C)c(n2C)=O O=c(c1c(ncn1C)n2C)n(c2=O)C O=c(c1c(ncn1C)n2C)n(C)c2=O O=c(c1c(ncn1C)n(c2=O)C)n2C O=c(c1c(ncn1C)n(C)c2=O)n2C O=c(c1c(n2C)ncn1C)n(c2=O)C O=c(c1c(n2C)ncn1C)n(C)c2=O O=c(c1c(n(c2=O)C)ncn1C)n2C O=c(c1c(n(C)c2=O)ncn1C)n2C O=c(c1n2C)n(c(=O)n(c1nc2)C)C O=c(c1n2C)n(c(=O)n(C)c1nc2)C O=c(c1n2C)n(c(n(c1nc2)C)=O)C O=c(c1n2C)n(c(n(C)c1nc2)=O)C O=c(c1n2C)n(C)c(=O)n(c1nc2)C O=c(c1n2C)n(C)c(=O)n(C)c1nc2 O=c(c1n2C)n(C)c(n(c1nc2)C)=O O=c(c1n2C)n(C)c(n(C)c1nc2)=O O=c(c1n(C)cnc1n2C)n(c2=O)C O=c(c1n(C)cnc1n2C)n(C)c2=O O=c(c1n(C)cnc1n(c2=O)C)n2C O=c(c1n(C)cnc1n(C)c2=O)n2C O=c(c1n(cnc1n2C)C)n(c2=O)C O=c(c1n(cnc1n2C)C)n(C)c2=O O=c(c1n(cnc1n(c2=O)C)C)n2C O=c(c1n(cnc1n(C)c2=O)C)n2C O=c(c(n1C)c2nc1)n(c(=O)n2C)C O=c(c(n1C)c2nc1)n(c(n2C)=O)C O=c(c(n1C)c2nc1)n(C)c(=O)n2C O=c(c(n1C)c2nc1)n(C)c(n2C)=O O=c(c(n1C)c(nc1)n2C)n(c2=O)C O=c(c(n1C)c(nc1)n2C)n(C)c2=O O=c(c(n1C)c(nc1)n(c2=O)C)n2C O=c(c(n1C)c(nc1)n(C)c2=O)n2C O=c(c(n1C)c(n2C)nc1)n(c2=O)C O=c(c(n1C)c(n2C)nc1)n(C)c2=O O=c(c(n1C)c(n(c2=O)C)nc1)n2C O=c(c(n1C)c(n(C)c2=O)nc1)n2C O=c(c(c1n2C)n(C)cn1)n(c2=O)C O=c(c(c1n2C)n(C)cn1)n(C)c2=O O=c(c(c1n2C)n(cn1)C)n(c2=O)C O=c(c(c1n2C)n(cn1)C)n(C)c2=O O=c(c(c1n(c2=O)C)n(C)cn1)n2C O=c(c(c1n(c2=O)C)n(cn1)C)n2C O=c(c(c1n(C)c2=O)n(C)cn1)n2C O=c(c(c1n(C)c2=O)n(cn1)C)n2C O=c(n1C)c2c(ncn2C)n(c1=O)C O=c(n1C)c2c(ncn2C)n(C)c1=O O=c(n1C)c2c(n(c1=O)C)ncn2C O=c(n1C)c2c(n(C)c1=O)ncn2C O=c(n1C)c2n(C)cnc2n(c1=O)C O=c(n1C)c2n(C)cnc2n(C)c1=O O=c(n1C)c2n(cnc2n(c1=O)C)C O=c(n1C)c2n(cnc2n(C)c1=O)C O=c(n1C)c(n2C)c(nc2)n(c1=O)C O=c(n1C)c(n2C)c(nc2)n(C)c1=O O=c(n1C)c(n2C)c(n(c1=O)C)nc2 O=c(n1C)c(n2C)c(n(C)c1=O)nc2 O=c(n1C)c(c2n(c1=O)C)n(C)cn2 O=c(n1C)c(c2n(c1=O)C)n(cn2)C O=c(n1C)c(c2n(C)c1=O)n(C)cn2 O=c(n1C)c(c2n(C)c1=O)n(cn2)C O=c(n(c1=O)C)c2c(ncn2C)n1C O=c(n(c1=O)C)c2c(n1C)ncn2C O=c(n(c1=O)C)c2n(C)cnc2n1C O=c(n(c1=O)C)c2n(cnc2n1C)C O=c(n(c1=O)C)c(n2C)c(nc2)n1C O=c(n(c1=O)C)c(n2C)c(n1C)nc2 O=c(n(c1=O)C)c(c2n1C)n(C)cn2 O=c(n(c1=O)C)c(c2n1C)n(cn2)C O=c(n(c(=O)n1C)C)c2c1ncn2C O=c(n(c(=O)n1C)C)c2n(C)cnc12 O=c(n(c(=O)n1C)C)c2n(C)cnc21 O=c(n(c(=O)n1C)C)c2n(cnc12)C O=c(n(c(=O)n1C)C)c2n(cnc21)C O=c(n(c(=O)n1C)C)c(n2C)c1nc2 O=c(n(c(=O)n(c1ncn2C)C)C)c21 O=c(n(c(=O)n(c1ncn2C)C)C)c12 O=c(n(c(=O)n(C)c1ncn2C)C)c21 O=c(n(c(=O)n(C)c1ncn2C)C)c12 O=c(n(c(n1C)=O)C)c2c1ncn2C O=c(n(c(n1C)=O)C)c2n(C)cnc12 O=c(n(c(n1C)=O)C)c2n(C)cnc21 O=c(n(c(n1C)=O)C)c2n(cnc12)C O=c(n(c(n1C)=O)C)c2n(cnc21)C O=c(n(c(n1C)=O)C)c(n2C)c1nc2 O=c(n(c(n(c1ncn2C)C)=O)C)c21 O=c(n(c(n(c1ncn2C)C)=O)C)c12 O=c(n(c(n(C)c1ncn2C)=O)C)c21 O=c(n(c(n(C)c1ncn2C)=O)C)c12 O=c(n(C)c1=O)c2c(ncn2C)n1C O=c(n(C)c1=O)c2c(n1C)ncn2C O=c(n(C)c1=O)c2n(C)cnc2n1C O=c(n(C)c1=O)c2n(cnc2n1C)C O=c(n(C)c1=O)c(n2C)c(nc2)n1C O=c(n(C)c1=O)c(n2C)c(n1C)nc2 O=c(n(C)c1=O)c(c2n1C)n(C)cn2 O=c(n(C)c1=O)c(c2n1C)n(cn2)C O=c(n(C)c(=O)n1C)c2c1ncn2C O=c(n(C)c(=O)n1C)c2n(C)cnc12 O=c(n(C)c(=O)n1C)c2n(C)cnc21 O=c(n(C)c(=O)n1C)c2n(cnc12)C O=c(n(C)c(=O)n1C)c2n(cnc21)C O=c(n(C)c(=O)n1C)c(n2C)c1nc2 O=c(n(C)c(=O)n(c1ncn2C)C)c21 O=c(n(C)c(=O)n(c1ncn2C)C)c12 O=c(n(C)c(=O)n(C)c1ncn2C)c21 O=c(n(C)c(=O)n(C)c1ncn2C)c12 O=c(n(C)c(n1C)=O)c2c1ncn2C O=c(n(C)c(n1C)=O)c2n(C)cnc12 O=c(n(C)c(n1C)=O)c2n(C)cnc21 O=c(n(C)c(n1C)=O)c2n(cnc12)C O=c(n(C)c(n1C)=O)c2n(cnc21)C O=c(n(C)c(n1C)=O)c(n2C)c1nc2 O=c(n(C)c(n(c1ncn2C)C)=O)c21 O=c(n(C)c(n(c1ncn2C)C)=O)c12 O=c(n(C)c(n(C)c1ncn2C)=O)c21 O=c(n(C)c(n(C)c1ncn2C)=O)c12 n1(c(=O)n(c2c(n(C)cn2)c1=O)C)C n1(c(=O)n(c2c(n(cn2)C)c1=O)C)C n1(c(=O)n(c2c(c1=O)n(C)cn2)C)C n1(c(=O)n(c2c(c1=O)n(cn2)C)C)C n1(c(=O)n(c2ncn(C)c2c1=O)C)C n1(c(=O)n(c2ncn(c2c1=O)C)C)C n1(c(=O)n(c(ncn2C)c2c1=O)C)C n1(c(=O)n(c(c2c1=O)ncn2C)C)C n1(c(=O)n(c(c(n2C)c1=O)nc2)C)C n1(c(=O)n(c(c(c1=O)n2C)nc2)C)C n1(c(=O)n(C)c2c(n(C)cn2)c1=O)C n1(c(=O)n(C)c2c(n(cn2)C)c1=O)C n1(c(=O)n(C)c2c(c1=O)n(C)cn2)C n1(c(=O)n(C)c2c(c1=O)n(cn2)C)C n1(c(=O)n(C)c2ncn(C)c2c1=O)C n1(c(=O)n(C)c2ncn(c2c1=O)C)C n1(c(=O)n(C)c(ncn2C)c2c1=O)C n1(c(=O)n(C)c(c2c1=O)ncn2C)C n1(c(=O)n(C)c(c(n2C)c1=O)nc2)C n1(c(=O)n(C)c(c(c1=O)n2C)nc2)C n1(c(n(c2c(n(C)cn2)c1=O)C)=O)C n1(c(n(c2c(n(cn2)C)c1=O)C)=O)C n1(c(n(c2c(c1=O)n(C)cn2)C)=O)C n1(c(n(c2c(c1=O)n(cn2)C)C)=O)C n1(c(n(c2ncn(C)c2c1=O)C)=O)C n1(c(n(c2ncn(c2c1=O)C)C)=O)C n1(c(n(c(ncn2C)c2c1=O)C)=O)C n1(c(n(c(c2c1=O)ncn2C)C)=O)C n1(c(n(c(c(n2C)c1=O)nc2)C)=O)C n1(c(n(c(c(c1=O)n2C)nc2)C)=O)C n1(c(n(C)c2c(n(C)cn2)c1=O)=O)C n1(c(n(C)c2c(n(cn2)C)c1=O)=O)C n1(c(n(C)c2c(c1=O)n(C)cn2)=O)C n1(c(n(C)c2c(c1=O)n(cn2)C)=O)C n1(c(n(C)c2ncn(C)c2c1=O)=O)C n1(c(n(C)c2ncn(c2c1=O)C)=O)C n1(c(n(C)c(ncn2C)c2c1=O)=O)C n1(c(n(C)c(c2c1=O)ncn2C)=O)C n1(c(n(C)c(c(n2C)c1=O)nc2)=O)C n1(c(n(C)c(c(c1=O)n2C)nc2)=O)C n1(C)c(=O)n(c2c(n(C)cn2)c1=O)C n1(C)c(=O)n(c2c(n(cn2)C)c1=O)C n1(C)c(=O)n(c2c(c1=O)n(C)cn2)C n1(C)c(=O)n(c2c(c1=O)n(cn2)C)C n1(C)c(=O)n(c2ncn(C)c2c1=O)C n1(C)c(=O)n(c2ncn(c2c1=O)C)C n1(C)c(=O)n(c(ncn2C)c2c1=O)C n1(C)c(=O)n(c(c2c1=O)ncn2C)C n1(C)c(=O)n(c(c(n2C)c1=O)nc2)C n1(C)c(=O)n(c(c(c1=O)n2C)nc2)C n1(C)c(=O)n(C)c2c(n(C)cn2)c1=O n1(C)c(=O)n(C)c2c(n(cn2)C)c1=O n1(C)c(=O)n(C)c2c(c1=O)n(C)cn2 n1(C)c(=O)n(C)c2c(c1=O)n(cn2)C n1(C)c(=O)n(C)c2ncn(C)c2c1=O n1(C)c(=O)n(C)c2ncn(c2c1=O)C n1(C)c(=O)n(C)c(ncn2C)c2c1=O n1(C)c(=O)n(C)c(c2c1=O)ncn2C n1(C)c(=O)n(C)c(c(n2C)c1=O)nc2 n1(C)c(=O)n(C)c(c(c1=O)n2C)nc2 n1(C)c(n(c2c(n(C)cn2)c1=O)C)=O n1(C)c(n(c2c(n(cn2)C)c1=O)C)=O n1(C)c(n(c2c(c1=O)n(C)cn2)C)=O n1(C)c(n(c2c(c1=O)n(cn2)C)C)=O n1(C)c(n(c2ncn(C)c2c1=O)C)=O n1(C)c(n(c2ncn(c2c1=O)C)C)=O n1(C)c(n(c(ncn2C)c2c1=O)C)=O n1(C)c(n(c(c2c1=O)ncn2C)C)=O n1(C)c(n(c(c(n2C)c1=O)nc2)C)=O n1(C)c(n(c(c(c1=O)n2C)nc2)C)=O n1(C)c(n(C)c2c(n(C)cn2)c1=O)=O n1(C)c(n(C)c2c(n(cn2)C)c1=O)=O n1(C)c(n(C)c2c(c1=O)n(C)cn2)=O n1(C)c(n(C)c2c(c1=O)n(cn2)C)=O n1(C)c(n(C)c2ncn(C)c2c1=O)=O n1(C)c(n(C)c2ncn(c2c1=O)C)=O n1(C)c(n(C)c(ncn2C)c2c1=O)=O n1(C)c(n(C)c(c2c1=O)ncn2C)=O n1(C)c(n(C)c(c(n2C)c1=O)nc2)=O n1(C)c(n(C)c(c(c1=O)n2C)nc2)=O n1(c(c2c(ncn2C)n(c1=O)C)=O)C n1(c(c2c(ncn2C)n(C)c1=O)=O)C n1(c(c2c(n(c1=O)C)ncn2C)=O)C n1(c(c2c(n(C)c1=O)ncn2C)=O)C n1(c(c2n(C)cnc2n(c1=O)C)=O)C n1(c(c2n(C)cnc2n(C)c1=O)=O)C n1(c(c2n(cnc2n(c1=O)C)C)=O)C n1(c(c2n(cnc2n(C)c1=O)C)=O)C n1(c(c(n2C)c(nc2)n(c1=O)C)=O)C n1(c(c(n2C)c(nc2)n(C)c1=O)=O)C n1(c(c(n2C)c(n(c1=O)C)nc2)=O)C n1(c(c(n2C)c(n(C)c1=O)nc2)=O)C n1(c(c(c2n(c1=O)C)n(C)cn2)=O)C n1(c(c(c2n(c1=O)C)n(cn2)C)=O)C n1(c(c(c2n(C)c1=O)n(C)cn2)=O)C n1(c(c(c2n(C)c1=O)n(cn2)C)=O)C n1(c(=O)c2c(ncn2C)n(c1=O)C)C n1(c(=O)c2c(ncn2C)n(C)c1=O)C n1(c(=O)c2c(n(c1=O)C)ncn2C)C n1(c(=O)c2c(n(C)c1=O)ncn2C)C n1(c(=O)c2n(C)cnc2n(c1=O)C)C n1(c(=O)c2n(C)cnc2n(C)c1=O)C n1(c(=O)c2n(cnc2n(c1=O)C)C)C n1(c(=O)c2n(cnc2n(C)c1=O)C)C n1(c(=O)c(n2C)c(nc2)n(c1=O)C)C n1(c(=O)c(n2C)c(nc2)n(C)c1=O)C n1(c(=O)c(n2C)c(n(c1=O)C)nc2)C n1(c(=O)c(n2C)c(n(C)c1=O)nc2)C n1(c(=O)c(c2n(c1=O)C)n(C)cn2)C n1(c(=O)c(c2n(c1=O)C)n(cn2)C)C n1(c(=O)c(c2n(C)c1=O)n(C)cn2)C n1(c(=O)c(c2n(C)c1=O)n(cn2)C)C n1(C)c(c2c(ncn2C)n(c1=O)C)=O n1(C)c(c2c(ncn2C)n(C)c1=O)=O n1(C)c(c2c(n(c1=O)C)ncn2C)=O n1(C)c(c2c(n(C)c1=O)ncn2C)=O n1(C)c(c2n(C)cnc2n(c1=O)C)=O n1(C)c(c2n(C)cnc2n(C)c1=O)=O n1(C)c(c2n(cnc2n(c1=O)C)C)=O n1(C)c(c2n(cnc2n(C)c1=O)C)=O n1(C)c(c(n2C)c(nc2)n(c1=O)C)=O n1(C)c(c(n2C)c(nc2)n(C)c1=O)=O n1(C)c(c(n2C)c(n(c1=O)C)nc2)=O n1(C)c(c(n2C)c(n(C)c1=O)nc2)=O n1(C)c(c(c2n(c1=O)C)n(C)cn2)=O n1(C)c(c(c2n(c1=O)C)n(cn2)C)=O n1(C)c(c(c2n(C)c1=O)n(C)cn2)=O n1(C)c(c(c2n(C)c1=O)n(cn2)C)=O n1(C)c(=O)c2c(ncn2C)n(c1=O)C n1(C)c(=O)c2c(ncn2C)n(C)c1=O n1(C)c(=O)c2c(n(c1=O)C)ncn2C n1(C)c(=O)c2c(n(C)c1=O)ncn2C n1(C)c(=O)c2n(C)cnc2n(c1=O)C n1(C)c(=O)c2n(C)cnc2n(C)c1=O n1(C)c(=O)c2n(cnc2n(c1=O)C)C n1(C)c(=O)c2n(cnc2n(C)c1=O)C n1(C)c(=O)c(n2C)c(nc2)n(c1=O)C n1(C)c(=O)c(n2C)c(nc2)n(C)c1=O n1(C)c(=O)c(n2C)c(n(c1=O)C)nc2 n1(C)c(=O)c(n2C)c(n(C)c1=O)nc2 n1(C)c(=O)c(c2n(c1=O)C)n(C)cn2 n1(C)c(=O)c(c2n(c1=O)C)n(cn2)C n1(C)c(=O)c(c2n(C)c1=O)n(C)cn2 n1(C)c(=O)c(c2n(C)c1=O)n(cn2)C c1(=O)n(c2c(n(C)cn2)c(=O)n1C)C c1(=O)n(c2c(n(C)cn2)c(n1C)=O)C c1(=O)n(c2c(n(cn2)C)c(=O)n1C)C c1(=O)n(c2c(n(cn2)C)c(n1C)=O)C c1(=O)n(c2c(c(=O)n1C)n(C)cn2)C c1(=O)n(c2c(c(=O)n1C)n(cn2)C)C c1(=O)n(c2c(c(n1C)=O)n(C)cn2)C c1(=O)n(c2c(c(n1C)=O)n(cn2)C)C c1(=O)n(c2ncn(C)c2c(=O)n1C)C c1(=O)n(c2ncn(C)c2c(n1C)=O)C c1(=O)n(c2ncn(c2c(=O)n1C)C)C c1(=O)n(c2ncn(c2c(n1C)=O)C)C c1(=O)n(c(ncn2C)c2c(=O)n1C)C c1(=O)n(c(ncn2C)c2c(n1C)=O)C c1(=O)n(c(c2c(=O)n1C)ncn2C)C c1(=O)n(c(c2c(n1C)=O)ncn2C)C c1(=O)n(c(c(n2C)c(=O)n1C)nc2)C c1(=O)n(c(c(n2C)c(n1C)=O)nc2)C c1(=O)n(c(c(c(=O)n1C)n2C)nc2)C c1(=O)n(c(c(c(n1C)=O)n2C)nc2)C c1(=O)n(C)c2c(n(C)cn2)c(=O)n1C c1(=O)n(C)c2c(n(C)cn2)c(n1C)=O c1(=O)n(C)c2c(n(cn2)C)c(=O)n1C c1(=O)n(C)c2c(n(cn2)C)c(n1C)=O c1(=O)n(C)c2c(c(=O)n1C)n(C)cn2 c1(=O)n(C)c2c(c(=O)n1C)n(cn2)C c1(=O)n(C)c2c(c(n1C)=O)n(C)cn2 c1(=O)n(C)c2c(c(n1C)=O)n(cn2)C c1(=O)n(C)c2ncn(C)c2c(=O)n1C c1(=O)n(C)c2ncn(C)c2c(n1C)=O c1(=O)n(C)c2ncn(c2c(=O)n1C)C c1(=O)n(C)c2ncn(c2c(n1C)=O)C c1(=O)n(C)c(ncn2C)c2c(=O)n1C c1(=O)n(C)c(ncn2C)c2c(n1C)=O c1(=O)n(C)c(c2c(=O)n1C)ncn2C c1(=O)n(C)c(c2c(n1C)=O)ncn2C c1(=O)n(C)c(c(n2C)c(=O)n1C)nc2 c1(=O)n(C)c(c(n2C)c(n1C)=O)nc2 c1(=O)n(C)c(c(c(=O)n1C)n2C)nc2 c1(=O)n(C)c(c(c(n1C)=O)n2C)nc2 c1(n(c2c(n(C)cn2)c(=O)n1C)C)=O c1(n(c2c(n(C)cn2)c(n1C)=O)C)=O c1(n(c2c(n(cn2)C)c(=O)n1C)C)=O c1(n(c2c(n(cn2)C)c(n1C)=O)C)=O c1(n(c2c(c(=O)n1C)n(C)cn2)C)=O c1(n(c2c(c(=O)n1C)n(cn2)C)C)=O c1(n(c2c(c(n1C)=O)n(C)cn2)C)=O c1(n(c2c(c(n1C)=O)n(cn2)C)C)=O c1(n(c2ncn(C)c2c(=O)n1C)C)=O c1(n(c2ncn(C)c2c(n1C)=O)C)=O c1(n(c2ncn(c2c(=O)n1C)C)C)=O c1(n(c2ncn(c2c(n1C)=O)C)C)=O c1(n(c(ncn2C)c2c(=O)n1C)C)=O c1(n(c(ncn2C)c2c(n1C)=O)C)=O c1(n(c(c2c(=O)n1C)ncn2C)C)=O c1(n(c(c2c(n1C)=O)ncn2C)C)=O c1(n(c(c(n2C)c(=O)n1C)nc2)C)=O c1(n(c(c(n2C)c(n1C)=O)nc2)C)=O c1(n(c(c(c(=O)n1C)n2C)nc2)C)=O c1(n(c(c(c(n1C)=O)n2C)nc2)C)=O c1(n(C)c2c(n(C)cn2)c(=O)n1C)=O c1(n(C)c2c(n(C)cn2)c(n1C)=O)=O c1(n(C)c2c(n(cn2)C)c(=O)n1C)=O c1(n(C)c2c(n(cn2)C)c(n1C)=O)=O c1(n(C)c2c(c(=O)n1C)n(C)cn2)=O c1(n(C)c2c(c(=O)n1C)n(cn2)C)=O c1(n(C)c2c(c(n1C)=O)n(C)cn2)=O c1(n(C)c2c(c(n1C)=O)n(cn2)C)=O c1(n(C)c2ncn(C)c2c(=O)n1C)=O c1(n(C)c2ncn(C)c2c(n1C)=O)=O c1(n(C)c2ncn(c2c(=O)n1C)C)=O c1(n(C)c2ncn(c2c(n1C)=O)C)=O c1(n(C)c(ncn2C)c2c(=O)n1C)=O c1(n(C)c(ncn2C)c2c(n1C)=O)=O c1(n(C)c(c2c(=O)n1C)ncn2C)=O c1(n(C)c(c2c(n1C)=O)ncn2C)=O c1(n(C)c(c(n2C)c(=O)n1C)nc2)=O c1(n(C)c(c(n2C)c(n1C)=O)nc2)=O c1(n(C)c(c(c(=O)n1C)n2C)nc2)=O c1(n(C)c(c(c(n1C)=O)n2C)nc2)=O c1(n(c(c2c(ncn2C)n1C)=O)C)=O c1(n(c(c2c(n1C)ncn2C)=O)C)=O c1(n(c(c2n(C)cnc2n1C)=O)C)=O c1(n(c(c2n(cnc2n1C)C)=O)C)=O c1(n(c(c(n2C)c(nc2)n1C)=O)C)=O c1(n(c(c(n2C)c(n1C)nc2)=O)C)=O c1(n(c(c(c2n1C)n(C)cn2)=O)C)=O c1(n(c(c(c2n1C)n(cn2)C)=O)C)=O c1(n(c(=O)c2c(ncn2C)n1C)C)=O c1(n(c(=O)c2c(n1C)ncn2C)C)=O c1(n(c(=O)c2n(C)cnc2n1C)C)=O c1(n(c(=O)c2n(cnc2n1C)C)C)=O c1(n(c(=O)c(n2C)c(nc2)n1C)C)=O c1(n(c(=O)c(n2C)c(n1C)nc2)C)=O c1(n(c(=O)c(c2n1C)n(C)cn2)C)=O c1(n(c(=O)c(c2n1C)n(cn2)C)C)=O c1(n(C)c(c2c(ncn2C)n1C)=O)=O c1(n(C)c(c2c(n1C)ncn2C)=O)=O c1(n(C)c(c2n(C)cnc2n1C)=O)=O c1(n(C)c(c2n(cnc2n1C)C)=O)=O c1(n(C)c(c(n2C)c(nc2)n1C)=O)=O c1(n(C)c(c(n2C)c(n1C)nc2)=O)=O c1(n(C)c(c(c2n1C)n(C)cn2)=O)=O c1(n(C)c(c(c2n1C)n(cn2)C)=O)=O c1(n(C)c(=O)c2c(ncn2C)n1C)=O c1(n(C)c(=O)c2c(n1C)ncn2C)=O c1(n(C)c(=O)c2n(C)cnc2n1C)=O c1(n(C)c(=O)c2n(cnc2n1C)C)=O c1(n(C)c(=O)c(n2C)c(nc2)n1C)=O c1(n(C)c(=O)c(n2C)c(n1C)nc2)=O c1(n(C)c(=O)c(c2n1C)n(C)cn2)=O c1(n(C)c(=O)c(c2n1C)n(cn2)C)=O c1(=O)n(c(c2c(ncn2C)n1C)=O)C c1(=O)n(c(c2c(n1C)ncn2C)=O)C c1(=O)n(c(c2n(C)cnc2n1C)=O)C c1(=O)n(c(c2n(cnc2n1C)C)=O)C c1(=O)n(c(c(n2C)c(nc2)n1C)=O)C c1(=O)n(c(c(n2C)c(n1C)nc2)=O)C c1(=O)n(c(c(c2n1C)n(C)cn2)=O)C c1(=O)n(c(c(c2n1C)n(cn2)C)=O)C c1(=O)n(c(=O)c2c(ncn2C)n1C)C c1(=O)n(c(=O)c2c(n1C)ncn2C)C c1(=O)n(c(=O)c2n(C)cnc2n1C)C c1(=O)n(c(=O)c2n(cnc2n1C)C)C c1(=O)n(c(=O)c(n2C)c(nc2)n1C)C c1(=O)n(c(=O)c(n2C)c(n1C)nc2)C c1(=O)n(c(=O)c(c2n1C)n(C)cn2)C c1(=O)n(c(=O)c(c2n1C)n(cn2)C)C c1(=O)n(C)c(c2c(ncn2C)n1C)=O c1(=O)n(C)c(c2c(n1C)ncn2C)=O c1(=O)n(C)c(c2n(C)cnc2n1C)=O c1(=O)n(C)c(c2n(cnc2n1C)C)=O c1(=O)n(C)c(c(n2C)c(nc2)n1C)=O c1(=O)n(C)c(c(n2C)c(n1C)nc2)=O c1(=O)n(C)c(c(c2n1C)n(C)cn2)=O c1(=O)n(C)c(c(c2n1C)n(cn2)C)=O c1(=O)n(C)c(=O)c2c(ncn2C)n1C c1(=O)n(C)c(=O)c2c(n1C)ncn2C c1(=O)n(C)c(=O)c2n(C)cnc2n1C c1(=O)n(C)c(=O)c2n(cnc2n1C)C c1(=O)n(C)c(=O)c(n2C)c(nc2)n1C c1(=O)n(C)c(=O)c(n2C)c(n1C)nc2 c1(=O)n(C)c(=O)c(c2n1C)n(C)cn2 c1(=O)n(C)c(=O)c(c2n1C)n(cn2)C O=c1n(c2c(n(C)cn2)c(=O)n1C)C O=c1n(c2c(n(C)cn2)c(n1C)=O)C O=c1n(c2c(n(cn2)C)c(=O)n1C)C O=c1n(c2c(n(cn2)C)c(n1C)=O)C O=c1n(c2c(c(=O)n1C)n(C)cn2)C O=c1n(c2c(c(=O)n1C)n(cn2)C)C O=c1n(c2c(c(n1C)=O)n(C)cn2)C O=c1n(c2c(c(n1C)=O)n(cn2)C)C O=c1n(c2ncn(C)c2c(=O)n1C)C O=c1n(c2ncn(C)c2c(n1C)=O)C O=c1n(c2ncn(c2c(=O)n1C)C)C O=c1n(c2ncn(c2c(n1C)=O)C)C O=c1n(c(ncn2C)c2c(=O)n1C)C O=c1n(c(ncn2C)c2c(n1C)=O)C O=c1n(c(c2c(=O)n1C)ncn2C)C O=c1n(c(c2c(n1C)=O)ncn2C)C O=c1n(c(c(n2C)c(=O)n1C)nc2)C O=c1n(c(c(n2C)c(n1C)=O)nc2)C O=c1n(c(c(c(=O)n1C)n2C)nc2)C O=c1n(c(c(c(n1C)=O)n2C)nc2)C O=c1n(C)c2c(n(C)cn2)c(=O)n1C O=c1n(C)c2c(n(C)cn2)c(n1C)=O O=c1n(C)c2c(n(cn2)C)c(=O)n1C O=c1n(C)c2c(n(cn2)C)c(n1C)=O O=c1n(C)c2c(c(=O)n1C)n(C)cn2 O=c1n(C)c2c(c(=O)n1C)n(cn2)C O=c1n(C)c2c(c(n1C)=O)n(C)cn2 O=c1n(C)c2c(c(n1C)=O)n(cn2)C O=c1n(C)c2ncn(C)c2c(=O)n1C O=c1n(C)c2ncn(C)c2c(n1C)=O O=c1n(C)c2ncn(c2c(=O)n1C)C O=c1n(C)c2ncn(c2c(n1C)=O)C O=c1n(C)c(ncn2C)c2c(=O)n1C O=c1n(C)c(ncn2C)c2c(n1C)=O O=c1n(C)c(c2c(=O)n1C)ncn2C O=c1n(C)c(c2c(n1C)=O)ncn2C O=c1n(C)c(c(n2C)c(=O)n1C)nc2 O=c1n(C)c(c(n2C)c(n1C)=O)nc2 O=c1n(C)c(c(c(=O)n1C)n2C)nc2 O=c1n(C)c(c(c(n1C)=O)n2C)nc2 O=c1n(c(c2c(ncn2C)n1C)=O)C O=c1n(c(c2c(n1C)ncn2C)=O)C O=c1n(c(c2n(C)cnc2n1C)=O)C O=c1n(c(c2n(cnc2n1C)C)=O)C O=c1n(c(c(n2C)c(nc2)n1C)=O)C O=c1n(c(c(n2C)c(n1C)nc2)=O)C O=c1n(c(c(c2n1C)n(C)cn2)=O)C O=c1n(c(c(c2n1C)n(cn2)C)=O)C O=c1n(c(=O)c2c(ncn2C)n1C)C O=c1n(c(=O)c2c(n1C)ncn2C)C O=c1n(c(=O)c2n(C)cnc2n1C)C O=c1n(c(=O)c2n(cnc2n1C)C)C O=c1n(c(=O)c(n2C)c(nc2)n1C)C O=c1n(c(=O)c(n2C)c(n1C)nc2)C O=c1n(c(=O)c(c2n1C)n(C)cn2)C O=c1n(c(=O)c(c2n1C)n(cn2)C)C O=c1n(C)c(c2c(ncn2C)n1C)=O O=c1n(C)c(c2c(n1C)ncn2C)=O O=c1n(C)c(c2n(C)cnc2n1C)=O O=c1n(C)c(c2n(cnc2n1C)C)=O O=c1n(C)c(c(n2C)c(nc2)n1C)=O O=c1n(C)c(c(n2C)c(n1C)nc2)=O O=c1n(C)c(c(c2n1C)n(C)cn2)=O O=c1n(C)c(c(c2n1C)n(cn2)C)=O O=c1n(C)c(=O)c2c(ncn2C)n1C O=c1n(C)c(=O)c2c(n1C)ncn2C O=c1n(C)c(=O)c2n(C)cnc2n1C O=c1n(C)c(=O)c2n(cnc2n1C)C O=c1n(C)c(=O)c(n2C)c(nc2)n1C O=c1n(C)c(=O)c(n2C)c(n1C)nc2 O=c1n(C)c(=O)c(c2n1C)n(C)cn2 O=c1n(C)c(=O)c(c2n1C)n(cn2)C O=c(n1C)n(c2c(n(C)cn2)c1=O)C O=c(n1C)n(c2c(n(cn2)C)c1=O)C O=c(n1C)n(c2c(c1=O)n(C)cn2)C O=c(n1C)n(c2c(c1=O)n(cn2)C)C O=c(n1C)n(c2ncn(C)c2c1=O)C O=c(n1C)n(c2ncn(c2c1=O)C)C O=c(n1C)n(c(ncn2C)c2c1=O)C O=c(n1C)n(c(c2c1=O)ncn2C)C O=c(n1C)n(c(c(n2C)c1=O)nc2)C O=c(n1C)n(c(c(c1=O)n2C)nc2)C O=c(n1C)n(C)c2c(n(C)cn2)c1=O O=c(n1C)n(C)c2c(n(cn2)C)c1=O O=c(n1C)n(C)c2c(c1=O)n(C)cn2 O=c(n1C)n(C)c2c(c1=O)n(cn2)C O=c(n1C)n(C)c2ncn(C)c2c1=O O=c(n1C)n(C)c2ncn(c2c1=O)C O=c(n1C)n(C)c(ncn2C)c2c1=O O=c(n1C)n(C)c(c2c1=O)ncn2C O=c(n1C)n(C)c(c(n2C)c1=O)nc2 O=c(n1C)n(C)c(c(c1=O)n2C)nc2 O=c(n(c1=O)C)n(c2c1n(C)cn2)C O=c(n(c1=O)C)n(c2c1n(cn2)C)C O=c(n(c1=O)C)n(c2ncn(C)c21)C O=c(n(c1=O)C)n(c2ncn(C)c12)C O=c(n(c1=O)C)n(c2ncn(c21)C)C O=c(n(c1=O)C)n(c2ncn(c12)C)C O=c(n(c1=O)C)n(c(ncn2C)c21)C O=c(n(c1=O)C)n(c(ncn2C)c12)C O=c(n(c1=O)C)n(c(c1n2C)nc2)C O=c(n(c1=O)C)n(C)c2c1n(C)cn2 O=c(n(c1=O)C)n(C)c2c1n(cn2)C O=c(n(c1=O)C)n(C)c2ncn(C)c21 O=c(n(c1=O)C)n(C)c2ncn(C)c12 O=c(n(c1=O)C)n(C)c2ncn(c21)C O=c(n(c1=O)C)n(C)c2ncn(c12)C O=c(n(c1=O)C)n(C)c(ncn2C)c21 O=c(n(c1=O)C)n(C)c(ncn2C)c12 O=c(n(c1=O)C)n(C)c(c1n2C)nc2 O=c(n(c(c1c2ncn1C)=O)C)n2C O=c(n(c(c1n2C)=O)C)n(c1nc2)C O=c(n(c(c1n2C)=O)C)n(C)c1nc2 O=c(n(c(c(n1C)c2nc1)=O)C)n2C O=c(n(c(=O)c1c2ncn1C)C)n2C O=c(n(c(=O)c1n2C)C)n(c1nc2)C O=c(n(c(=O)c1n2C)C)n(C)c1nc2 O=c(n(c(=O)c(n1C)c2nc1)C)n2C O=c(n(C)c1=O)n(c2c1n(C)cn2)C O=c(n(C)c1=O)n(c2c1n(cn2)C)C O=c(n(C)c1=O)n(c2ncn(C)c21)C O=c(n(C)c1=O)n(c2ncn(C)c12)C O=c(n(C)c1=O)n(c2ncn(c21)C)C O=c(n(C)c1=O)n(c2ncn(c12)C)C O=c(n(C)c1=O)n(c(ncn2C)c21)C O=c(n(C)c1=O)n(c(ncn2C)c12)C O=c(n(C)c1=O)n(c(c1n2C)nc2)C O=c(n(C)c1=O)n(C)c2c1n(C)cn2 O=c(n(C)c1=O)n(C)c2c1n(cn2)C O=c(n(C)c1=O)n(C)c2ncn(C)c21 O=c(n(C)c1=O)n(C)c2ncn(C)c12 O=c(n(C)c1=O)n(C)c2ncn(c21)C O=c(n(C)c1=O)n(C)c2ncn(c12)C O=c(n(C)c1=O)n(C)c(ncn2C)c21 O=c(n(C)c1=O)n(C)c(ncn2C)c12 O=c(n(C)c1=O)n(C)c(c1n2C)nc2 O=c(n(C)c(c1c2ncn1C)=O)n2C O=c(n(C)c(c1n2C)=O)n(c1nc2)C O=c(n(C)c(c1n2C)=O)n(C)c1nc2 O=c(n(C)c(c(n1C)c2nc1)=O)n2C O=c(n(C)c(=O)c1c2ncn1C)n2C O=c(n(C)c(=O)c1n2C)n(c1nc2)C O=c(n(C)c(=O)c1n2C)n(C)c1nc2 O=c(n(C)c(=O)c(n1C)c2nc1)n2C O=c(n1C)n(c(c2c1ncn2C)=O)C O=c(n1C)n(c(c2n(C)cnc12)=O)C O=c(n1C)n(c(c2n(C)cnc21)=O)C O=c(n1C)n(c(c2n(cnc12)C)=O)C O=c(n1C)n(c(c2n(cnc21)C)=O)C O=c(n1C)n(c(c(n2C)c1nc2)=O)C O=c(n1C)n(c(=O)c2c1ncn2C)C O=c(n1C)n(c(=O)c2n(C)cnc12)C O=c(n1C)n(c(=O)c2n(C)cnc21)C O=c(n1C)n(c(=O)c2n(cnc12)C)C O=c(n1C)n(c(=O)c2n(cnc21)C)C O=c(n1C)n(c(=O)c(n2C)c1nc2)C O=c(n1C)n(C)c(c2c1ncn2C)=O O=c(n1C)n(C)c(c2n(C)cnc12)=O O=c(n1C)n(C)c(c2n(C)cnc21)=O O=c(n1C)n(C)c(c2n(cnc12)C)=O O=c(n1C)n(C)c(c2n(cnc21)C)=O O=c(n1C)n(C)c(c(n2C)c1nc2)=O O=c(n1C)n(C)c(=O)c2c1ncn2C O=c(n1C)n(C)c(=O)c2n(C)cnc12 O=c(n1C)n(C)c(=O)c2n(C)cnc21 O=c(n1C)n(C)c(=O)c2n(cnc12)C O=c(n1C)n(C)c(=O)c2n(cnc21)C O=c(n1C)n(C)c(=O)c(n2C)c1nc2 O=c(n(c1c2n(C)cn1)C)n(c2=O)C O=c(n(c1c2n(C)cn1)C)n(C)c2=O O=c(n(c1c2n(cn1)C)C)n(c2=O)C O=c(n(c1c2n(cn1)C)C)n(C)c2=O O=c(n(c1c(n(C)cn1)c2=O)C)n2C O=c(n(c1c(n(cn1)C)c2=O)C)n2C O=c(n(c1c(c2=O)n(C)cn1)C)n2C O=c(n(c1c(c2=O)n(cn1)C)C)n2C O=c(n(c1ncn2C)C)n(c(c21)=O)C O=c(n(c1ncn2C)C)n(c(c12)=O)C O=c(n(c1ncn2C)C)n(c(=O)c21)C O=c(n(c1ncn2C)C)n(c(=O)c12)C O=c(n(c1ncn2C)C)n(C)c(c21)=O O=c(n(c1ncn2C)C)n(C)c(c12)=O O=c(n(c1ncn2C)C)n(C)c(=O)c21 O=c(n(c1ncn2C)C)n(C)c(=O)c12 O=c(n(c1ncn(C)c1c2=O)C)n2C O=c(n(c1ncn(c1c2=O)C)C)n2C O=c(n(c(ncn1C)c1c2=O)C)n2C O=c(n(c(c1c2=O)ncn1C)C)n2C O=c(n(c(c1n2C)nc2)C)n(c1=O)C O=c(n(c(c1n2C)nc2)C)n(C)c1=O O=c(n(c(c(n1C)c2=O)nc1)C)n2C O=c(n(c(c(c1=O)n2C)nc2)C)n1C O=c(n(C)c1c2n(C)cn1)n(c2=O)C O=c(n(C)c1c2n(C)cn1)n(C)c2=O O=c(n(C)c1c2n(cn1)C)n(c2=O)C O=c(n(C)c1c2n(cn1)C)n(C)c2=O O=c(n(C)c1c(n(C)cn1)c2=O)n2C O=c(n(C)c1c(n(cn1)C)c2=O)n2C O=c(n(C)c1c(c2=O)n(C)cn1)n2C O=c(n(C)c1c(c2=O)n(cn1)C)n2C O=c(n(C)c1ncn2C)n(c(c21)=O)C O=c(n(C)c1ncn2C)n(c(c12)=O)C O=c(n(C)c1ncn2C)n(c(=O)c21)C O=c(n(C)c1ncn2C)n(c(=O)c12)C O=c(n(C)c1ncn2C)n(C)c(c21)=O O=c(n(C)c1ncn2C)n(C)c(c12)=O O=c(n(C)c1ncn2C)n(C)c(=O)c21 O=c(n(C)c1ncn2C)n(C)c(=O)c12 O=c(n(C)c1ncn(C)c1c2=O)n2C O=c(n(C)c1ncn(c1c2=O)C)n2C O=c(n(C)c(ncn1C)c1c2=O)n2C O=c(n(C)c(c1c2=O)ncn1C)n2C O=c(n(C)c(c1n2C)nc2)n(c1=O)C O=c(n(C)c(c1n2C)nc2)n(C)c1=O O=c(n(C)c(c(n1C)c2=O)nc1)n2C O=c(n(C)c(c(c1=O)n2C)nc2)n1C n1(c(n(c(c2c1ncn2C)=O)C)=O)C n1(c(n(c(c2n(C)cnc12)=O)C)=O)C n1(c(n(c(c2n(C)cnc21)=O)C)=O)C n1(c(n(c(c2n(cnc12)C)=O)C)=O)C n1(c(n(c(c2n(cnc21)C)=O)C)=O)C n1(c(n(c(c(n2C)c1nc2)=O)C)=O)C n1(c(n(c(=O)c2c1ncn2C)C)=O)C n1(c(n(c(=O)c2n(C)cnc12)C)=O)C n1(c(n(c(=O)c2n(C)cnc21)C)=O)C n1(c(n(c(=O)c2n(cnc12)C)C)=O)C n1(c(n(c(=O)c2n(cnc21)C)C)=O)C n1(c(n(c(=O)c(n2C)c1nc2)C)=O)C n1(c(n(C)c(c2c1ncn2C)=O)=O)C n1(c(n(C)c(c2n(C)cnc12)=O)=O)C n1(c(n(C)c(c2n(C)cnc21)=O)=O)C n1(c(n(C)c(c2n(cnc12)C)=O)=O)C n1(c(n(C)c(c2n(cnc21)C)=O)=O)C n1(c(n(C)c(c(n2C)c1nc2)=O)=O)C n1(c(n(C)c(=O)c2c1ncn2C)=O)C n1(c(n(C)c(=O)c2n(C)cnc12)=O)C n1(c(n(C)c(=O)c2n(C)cnc21)=O)C n1(c(n(C)c(=O)c2n(cnc12)C)=O)C n1(c(n(C)c(=O)c2n(cnc21)C)=O)C n1(c(n(C)c(=O)c(n2C)c1nc2)=O)C n1(c(=O)n(c(c2c1ncn2C)=O)C)C n1(c(=O)n(c(c2n(C)cnc12)=O)C)C n1(c(=O)n(c(c2n(C)cnc21)=O)C)C n1(c(=O)n(c(c2n(cnc12)C)=O)C)C n1(c(=O)n(c(c2n(cnc21)C)=O)C)C n1(c(=O)n(c(c(n2C)c1nc2)=O)C)C n1(c(=O)n(c(=O)c2c1ncn2C)C)C n1(c(=O)n(c(=O)c2n(C)cnc12)C)C n1(c(=O)n(c(=O)c2n(C)cnc21)C)C n1(c(=O)n(c(=O)c2n(cnc12)C)C)C n1(c(=O)n(c(=O)c2n(cnc21)C)C)C n1(c(=O)n(c(=O)c(n2C)c1nc2)C)C n1(c(=O)n(C)c(c2c1ncn2C)=O)C n1(c(=O)n(C)c(c2n(C)cnc12)=O)C n1(c(=O)n(C)c(c2n(C)cnc21)=O)C n1(c(=O)n(C)c(c2n(cnc12)C)=O)C n1(c(=O)n(C)c(c2n(cnc21)C)=O)C n1(c(=O)n(C)c(c(n2C)c1nc2)=O)C n1(c(=O)n(C)c(=O)c2c1ncn2C)C n1(c(=O)n(C)c(=O)c2n(C)cnc12)C n1(c(=O)n(C)c(=O)c2n(C)cnc21)C n1(c(=O)n(C)c(=O)c2n(cnc12)C)C n1(c(=O)n(C)c(=O)c2n(cnc21)C)C n1(c(=O)n(C)c(=O)c(n2C)c1nc2)C n1(C)c(n(c(c2c1ncn2C)=O)C)=O n1(C)c(n(c(c2n(C)cnc12)=O)C)=O n1(C)c(n(c(c2n(C)cnc21)=O)C)=O n1(C)c(n(c(c2n(cnc12)C)=O)C)=O n1(C)c(n(c(c2n(cnc21)C)=O)C)=O n1(C)c(n(c(c(n2C)c1nc2)=O)C)=O n1(C)c(n(c(=O)c2c1ncn2C)C)=O n1(C)c(n(c(=O)c2n(C)cnc12)C)=O n1(C)c(n(c(=O)c2n(C)cnc21)C)=O n1(C)c(n(c(=O)c2n(cnc12)C)C)=O n1(C)c(n(c(=O)c2n(cnc21)C)C)=O n1(C)c(n(c(=O)c(n2C)c1nc2)C)=O n1(C)c(n(C)c(c2c1ncn2C)=O)=O n1(C)c(n(C)c(c2n(C)cnc12)=O)=O n1(C)c(n(C)c(c2n(C)cnc21)=O)=O n1(C)c(n(C)c(c2n(cnc12)C)=O)=O n1(C)c(n(C)c(c2n(cnc21)C)=O)=O n1(C)c(n(C)c(c(n2C)c1nc2)=O)=O n1(C)c(n(C)c(=O)c2c1ncn2C)=O n1(C)c(n(C)c(=O)c2n(C)cnc12)=O n1(C)c(n(C)c(=O)c2n(C)cnc21)=O n1(C)c(n(C)c(=O)c2n(cnc12)C)=O n1(C)c(n(C)c(=O)c2n(cnc21)C)=O n1(C)c(n(C)c(=O)c(n2C)c1nc2)=O n1(C)c(=O)n(c(c2c1ncn2C)=O)C n1(C)c(=O)n(c(c2n(C)cnc12)=O)C n1(C)c(=O)n(c(c2n(C)cnc21)=O)C n1(C)c(=O)n(c(c2n(cnc12)C)=O)C n1(C)c(=O)n(c(c2n(cnc21)C)=O)C n1(C)c(=O)n(c(c(n2C)c1nc2)=O)C n1(C)c(=O)n(c(=O)c2c1ncn2C)C n1(C)c(=O)n(c(=O)c2n(C)cnc12)C n1(C)c(=O)n(c(=O)c2n(C)cnc21)C n1(C)c(=O)n(c(=O)c2n(cnc12)C)C n1(C)c(=O)n(c(=O)c2n(cnc21)C)C n1(C)c(=O)n(c(=O)c(n2C)c1nc2)C n1(C)c(=O)n(C)c(c2c1ncn2C)=O n1(C)c(=O)n(C)c(c2n(C)cnc12)=O n1(C)c(=O)n(C)c(c2n(C)cnc21)=O n1(C)c(=O)n(C)c(c2n(cnc12)C)=O n1(C)c(=O)n(C)c(c2n(cnc21)C)=O n1(C)c(=O)n(C)c(c(n2C)c1nc2)=O n1(C)c(=O)n(C)c(=O)c2c1ncn2C n1(C)c(=O)n(C)c(=O)c2n(C)cnc12 n1(C)c(=O)n(C)c(=O)c2n(C)cnc21 n1(C)c(=O)n(C)c(=O)c2n(cnc12)C n1(C)c(=O)n(C)c(=O)c2n(cnc21)C n1(C)c(=O)n(C)c(=O)c(n2C)c1nc2 n1(c2c(n(C)cn2)c(=O)n(c1=O)C)C n1(c2c(n(C)cn2)c(=O)n(C)c1=O)C n1(c2c(n(C)cn2)c(n(c1=O)C)=O)C n1(c2c(n(C)cn2)c(n(C)c1=O)=O)C n1(c2c(n(cn2)C)c(=O)n(c1=O)C)C n1(c2c(n(cn2)C)c(=O)n(C)c1=O)C n1(c2c(n(cn2)C)c(n(c1=O)C)=O)C n1(c2c(n(cn2)C)c(n(C)c1=O)=O)C n1(c2c(c(=O)n(c1=O)C)n(C)cn2)C n1(c2c(c(=O)n(c1=O)C)n(cn2)C)C n1(c2c(c(=O)n(C)c1=O)n(C)cn2)C n1(c2c(c(=O)n(C)c1=O)n(cn2)C)C n1(c2c(c(n(c1=O)C)=O)n(C)cn2)C n1(c2c(c(n(c1=O)C)=O)n(cn2)C)C n1(c2c(c(n(C)c1=O)=O)n(C)cn2)C n1(c2c(c(n(C)c1=O)=O)n(cn2)C)C n1(c2ncn(C)c2c(=O)n(c1=O)C)C n1(c2ncn(C)c2c(=O)n(C)c1=O)C n1(c2ncn(C)c2c(n(c1=O)C)=O)C n1(c2ncn(C)c2c(n(C)c1=O)=O)C n1(c2ncn(c2c(=O)n(c1=O)C)C)C n1(c2ncn(c2c(=O)n(C)c1=O)C)C n1(c2ncn(c2c(n(c1=O)C)=O)C)C n1(c2ncn(c2c(n(C)c1=O)=O)C)C n1(c(ncn2C)c2c(=O)n(c1=O)C)C n1(c(ncn2C)c2c(=O)n(C)c1=O)C n1(c(ncn2C)c2c(n(c1=O)C)=O)C n1(c(ncn2C)c2c(n(C)c1=O)=O)C n1(c(c2c(=O)n(c1=O)C)ncn2C)C n1(c(c2c(=O)n(C)c1=O)ncn2C)C n1(c(c2c(n(c1=O)C)=O)ncn2C)C n1(c(c2c(n(C)c1=O)=O)ncn2C)C n1(c(c(n2C)c(=O)n(c1=O)C)nc2)C n1(c(c(n2C)c(=O)n(C)c1=O)nc2)C n1(c(c(n2C)c(n(c1=O)C)=O)nc2)C n1(c(c(n2C)c(n(C)c1=O)=O)nc2)C n1(c(c(c(=O)n(c1=O)C)n2C)nc2)C n1(c(c(c(=O)n(C)c1=O)n2C)nc2)C n1(c(c(c(n(c1=O)C)=O)n2C)nc2)C n1(c(c(c(n(C)c1=O)=O)n2C)nc2)C n1(C)c2c(n(C)cn2)c(=O)n(c1=O)C n1(C)c2c(n(C)cn2)c(=O)n(C)c1=O n1(C)c2c(n(C)cn2)c(n(c1=O)C)=O n1(C)c2c(n(C)cn2)c(n(C)c1=O)=O n1(C)c2c(n(cn2)C)c(=O)n(c1=O)C n1(C)c2c(n(cn2)C)c(=O)n(C)c1=O n1(C)c2c(n(cn2)C)c(n(c1=O)C)=O n1(C)c2c(n(cn2)C)c(n(C)c1=O)=O n1(C)c2c(c(=O)n(c1=O)C)n(C)cn2 n1(C)c2c(c(=O)n(c1=O)C)n(cn2)C n1(C)c2c(c(=O)n(C)c1=O)n(C)cn2 n1(C)c2c(c(=O)n(C)c1=O)n(cn2)C n1(C)c2c(c(n(c1=O)C)=O)n(C)cn2 n1(C)c2c(c(n(c1=O)C)=O)n(cn2)C n1(C)c2c(c(n(C)c1=O)=O)n(C)cn2 n1(C)c2c(c(n(C)c1=O)=O)n(cn2)C n1(C)c2ncn(C)c2c(=O)n(c1=O)C n1(C)c2ncn(C)c2c(=O)n(C)c1=O n1(C)c2ncn(C)c2c(n(c1=O)C)=O n1(C)c2ncn(C)c2c(n(C)c1=O)=O n1(C)c2ncn(c2c(=O)n(c1=O)C)C n1(C)c2ncn(c2c(=O)n(C)c1=O)C n1(C)c2ncn(c2c(n(c1=O)C)=O)C n1(C)c2ncn(c2c(n(C)c1=O)=O)C n1(C)c(ncn2C)c2c(=O)n(c1=O)C n1(C)c(ncn2C)c2c(=O)n(C)c1=O n1(C)c(ncn2C)c2c(n(c1=O)C)=O n1(C)c(ncn2C)c2c(n(C)c1=O)=O n1(C)c(c2c(=O)n(c1=O)C)ncn2C n1(C)c(c2c(=O)n(C)c1=O)ncn2C n1(C)c(c2c(n(c1=O)C)=O)ncn2C n1(C)c(c2c(n(C)c1=O)=O)ncn2C n1(C)c(c(n2C)c(=O)n(c1=O)C)nc2 n1(C)c(c(n2C)c(=O)n(C)c1=O)nc2 n1(C)c(c(n2C)c(n(c1=O)C)=O)nc2 n1(C)c(c(n2C)c(n(C)c1=O)=O)nc2 n1(C)c(c(c(=O)n(c1=O)C)n2C)nc2 n1(C)c(c(c(=O)n(C)c1=O)n2C)nc2 n1(C)c(c(c(n(c1=O)C)=O)n2C)nc2 n1(C)c(c(c(n(C)c1=O)=O)n2C)nc2 Cn1c(n(c(c2c1ncn2C)=O)C)=O Cn1c(n(c(c2n(C)cnc12)=O)C)=O Cn1c(n(c(c2n(C)cnc21)=O)C)=O Cn1c(n(c(c2n(cnc12)C)=O)C)=O Cn1c(n(c(c2n(cnc21)C)=O)C)=O Cn1c(n(c(c(n2C)c1nc2)=O)C)=O Cn1c(n(c(=O)c2c1ncn2C)C)=O Cn1c(n(c(=O)c2n(C)cnc12)C)=O Cn1c(n(c(=O)c2n(C)cnc21)C)=O Cn1c(n(c(=O)c2n(cnc12)C)C)=O Cn1c(n(c(=O)c2n(cnc21)C)C)=O Cn1c(n(c(=O)c(n2C)c1nc2)C)=O Cn1c(n(C)c(c2c1ncn2C)=O)=O Cn1c(n(C)c(c2n(C)cnc12)=O)=O Cn1c(n(C)c(c2n(C)cnc21)=O)=O Cn1c(n(C)c(c2n(cnc12)C)=O)=O Cn1c(n(C)c(c2n(cnc21)C)=O)=O Cn1c(n(C)c(c(n2C)c1nc2)=O)=O Cn1c(n(C)c(=O)c2c1ncn2C)=O Cn1c(n(C)c(=O)c2n(C)cnc12)=O Cn1c(n(C)c(=O)c2n(C)cnc21)=O Cn1c(n(C)c(=O)c2n(cnc12)C)=O Cn1c(n(C)c(=O)c2n(cnc21)C)=O Cn1c(n(C)c(=O)c(n2C)c1nc2)=O Cn1c(=O)n(c(c2c1ncn2C)=O)C Cn1c(=O)n(c(c2n(C)cnc12)=O)C Cn1c(=O)n(c(c2n(C)cnc21)=O)C Cn1c(=O)n(c(c2n(cnc12)C)=O)C Cn1c(=O)n(c(c2n(cnc21)C)=O)C Cn1c(=O)n(c(c(n2C)c1nc2)=O)C Cn1c(=O)n(c(=O)c2c1ncn2C)C Cn1c(=O)n(c(=O)c2n(C)cnc12)C Cn1c(=O)n(c(=O)c2n(C)cnc21)C Cn1c(=O)n(c(=O)c2n(cnc12)C)C Cn1c(=O)n(c(=O)c2n(cnc21)C)C Cn1c(=O)n(c(=O)c(n2C)c1nc2)C Cn1c(=O)n(C)c(c2c1ncn2C)=O Cn1c(=O)n(C)c(c2n(C)cnc12)=O Cn1c(=O)n(C)c(c2n(C)cnc21)=O Cn1c(=O)n(C)c(c2n(cnc12)C)=O Cn1c(=O)n(C)c(c2n(cnc21)C)=O Cn1c(=O)n(C)c(c(n2C)c1nc2)=O Cn1c(=O)n(C)c(=O)c2c1ncn2C Cn1c(=O)n(C)c(=O)c2n(C)cnc12 Cn1c(=O)n(C)c(=O)c2n(C)cnc21 Cn1c(=O)n(C)c(=O)c2n(cnc12)C Cn1c(=O)n(C)c(=O)c2n(cnc21)C Cn1c(=O)n(C)c(=O)c(n2C)c1nc2 Cn1c2c(n(C)cn2)c(=O)n(c1=O)C Cn1c2c(n(C)cn2)c(=O)n(C)c1=O Cn1c2c(n(C)cn2)c(n(c1=O)C)=O Cn1c2c(n(C)cn2)c(n(C)c1=O)=O Cn1c2c(n(cn2)C)c(=O)n(c1=O)C Cn1c2c(n(cn2)C)c(=O)n(C)c1=O Cn1c2c(n(cn2)C)c(n(c1=O)C)=O Cn1c2c(n(cn2)C)c(n(C)c1=O)=O Cn1c2c(c(=O)n(c1=O)C)n(C)cn2 Cn1c2c(c(=O)n(c1=O)C)n(cn2)C Cn1c2c(c(=O)n(C)c1=O)n(C)cn2 Cn1c2c(c(=O)n(C)c1=O)n(cn2)C Cn1c2c(c(n(c1=O)C)=O)n(C)cn2 Cn1c2c(c(n(c1=O)C)=O)n(cn2)C Cn1c2c(c(n(C)c1=O)=O)n(C)cn2 Cn1c2c(c(n(C)c1=O)=O)n(cn2)C Cn1c2ncn(C)c2c(=O)n(c1=O)C Cn1c2ncn(C)c2c(=O)n(C)c1=O Cn1c2ncn(C)c2c(n(c1=O)C)=O Cn1c2ncn(C)c2c(n(C)c1=O)=O Cn1c2ncn(c2c(=O)n(c1=O)C)C Cn1c2ncn(c2c(=O)n(C)c1=O)C Cn1c2ncn(c2c(n(c1=O)C)=O)C Cn1c2ncn(c2c(n(C)c1=O)=O)C Cn1c(ncn2C)c2c(=O)n(c1=O)C Cn1c(ncn2C)c2c(=O)n(C)c1=O Cn1c(ncn2C)c2c(n(c1=O)C)=O Cn1c(ncn2C)c2c(n(C)c1=O)=O Cn1c(c2c(=O)n(c1=O)C)ncn2C Cn1c(c2c(=O)n(C)c1=O)ncn2C Cn1c(c2c(n(c1=O)C)=O)ncn2C Cn1c(c2c(n(C)c1=O)=O)ncn2C Cn1c(c(n2C)c(=O)n(c1=O)C)nc2 Cn1c(c(n2C)c(=O)n(C)c1=O)nc2 Cn1c(c(n2C)c(n(c1=O)C)=O)nc2 Cn1c(c(n2C)c(n(C)c1=O)=O)nc2 Cn1c(c(c(=O)n(c1=O)C)n2C)nc2 Cn1c(c(c(=O)n(C)c1=O)n2C)nc2 Cn1c(c(c(n(c1=O)C)=O)n2C)nc2 Cn1c(c(c(n(C)c1=O)=O)n2C)nc2 Cn(c1c2n(C)cn1)c(n(c2=O)C)=O Cn(c1c2n(C)cn1)c(n(C)c2=O)=O Cn(c1c2n(C)cn1)c(=O)n(c2=O)C Cn(c1c2n(C)cn1)c(=O)n(C)c2=O Cn(c1c2n(cn1)C)c(n(c2=O)C)=O Cn(c1c2n(cn1)C)c(n(C)c2=O)=O Cn(c1c2n(cn1)C)c(=O)n(c2=O)C Cn(c1c2n(cn1)C)c(=O)n(C)c2=O Cn(c1c(n(C)cn1)c2=O)c(n2C)=O Cn(c1c(n(C)cn1)c2=O)c(=O)n2C Cn(c1c(n(C)cn1)c(=O)n2C)c2=O Cn(c1c(n(C)cn1)c(n2C)=O)c2=O Cn(c1c(n(cn1)C)c2=O)c(n2C)=O Cn(c1c(n(cn1)C)c2=O)c(=O)n2C Cn(c1c(n(cn1)C)c(=O)n2C)c2=O Cn(c1c(n(cn1)C)c(n2C)=O)c2=O Cn(c1c(c2=O)n(C)cn1)c(n2C)=O Cn(c1c(c2=O)n(C)cn1)c(=O)n2C Cn(c1c(c2=O)n(cn1)C)c(n2C)=O Cn(c1c(c2=O)n(cn1)C)c(=O)n2C Cn(c1c(c(=O)n2C)n(C)cn1)c2=O Cn(c1c(c(=O)n2C)n(cn1)C)c2=O Cn(c1c(c(n2C)=O)n(C)cn1)c2=O Cn(c1c(c(n2C)=O)n(cn1)C)c2=O Cn(c1ncn2C)c(n(c(c21)=O)C)=O Cn(c1ncn2C)c(n(c(c12)=O)C)=O Cn(c1ncn2C)c(n(c(=O)c21)C)=O Cn(c1ncn2C)c(n(c(=O)c12)C)=O Cn(c1ncn2C)c(n(C)c(c21)=O)=O Cn(c1ncn2C)c(n(C)c(c12)=O)=O Cn(c1ncn2C)c(n(C)c(=O)c21)=O Cn(c1ncn2C)c(n(C)c(=O)c12)=O Cn(c1ncn2C)c(=O)n(c(c21)=O)C Cn(c1ncn2C)c(=O)n(c(c12)=O)C Cn(c1ncn2C)c(=O)n(c(=O)c21)C Cn(c1ncn2C)c(=O)n(c(=O)c12)C Cn(c1ncn2C)c(=O)n(C)c(c21)=O Cn(c1ncn2C)c(=O)n(C)c(c12)=O Cn(c1ncn2C)c(=O)n(C)c(=O)c21 Cn(c1ncn2C)c(=O)n(C)c(=O)c12 Cn(c1ncn(C)c1c2=O)c(n2C)=O Cn(c1ncn(C)c1c2=O)c(=O)n2C Cn(c1ncn(C)c1c(=O)n2C)c2=O Cn(c1ncn(C)c1c(n2C)=O)c2=O Cn(c1ncn(c1c2=O)C)c(n2C)=O Cn(c1ncn(c1c2=O)C)c(=O)n2C Cn(c1ncn(c1c(=O)n2C)C)c2=O Cn(c1ncn(c1c(n2C)=O)C)c2=O Cn(c(ncn1C)c1c2=O)c(n2C)=O Cn(c(ncn1C)c1c2=O)c(=O)n2C Cn(c(ncn1C)c1c(=O)n2C)c2=O Cn(c(ncn1C)c1c(n2C)=O)c2=O Cn(c(c1c2=O)ncn1C)c(n2C)=O Cn(c(c1c2=O)ncn1C)c(=O)n2C Cn(c(c1c(=O)n2C)ncn1C)c2=O Cn(c(c1c(n2C)=O)ncn1C)c2=O Cn(c(c1n2C)nc2)c(n(c1=O)C)=O Cn(c(c1n2C)nc2)c(n(C)c1=O)=O Cn(c(c1n2C)nc2)c(=O)n(c1=O)C Cn(c(c1n2C)nc2)c(=O)n(C)c1=O Cn(c(c(n1C)c2=O)nc1)c(n2C)=O Cn(c(c(n1C)c2=O)nc1)c(=O)n2C Cn(c(c(n1C)c(=O)n2C)nc1)c2=O Cn(c(c(n1C)c(n2C)=O)nc1)c2=O Cn(c(c(c1=O)n2C)nc2)c(n1C)=O Cn(c(c(c1=O)n2C)nc2)c(=O)n1C Cn(c(c(c(=O)n1C)n2C)nc2)c1=O Cn(c(c(c(n1C)=O)n2C)nc2)c1=O Cn(c1=O)c2c(n(C)cn2)c(=O)n1C Cn(c1=O)c2c(n(C)cn2)c(n1C)=O Cn(c1=O)c2c(n(cn2)C)c(=O)n1C Cn(c1=O)c2c(n(cn2)C)c(n1C)=O Cn(c1=O)c2c(c(=O)n1C)n(C)cn2 Cn(c1=O)c2c(c(=O)n1C)n(cn2)C Cn(c1=O)c2c(c(n1C)=O)n(C)cn2 Cn(c1=O)c2c(c(n1C)=O)n(cn2)C Cn(c1=O)c2ncn(C)c2c(=O)n1C Cn(c1=O)c2ncn(C)c2c(n1C)=O Cn(c1=O)c2ncn(c2c(=O)n1C)C Cn(c1=O)c2ncn(c2c(n1C)=O)C Cn(c1=O)c(ncn2C)c2c(=O)n1C Cn(c1=O)c(ncn2C)c2c(n1C)=O Cn(c1=O)c(c2c(=O)n1C)ncn2C Cn(c1=O)c(c2c(n1C)=O)ncn2C Cn(c1=O)c(c(n2C)c(=O)n1C)nc2 Cn(c1=O)c(c(n2C)c(n1C)=O)nc2 Cn(c1=O)c(c(c(=O)n1C)n2C)nc2 Cn(c1=O)c(c(c(n1C)=O)n2C)nc2 Cn(c(n1C)=O)c2c(n(C)cn2)c1=O Cn(c(n1C)=O)c2c(n(cn2)C)c1=O Cn(c(n1C)=O)c2c(c1=O)n(C)cn2 Cn(c(n1C)=O)c2c(c1=O)n(cn2)C Cn(c(n1C)=O)c2ncn(C)c2c1=O Cn(c(n1C)=O)c2ncn(c2c1=O)C Cn(c(n1C)=O)c(ncn2C)c2c1=O Cn(c(n1C)=O)c(c2c1=O)ncn2C Cn(c(n1C)=O)c(c(n2C)c1=O)nc2 Cn(c(n1C)=O)c(c(c1=O)n2C)nc2 Cn(c(n(c1=O)C)=O)c2c1n(C)cn2 Cn(c(n(c1=O)C)=O)c2c1n(cn2)C Cn(c(n(c1=O)C)=O)c2ncn(C)c21 Cn(c(n(c1=O)C)=O)c2ncn(C)c12 Cn(c(n(c1=O)C)=O)c2ncn(c21)C Cn(c(n(c1=O)C)=O)c2ncn(c12)C Cn(c(n(c1=O)C)=O)c(ncn2C)c21 Cn(c(n(c1=O)C)=O)c(ncn2C)c12 Cn(c(n(c1=O)C)=O)c(c1n2C)nc2 Cn(c(n(c(c1n2C)=O)C)=O)c1nc2 Cn(c(n(c(=O)c1n2C)C)=O)c1nc2 Cn(c(n(C)c1=O)=O)c2c1n(C)cn2 Cn(c(n(C)c1=O)=O)c2c1n(cn2)C Cn(c(n(C)c1=O)=O)c2ncn(C)c21 Cn(c(n(C)c1=O)=O)c2ncn(C)c12 Cn(c(n(C)c1=O)=O)c2ncn(c21)C Cn(c(n(C)c1=O)=O)c2ncn(c12)C Cn(c(n(C)c1=O)=O)c(ncn2C)c21 Cn(c(n(C)c1=O)=O)c(ncn2C)c12 Cn(c(n(C)c1=O)=O)c(c1n2C)nc2 Cn(c(n(C)c(c1n2C)=O)=O)c1nc2 Cn(c(n(C)c(=O)c1n2C)=O)c1nc2 Cn(c(=O)n1C)c2c(n(C)cn2)c1=O Cn(c(=O)n1C)c2c(n(cn2)C)c1=O Cn(c(=O)n1C)c2c(c1=O)n(C)cn2 Cn(c(=O)n1C)c2c(c1=O)n(cn2)C Cn(c(=O)n1C)c2ncn(C)c2c1=O Cn(c(=O)n1C)c2ncn(c2c1=O)C Cn(c(=O)n1C)c(ncn2C)c2c1=O Cn(c(=O)n1C)c(c2c1=O)ncn2C Cn(c(=O)n1C)c(c(n2C)c1=O)nc2 Cn(c(=O)n1C)c(c(c1=O)n2C)nc2 Cn(c(=O)n(c1=O)C)c2c1n(C)cn2 Cn(c(=O)n(c1=O)C)c2c1n(cn2)C Cn(c(=O)n(c1=O)C)c2ncn(C)c21 Cn(c(=O)n(c1=O)C)c2ncn(C)c12 Cn(c(=O)n(c1=O)C)c2ncn(c21)C Cn(c(=O)n(c1=O)C)c2ncn(c12)C Cn(c(=O)n(c1=O)C)c(ncn2C)c21 Cn(c(=O)n(c1=O)C)c(ncn2C)c12 Cn(c(=O)n(c1=O)C)c(c1n2C)nc2 Cn(c(=O)n(c(c1n2C)=O)C)c1nc2 Cn(c(=O)n(c(=O)c1n2C)C)c1nc2 Cn(c(=O)n(C)c1=O)c2c1n(C)cn2 Cn(c(=O)n(C)c1=O)c2c1n(cn2)C Cn(c(=O)n(C)c1=O)c2ncn(C)c21 Cn(c(=O)n(C)c1=O)c2ncn(C)c12 Cn(c(=O)n(C)c1=O)c2ncn(c21)C Cn(c(=O)n(C)c1=O)c2ncn(c12)C Cn(c(=O)n(C)c1=O)c(ncn2C)c21 Cn(c(=O)n(C)c1=O)c(ncn2C)c12 Cn(c(=O)n(C)c1=O)c(c1n2C)nc2 Cn(c(=O)n(C)c(c1n2C)=O)c1nc2 Cn(c(=O)n(C)c(=O)c1n2C)c1nc2 Cn1c(=O)n(c2c(n(C)cn2)c1=O)C Cn1c(=O)n(c2c(n(cn2)C)c1=O)C Cn1c(=O)n(c2c(c1=O)n(C)cn2)C Cn1c(=O)n(c2c(c1=O)n(cn2)C)C Cn1c(=O)n(c2ncn(C)c2c1=O)C Cn1c(=O)n(c2ncn(c2c1=O)C)C Cn1c(=O)n(c(ncn2C)c2c1=O)C Cn1c(=O)n(c(c2c1=O)ncn2C)C Cn1c(=O)n(c(c(n2C)c1=O)nc2)C Cn1c(=O)n(c(c(c1=O)n2C)nc2)C Cn1c(=O)n(C)c2c(n(C)cn2)c1=O Cn1c(=O)n(C)c2c(n(cn2)C)c1=O Cn1c(=O)n(C)c2c(c1=O)n(C)cn2 Cn1c(=O)n(C)c2c(c1=O)n(cn2)C Cn1c(=O)n(C)c2ncn(C)c2c1=O Cn1c(=O)n(C)c2ncn(c2c1=O)C Cn1c(=O)n(C)c(ncn2C)c2c1=O Cn1c(=O)n(C)c(c2c1=O)ncn2C Cn1c(=O)n(C)c(c(n2C)c1=O)nc2 Cn1c(=O)n(C)c(c(c1=O)n2C)nc2 Cn1c(n(c2c(n(C)cn2)c1=O)C)=O Cn1c(n(c2c(n(cn2)C)c1=O)C)=O Cn1c(n(c2c(c1=O)n(C)cn2)C)=O Cn1c(n(c2c(c1=O)n(cn2)C)C)=O Cn1c(n(c2ncn(C)c2c1=O)C)=O Cn1c(n(c2ncn(c2c1=O)C)C)=O Cn1c(n(c(ncn2C)c2c1=O)C)=O Cn1c(n(c(c2c1=O)ncn2C)C)=O Cn1c(n(c(c(n2C)c1=O)nc2)C)=O Cn1c(n(c(c(c1=O)n2C)nc2)C)=O Cn1c(n(C)c2c(n(C)cn2)c1=O)=O Cn1c(n(C)c2c(n(cn2)C)c1=O)=O Cn1c(n(C)c2c(c1=O)n(C)cn2)=O Cn1c(n(C)c2c(c1=O)n(cn2)C)=O Cn1c(n(C)c2ncn(C)c2c1=O)=O Cn1c(n(C)c2ncn(c2c1=O)C)=O Cn1c(n(C)c(ncn2C)c2c1=O)=O Cn1c(n(C)c(c2c1=O)ncn2C)=O Cn1c(n(C)c(c(n2C)c1=O)nc2)=O Cn1c(n(C)c(c(c1=O)n2C)nc2)=O Cn1c(c2c(ncn2C)n(c1=O)C)=O Cn1c(c2c(ncn2C)n(C)c1=O)=O Cn1c(c2c(n(c1=O)C)ncn2C)=O Cn1c(c2c(n(C)c1=O)ncn2C)=O Cn1c(c2n(C)cnc2n(c1=O)C)=O Cn1c(c2n(C)cnc2n(C)c1=O)=O Cn1c(c2n(cnc2n(c1=O)C)C)=O Cn1c(c2n(cnc2n(C)c1=O)C)=O Cn1c(c(n2C)c(nc2)n(c1=O)C)=O Cn1c(c(n2C)c(nc2)n(C)c1=O)=O Cn1c(c(n2C)c(n(c1=O)C)nc2)=O Cn1c(c(n2C)c(n(C)c1=O)nc2)=O Cn1c(c(c2n(c1=O)C)n(C)cn2)=O Cn1c(c(c2n(c1=O)C)n(cn2)C)=O Cn1c(c(c2n(C)c1=O)n(C)cn2)=O Cn1c(c(c2n(C)c1=O)n(cn2)C)=O Cn1c(=O)c2c(ncn2C)n(c1=O)C Cn1c(=O)c2c(ncn2C)n(C)c1=O Cn1c(=O)c2c(n(c1=O)C)ncn2C Cn1c(=O)c2c(n(C)c1=O)ncn2C Cn1c(=O)c2n(C)cnc2n(c1=O)C Cn1c(=O)c2n(C)cnc2n(C)c1=O Cn1c(=O)c2n(cnc2n(c1=O)C)C Cn1c(=O)c2n(cnc2n(C)c1=O)C Cn1c(=O)c(n2C)c(nc2)n(c1=O)C Cn1c(=O)c(n2C)c(nc2)n(C)c1=O Cn1c(=O)c(n2C)c(n(c1=O)C)nc2 Cn1c(=O)c(n2C)c(n(C)c1=O)nc2 Cn1c(=O)c(c2n(c1=O)C)n(C)cn2 Cn1c(=O)c(c2n(c1=O)C)n(cn2)C Cn1c(=O)c(c2n(C)c1=O)n(C)cn2 Cn1c(=O)c(c2n(C)c1=O)n(cn2)C Cn(c1=O)c(=O)n(c2c1n(C)cn2)C Cn(c1=O)c(=O)n(c2c1n(cn2)C)C Cn(c1=O)c(=O)n(c2ncn(C)c21)C Cn(c1=O)c(=O)n(c2ncn(C)c12)C Cn(c1=O)c(=O)n(c2ncn(c21)C)C Cn(c1=O)c(=O)n(c2ncn(c12)C)C Cn(c1=O)c(=O)n(c(ncn2C)c21)C Cn(c1=O)c(=O)n(c(ncn2C)c12)C Cn(c1=O)c(=O)n(c(c1n2C)nc2)C Cn(c1=O)c(=O)n(C)c2c1n(C)cn2 Cn(c1=O)c(=O)n(C)c2c1n(cn2)C Cn(c1=O)c(=O)n(C)c2ncn(C)c21 Cn(c1=O)c(=O)n(C)c2ncn(C)c12 Cn(c1=O)c(=O)n(C)c2ncn(c21)C Cn(c1=O)c(=O)n(C)c2ncn(c12)C Cn(c1=O)c(=O)n(C)c(ncn2C)c21 Cn(c1=O)c(=O)n(C)c(ncn2C)c12 Cn(c1=O)c(=O)n(C)c(c1n2C)nc2 Cn(c1=O)c(n(c2c1n(C)cn2)C)=O Cn(c1=O)c(n(c2c1n(cn2)C)C)=O Cn(c1=O)c(n(c2ncn(C)c21)C)=O Cn(c1=O)c(n(c2ncn(C)c12)C)=O Cn(c1=O)c(n(c2ncn(c21)C)C)=O Cn(c1=O)c(n(c2ncn(c12)C)C)=O Cn(c1=O)c(n(c(ncn2C)c21)C)=O Cn(c1=O)c(n(c(ncn2C)c12)C)=O Cn(c1=O)c(n(c(c1n2C)nc2)C)=O Cn(c1=O)c(n(C)c2c1n(C)cn2)=O Cn(c1=O)c(n(C)c2c1n(cn2)C)=O Cn(c1=O)c(n(C)c2ncn(C)c21)=O Cn(c1=O)c(n(C)c2ncn(C)c12)=O Cn(c1=O)c(n(C)c2ncn(c21)C)=O Cn(c1=O)c(n(C)c2ncn(c12)C)=O Cn(c1=O)c(n(C)c(ncn2C)c21)=O Cn(c1=O)c(n(C)c(ncn2C)c12)=O Cn(c1=O)c(n(C)c(c1n2C)nc2)=O Cn(c(c1c2ncn1C)=O)c(=O)n2C Cn(c(c1c2ncn1C)=O)c(n2C)=O Cn(c(c1c(ncn1C)n2C)=O)c2=O Cn(c(c1c(n2C)ncn1C)=O)c2=O Cn(c(c1n2C)=O)c(=O)n(c1nc2)C Cn(c(c1n2C)=O)c(=O)n(C)c1nc2 Cn(c(c1n2C)=O)c(n(c1nc2)C)=O Cn(c(c1n2C)=O)c(n(C)c1nc2)=O Cn(c(c1n(C)cnc1n2C)=O)c2=O Cn(c(c1n(cnc1n2C)C)=O)c2=O Cn(c(c(n1C)c2nc1)=O)c(=O)n2C Cn(c(c(n1C)c2nc1)=O)c(n2C)=O Cn(c(c(n1C)c(nc1)n2C)=O)c2=O Cn(c(c(n1C)c(n2C)nc1)=O)c2=O Cn(c(c(c1n2C)n(C)cn1)=O)c2=O Cn(c(c(c1n2C)n(cn1)C)=O)c2=O Cn(c(=O)c1c2ncn1C)c(=O)n2C Cn(c(=O)c1c2ncn1C)c(n2C)=O Cn(c(=O)c1c(ncn1C)n2C)c2=O Cn(c(=O)c1c(n2C)ncn1C)c2=O Cn(c(=O)c1n2C)c(=O)n(c1nc2)C Cn(c(=O)c1n2C)c(=O)n(C)c1nc2 Cn(c(=O)c1n2C)c(n(c1nc2)C)=O Cn(c(=O)c1n2C)c(n(C)c1nc2)=O Cn(c(=O)c1n(C)cnc1n2C)c2=O Cn(c(=O)c1n(cnc1n2C)C)c2=O Cn(c(=O)c(n1C)c2nc1)c(=O)n2C Cn(c(=O)c(n1C)c2nc1)c(n2C)=O Cn(c(=O)c(n1C)c(nc1)n2C)c2=O Cn(c(=O)c(n1C)c(n2C)nc1)c2=O Cn(c(=O)c(c1n2C)n(C)cn1)c2=O Cn(c(=O)c(c1n2C)n(cn1)C)c2=O Cn(c1=O)c(c2c(ncn2C)n1C)=O Cn(c1=O)c(c2c(n1C)ncn2C)=O Cn(c1=O)c(c2n(C)cnc2n1C)=O Cn(c1=O)c(c2n(cnc2n1C)C)=O Cn(c1=O)c(c(n2C)c(nc2)n1C)=O Cn(c1=O)c(c(n2C)c(n1C)nc2)=O Cn(c1=O)c(c(c2n1C)n(C)cn2)=O Cn(c1=O)c(c(c2n1C)n(cn2)C)=O Cn(c1=O)c(=O)c2c(ncn2C)n1C Cn(c1=O)c(=O)c2c(n1C)ncn2C Cn(c1=O)c(=O)c2n(C)cnc2n1C Cn(c1=O)c(=O)c2n(cnc2n1C)C Cn(c1=O)c(=O)c(n2C)c(nc2)n1C Cn(c1=O)c(=O)c(n2C)c(n1C)nc2 Cn(c1=O)c(=O)c(c2n1C)n(C)cn2 Cn(c1=O)c(=O)c(c2n1C)n(cn2)C Cn(c(=O)n1C)c(c2c1ncn2C)=O Cn(c(=O)n1C)c(c2n(C)cnc12)=O Cn(c(=O)n1C)c(c2n(C)cnc21)=O Cn(c(=O)n1C)c(c2n(cnc12)C)=O Cn(c(=O)n1C)c(c2n(cnc21)C)=O Cn(c(=O)n1C)c(c(n2C)c1nc2)=O Cn(c(=O)n1C)c(=O)c2c1ncn2C Cn(c(=O)n1C)c(=O)c2n(C)cnc12 Cn(c(=O)n1C)c(=O)c2n(C)cnc21 Cn(c(=O)n1C)c(=O)c2n(cnc12)C Cn(c(=O)n1C)c(=O)c2n(cnc21)C Cn(c(=O)n1C)c(=O)c(n2C)c1nc2 Cn(c(=O)n(c1c2n(C)cn1)C)c2=O Cn(c(=O)n(c1c2n(cn1)C)C)c2=O Cn(c(=O)n(c1ncn2C)C)c(c21)=O Cn(c(=O)n(c1ncn2C)C)c(c12)=O Cn(c(=O)n(c1ncn2C)C)c(=O)c21 Cn(c(=O)n(c1ncn2C)C)c(=O)c12 Cn(c(=O)n(c(c1n2C)nc2)C)c1=O Cn(c(=O)n(C)c1c2n(C)cn1)c2=O Cn(c(=O)n(C)c1c2n(cn1)C)c2=O Cn(c(=O)n(C)c1ncn2C)c(c21)=O Cn(c(=O)n(C)c1ncn2C)c(c12)=O Cn(c(=O)n(C)c1ncn2C)c(=O)c21 Cn(c(=O)n(C)c1ncn2C)c(=O)c12 Cn(c(=O)n(C)c(c1n2C)nc2)c1=O Cn(c(n1C)=O)c(c2c1ncn2C)=O Cn(c(n1C)=O)c(c2n(C)cnc12)=O Cn(c(n1C)=O)c(c2n(C)cnc21)=O Cn(c(n1C)=O)c(c2n(cnc12)C)=O Cn(c(n1C)=O)c(c2n(cnc21)C)=O Cn(c(n1C)=O)c(c(n2C)c1nc2)=O Cn(c(n1C)=O)c(=O)c2c1ncn2C Cn(c(n1C)=O)c(=O)c2n(C)cnc12 Cn(c(n1C)=O)c(=O)c2n(C)cnc21 Cn(c(n1C)=O)c(=O)c2n(cnc12)C Cn(c(n1C)=O)c(=O)c2n(cnc21)C Cn(c(n1C)=O)c(=O)c(n2C)c1nc2 Cn(c(n(c1c2n(C)cn1)C)=O)c2=O Cn(c(n(c1c2n(cn1)C)C)=O)c2=O Cn(c(n(c1ncn2C)C)=O)c(c21)=O Cn(c(n(c1ncn2C)C)=O)c(c12)=O Cn(c(n(c1ncn2C)C)=O)c(=O)c21 Cn(c(n(c1ncn2C)C)=O)c(=O)c12 Cn(c(n(c(c1n2C)nc2)C)=O)c1=O Cn(c(n(C)c1c2n(C)cn1)=O)c2=O Cn(c(n(C)c1c2n(cn1)C)=O)c2=O Cn(c(n(C)c1ncn2C)=O)c(c21)=O Cn(c(n(C)c1ncn2C)=O)c(c12)=O Cn(c(n(C)c1ncn2C)=O)c(=O)c21 Cn(c(n(C)c1ncn2C)=O)c(=O)c12 Cn(c(n(C)c(c1n2C)nc2)=O)c1=O
Compared to connection tables, such as MDL Mol files, this permutation count is actually quite limited. A molecule with n atoms and m bonds typically has n!m!2m possible connection tables. For Caffeine, with 14 heavy atoms and 15 bonds between them, this is over 3.735×1027 equivalent connection tables.
However, the 4160 permuted SMILES orderings above are just the tip of the iceberg of the true potential number of valid SMILES representations that have the exact same Caffeine InChI.
As Roger Rabbit aptly said in the film ‘Who Framed Roger Rabbit?’, “Let me count the ways… One one-thousand…”
Next, we can consider the possible of lexical forms of each atom. Rather than the single character atoms used in Cn1cnc2c1c(=O)n(c(=O)n2C)C, we can instead (optionally and independently) use bracketed forms for each atom such as:
Cn1[cH]nc2c1c(=O)n(c(=O)n2C)C C[n]1cnc2c1c(=O)[n](c(=O)[n]2C)C [CH3][n]1[cH][n][c]2[c]1[c](=[O])[n]([c](=[O])[n]2[CH3])[CH3]
This alone leads to 16384 variants for each of the 4160 permutations above.
Next, we can consider the effects of aromaticity, as each aromatic ring may be represented as either aromatic or explicitly in each of its conjugated Kekule forms. Four Caffeine case study, examples include:
Cn1cnc2c1c(=O)n(c(=O)n2C)C Cn1cnc2c1C(=O)N(C(=O)N2C)C CN1C=NC2=C1C(=O)N(C(=O)N2C)C
Next, we can consider the use of explicit vs. implicit hydrogen atoms. Zero, some or all of the hydrogen atoms on each heavy atom may be denoted explicitly. With three methyl groups and hydrogen bearing aromatic carbon, this leads us to 4*4*4*2=128 explicit hydrogen variants, including:
[H]C([H])([H])n1c([H])nc2c1c(=O)n(c(=O)n2C([H])([H])[H])C([H])([H])[H] [H]Cn1c([H])nc2c1c(=O)n(c(=O)n2C[H])C[H] [H]Cn1cnc2c1c(=O)n(c(=O)n2C[H])C[H] Cn1c([H])nc2c1c(=O)n(c(=O)n2C)C
Alas, there are no polar hydrogen atoms in Caffeine, so alternate tautomeric forms, potentially one of the richest sources of SMILES with the same InChI, aren’t applicable in this example.
However, even more mind-bending than tautomerism are the multiple potential mesomeric forms of molecule, created by shuffling formal charges around a molecule whilst respecting the valency rules at each atom. Zwitterionic forms of Caffeine include:
C[n+]1c[n-]c2c1c(=O)n(c(=O)n2C)C Cn1cnc2c1c([O-])[n+](c(=O)n2C)C Cn1cnc2c1c(=O)[n+](c([O-])n2C)C Cn1cnc2c1c(=O)n(c([O-])[n+]2C)C Cn1cnc2c1c([O-])n(c(=O)[n+]2C)C C[n+]1c[n-]c2c1c([O-])[n+](c(=O)n2C)C C[n+]1c[n-]c2c1c(=O)[n+](c([O-])n2C)C C[n+]1c[n-]c2c1c(=O)n(c([O-])[n+]2C)C C[n+]1c[n-]c2c1c2c1c([O-])n(c(=O)[n+]2C)C Cn1cnc2c1c([O-])[n+](c([O-])[n+]2C)C C[n+]1c[n-]c2c1c([O-])[n+](c([O-])[n+]2C)C C[n+]1c[n-]c2c1c([O-])[n+](c([O-])[n+]2C)C
All of the above zwitterions are “traditional”, only placing formal charges on polar atoms, but continuing the madness even further considers all the following to be mesomeric forms of Caffeine:
Cn1cnc2c1[c+]([O-])n(c(=O)n2C)C Cn1cnc2c1c(=O)n([c+]([O-])n2C)C Cn1cnc2c1[c+]([O-])n([c+]([O-])n2C)C
Finally, ylid-like mesomerism may often be used to eliminate bond orders from connection tables, producing one of my favourite representations of Caffeine, one without any double bonds:
Cn1[cH+][n-][c+]2[c-]1[c+]([O-])n([c+]([O-])n2C)C
This, along with all of the millions of Caffeine SMILES variants outlined above, has the exact same InChI:
InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
That all of these SMILES are represented by the same unique InChI is very useful in many applications. However, that any of these SMILES may potentially be presented to the user as a legitimate example/depiction of that InChI can also be a liability. Whoops – I said no discussion of InChI versus SMILES. 🙂
Image credit: oswaldo on Twitter.
