Category: Uncategorized

Using experimental data to update the Topliss Tree

A recurring task in medicinal chemistry is the optimization of R groups around a ring in order to improve biological activity. In a landmark paper in 1972, John Topliss (then at Schering) described a scheme for deciding what substituted phenyl to make next based on the relative potencies of the compounds made so far. This has become known as the Topliss Tree.

To begin with, Topliss suggested making the unsubstituted phenyl and the 4-chlorophenyl. Depending on their relative potencies, he went on to suggest either 4-methoxyphenyl or 3,4-dichlorophenyl. Based on the relative potency of that, the tree continued downwards. An abbreviated version of the tree is shown below.

Topliss Tree

So how did Topliss come up with his suggestions? He based it all on the Hansch parameters (σ and π) for different phenyl substituents, and the inferred relationship (either positive or negative) between the Hansch parameters and the potency. (This is less complicated than it sounds – it’s like identifying that potency is increasing with electron-withdrawing strength and so let’s try a stronger EWG.)

Today we have access to large amounts of experimental data on potency orders (for example, in ChEMBL), and so we can check whether that data agrees with the suggestions of the Topliss Tree. Back in March, we published a paper describing a method that uses a database of experimental results to suggest what R group would increase activity based on observed activity order. This is exactly the scenario described by Topliss and so we can come at the same question from a compeletely different angle. I briefly addressed this question in the paper, but I returned to it in more detail (and with more experimental data) for a talk I gave to MEDI at the recent ACS meeting in San Francisco: Revising the Topliss decision tree based on 30 years of medicinal chemistry literature [PDF]

The conclusions were that in the main the data in ChEMBL agreed with Topliss. However, particular points of disagreement were the suggestion of 4-OMe instead of 4-OH (if H > 4-Cl), and the suggestion of 4-CF3 (if 4-Cl > 3,4-diCl). This then raises the question, what would we recommend instead?…enter the Matsy Tree:

Matsy Tree

Since we can generate a similar tree for any situation or data, we can limit the data to particular targets (e.g. kinases) or apply ligand-efficiency rules to the predictions. For more details see the talk above.

If you are interested in an evaluation version of the software used here, Matsy, send an email to matsy@nextmovesoftware.com.

What is a med chemist’s favourite phenyl substituent?

In the course of preparing a talk for the recent ACS meeting (more on this later), I thought it would be interesting to give an overview of the ChEMBL data on substituted phenyls. What I did was take all those matched series* with associated IC50 data containing 4 or more phenyl substituents, and then count the frequency of each particular phenyl.

In other words, when a medicinal chemist was trying to optimize the substituents around a phenyl ring, which were the most frequent groups tested?

The most popular substituted phenyls
The most popular substituted phenyls

The order of popularity at the 4 position is OMe > Cl > F > Me, while at the 2 and 3 positions it’s Cl > OMe > F > Me. For these groups, in general the corresponding frequencies are in the order 4 >> 3 > 2. It would be interesting to know whether this corresponds to the ease of synthesis of these groups (in the general case) or whether other factors are at play.

In response to a query about whether the preferences have changed over time, I’ve generated the following image (click for bigger) that provides this information for the period 1990-2013 (the x-axis). The y-axis shows frequencies divided by the total number of substituted phenyls that year.

Changes in frequencies over time
Changes in frequencies over time
It’s a bit hard to draw any conclusions, but possibly 4-nitrile is becoming more popular, along with 3-F, while 2-NO2 and 2,3,4-OMe are going down.

*A matched (molecular) series is a series of analogs with same scaffold but different R groups (all at the same position). In this context, each matched series contains only molecules from the same assay and paper.

See you at the ACS?

NextMovers will be present and presenting at the 248th ACS National Meeting in San Francisco, which starts this Sunday.

As well as having a booth (come by if interested in picking up an evaluation copy of Matsy), we will be giving the following presentations:

Sunday
11 – Classification, representation, and analysis of cyclic peptides and peptide-like analogs
Authors: Dr Roger A Sayle, Dr Daniel M Lowe, Dr Noel M O’Boyle
Division: CINF: Division of Chemical Information
Date/Time: Sunday, August 10, 2014 – 08:35 AM
Session Info: Computational Methods and the Development/Production of Biologics and Biosimilars (08:30 AM – 09:35 AM)
Location: Palace Hotel
Room: California Parlor

6 – Chemistry and reactions from non-US patents
Authors: Dr Daniel M Lowe, Dr Roger A Sayle
Division: CINF: Division of Chemical Information
Date/Time: Sunday, August 10, 2014 – 09:20 AM
Session Info: Hunting for Hidden Treasures: Chemistry Text Mining in Patents and Other Documents (08:40 AM – 12:00 PM)
Location: Palace Hotel
Room: Presidio

22 – Revising the Topliss decision tree based on 30 years of medicinal chemistry literature
Authors: Noel M O’Boyle, Jonas Boström, Roger A Sayle, Adrian Gill
Division: MEDI: Division of Medicinal Chemistry
Date/Time: Sunday, August 10, 2014 – 11:30 AM
Session Info: General Oral Session (08:30 AM – 12:10 PM)
Location: Moscone Center, West Bldg.
Room: 3008

Tuesday
394 – Using matched series to predict R groups that improve biological activity
Authors: Noel M O’Boyle, Jonas Boström, Roger A Sayle, Adrian Gill
Division: COMP: Division of Computers in Chemistry
Date/Time: Tuesday, August 12, 2014 – 06:00 PM
Session Info: Poster Session (06:00 PM – 08:00 PM)
Location: San Francisco Marriott Marquis
Room: Golden Gate Section A/B

How do I write thee? Let me count the ways

Caffeine for the Creative Mind book coverA recent posting to the CHMINF-L mailing list at the University of Indiana reiterates a point made by Steve Heller in his recent keynote address to the 2014 ICCS/GCC meeting in Noordwijkerhout. In that presentation, Steve argues for the need for chemical structure canonicalization by showing 172 possible valid SMILES strings for the molecule Caffeine.

The representational degeneracy of line notations, connection tables and even structure diagrams is one of the main challenges of cheminformatics. A chemist’s concept of sameness doesn’t always match the classical “bond order” representation/model of organic chemistry.  I’ll save a discussion of pros and cons of InChI vs SMILES for a future post, but for now we’ll investigate the core property that multiple SMILES map to a single InChI.

The original 172 SMILES for Caffeine were automatically generated by Ian Watson at Eli Lilly as described in his September 2010 CHMINF-L posting, but no claims were made as to whether this list is, or was intended to be, exhaustive.

A quick back-of-the-envelope calculation reveals that 172 is too low a bound for the number of possible SMILES permutations for Caffeine. SMILES generation resembles the depth-first traversal of an un-rooted undirected graph, potentially starting from any atom and making an arbitrary ordering decision at each branch point, i.e. each atom with more than two atom neighbours. Caffeine has 14 heavy atoms, two rings, 7 atoms with heavy atom degree three, and no symmetries.  This means that Caffeine should have at least 14*2^(7-2)=448 SMILES.  This calculation assumes that the SMILES string can start at any atom, and underestimates the branch points by subtracting the number of ring closures.

In fact, with a little programming magic (exercise left to the reader), it’s possible to come up with the following list of 4160 SMILES, all of which should canonicalize to the exact same form:

Cn1cnc2c1c(=O)n(c(=O)n2C)C
Cn1cnc2c1c(=O)n(c(n2C)=O)C
Cn1cnc2c1c(=O)n(C)c(=O)n2C
Cn1cnc2c1c(=O)n(C)c(n2C)=O
Cn1cnc2c1c(n(c(=O)n2C)C)=O
Cn1cnc2c1c(n(c(n2C)=O)C)=O
Cn1cnc2c1c(n(C)c(=O)n2C)=O
Cn1cnc2c1c(n(C)c(n2C)=O)=O
Cn1cnc2n(c(n(c(c12)=O)C)=O)C
Cn1cnc2n(c(n(c(c21)=O)C)=O)C
Cn1cnc2n(c(n(c(=O)c12)C)=O)C
Cn1cnc2n(c(n(c(=O)c21)C)=O)C
Cn1cnc2n(c(n(C)c(c12)=O)=O)C
Cn1cnc2n(c(n(C)c(c21)=O)=O)C
Cn1cnc2n(c(n(C)c(=O)c12)=O)C
Cn1cnc2n(c(n(C)c(=O)c21)=O)C
Cn1cnc2n(c(=O)n(c(c12)=O)C)C
Cn1cnc2n(c(=O)n(c(c21)=O)C)C
Cn1cnc2n(c(=O)n(c(=O)c12)C)C
Cn1cnc2n(c(=O)n(c(=O)c21)C)C
Cn1cnc2n(c(=O)n(C)c(c12)=O)C
Cn1cnc2n(c(=O)n(C)c(c21)=O)C
Cn1cnc2n(c(=O)n(C)c(=O)c12)C
Cn1cnc2n(c(=O)n(C)c(=O)c21)C
Cn1cnc2n(C)c(n(c(c12)=O)C)=O
Cn1cnc2n(C)c(n(c(c21)=O)C)=O
Cn1cnc2n(C)c(n(c(=O)c12)C)=O
Cn1cnc2n(C)c(n(c(=O)c21)C)=O
Cn1cnc2n(C)c(n(C)c(c12)=O)=O
Cn1cnc2n(C)c(n(C)c(c21)=O)=O
Cn1cnc2n(C)c(n(C)c(=O)c12)=O
Cn1cnc2n(C)c(n(C)c(=O)c21)=O
Cn1cnc2n(C)c(=O)n(c(c12)=O)C
Cn1cnc2n(C)c(=O)n(c(c21)=O)C
Cn1cnc2n(C)c(=O)n(c(=O)c12)C
Cn1cnc2n(C)c(=O)n(c(=O)c21)C
Cn1cnc2n(C)c(=O)n(C)c(c12)=O
Cn1cnc2n(C)c(=O)n(C)c(c21)=O
Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Cn1cnc2n(C)c(=O)n(C)c(=O)c21
Cn1cnc(n2C)c1c(=O)n(c2=O)C
Cn1cnc(n2C)c1c(=O)n(C)c2=O
Cn1cnc(n2C)c1c(n(c2=O)C)=O
Cn1cnc(n2C)c1c(n(C)c2=O)=O
Cn1cnc(n(c2=O)C)c1c(=O)n2C
Cn1cnc(n(c2=O)C)c1c(n2C)=O
Cn1cnc(n(c(n2C)=O)C)c1c2=O
Cn1cnc(n(c(n(c2=O)C)=O)C)c12
Cn1cnc(n(c(n(c2=O)C)=O)C)c21
Cn1cnc(n(c(n(C)c2=O)=O)C)c12
Cn1cnc(n(c(n(C)c2=O)=O)C)c21
Cn1cnc(n(c(=O)n2C)C)c1c2=O
Cn1cnc(n(c(=O)n(c2=O)C)C)c12
Cn1cnc(n(c(=O)n(c2=O)C)C)c21
Cn1cnc(n(c(=O)n(C)c2=O)C)c12
Cn1cnc(n(c(=O)n(C)c2=O)C)c21
Cn1cnc(n(C)c2=O)c1c(=O)n2C
Cn1cnc(n(C)c2=O)c1c(n2C)=O
Cn1cnc(n(C)c(n2C)=O)c1c2=O
Cn1cnc(n(C)c(n(c2=O)C)=O)c12
Cn1cnc(n(C)c(n(c2=O)C)=O)c21
Cn1cnc(n(C)c(n(C)c2=O)=O)c12
Cn1cnc(n(C)c(n(C)c2=O)=O)c21
Cn1cnc(n(C)c(=O)n2C)c1c2=O
Cn1cnc(n(C)c(=O)n(c2=O)C)c12
Cn1cnc(n(C)c(=O)n(c2=O)C)c21
Cn1cnc(n(C)c(=O)n(C)c2=O)c12
Cn1cnc(n(C)c(=O)n(C)c2=O)c21
Cn1cnc(c1c2=O)n(c(n2C)=O)C
Cn1cnc(c1c2=O)n(c(=O)n2C)C
Cn1cnc(c1c2=O)n(C)c(n2C)=O
Cn1cnc(c1c2=O)n(C)c(=O)n2C
Cn1cnc(c1c(=O)n2C)n(c2=O)C
Cn1cnc(c1c(=O)n2C)n(C)c2=O
Cn1cnc(c1c(=O)n(c2=O)C)n2C
Cn1cnc(c1c(=O)n(C)c2=O)n2C
Cn1cnc(c1c(n2C)=O)n(c2=O)C
Cn1cnc(c1c(n2C)=O)n(C)c2=O
Cn1cnc(c1c(n(c2=O)C)=O)n2C
Cn1cnc(c1c(n(C)c2=O)=O)n2C
Cn1c2c(=O)n(c(=O)n(c2nc1)C)C
Cn1c2c(=O)n(c(=O)n(C)c2nc1)C
Cn1c2c(=O)n(c(n(c2nc1)C)=O)C
Cn1c2c(=O)n(c(n(C)c2nc1)=O)C
Cn1c2c(=O)n(C)c(=O)n(c2nc1)C
Cn1c2c(=O)n(C)c(=O)n(C)c2nc1
Cn1c2c(=O)n(C)c(n(c2nc1)C)=O
Cn1c2c(=O)n(C)c(n(C)c2nc1)=O
Cn1c2c(n(c(=O)n(c2nc1)C)C)=O
Cn1c2c(n(c(=O)n(C)c2nc1)C)=O
Cn1c2c(n(c(n(c2nc1)C)=O)C)=O
Cn1c2c(n(c(n(C)c2nc1)=O)C)=O
Cn1c2c(n(C)c(=O)n(c2nc1)C)=O
Cn1c2c(n(C)c(=O)n(C)c2nc1)=O
Cn1c2c(n(C)c(n(c2nc1)C)=O)=O
Cn1c2c(n(C)c(n(C)c2nc1)=O)=O
Cn1c2c(nc1)n(c(n(c2=O)C)=O)C
Cn1c2c(nc1)n(c(n(C)c2=O)=O)C
Cn1c2c(nc1)n(c(=O)n(c2=O)C)C
Cn1c2c(nc1)n(c(=O)n(C)c2=O)C
Cn1c2c(nc1)n(C)c(n(c2=O)C)=O
Cn1c2c(nc1)n(C)c(n(C)c2=O)=O
Cn1c2c(nc1)n(C)c(=O)n(c2=O)C
Cn1c2c(nc1)n(C)c(=O)n(C)c2=O
Cn1c2c(n(c(n(c2=O)C)=O)C)nc1
Cn1c2c(n(c(n(C)c2=O)=O)C)nc1
Cn1c2c(n(c(=O)n(c2=O)C)C)nc1
Cn1c2c(n(c(=O)n(C)c2=O)C)nc1
Cn1c2c(n(C)c(n(c2=O)C)=O)nc1
Cn1c2c(n(C)c(n(C)c2=O)=O)nc1
Cn1c2c(n(C)c(=O)n(c2=O)C)nc1
Cn1c2c(n(C)c(=O)n(C)c2=O)nc1
Cn1c(c2nc1)c(=O)n(c(=O)n2C)C
Cn1c(c2nc1)c(=O)n(c(n2C)=O)C
Cn1c(c2nc1)c(=O)n(C)c(=O)n2C
Cn1c(c2nc1)c(=O)n(C)c(n2C)=O
Cn1c(c2nc1)c(n(c(=O)n2C)C)=O
Cn1c(c2nc1)c(n(c(n2C)=O)C)=O
Cn1c(c2nc1)c(n(C)c(=O)n2C)=O
Cn1c(c2nc1)c(n(C)c(n2C)=O)=O
Cn1c(c(nc1)n2C)c(=O)n(c2=O)C
Cn1c(c(nc1)n2C)c(=O)n(C)c2=O
Cn1c(c(nc1)n2C)c(n(c2=O)C)=O
Cn1c(c(nc1)n2C)c(n(C)c2=O)=O
Cn1c(c(nc1)n(c2=O)C)c(=O)n2C
Cn1c(c(nc1)n(c2=O)C)c(n2C)=O
Cn1c(c(nc1)n(c(n2C)=O)C)c2=O
Cn1c(c(nc1)n(c(=O)n2C)C)c2=O
Cn1c(c(nc1)n(C)c2=O)c(=O)n2C
Cn1c(c(nc1)n(C)c2=O)c(n2C)=O
Cn1c(c(nc1)n(C)c(n2C)=O)c2=O
Cn1c(c(nc1)n(C)c(=O)n2C)c2=O
Cn1c(c(n2C)nc1)c(=O)n(c2=O)C
Cn1c(c(n2C)nc1)c(=O)n(C)c2=O
Cn1c(c(n2C)nc1)c(n(c2=O)C)=O
Cn1c(c(n2C)nc1)c(n(C)c2=O)=O
Cn1c(c(n(c2=O)C)nc1)c(=O)n2C
Cn1c(c(n(c2=O)C)nc1)c(n2C)=O
Cn1c(c(n(c(n2C)=O)C)nc1)c2=O
Cn1c(c(n(c(=O)n2C)C)nc1)c2=O
Cn1c(c(n(C)c2=O)nc1)c(=O)n2C
Cn1c(c(n(C)c2=O)nc1)c(n2C)=O
Cn1c(c(n(C)c(n2C)=O)nc1)c2=O
Cn1c(c(n(C)c(=O)n2C)nc1)c2=O
Cn1c(c2=O)c(nc1)n(c(n2C)=O)C
Cn1c(c2=O)c(nc1)n(c(=O)n2C)C
Cn1c(c2=O)c(nc1)n(C)c(n2C)=O
Cn1c(c2=O)c(nc1)n(C)c(=O)n2C
Cn1c(c2=O)c(n(c(n2C)=O)C)nc1
Cn1c(c2=O)c(n(c(=O)n2C)C)nc1
Cn1c(c2=O)c(n(C)c(n2C)=O)nc1
Cn1c(c2=O)c(n(C)c(=O)n2C)nc1
Cn1c(c(=O)n2C)c(nc1)n(c2=O)C
Cn1c(c(=O)n2C)c(nc1)n(C)c2=O
Cn1c(c(=O)n2C)c(n(c2=O)C)nc1
Cn1c(c(=O)n2C)c(n(C)c2=O)nc1
Cn1c(c(=O)n(c2=O)C)c(nc1)n2C
Cn1c(c(=O)n(c2=O)C)c(n2C)nc1
Cn1c(c(=O)n(c(=O)n2C)C)c2nc1
Cn1c(c(=O)n(c(n2C)=O)C)c2nc1
Cn1c(c(=O)n(C)c2=O)c(nc1)n2C
Cn1c(c(=O)n(C)c2=O)c(n2C)nc1
Cn1c(c(=O)n(C)c(=O)n2C)c2nc1
Cn1c(c(=O)n(C)c(n2C)=O)c2nc1
Cn1c(c(n2C)=O)c(nc1)n(c2=O)C
Cn1c(c(n2C)=O)c(nc1)n(C)c2=O
Cn1c(c(n2C)=O)c(n(c2=O)C)nc1
Cn1c(c(n2C)=O)c(n(C)c2=O)nc1
Cn1c(c(n(c2=O)C)=O)c(nc1)n2C
Cn1c(c(n(c2=O)C)=O)c(n2C)nc1
Cn1c(c(n(c(=O)n2C)C)=O)c2nc1
Cn1c(c(n(c(n2C)=O)C)=O)c2nc1
Cn1c(c(n(C)c2=O)=O)c(nc1)n2C
Cn1c(c(n(C)c2=O)=O)c(n2C)nc1
Cn1c(c(n(C)c(=O)n2C)=O)c2nc1
Cn1c(c(n(C)c(n2C)=O)=O)c2nc1
Cn(c1c2=O)cnc1n(c(n2C)=O)C
Cn(c1c2=O)cnc1n(c(=O)n2C)C
Cn(c1c2=O)cnc1n(C)c(n2C)=O
Cn(c1c2=O)cnc1n(C)c(=O)n2C
Cn(c1c(=O)n2C)cnc1n(c2=O)C
Cn(c1c(=O)n2C)cnc1n(C)c2=O
Cn(c1c(=O)n(c2=O)C)cnc1n2C
Cn(c1c(=O)n(c(=O)n2C)C)cnc21
Cn(c1c(=O)n(c(=O)n2C)C)cnc12
Cn(c1c(=O)n(c(n2C)=O)C)cnc21
Cn(c1c(=O)n(c(n2C)=O)C)cnc12
Cn(c1c(=O)n(C)c2=O)cnc1n2C
Cn(c1c(=O)n(C)c(=O)n2C)cnc21
Cn(c1c(=O)n(C)c(=O)n2C)cnc12
Cn(c1c(=O)n(C)c(n2C)=O)cnc21
Cn(c1c(=O)n(C)c(n2C)=O)cnc12
Cn(c1c(n2C)=O)cnc1n(c2=O)C
Cn(c1c(n2C)=O)cnc1n(C)c2=O
Cn(c1c(n(c2=O)C)=O)cnc1n2C
Cn(c1c(n(c(=O)n2C)C)=O)cnc21
Cn(c1c(n(c(=O)n2C)C)=O)cnc12
Cn(c1c(n(c(n2C)=O)C)=O)cnc21
Cn(c1c(n(c(n2C)=O)C)=O)cnc12
Cn(c1c(n(C)c2=O)=O)cnc1n2C
Cn(c1c(n(C)c(=O)n2C)=O)cnc21
Cn(c1c(n(C)c(=O)n2C)=O)cnc12
Cn(c1c(n(C)c(n2C)=O)=O)cnc21
Cn(c1c(n(C)c(n2C)=O)=O)cnc12
Cn(c1c2n(c(n(c1=O)C)=O)C)cn2
Cn(c1c2n(c(n(C)c1=O)=O)C)cn2
Cn(c1c2n(c(=O)n(c1=O)C)C)cn2
Cn(c1c2n(c(=O)n(C)c1=O)C)cn2
Cn(c1c2n(C)c(n(c1=O)C)=O)cn2
Cn(c1c2n(C)c(n(C)c1=O)=O)cn2
Cn(c1c2n(C)c(=O)n(c1=O)C)cn2
Cn(c1c2n(C)c(=O)n(C)c1=O)cn2
Cn(c(c1n2C)c(=O)n(c2=O)C)cn1
Cn(c(c1n2C)c(=O)n(C)c2=O)cn1
Cn(c(c1n2C)c(n(c2=O)C)=O)cn1
Cn(c(c1n2C)c(n(C)c2=O)=O)cn1
Cn(c(c1n(c2=O)C)c(=O)n2C)cn1
Cn(c(c1n(c2=O)C)c(n2C)=O)cn1
Cn(c(c1n(c(n2C)=O)C)c2=O)cn1
Cn(c(c1n(c(=O)n2C)C)c2=O)cn1
Cn(c(c1n(C)c2=O)c(=O)n2C)cn1
Cn(c(c1n(C)c2=O)c(n2C)=O)cn1
Cn(c(c1n(C)c(n2C)=O)c2=O)cn1
Cn(c(c1n(C)c(=O)n2C)c2=O)cn1
Cn(c(c1=O)c2n(c(n1C)=O)C)cn2
Cn(c(c1=O)c2n(c(=O)n1C)C)cn2
Cn(c(c1=O)c2n(C)c(n1C)=O)cn2
Cn(c(c1=O)c2n(C)c(=O)n1C)cn2
Cn(c(c(=O)n1C)c2n(c1=O)C)cn2
Cn(c(c(=O)n1C)c2n(C)c1=O)cn2
Cn(c(c(=O)n(c1=O)C)c2n1C)cn2
Cn(c(c(=O)n(C)c1=O)c2n1C)cn2
Cn(c(c(n1C)=O)c2n(c1=O)C)cn2
Cn(c(c(n1C)=O)c2n(C)c1=O)cn2
Cn(c(c(n(c1=O)C)=O)c2n1C)cn2
Cn(c(c(n(C)c1=O)=O)c2n1C)cn2
Cn(cnc1n2C)c1c(=O)n(c2=O)C
Cn(cnc1n2C)c1c(=O)n(C)c2=O
Cn(cnc1n2C)c1c(n(c2=O)C)=O
Cn(cnc1n2C)c1c(n(C)c2=O)=O
Cn(cnc1n(c2=O)C)c1c(=O)n2C
Cn(cnc1n(c2=O)C)c1c(n2C)=O
Cn(cnc1n(c(n2C)=O)C)c1c2=O
Cn(cnc1n(c(n(c2=O)C)=O)C)c12
Cn(cnc1n(c(n(c2=O)C)=O)C)c21
Cn(cnc1n(c(n(C)c2=O)=O)C)c12
Cn(cnc1n(c(n(C)c2=O)=O)C)c21
Cn(cnc1n(c(=O)n2C)C)c1c2=O
Cn(cnc1n(c(=O)n(c2=O)C)C)c12
Cn(cnc1n(c(=O)n(c2=O)C)C)c21
Cn(cnc1n(c(=O)n(C)c2=O)C)c12
Cn(cnc1n(c(=O)n(C)c2=O)C)c21
Cn(cnc1n(C)c2=O)c1c(=O)n2C
Cn(cnc1n(C)c2=O)c1c(n2C)=O
Cn(cnc1n(C)c(n2C)=O)c1c2=O
Cn(cnc1n(C)c(n(c2=O)C)=O)c12
Cn(cnc1n(C)c(n(c2=O)C)=O)c21
Cn(cnc1n(C)c(n(C)c2=O)=O)c12
Cn(cnc1n(C)c(n(C)c2=O)=O)c21
Cn(cnc1n(C)c(=O)n2C)c1c2=O
Cn(cnc1n(C)c(=O)n(c2=O)C)c12
Cn(cnc1n(C)c(=O)n(c2=O)C)c21
Cn(cnc1n(C)c(=O)n(C)c2=O)c12
Cn(cnc1n(C)c(=O)n(C)c2=O)c21
n1(C)cnc2c1c(=O)n(c(=O)n2C)C
n1(C)cnc2c1c(=O)n(c(n2C)=O)C
n1(C)cnc2c1c(=O)n(C)c(=O)n2C
n1(C)cnc2c1c(=O)n(C)c(n2C)=O
n1(C)cnc2c1c(n(c(=O)n2C)C)=O
n1(C)cnc2c1c(n(c(n2C)=O)C)=O
n1(C)cnc2c1c(n(C)c(=O)n2C)=O
n1(C)cnc2c1c(n(C)c(n2C)=O)=O
n1(C)cnc2n(c(n(c(c12)=O)C)=O)C
n1(C)cnc2n(c(n(c(c21)=O)C)=O)C
n1(C)cnc2n(c(n(c(=O)c12)C)=O)C
n1(C)cnc2n(c(n(c(=O)c21)C)=O)C
n1(C)cnc2n(c(n(C)c(c12)=O)=O)C
n1(C)cnc2n(c(n(C)c(c21)=O)=O)C
n1(C)cnc2n(c(n(C)c(=O)c12)=O)C
n1(C)cnc2n(c(n(C)c(=O)c21)=O)C
n1(C)cnc2n(c(=O)n(c(c12)=O)C)C
n1(C)cnc2n(c(=O)n(c(c21)=O)C)C
n1(C)cnc2n(c(=O)n(c(=O)c12)C)C
n1(C)cnc2n(c(=O)n(c(=O)c21)C)C
n1(C)cnc2n(c(=O)n(C)c(c12)=O)C
n1(C)cnc2n(c(=O)n(C)c(c21)=O)C
n1(C)cnc2n(c(=O)n(C)c(=O)c12)C
n1(C)cnc2n(c(=O)n(C)c(=O)c21)C
n1(C)cnc2n(C)c(n(c(c12)=O)C)=O
n1(C)cnc2n(C)c(n(c(c21)=O)C)=O
n1(C)cnc2n(C)c(n(c(=O)c12)C)=O
n1(C)cnc2n(C)c(n(c(=O)c21)C)=O
n1(C)cnc2n(C)c(n(C)c(c12)=O)=O
n1(C)cnc2n(C)c(n(C)c(c21)=O)=O
n1(C)cnc2n(C)c(n(C)c(=O)c12)=O
n1(C)cnc2n(C)c(n(C)c(=O)c21)=O
n1(C)cnc2n(C)c(=O)n(c(c12)=O)C
n1(C)cnc2n(C)c(=O)n(c(c21)=O)C
n1(C)cnc2n(C)c(=O)n(c(=O)c12)C
n1(C)cnc2n(C)c(=O)n(c(=O)c21)C
n1(C)cnc2n(C)c(=O)n(C)c(c12)=O
n1(C)cnc2n(C)c(=O)n(C)c(c21)=O
n1(C)cnc2n(C)c(=O)n(C)c(=O)c12
n1(C)cnc2n(C)c(=O)n(C)c(=O)c21
n1(C)cnc(n2C)c1c(=O)n(c2=O)C
n1(C)cnc(n2C)c1c(=O)n(C)c2=O
n1(C)cnc(n2C)c1c(n(c2=O)C)=O
n1(C)cnc(n2C)c1c(n(C)c2=O)=O
n1(C)cnc(n(c2=O)C)c1c(=O)n2C
n1(C)cnc(n(c2=O)C)c1c(n2C)=O
n1(C)cnc(n(c(n2C)=O)C)c1c2=O
n1(C)cnc(n(c(n(c2=O)C)=O)C)c12
n1(C)cnc(n(c(n(c2=O)C)=O)C)c21
n1(C)cnc(n(c(n(C)c2=O)=O)C)c12
n1(C)cnc(n(c(n(C)c2=O)=O)C)c21
n1(C)cnc(n(c(=O)n2C)C)c1c2=O
n1(C)cnc(n(c(=O)n(c2=O)C)C)c12
n1(C)cnc(n(c(=O)n(c2=O)C)C)c21
n1(C)cnc(n(c(=O)n(C)c2=O)C)c12
n1(C)cnc(n(c(=O)n(C)c2=O)C)c21
n1(C)cnc(n(C)c2=O)c1c(=O)n2C
n1(C)cnc(n(C)c2=O)c1c(n2C)=O
n1(C)cnc(n(C)c(n2C)=O)c1c2=O
n1(C)cnc(n(C)c(n(c2=O)C)=O)c12
n1(C)cnc(n(C)c(n(c2=O)C)=O)c21
n1(C)cnc(n(C)c(n(C)c2=O)=O)c12
n1(C)cnc(n(C)c(n(C)c2=O)=O)c21
n1(C)cnc(n(C)c(=O)n2C)c1c2=O
n1(C)cnc(n(C)c(=O)n(c2=O)C)c12
n1(C)cnc(n(C)c(=O)n(c2=O)C)c21
n1(C)cnc(n(C)c(=O)n(C)c2=O)c12
n1(C)cnc(n(C)c(=O)n(C)c2=O)c21
n1(C)cnc(c1c2=O)n(c(n2C)=O)C
n1(C)cnc(c1c2=O)n(c(=O)n2C)C
n1(C)cnc(c1c2=O)n(C)c(n2C)=O
n1(C)cnc(c1c2=O)n(C)c(=O)n2C
n1(C)cnc(c1c(=O)n2C)n(c2=O)C
n1(C)cnc(c1c(=O)n2C)n(C)c2=O
n1(C)cnc(c1c(=O)n(c2=O)C)n2C
n1(C)cnc(c1c(=O)n(C)c2=O)n2C
n1(C)cnc(c1c(n2C)=O)n(c2=O)C
n1(C)cnc(c1c(n2C)=O)n(C)c2=O
n1(C)cnc(c1c(n(c2=O)C)=O)n2C
n1(C)cnc(c1c(n(C)c2=O)=O)n2C
n1(cnc2c1c(=O)n(c(=O)n2C)C)C
n1(cnc2c1c(=O)n(c(n2C)=O)C)C
n1(cnc2c1c(=O)n(C)c(=O)n2C)C
n1(cnc2c1c(=O)n(C)c(n2C)=O)C
n1(cnc2c1c(n(c(=O)n2C)C)=O)C
n1(cnc2c1c(n(c(n2C)=O)C)=O)C
n1(cnc2c1c(n(C)c(=O)n2C)=O)C
n1(cnc2c1c(n(C)c(n2C)=O)=O)C
n1(cnc2n(c(n(c(c12)=O)C)=O)C)C
n1(cnc2n(c(n(c(c21)=O)C)=O)C)C
n1(cnc2n(c(n(c(=O)c12)C)=O)C)C
n1(cnc2n(c(n(c(=O)c21)C)=O)C)C
n1(cnc2n(c(n(C)c(c12)=O)=O)C)C
n1(cnc2n(c(n(C)c(c21)=O)=O)C)C
n1(cnc2n(c(n(C)c(=O)c12)=O)C)C
n1(cnc2n(c(n(C)c(=O)c21)=O)C)C
n1(cnc2n(c(=O)n(c(c12)=O)C)C)C
n1(cnc2n(c(=O)n(c(c21)=O)C)C)C
n1(cnc2n(c(=O)n(c(=O)c12)C)C)C
n1(cnc2n(c(=O)n(c(=O)c21)C)C)C
n1(cnc2n(c(=O)n(C)c(c12)=O)C)C
n1(cnc2n(c(=O)n(C)c(c21)=O)C)C
n1(cnc2n(c(=O)n(C)c(=O)c12)C)C
n1(cnc2n(c(=O)n(C)c(=O)c21)C)C
n1(cnc2n(C)c(n(c(c12)=O)C)=O)C
n1(cnc2n(C)c(n(c(c21)=O)C)=O)C
n1(cnc2n(C)c(n(c(=O)c12)C)=O)C
n1(cnc2n(C)c(n(c(=O)c21)C)=O)C
n1(cnc2n(C)c(n(C)c(c12)=O)=O)C
n1(cnc2n(C)c(n(C)c(c21)=O)=O)C
n1(cnc2n(C)c(n(C)c(=O)c12)=O)C
n1(cnc2n(C)c(n(C)c(=O)c21)=O)C
n1(cnc2n(C)c(=O)n(c(c12)=O)C)C
n1(cnc2n(C)c(=O)n(c(c21)=O)C)C
n1(cnc2n(C)c(=O)n(c(=O)c12)C)C
n1(cnc2n(C)c(=O)n(c(=O)c21)C)C
n1(cnc2n(C)c(=O)n(C)c(c12)=O)C
n1(cnc2n(C)c(=O)n(C)c(c21)=O)C
n1(cnc2n(C)c(=O)n(C)c(=O)c12)C
n1(cnc2n(C)c(=O)n(C)c(=O)c21)C
n1(cnc(n2C)c1c(=O)n(c2=O)C)C
n1(cnc(n2C)c1c(=O)n(C)c2=O)C
n1(cnc(n2C)c1c(n(c2=O)C)=O)C
n1(cnc(n2C)c1c(n(C)c2=O)=O)C
n1(cnc(n(c2=O)C)c1c(=O)n2C)C
n1(cnc(n(c2=O)C)c1c(n2C)=O)C
n1(cnc(n(c(n2C)=O)C)c1c2=O)C
n1(cnc(n(c(n(c2=O)C)=O)C)c12)C
n1(cnc(n(c(n(c2=O)C)=O)C)c21)C
n1(cnc(n(c(n(C)c2=O)=O)C)c12)C
n1(cnc(n(c(n(C)c2=O)=O)C)c21)C
n1(cnc(n(c(=O)n2C)C)c1c2=O)C
n1(cnc(n(c(=O)n(c2=O)C)C)c12)C
n1(cnc(n(c(=O)n(c2=O)C)C)c21)C
n1(cnc(n(c(=O)n(C)c2=O)C)c12)C
n1(cnc(n(c(=O)n(C)c2=O)C)c21)C
n1(cnc(n(C)c2=O)c1c(=O)n2C)C
n1(cnc(n(C)c2=O)c1c(n2C)=O)C
n1(cnc(n(C)c(n2C)=O)c1c2=O)C
n1(cnc(n(C)c(n(c2=O)C)=O)c12)C
n1(cnc(n(C)c(n(c2=O)C)=O)c21)C
n1(cnc(n(C)c(n(C)c2=O)=O)c12)C
n1(cnc(n(C)c(n(C)c2=O)=O)c21)C
n1(cnc(n(C)c(=O)n2C)c1c2=O)C
n1(cnc(n(C)c(=O)n(c2=O)C)c12)C
n1(cnc(n(C)c(=O)n(c2=O)C)c21)C
n1(cnc(n(C)c(=O)n(C)c2=O)c12)C
n1(cnc(n(C)c(=O)n(C)c2=O)c21)C
n1(cnc(c1c2=O)n(c(n2C)=O)C)C
n1(cnc(c1c2=O)n(c(=O)n2C)C)C
n1(cnc(c1c2=O)n(C)c(n2C)=O)C
n1(cnc(c1c2=O)n(C)c(=O)n2C)C
n1(cnc(c1c(=O)n2C)n(c2=O)C)C
n1(cnc(c1c(=O)n2C)n(C)c2=O)C
n1(cnc(c1c(=O)n(c2=O)C)n2C)C
n1(cnc(c1c(=O)n(C)c2=O)n2C)C
n1(cnc(c1c(n2C)=O)n(c2=O)C)C
n1(cnc(c1c(n2C)=O)n(C)c2=O)C
n1(cnc(c1c(n(c2=O)C)=O)n2C)C
n1(cnc(c1c(n(C)c2=O)=O)n2C)C
n1(C)c2c(=O)n(c(=O)n(c2nc1)C)C
n1(C)c2c(=O)n(c(=O)n(C)c2nc1)C
n1(C)c2c(=O)n(c(n(c2nc1)C)=O)C
n1(C)c2c(=O)n(c(n(C)c2nc1)=O)C
n1(C)c2c(=O)n(C)c(=O)n(c2nc1)C
n1(C)c2c(=O)n(C)c(=O)n(C)c2nc1
n1(C)c2c(=O)n(C)c(n(c2nc1)C)=O
n1(C)c2c(=O)n(C)c(n(C)c2nc1)=O
n1(C)c2c(n(c(=O)n(c2nc1)C)C)=O
n1(C)c2c(n(c(=O)n(C)c2nc1)C)=O
n1(C)c2c(n(c(n(c2nc1)C)=O)C)=O
n1(C)c2c(n(c(n(C)c2nc1)=O)C)=O
n1(C)c2c(n(C)c(=O)n(c2nc1)C)=O
n1(C)c2c(n(C)c(=O)n(C)c2nc1)=O
n1(C)c2c(n(C)c(n(c2nc1)C)=O)=O
n1(C)c2c(n(C)c(n(C)c2nc1)=O)=O
n1(C)c2c(nc1)n(c(n(c2=O)C)=O)C
n1(C)c2c(nc1)n(c(n(C)c2=O)=O)C
n1(C)c2c(nc1)n(c(=O)n(c2=O)C)C
n1(C)c2c(nc1)n(c(=O)n(C)c2=O)C
n1(C)c2c(nc1)n(C)c(n(c2=O)C)=O
n1(C)c2c(nc1)n(C)c(n(C)c2=O)=O
n1(C)c2c(nc1)n(C)c(=O)n(c2=O)C
n1(C)c2c(nc1)n(C)c(=O)n(C)c2=O
n1(C)c2c(n(c(n(c2=O)C)=O)C)nc1
n1(C)c2c(n(c(n(C)c2=O)=O)C)nc1
n1(C)c2c(n(c(=O)n(c2=O)C)C)nc1
n1(C)c2c(n(c(=O)n(C)c2=O)C)nc1
n1(C)c2c(n(C)c(n(c2=O)C)=O)nc1
n1(C)c2c(n(C)c(n(C)c2=O)=O)nc1
n1(C)c2c(n(C)c(=O)n(c2=O)C)nc1
n1(C)c2c(n(C)c(=O)n(C)c2=O)nc1
n1(C)c(c2nc1)c(=O)n(c(=O)n2C)C
n1(C)c(c2nc1)c(=O)n(c(n2C)=O)C
n1(C)c(c2nc1)c(=O)n(C)c(=O)n2C
n1(C)c(c2nc1)c(=O)n(C)c(n2C)=O
n1(C)c(c2nc1)c(n(c(=O)n2C)C)=O
n1(C)c(c2nc1)c(n(c(n2C)=O)C)=O
n1(C)c(c2nc1)c(n(C)c(=O)n2C)=O
n1(C)c(c2nc1)c(n(C)c(n2C)=O)=O
n1(C)c(c(nc1)n2C)c(=O)n(c2=O)C
n1(C)c(c(nc1)n2C)c(=O)n(C)c2=O
n1(C)c(c(nc1)n2C)c(n(c2=O)C)=O
n1(C)c(c(nc1)n2C)c(n(C)c2=O)=O
n1(C)c(c(nc1)n(c2=O)C)c(=O)n2C
n1(C)c(c(nc1)n(c2=O)C)c(n2C)=O
n1(C)c(c(nc1)n(c(n2C)=O)C)c2=O
n1(C)c(c(nc1)n(c(=O)n2C)C)c2=O
n1(C)c(c(nc1)n(C)c2=O)c(=O)n2C
n1(C)c(c(nc1)n(C)c2=O)c(n2C)=O
n1(C)c(c(nc1)n(C)c(n2C)=O)c2=O
n1(C)c(c(nc1)n(C)c(=O)n2C)c2=O
n1(C)c(c(n2C)nc1)c(=O)n(c2=O)C
n1(C)c(c(n2C)nc1)c(=O)n(C)c2=O
n1(C)c(c(n2C)nc1)c(n(c2=O)C)=O
n1(C)c(c(n2C)nc1)c(n(C)c2=O)=O
n1(C)c(c(n(c2=O)C)nc1)c(=O)n2C
n1(C)c(c(n(c2=O)C)nc1)c(n2C)=O
n1(C)c(c(n(c(n2C)=O)C)nc1)c2=O
n1(C)c(c(n(c(=O)n2C)C)nc1)c2=O
n1(C)c(c(n(C)c2=O)nc1)c(=O)n2C
n1(C)c(c(n(C)c2=O)nc1)c(n2C)=O
n1(C)c(c(n(C)c(n2C)=O)nc1)c2=O
n1(C)c(c(n(C)c(=O)n2C)nc1)c2=O
n1(C)c(c2=O)c(nc1)n(c(n2C)=O)C
n1(C)c(c2=O)c(nc1)n(c(=O)n2C)C
n1(C)c(c2=O)c(nc1)n(C)c(n2C)=O
n1(C)c(c2=O)c(nc1)n(C)c(=O)n2C
n1(C)c(c2=O)c(n(c(n2C)=O)C)nc1
n1(C)c(c2=O)c(n(c(=O)n2C)C)nc1
n1(C)c(c2=O)c(n(C)c(n2C)=O)nc1
n1(C)c(c2=O)c(n(C)c(=O)n2C)nc1
n1(C)c(c(=O)n2C)c(nc1)n(c2=O)C
n1(C)c(c(=O)n2C)c(nc1)n(C)c2=O
n1(C)c(c(=O)n2C)c(n(c2=O)C)nc1
n1(C)c(c(=O)n2C)c(n(C)c2=O)nc1
n1(C)c(c(=O)n(c2=O)C)c(nc1)n2C
n1(C)c(c(=O)n(c2=O)C)c(n2C)nc1
n1(C)c(c(=O)n(c(=O)n2C)C)c2nc1
n1(C)c(c(=O)n(c(n2C)=O)C)c2nc1
n1(C)c(c(=O)n(C)c2=O)c(nc1)n2C
n1(C)c(c(=O)n(C)c2=O)c(n2C)nc1
n1(C)c(c(=O)n(C)c(=O)n2C)c2nc1
n1(C)c(c(=O)n(C)c(n2C)=O)c2nc1
n1(C)c(c(n2C)=O)c(nc1)n(c2=O)C
n1(C)c(c(n2C)=O)c(nc1)n(C)c2=O
n1(C)c(c(n2C)=O)c(n(c2=O)C)nc1
n1(C)c(c(n2C)=O)c(n(C)c2=O)nc1
n1(C)c(c(n(c2=O)C)=O)c(nc1)n2C
n1(C)c(c(n(c2=O)C)=O)c(n2C)nc1
n1(C)c(c(n(c(=O)n2C)C)=O)c2nc1
n1(C)c(c(n(c(n2C)=O)C)=O)c2nc1
n1(C)c(c(n(C)c2=O)=O)c(nc1)n2C
n1(C)c(c(n(C)c2=O)=O)c(n2C)nc1
n1(C)c(c(n(C)c(=O)n2C)=O)c2nc1
n1(C)c(c(n(C)c(n2C)=O)=O)c2nc1
n1(c2c(=O)n(c(=O)n(c2nc1)C)C)C
n1(c2c(=O)n(c(=O)n(C)c2nc1)C)C
n1(c2c(=O)n(c(n(c2nc1)C)=O)C)C
n1(c2c(=O)n(c(n(C)c2nc1)=O)C)C
n1(c2c(=O)n(C)c(=O)n(c2nc1)C)C
n1(c2c(=O)n(C)c(=O)n(C)c2nc1)C
n1(c2c(=O)n(C)c(n(c2nc1)C)=O)C
n1(c2c(=O)n(C)c(n(C)c2nc1)=O)C
n1(c2c(n(c(=O)n(c2nc1)C)C)=O)C
n1(c2c(n(c(=O)n(C)c2nc1)C)=O)C
n1(c2c(n(c(n(c2nc1)C)=O)C)=O)C
n1(c2c(n(c(n(C)c2nc1)=O)C)=O)C
n1(c2c(n(C)c(=O)n(c2nc1)C)=O)C
n1(c2c(n(C)c(=O)n(C)c2nc1)=O)C
n1(c2c(n(C)c(n(c2nc1)C)=O)=O)C
n1(c2c(n(C)c(n(C)c2nc1)=O)=O)C
n1(c2c(nc1)n(c(n(c2=O)C)=O)C)C
n1(c2c(nc1)n(c(n(C)c2=O)=O)C)C
n1(c2c(nc1)n(c(=O)n(c2=O)C)C)C
n1(c2c(nc1)n(c(=O)n(C)c2=O)C)C
n1(c2c(nc1)n(C)c(n(c2=O)C)=O)C
n1(c2c(nc1)n(C)c(n(C)c2=O)=O)C
n1(c2c(nc1)n(C)c(=O)n(c2=O)C)C
n1(c2c(nc1)n(C)c(=O)n(C)c2=O)C
n1(c2c(n(c(n(c2=O)C)=O)C)nc1)C
n1(c2c(n(c(n(C)c2=O)=O)C)nc1)C
n1(c2c(n(c(=O)n(c2=O)C)C)nc1)C
n1(c2c(n(c(=O)n(C)c2=O)C)nc1)C
n1(c2c(n(C)c(n(c2=O)C)=O)nc1)C
n1(c2c(n(C)c(n(C)c2=O)=O)nc1)C
n1(c2c(n(C)c(=O)n(c2=O)C)nc1)C
n1(c2c(n(C)c(=O)n(C)c2=O)nc1)C
n1(c(c2nc1)c(=O)n(c(=O)n2C)C)C
n1(c(c2nc1)c(=O)n(c(n2C)=O)C)C
n1(c(c2nc1)c(=O)n(C)c(=O)n2C)C
n1(c(c2nc1)c(=O)n(C)c(n2C)=O)C
n1(c(c2nc1)c(n(c(=O)n2C)C)=O)C
n1(c(c2nc1)c(n(c(n2C)=O)C)=O)C
n1(c(c2nc1)c(n(C)c(=O)n2C)=O)C
n1(c(c2nc1)c(n(C)c(n2C)=O)=O)C
n1(c(c(nc1)n2C)c(=O)n(c2=O)C)C
n1(c(c(nc1)n2C)c(=O)n(C)c2=O)C
n1(c(c(nc1)n2C)c(n(c2=O)C)=O)C
n1(c(c(nc1)n2C)c(n(C)c2=O)=O)C
n1(c(c(nc1)n(c2=O)C)c(=O)n2C)C
n1(c(c(nc1)n(c2=O)C)c(n2C)=O)C
n1(c(c(nc1)n(c(n2C)=O)C)c2=O)C
n1(c(c(nc1)n(c(=O)n2C)C)c2=O)C
n1(c(c(nc1)n(C)c2=O)c(=O)n2C)C
n1(c(c(nc1)n(C)c2=O)c(n2C)=O)C
n1(c(c(nc1)n(C)c(n2C)=O)c2=O)C
n1(c(c(nc1)n(C)c(=O)n2C)c2=O)C
n1(c(c(n2C)nc1)c(=O)n(c2=O)C)C
n1(c(c(n2C)nc1)c(=O)n(C)c2=O)C
n1(c(c(n2C)nc1)c(n(c2=O)C)=O)C
n1(c(c(n2C)nc1)c(n(C)c2=O)=O)C
n1(c(c(n(c2=O)C)nc1)c(=O)n2C)C
n1(c(c(n(c2=O)C)nc1)c(n2C)=O)C
n1(c(c(n(c(n2C)=O)C)nc1)c2=O)C
n1(c(c(n(c(=O)n2C)C)nc1)c2=O)C
n1(c(c(n(C)c2=O)nc1)c(=O)n2C)C
n1(c(c(n(C)c2=O)nc1)c(n2C)=O)C
n1(c(c(n(C)c(n2C)=O)nc1)c2=O)C
n1(c(c(n(C)c(=O)n2C)nc1)c2=O)C
n1(c(c2=O)c(nc1)n(c(n2C)=O)C)C
n1(c(c2=O)c(nc1)n(c(=O)n2C)C)C
n1(c(c2=O)c(nc1)n(C)c(n2C)=O)C
n1(c(c2=O)c(nc1)n(C)c(=O)n2C)C
n1(c(c2=O)c(n(c(n2C)=O)C)nc1)C
n1(c(c2=O)c(n(c(=O)n2C)C)nc1)C
n1(c(c2=O)c(n(C)c(n2C)=O)nc1)C
n1(c(c2=O)c(n(C)c(=O)n2C)nc1)C
n1(c(c(=O)n2C)c(nc1)n(c2=O)C)C
n1(c(c(=O)n2C)c(nc1)n(C)c2=O)C
n1(c(c(=O)n2C)c(n(c2=O)C)nc1)C
n1(c(c(=O)n2C)c(n(C)c2=O)nc1)C
n1(c(c(=O)n(c2=O)C)c(nc1)n2C)C
n1(c(c(=O)n(c2=O)C)c(n2C)nc1)C
n1(c(c(=O)n(c(=O)n2C)C)c2nc1)C
n1(c(c(=O)n(c(n2C)=O)C)c2nc1)C
n1(c(c(=O)n(C)c2=O)c(nc1)n2C)C
n1(c(c(=O)n(C)c2=O)c(n2C)nc1)C
n1(c(c(=O)n(C)c(=O)n2C)c2nc1)C
n1(c(c(=O)n(C)c(n2C)=O)c2nc1)C
n1(c(c(n2C)=O)c(nc1)n(c2=O)C)C
n1(c(c(n2C)=O)c(nc1)n(C)c2=O)C
n1(c(c(n2C)=O)c(n(c2=O)C)nc1)C
n1(c(c(n2C)=O)c(n(C)c2=O)nc1)C
n1(c(c(n(c2=O)C)=O)c(nc1)n2C)C
n1(c(c(n(c2=O)C)=O)c(n2C)nc1)C
n1(c(c(n(c(=O)n2C)C)=O)c2nc1)C
n1(c(c(n(c(n2C)=O)C)=O)c2nc1)C
n1(c(c(n(C)c2=O)=O)c(nc1)n2C)C
n1(c(c(n(C)c2=O)=O)c(n2C)nc1)C
n1(c(c(n(C)c(=O)n2C)=O)c2nc1)C
n1(c(c(n(C)c(n2C)=O)=O)c2nc1)C
c1nc2c(n1C)c(=O)n(c(=O)n2C)C
c1nc2c(n1C)c(=O)n(c(n2C)=O)C
c1nc2c(n1C)c(=O)n(C)c(=O)n2C
c1nc2c(n1C)c(=O)n(C)c(n2C)=O
c1nc2c(n1C)c(n(c(=O)n2C)C)=O
c1nc2c(n1C)c(n(c(n2C)=O)C)=O
c1nc2c(n1C)c(n(C)c(=O)n2C)=O
c1nc2c(n1C)c(n(C)c(n2C)=O)=O
c1nc2c(c(=O)n(c(=O)n2C)C)n1C
c1nc2c(c(=O)n(c(n2C)=O)C)n1C
c1nc2c(c(=O)n(C)c(=O)n2C)n1C
c1nc2c(c(=O)n(C)c(n2C)=O)n1C
c1nc2c(c(n(c(=O)n2C)C)=O)n1C
c1nc2c(c(n(c(n2C)=O)C)=O)n1C
c1nc2c(c(n(C)c(=O)n2C)=O)n1C
c1nc2c(c(n(C)c(n2C)=O)=O)n1C
c1nc2n(c(n(c(c2n1C)=O)C)=O)C
c1nc2n(c(n(c(=O)c2n1C)C)=O)C
c1nc2n(c(n(C)c(c2n1C)=O)=O)C
c1nc2n(c(n(C)c(=O)c2n1C)=O)C
c1nc2n(c(=O)n(c(c2n1C)=O)C)C
c1nc2n(c(=O)n(c(=O)c2n1C)C)C
c1nc2n(c(=O)n(C)c(c2n1C)=O)C
c1nc2n(c(=O)n(C)c(=O)c2n1C)C
c1nc2n(C)c(n(c(c2n1C)=O)C)=O
c1nc2n(C)c(n(c(=O)c2n1C)C)=O
c1nc2n(C)c(n(C)c(c2n1C)=O)=O
c1nc2n(C)c(n(C)c(=O)c2n1C)=O
c1nc2n(C)c(=O)n(c(c2n1C)=O)C
c1nc2n(C)c(=O)n(c(=O)c2n1C)C
c1nc2n(C)c(=O)n(C)c(c2n1C)=O
c1nc2n(C)c(=O)n(C)c(=O)c2n1C
c1nc(n2C)c(n1C)c(=O)n(c2=O)C
c1nc(n2C)c(n1C)c(=O)n(C)c2=O
c1nc(n2C)c(n1C)c(n(c2=O)C)=O
c1nc(n2C)c(n1C)c(n(C)c2=O)=O
c1nc(n2C)c(c(=O)n(c2=O)C)n1C
c1nc(n2C)c(c(=O)n(C)c2=O)n1C
c1nc(n2C)c(c(n(c2=O)C)=O)n1C
c1nc(n2C)c(c(n(C)c2=O)=O)n1C
c1nc(n(c2=O)C)c(n1C)c(=O)n2C
c1nc(n(c2=O)C)c(n1C)c(n2C)=O
c1nc(n(c2=O)C)c(c(=O)n2C)n1C
c1nc(n(c2=O)C)c(c(n2C)=O)n1C
c1nc(n(c(n2C)=O)C)c(n1C)c2=O
c1nc(n(c(n2C)=O)C)c(c2=O)n1C
c1nc(n(c(n(c2=O)C)=O)C)c2n1C
c1nc(n(c(n(C)c2=O)=O)C)c2n1C
c1nc(n(c(=O)n2C)C)c(n1C)c2=O
c1nc(n(c(=O)n2C)C)c(c2=O)n1C
c1nc(n(c(=O)n(c2=O)C)C)c2n1C
c1nc(n(c(=O)n(C)c2=O)C)c2n1C
c1nc(n(C)c2=O)c(n1C)c(=O)n2C
c1nc(n(C)c2=O)c(n1C)c(n2C)=O
c1nc(n(C)c2=O)c(c(=O)n2C)n1C
c1nc(n(C)c2=O)c(c(n2C)=O)n1C
c1nc(n(C)c(n2C)=O)c(n1C)c2=O
c1nc(n(C)c(n2C)=O)c(c2=O)n1C
c1nc(n(C)c(n(c2=O)C)=O)c2n1C
c1nc(n(C)c(n(C)c2=O)=O)c2n1C
c1nc(n(C)c(=O)n2C)c(n1C)c2=O
c1nc(n(C)c(=O)n2C)c(c2=O)n1C
c1nc(n(C)c(=O)n(c2=O)C)c2n1C
c1nc(n(C)c(=O)n(C)c2=O)c2n1C
c1nc(c2n1C)n(c(n(c2=O)C)=O)C
c1nc(c2n1C)n(c(n(C)c2=O)=O)C
c1nc(c2n1C)n(c(=O)n(c2=O)C)C
c1nc(c2n1C)n(c(=O)n(C)c2=O)C
c1nc(c2n1C)n(C)c(n(c2=O)C)=O
c1nc(c2n1C)n(C)c(n(C)c2=O)=O
c1nc(c2n1C)n(C)c(=O)n(c2=O)C
c1nc(c2n1C)n(C)c(=O)n(C)c2=O
c1nc(c(n1C)c2=O)n(c(n2C)=O)C
c1nc(c(n1C)c2=O)n(c(=O)n2C)C
c1nc(c(n1C)c2=O)n(C)c(n2C)=O
c1nc(c(n1C)c2=O)n(C)c(=O)n2C
c1nc(c(n1C)c(=O)n2C)n(c2=O)C
c1nc(c(n1C)c(=O)n2C)n(C)c2=O
c1nc(c(n1C)c(=O)n(c2=O)C)n2C
c1nc(c(n1C)c(=O)n(C)c2=O)n2C
c1nc(c(n1C)c(n2C)=O)n(c2=O)C
c1nc(c(n1C)c(n2C)=O)n(C)c2=O
c1nc(c(n1C)c(n(c2=O)C)=O)n2C
c1nc(c(n1C)c(n(C)c2=O)=O)n2C
c1nc(c(c2=O)n1C)n(c(n2C)=O)C
c1nc(c(c2=O)n1C)n(c(=O)n2C)C
c1nc(c(c2=O)n1C)n(C)c(n2C)=O
c1nc(c(c2=O)n1C)n(C)c(=O)n2C
c1nc(c(c(=O)n2C)n1C)n(c2=O)C
c1nc(c(c(=O)n2C)n1C)n(C)c2=O
c1nc(c(c(=O)n(c2=O)C)n1C)n2C
c1nc(c(c(=O)n(C)c2=O)n1C)n2C
c1nc(c(c(n2C)=O)n1C)n(c2=O)C
c1nc(c(c(n2C)=O)n1C)n(C)c2=O
c1nc(c(c(n(c2=O)C)=O)n1C)n2C
c1nc(c(c(n(C)c2=O)=O)n1C)n2C
c1n(C)c2c(=O)n(c(=O)n(c2n1)C)C
c1n(C)c2c(=O)n(c(=O)n(C)c2n1)C
c1n(C)c2c(=O)n(c(n(c2n1)C)=O)C
c1n(C)c2c(=O)n(c(n(C)c2n1)=O)C
c1n(C)c2c(=O)n(C)c(=O)n(c2n1)C
c1n(C)c2c(=O)n(C)c(=O)n(C)c2n1
c1n(C)c2c(=O)n(C)c(n(c2n1)C)=O
c1n(C)c2c(=O)n(C)c(n(C)c2n1)=O
c1n(C)c2c(n(c(=O)n(c2n1)C)C)=O
c1n(C)c2c(n(c(=O)n(C)c2n1)C)=O
c1n(C)c2c(n(c(n(c2n1)C)=O)C)=O
c1n(C)c2c(n(c(n(C)c2n1)=O)C)=O
c1n(C)c2c(n(C)c(=O)n(c2n1)C)=O
c1n(C)c2c(n(C)c(=O)n(C)c2n1)=O
c1n(C)c2c(n(C)c(n(c2n1)C)=O)=O
c1n(C)c2c(n(C)c(n(C)c2n1)=O)=O
c1n(C)c2c(n1)n(c(n(c2=O)C)=O)C
c1n(C)c2c(n1)n(c(n(C)c2=O)=O)C
c1n(C)c2c(n1)n(c(=O)n(c2=O)C)C
c1n(C)c2c(n1)n(c(=O)n(C)c2=O)C
c1n(C)c2c(n1)n(C)c(n(c2=O)C)=O
c1n(C)c2c(n1)n(C)c(n(C)c2=O)=O
c1n(C)c2c(n1)n(C)c(=O)n(c2=O)C
c1n(C)c2c(n1)n(C)c(=O)n(C)c2=O
c1n(C)c2c(n(c(n(c2=O)C)=O)C)n1
c1n(C)c2c(n(c(n(C)c2=O)=O)C)n1
c1n(C)c2c(n(c(=O)n(c2=O)C)C)n1
c1n(C)c2c(n(c(=O)n(C)c2=O)C)n1
c1n(C)c2c(n(C)c(n(c2=O)C)=O)n1
c1n(C)c2c(n(C)c(n(C)c2=O)=O)n1
c1n(C)c2c(n(C)c(=O)n(c2=O)C)n1
c1n(C)c2c(n(C)c(=O)n(C)c2=O)n1
c1n(C)c(c2n1)c(=O)n(c(=O)n2C)C
c1n(C)c(c2n1)c(=O)n(c(n2C)=O)C
c1n(C)c(c2n1)c(=O)n(C)c(=O)n2C
c1n(C)c(c2n1)c(=O)n(C)c(n2C)=O
c1n(C)c(c2n1)c(n(c(=O)n2C)C)=O
c1n(C)c(c2n1)c(n(c(n2C)=O)C)=O
c1n(C)c(c2n1)c(n(C)c(=O)n2C)=O
c1n(C)c(c2n1)c(n(C)c(n2C)=O)=O
c1n(C)c(c(n1)n2C)c(=O)n(c2=O)C
c1n(C)c(c(n1)n2C)c(=O)n(C)c2=O
c1n(C)c(c(n1)n2C)c(n(c2=O)C)=O
c1n(C)c(c(n1)n2C)c(n(C)c2=O)=O
c1n(C)c(c(n1)n(c2=O)C)c(=O)n2C
c1n(C)c(c(n1)n(c2=O)C)c(n2C)=O
c1n(C)c(c(n1)n(c(n2C)=O)C)c2=O
c1n(C)c(c(n1)n(c(=O)n2C)C)c2=O
c1n(C)c(c(n1)n(C)c2=O)c(=O)n2C
c1n(C)c(c(n1)n(C)c2=O)c(n2C)=O
c1n(C)c(c(n1)n(C)c(n2C)=O)c2=O
c1n(C)c(c(n1)n(C)c(=O)n2C)c2=O
c1n(C)c(c(n2C)n1)c(=O)n(c2=O)C
c1n(C)c(c(n2C)n1)c(=O)n(C)c2=O
c1n(C)c(c(n2C)n1)c(n(c2=O)C)=O
c1n(C)c(c(n2C)n1)c(n(C)c2=O)=O
c1n(C)c(c(n(c2=O)C)n1)c(=O)n2C
c1n(C)c(c(n(c2=O)C)n1)c(n2C)=O
c1n(C)c(c(n(c(n2C)=O)C)n1)c2=O
c1n(C)c(c(n(c(=O)n2C)C)n1)c2=O
c1n(C)c(c(n(C)c2=O)n1)c(=O)n2C
c1n(C)c(c(n(C)c2=O)n1)c(n2C)=O
c1n(C)c(c(n(C)c(n2C)=O)n1)c2=O
c1n(C)c(c(n(C)c(=O)n2C)n1)c2=O
c1n(C)c(c2=O)c(n1)n(c(n2C)=O)C
c1n(C)c(c2=O)c(n1)n(c(=O)n2C)C
c1n(C)c(c2=O)c(n1)n(C)c(n2C)=O
c1n(C)c(c2=O)c(n1)n(C)c(=O)n2C
c1n(C)c(c2=O)c(n(c(n2C)=O)C)n1
c1n(C)c(c2=O)c(n(c(=O)n2C)C)n1
c1n(C)c(c2=O)c(n(C)c(n2C)=O)n1
c1n(C)c(c2=O)c(n(C)c(=O)n2C)n1
c1n(C)c(c(=O)n2C)c(n1)n(c2=O)C
c1n(C)c(c(=O)n2C)c(n1)n(C)c2=O
c1n(C)c(c(=O)n2C)c(n(c2=O)C)n1
c1n(C)c(c(=O)n2C)c(n(C)c2=O)n1
c1n(C)c(c(=O)n(c2=O)C)c(n1)n2C
c1n(C)c(c(=O)n(c2=O)C)c(n2C)n1
c1n(C)c(c(=O)n(c(=O)n2C)C)c2n1
c1n(C)c(c(=O)n(c(n2C)=O)C)c2n1
c1n(C)c(c(=O)n(C)c2=O)c(n1)n2C
c1n(C)c(c(=O)n(C)c2=O)c(n2C)n1
c1n(C)c(c(=O)n(C)c(=O)n2C)c2n1
c1n(C)c(c(=O)n(C)c(n2C)=O)c2n1
c1n(C)c(c(n2C)=O)c(n1)n(c2=O)C
c1n(C)c(c(n2C)=O)c(n1)n(C)c2=O
c1n(C)c(c(n2C)=O)c(n(c2=O)C)n1
c1n(C)c(c(n2C)=O)c(n(C)c2=O)n1
c1n(C)c(c(n(c2=O)C)=O)c(n1)n2C
c1n(C)c(c(n(c2=O)C)=O)c(n2C)n1
c1n(C)c(c(n(c(=O)n2C)C)=O)c2n1
c1n(C)c(c(n(c(n2C)=O)C)=O)c2n1
c1n(C)c(c(n(C)c2=O)=O)c(n1)n2C
c1n(C)c(c(n(C)c2=O)=O)c(n2C)n1
c1n(C)c(c(n(C)c(=O)n2C)=O)c2n1
c1n(C)c(c(n(C)c(n2C)=O)=O)c2n1
c1n(c2c(=O)n(c(=O)n(c2n1)C)C)C
c1n(c2c(=O)n(c(=O)n(C)c2n1)C)C
c1n(c2c(=O)n(c(n(c2n1)C)=O)C)C
c1n(c2c(=O)n(c(n(C)c2n1)=O)C)C
c1n(c2c(=O)n(C)c(=O)n(c2n1)C)C
c1n(c2c(=O)n(C)c(=O)n(C)c2n1)C
c1n(c2c(=O)n(C)c(n(c2n1)C)=O)C
c1n(c2c(=O)n(C)c(n(C)c2n1)=O)C
c1n(c2c(n(c(=O)n(c2n1)C)C)=O)C
c1n(c2c(n(c(=O)n(C)c2n1)C)=O)C
c1n(c2c(n(c(n(c2n1)C)=O)C)=O)C
c1n(c2c(n(c(n(C)c2n1)=O)C)=O)C
c1n(c2c(n(C)c(=O)n(c2n1)C)=O)C
c1n(c2c(n(C)c(=O)n(C)c2n1)=O)C
c1n(c2c(n(C)c(n(c2n1)C)=O)=O)C
c1n(c2c(n(C)c(n(C)c2n1)=O)=O)C
c1n(c2c(n1)n(c(n(c2=O)C)=O)C)C
c1n(c2c(n1)n(c(n(C)c2=O)=O)C)C
c1n(c2c(n1)n(c(=O)n(c2=O)C)C)C
c1n(c2c(n1)n(c(=O)n(C)c2=O)C)C
c1n(c2c(n1)n(C)c(n(c2=O)C)=O)C
c1n(c2c(n1)n(C)c(n(C)c2=O)=O)C
c1n(c2c(n1)n(C)c(=O)n(c2=O)C)C
c1n(c2c(n1)n(C)c(=O)n(C)c2=O)C
c1n(c2c(n(c(n(c2=O)C)=O)C)n1)C
c1n(c2c(n(c(n(C)c2=O)=O)C)n1)C
c1n(c2c(n(c(=O)n(c2=O)C)C)n1)C
c1n(c2c(n(c(=O)n(C)c2=O)C)n1)C
c1n(c2c(n(C)c(n(c2=O)C)=O)n1)C
c1n(c2c(n(C)c(n(C)c2=O)=O)n1)C
c1n(c2c(n(C)c(=O)n(c2=O)C)n1)C
c1n(c2c(n(C)c(=O)n(C)c2=O)n1)C
c1n(c(c2n1)c(=O)n(c(=O)n2C)C)C
c1n(c(c2n1)c(=O)n(c(n2C)=O)C)C
c1n(c(c2n1)c(=O)n(C)c(=O)n2C)C
c1n(c(c2n1)c(=O)n(C)c(n2C)=O)C
c1n(c(c2n1)c(n(c(=O)n2C)C)=O)C
c1n(c(c2n1)c(n(c(n2C)=O)C)=O)C
c1n(c(c2n1)c(n(C)c(=O)n2C)=O)C
c1n(c(c2n1)c(n(C)c(n2C)=O)=O)C
c1n(c(c(n1)n2C)c(=O)n(c2=O)C)C
c1n(c(c(n1)n2C)c(=O)n(C)c2=O)C
c1n(c(c(n1)n2C)c(n(c2=O)C)=O)C
c1n(c(c(n1)n2C)c(n(C)c2=O)=O)C
c1n(c(c(n1)n(c2=O)C)c(=O)n2C)C
c1n(c(c(n1)n(c2=O)C)c(n2C)=O)C
c1n(c(c(n1)n(c(n2C)=O)C)c2=O)C
c1n(c(c(n1)n(c(=O)n2C)C)c2=O)C
c1n(c(c(n1)n(C)c2=O)c(=O)n2C)C
c1n(c(c(n1)n(C)c2=O)c(n2C)=O)C
c1n(c(c(n1)n(C)c(n2C)=O)c2=O)C
c1n(c(c(n1)n(C)c(=O)n2C)c2=O)C
c1n(c(c(n2C)n1)c(=O)n(c2=O)C)C
c1n(c(c(n2C)n1)c(=O)n(C)c2=O)C
c1n(c(c(n2C)n1)c(n(c2=O)C)=O)C
c1n(c(c(n2C)n1)c(n(C)c2=O)=O)C
c1n(c(c(n(c2=O)C)n1)c(=O)n2C)C
c1n(c(c(n(c2=O)C)n1)c(n2C)=O)C
c1n(c(c(n(c(n2C)=O)C)n1)c2=O)C
c1n(c(c(n(c(=O)n2C)C)n1)c2=O)C
c1n(c(c(n(C)c2=O)n1)c(=O)n2C)C
c1n(c(c(n(C)c2=O)n1)c(n2C)=O)C
c1n(c(c(n(C)c(n2C)=O)n1)c2=O)C
c1n(c(c(n(C)c(=O)n2C)n1)c2=O)C
c1n(c(c2=O)c(n1)n(c(n2C)=O)C)C
c1n(c(c2=O)c(n1)n(c(=O)n2C)C)C
c1n(c(c2=O)c(n1)n(C)c(n2C)=O)C
c1n(c(c2=O)c(n1)n(C)c(=O)n2C)C
c1n(c(c2=O)c(n(c(n2C)=O)C)n1)C
c1n(c(c2=O)c(n(c(=O)n2C)C)n1)C
c1n(c(c2=O)c(n(C)c(n2C)=O)n1)C
c1n(c(c2=O)c(n(C)c(=O)n2C)n1)C
c1n(c(c(=O)n2C)c(n1)n(c2=O)C)C
c1n(c(c(=O)n2C)c(n1)n(C)c2=O)C
c1n(c(c(=O)n2C)c(n(c2=O)C)n1)C
c1n(c(c(=O)n2C)c(n(C)c2=O)n1)C
c1n(c(c(=O)n(c2=O)C)c(n1)n2C)C
c1n(c(c(=O)n(c2=O)C)c(n2C)n1)C
c1n(c(c(=O)n(c(=O)n2C)C)c2n1)C
c1n(c(c(=O)n(c(n2C)=O)C)c2n1)C
c1n(c(c(=O)n(C)c2=O)c(n1)n2C)C
c1n(c(c(=O)n(C)c2=O)c(n2C)n1)C
c1n(c(c(=O)n(C)c(=O)n2C)c2n1)C
c1n(c(c(=O)n(C)c(n2C)=O)c2n1)C
c1n(c(c(n2C)=O)c(n1)n(c2=O)C)C
c1n(c(c(n2C)=O)c(n1)n(C)c2=O)C
c1n(c(c(n2C)=O)c(n(c2=O)C)n1)C
c1n(c(c(n2C)=O)c(n(C)c2=O)n1)C
c1n(c(c(n(c2=O)C)=O)c(n1)n2C)C
c1n(c(c(n(c2=O)C)=O)c(n2C)n1)C
c1n(c(c(n(c(=O)n2C)C)=O)c2n1)C
c1n(c(c(n(c(n2C)=O)C)=O)c2n1)C
c1n(c(c(n(C)c2=O)=O)c(n1)n2C)C
c1n(c(c(n(C)c2=O)=O)c(n2C)n1)C
c1n(c(c(n(C)c(=O)n2C)=O)c2n1)C
c1n(c(c(n(C)c(n2C)=O)=O)c2n1)C
c(n1C)nc2c1c(=O)n(c(=O)n2C)C
c(n1C)nc2c1c(=O)n(c(n2C)=O)C
c(n1C)nc2c1c(=O)n(C)c(=O)n2C
c(n1C)nc2c1c(=O)n(C)c(n2C)=O
c(n1C)nc2c1c(n(c(=O)n2C)C)=O
c(n1C)nc2c1c(n(c(n2C)=O)C)=O
c(n1C)nc2c1c(n(C)c(=O)n2C)=O
c(n1C)nc2c1c(n(C)c(n2C)=O)=O
c(n1C)nc2n(c(n(c(c12)=O)C)=O)C
c(n1C)nc2n(c(n(c(c21)=O)C)=O)C
c(n1C)nc2n(c(n(c(=O)c12)C)=O)C
c(n1C)nc2n(c(n(c(=O)c21)C)=O)C
c(n1C)nc2n(c(n(C)c(c12)=O)=O)C
c(n1C)nc2n(c(n(C)c(c21)=O)=O)C
c(n1C)nc2n(c(n(C)c(=O)c12)=O)C
c(n1C)nc2n(c(n(C)c(=O)c21)=O)C
c(n1C)nc2n(c(=O)n(c(c12)=O)C)C
c(n1C)nc2n(c(=O)n(c(c21)=O)C)C
c(n1C)nc2n(c(=O)n(c(=O)c12)C)C
c(n1C)nc2n(c(=O)n(c(=O)c21)C)C
c(n1C)nc2n(c(=O)n(C)c(c12)=O)C
c(n1C)nc2n(c(=O)n(C)c(c21)=O)C
c(n1C)nc2n(c(=O)n(C)c(=O)c12)C
c(n1C)nc2n(c(=O)n(C)c(=O)c21)C
c(n1C)nc2n(C)c(n(c(c12)=O)C)=O
c(n1C)nc2n(C)c(n(c(c21)=O)C)=O
c(n1C)nc2n(C)c(n(c(=O)c12)C)=O
c(n1C)nc2n(C)c(n(c(=O)c21)C)=O
c(n1C)nc2n(C)c(n(C)c(c12)=O)=O
c(n1C)nc2n(C)c(n(C)c(c21)=O)=O
c(n1C)nc2n(C)c(n(C)c(=O)c12)=O
c(n1C)nc2n(C)c(n(C)c(=O)c21)=O
c(n1C)nc2n(C)c(=O)n(c(c12)=O)C
c(n1C)nc2n(C)c(=O)n(c(c21)=O)C
c(n1C)nc2n(C)c(=O)n(c(=O)c12)C
c(n1C)nc2n(C)c(=O)n(c(=O)c21)C
c(n1C)nc2n(C)c(=O)n(C)c(c12)=O
c(n1C)nc2n(C)c(=O)n(C)c(c21)=O
c(n1C)nc2n(C)c(=O)n(C)c(=O)c12
c(n1C)nc2n(C)c(=O)n(C)c(=O)c21
c(n1C)nc(n2C)c1c(=O)n(c2=O)C
c(n1C)nc(n2C)c1c(=O)n(C)c2=O
c(n1C)nc(n2C)c1c(n(c2=O)C)=O
c(n1C)nc(n2C)c1c(n(C)c2=O)=O
c(n1C)nc(n(c2=O)C)c1c(=O)n2C
c(n1C)nc(n(c2=O)C)c1c(n2C)=O
c(n1C)nc(n(c(n2C)=O)C)c1c2=O
c(n1C)nc(n(c(n(c2=O)C)=O)C)c12
c(n1C)nc(n(c(n(c2=O)C)=O)C)c21
c(n1C)nc(n(c(n(C)c2=O)=O)C)c12
c(n1C)nc(n(c(n(C)c2=O)=O)C)c21
c(n1C)nc(n(c(=O)n2C)C)c1c2=O
c(n1C)nc(n(c(=O)n(c2=O)C)C)c12
c(n1C)nc(n(c(=O)n(c2=O)C)C)c21
c(n1C)nc(n(c(=O)n(C)c2=O)C)c12
c(n1C)nc(n(c(=O)n(C)c2=O)C)c21
c(n1C)nc(n(C)c2=O)c1c(=O)n2C
c(n1C)nc(n(C)c2=O)c1c(n2C)=O
c(n1C)nc(n(C)c(n2C)=O)c1c2=O
c(n1C)nc(n(C)c(n(c2=O)C)=O)c12
c(n1C)nc(n(C)c(n(c2=O)C)=O)c21
c(n1C)nc(n(C)c(n(C)c2=O)=O)c12
c(n1C)nc(n(C)c(n(C)c2=O)=O)c21
c(n1C)nc(n(C)c(=O)n2C)c1c2=O
c(n1C)nc(n(C)c(=O)n(c2=O)C)c12
c(n1C)nc(n(C)c(=O)n(c2=O)C)c21
c(n1C)nc(n(C)c(=O)n(C)c2=O)c12
c(n1C)nc(n(C)c(=O)n(C)c2=O)c21
c(n1C)nc(c1c2=O)n(c(n2C)=O)C
c(n1C)nc(c1c2=O)n(c(=O)n2C)C
c(n1C)nc(c1c2=O)n(C)c(n2C)=O
c(n1C)nc(c1c2=O)n(C)c(=O)n2C
c(n1C)nc(c1c(=O)n2C)n(c2=O)C
c(n1C)nc(c1c(=O)n2C)n(C)c2=O
c(n1C)nc(c1c(=O)n(c2=O)C)n2C
c(n1C)nc(c1c(=O)n(C)c2=O)n2C
c(n1C)nc(c1c(n2C)=O)n(c2=O)C
c(n1C)nc(c1c(n2C)=O)n(C)c2=O
c(n1C)nc(c1c(n(c2=O)C)=O)n2C
c(n1C)nc(c1c(n(C)c2=O)=O)n2C
c(n(C)c1c2=O)nc1n(c(n2C)=O)C
c(n(C)c1c2=O)nc1n(c(=O)n2C)C
c(n(C)c1c2=O)nc1n(C)c(n2C)=O
c(n(C)c1c2=O)nc1n(C)c(=O)n2C
c(n(C)c1c(=O)n2C)nc1n(c2=O)C
c(n(C)c1c(=O)n2C)nc1n(C)c2=O
c(n(C)c1c(=O)n(c2=O)C)nc1n2C
c(n(C)c1c(=O)n(c(=O)n2C)C)nc21
c(n(C)c1c(=O)n(c(=O)n2C)C)nc12
c(n(C)c1c(=O)n(c(n2C)=O)C)nc21
c(n(C)c1c(=O)n(c(n2C)=O)C)nc12
c(n(C)c1c(=O)n(C)c2=O)nc1n2C
c(n(C)c1c(=O)n(C)c(=O)n2C)nc21
c(n(C)c1c(=O)n(C)c(=O)n2C)nc12
c(n(C)c1c(=O)n(C)c(n2C)=O)nc21
c(n(C)c1c(=O)n(C)c(n2C)=O)nc12
c(n(C)c1c(n2C)=O)nc1n(c2=O)C
c(n(C)c1c(n2C)=O)nc1n(C)c2=O
c(n(C)c1c(n(c2=O)C)=O)nc1n2C
c(n(C)c1c(n(c(=O)n2C)C)=O)nc21
c(n(C)c1c(n(c(=O)n2C)C)=O)nc12
c(n(C)c1c(n(c(n2C)=O)C)=O)nc21
c(n(C)c1c(n(c(n2C)=O)C)=O)nc12
c(n(C)c1c(n(C)c2=O)=O)nc1n2C
c(n(C)c1c(n(C)c(=O)n2C)=O)nc21
c(n(C)c1c(n(C)c(=O)n2C)=O)nc12
c(n(C)c1c(n(C)c(n2C)=O)=O)nc21
c(n(C)c1c(n(C)c(n2C)=O)=O)nc12
c(n(C)c1c2n(c(n(c1=O)C)=O)C)n2
c(n(C)c1c2n(c(n(C)c1=O)=O)C)n2
c(n(C)c1c2n(c(=O)n(c1=O)C)C)n2
c(n(C)c1c2n(c(=O)n(C)c1=O)C)n2
c(n(C)c1c2n(C)c(n(c1=O)C)=O)n2
c(n(C)c1c2n(C)c(n(C)c1=O)=O)n2
c(n(C)c1c2n(C)c(=O)n(c1=O)C)n2
c(n(C)c1c2n(C)c(=O)n(C)c1=O)n2
c(n(C)c(c1n2C)c(=O)n(c2=O)C)n1
c(n(C)c(c1n2C)c(=O)n(C)c2=O)n1
c(n(C)c(c1n2C)c(n(c2=O)C)=O)n1
c(n(C)c(c1n2C)c(n(C)c2=O)=O)n1
c(n(C)c(c1n(c2=O)C)c(=O)n2C)n1
c(n(C)c(c1n(c2=O)C)c(n2C)=O)n1
c(n(C)c(c1n(c(n2C)=O)C)c2=O)n1
c(n(C)c(c1n(c(=O)n2C)C)c2=O)n1
c(n(C)c(c1n(C)c2=O)c(=O)n2C)n1
c(n(C)c(c1n(C)c2=O)c(n2C)=O)n1
c(n(C)c(c1n(C)c(n2C)=O)c2=O)n1
c(n(C)c(c1n(C)c(=O)n2C)c2=O)n1
c(n(C)c(c1=O)c2n(c(n1C)=O)C)n2
c(n(C)c(c1=O)c2n(c(=O)n1C)C)n2
c(n(C)c(c1=O)c2n(C)c(n1C)=O)n2
c(n(C)c(c1=O)c2n(C)c(=O)n1C)n2
c(n(C)c(c(=O)n1C)c2n(c1=O)C)n2
c(n(C)c(c(=O)n1C)c2n(C)c1=O)n2
c(n(C)c(c(=O)n(c1=O)C)c2n1C)n2
c(n(C)c(c(=O)n(C)c1=O)c2n1C)n2
c(n(C)c(c(n1C)=O)c2n(c1=O)C)n2
c(n(C)c(c(n1C)=O)c2n(C)c1=O)n2
c(n(C)c(c(n(c1=O)C)=O)c2n1C)n2
c(n(C)c(c(n(C)c1=O)=O)c2n1C)n2
c(n(c1c2=O)C)nc1n(c(n2C)=O)C
c(n(c1c2=O)C)nc1n(c(=O)n2C)C
c(n(c1c2=O)C)nc1n(C)c(n2C)=O
c(n(c1c2=O)C)nc1n(C)c(=O)n2C
c(n(c1c(=O)n2C)C)nc1n(c2=O)C
c(n(c1c(=O)n2C)C)nc1n(C)c2=O
c(n(c1c(=O)n(c2=O)C)C)nc1n2C
c(n(c1c(=O)n(c(=O)n2C)C)C)nc21
c(n(c1c(=O)n(c(=O)n2C)C)C)nc12
c(n(c1c(=O)n(c(n2C)=O)C)C)nc21
c(n(c1c(=O)n(c(n2C)=O)C)C)nc12
c(n(c1c(=O)n(C)c2=O)C)nc1n2C
c(n(c1c(=O)n(C)c(=O)n2C)C)nc21
c(n(c1c(=O)n(C)c(=O)n2C)C)nc12
c(n(c1c(=O)n(C)c(n2C)=O)C)nc21
c(n(c1c(=O)n(C)c(n2C)=O)C)nc12
c(n(c1c(n2C)=O)C)nc1n(c2=O)C
c(n(c1c(n2C)=O)C)nc1n(C)c2=O
c(n(c1c(n(c2=O)C)=O)C)nc1n2C
c(n(c1c(n(c(=O)n2C)C)=O)C)nc21
c(n(c1c(n(c(=O)n2C)C)=O)C)nc12
c(n(c1c(n(c(n2C)=O)C)=O)C)nc21
c(n(c1c(n(c(n2C)=O)C)=O)C)nc12
c(n(c1c(n(C)c2=O)=O)C)nc1n2C
c(n(c1c(n(C)c(=O)n2C)=O)C)nc21
c(n(c1c(n(C)c(=O)n2C)=O)C)nc12
c(n(c1c(n(C)c(n2C)=O)=O)C)nc21
c(n(c1c(n(C)c(n2C)=O)=O)C)nc12
c(n(c1c2n(c(n(c1=O)C)=O)C)C)n2
c(n(c1c2n(c(n(C)c1=O)=O)C)C)n2
c(n(c1c2n(c(=O)n(c1=O)C)C)C)n2
c(n(c1c2n(c(=O)n(C)c1=O)C)C)n2
c(n(c1c2n(C)c(n(c1=O)C)=O)C)n2
c(n(c1c2n(C)c(n(C)c1=O)=O)C)n2
c(n(c1c2n(C)c(=O)n(c1=O)C)C)n2
c(n(c1c2n(C)c(=O)n(C)c1=O)C)n2
c(n(c(c1n2C)c(=O)n(c2=O)C)C)n1
c(n(c(c1n2C)c(=O)n(C)c2=O)C)n1
c(n(c(c1n2C)c(n(c2=O)C)=O)C)n1
c(n(c(c1n2C)c(n(C)c2=O)=O)C)n1
c(n(c(c1n(c2=O)C)c(=O)n2C)C)n1
c(n(c(c1n(c2=O)C)c(n2C)=O)C)n1
c(n(c(c1n(c(n2C)=O)C)c2=O)C)n1
c(n(c(c1n(c(=O)n2C)C)c2=O)C)n1
c(n(c(c1n(C)c2=O)c(=O)n2C)C)n1
c(n(c(c1n(C)c2=O)c(n2C)=O)C)n1
c(n(c(c1n(C)c(n2C)=O)c2=O)C)n1
c(n(c(c1n(C)c(=O)n2C)c2=O)C)n1
c(n(c(c1=O)c2n(c(n1C)=O)C)C)n2
c(n(c(c1=O)c2n(c(=O)n1C)C)C)n2
c(n(c(c1=O)c2n(C)c(n1C)=O)C)n2
c(n(c(c1=O)c2n(C)c(=O)n1C)C)n2
c(n(c(c(=O)n1C)c2n(c1=O)C)C)n2
c(n(c(c(=O)n1C)c2n(C)c1=O)C)n2
c(n(c(c(=O)n(c1=O)C)c2n1C)C)n2
c(n(c(c(=O)n(C)c1=O)c2n1C)C)n2
c(n(c(c(n1C)=O)c2n(c1=O)C)C)n2
c(n(c(c(n1C)=O)c2n(C)c1=O)C)n2
c(n(c(c(n(c1=O)C)=O)c2n1C)C)n2
c(n(c(c(n(C)c1=O)=O)c2n1C)C)n2
c(nc1c2c(=O)n(c(=O)n1C)C)n2C
c(nc1c2c(=O)n(c(n1C)=O)C)n2C
c(nc1c2c(=O)n(C)c(=O)n1C)n2C
c(nc1c2c(=O)n(C)c(n1C)=O)n2C
c(nc1c2c(n(c(=O)n1C)C)=O)n2C
c(nc1c2c(n(c(n1C)=O)C)=O)n2C
c(nc1c2c(n(C)c(=O)n1C)=O)n2C
c(nc1c2c(n(C)c(n1C)=O)=O)n2C
c(nc1n2C)n(C)c1c(=O)n(c2=O)C
c(nc1n2C)n(C)c1c(=O)n(C)c2=O
c(nc1n2C)n(C)c1c(n(c2=O)C)=O
c(nc1n2C)n(C)c1c(n(C)c2=O)=O
c(nc1n2C)n(c1c(=O)n(c2=O)C)C
c(nc1n2C)n(c1c(=O)n(C)c2=O)C
c(nc1n2C)n(c1c(n(c2=O)C)=O)C
c(nc1n2C)n(c1c(n(C)c2=O)=O)C
c(nc1n(c2=O)C)n(C)c1c(=O)n2C
c(nc1n(c2=O)C)n(C)c1c(n2C)=O
c(nc1n(c2=O)C)n(c1c(=O)n2C)C
c(nc1n(c2=O)C)n(c1c(n2C)=O)C
c(nc1n(c(n2C)=O)C)n(C)c1c2=O
c(nc1n(c(n2C)=O)C)n(c1c2=O)C
c(nc1n(c(n(c2=O)C)=O)C)n(C)c12
c(nc1n(c(n(c2=O)C)=O)C)n(C)c21
c(nc1n(c(n(c2=O)C)=O)C)n(c12)C
c(nc1n(c(n(c2=O)C)=O)C)n(c21)C
c(nc1n(c(n(C)c2=O)=O)C)n(C)c12
c(nc1n(c(n(C)c2=O)=O)C)n(C)c21
c(nc1n(c(n(C)c2=O)=O)C)n(c12)C
c(nc1n(c(n(C)c2=O)=O)C)n(c21)C
c(nc1n(c(=O)n2C)C)n(C)c1c2=O
c(nc1n(c(=O)n2C)C)n(c1c2=O)C
c(nc1n(c(=O)n(c2=O)C)C)n(C)c12
c(nc1n(c(=O)n(c2=O)C)C)n(C)c21
c(nc1n(c(=O)n(c2=O)C)C)n(c12)C
c(nc1n(c(=O)n(c2=O)C)C)n(c21)C
c(nc1n(c(=O)n(C)c2=O)C)n(C)c12
c(nc1n(c(=O)n(C)c2=O)C)n(C)c21
c(nc1n(c(=O)n(C)c2=O)C)n(c12)C
c(nc1n(c(=O)n(C)c2=O)C)n(c21)C
c(nc1n(C)c2=O)n(C)c1c(=O)n2C
c(nc1n(C)c2=O)n(C)c1c(n2C)=O
c(nc1n(C)c2=O)n(c1c(=O)n2C)C
c(nc1n(C)c2=O)n(c1c(n2C)=O)C
c(nc1n(C)c(n2C)=O)n(C)c1c2=O
c(nc1n(C)c(n2C)=O)n(c1c2=O)C
c(nc1n(C)c(n(c2=O)C)=O)n(C)c12
c(nc1n(C)c(n(c2=O)C)=O)n(C)c21
c(nc1n(C)c(n(c2=O)C)=O)n(c12)C
c(nc1n(C)c(n(c2=O)C)=O)n(c21)C
c(nc1n(C)c(n(C)c2=O)=O)n(C)c12
c(nc1n(C)c(n(C)c2=O)=O)n(C)c21
c(nc1n(C)c(n(C)c2=O)=O)n(c12)C
c(nc1n(C)c(n(C)c2=O)=O)n(c21)C
c(nc1n(C)c(=O)n2C)n(C)c1c2=O
c(nc1n(C)c(=O)n2C)n(c1c2=O)C
c(nc1n(C)c(=O)n(c2=O)C)n(C)c12
c(nc1n(C)c(=O)n(c2=O)C)n(C)c21
c(nc1n(C)c(=O)n(c2=O)C)n(c12)C
c(nc1n(C)c(=O)n(c2=O)C)n(c21)C
c(nc1n(C)c(=O)n(C)c2=O)n(C)c12
c(nc1n(C)c(=O)n(C)c2=O)n(C)c21
c(nc1n(C)c(=O)n(C)c2=O)n(c12)C
c(nc1n(C)c(=O)n(C)c2=O)n(c21)C
c(nc(n1C)c2c(=O)n(c1=O)C)n2C
c(nc(n1C)c2c(=O)n(C)c1=O)n2C
c(nc(n1C)c2c(n(c1=O)C)=O)n2C
c(nc(n1C)c2c(n(C)c1=O)=O)n2C
c(nc(n(c1=O)C)c2c(=O)n1C)n2C
c(nc(n(c1=O)C)c2c(n1C)=O)n2C
c(nc(n(c(n1C)=O)C)c2c1=O)n2C
c(nc(n(c(=O)n1C)C)c2c1=O)n2C
c(nc(n(C)c1=O)c2c(=O)n1C)n2C
c(nc(n(C)c1=O)c2c(n1C)=O)n2C
c(nc(n(C)c(n1C)=O)c2c1=O)n2C
c(nc(n(C)c(=O)n1C)c2c1=O)n2C
c(nc(c1c2=O)n(c(n2C)=O)C)n1C
c(nc(c1c2=O)n(c(=O)n2C)C)n1C
c(nc(c1c2=O)n(C)c(n2C)=O)n1C
c(nc(c1c2=O)n(C)c(=O)n2C)n1C
c(nc(c1c(=O)n2C)n(c2=O)C)n1C
c(nc(c1c(=O)n2C)n(C)c2=O)n1C
c(nc(c1c(=O)n(c2=O)C)n2C)n1C
c(nc(c1c(=O)n(C)c2=O)n2C)n1C
c(nc(c1c(n2C)=O)n(c2=O)C)n1C
c(nc(c1c(n2C)=O)n(C)c2=O)n1C
c(nc(c1c(n(c2=O)C)=O)n2C)n1C
c(nc(c1c(n(C)c2=O)=O)n2C)n1C
n1c2c(n(C)c1)c(=O)n(c(=O)n2C)C
n1c2c(n(C)c1)c(=O)n(c(n2C)=O)C
n1c2c(n(C)c1)c(=O)n(C)c(=O)n2C
n1c2c(n(C)c1)c(=O)n(C)c(n2C)=O
n1c2c(n(C)c1)c(n(c(=O)n2C)C)=O
n1c2c(n(C)c1)c(n(c(n2C)=O)C)=O
n1c2c(n(C)c1)c(n(C)c(=O)n2C)=O
n1c2c(n(C)c1)c(n(C)c(n2C)=O)=O
n1c2c(n(c1)C)c(=O)n(c(=O)n2C)C
n1c2c(n(c1)C)c(=O)n(c(n2C)=O)C
n1c2c(n(c1)C)c(=O)n(C)c(=O)n2C
n1c2c(n(c1)C)c(=O)n(C)c(n2C)=O
n1c2c(n(c1)C)c(n(c(=O)n2C)C)=O
n1c2c(n(c1)C)c(n(c(n2C)=O)C)=O
n1c2c(n(c1)C)c(n(C)c(=O)n2C)=O
n1c2c(n(c1)C)c(n(C)c(n2C)=O)=O
n1c2c(c(=O)n(c(=O)n2C)C)n(C)c1
n1c2c(c(=O)n(c(=O)n2C)C)n(c1)C
n1c2c(c(=O)n(c(n2C)=O)C)n(C)c1
n1c2c(c(=O)n(c(n2C)=O)C)n(c1)C
n1c2c(c(=O)n(C)c(=O)n2C)n(C)c1
n1c2c(c(=O)n(C)c(=O)n2C)n(c1)C
n1c2c(c(=O)n(C)c(n2C)=O)n(C)c1
n1c2c(c(=O)n(C)c(n2C)=O)n(c1)C
n1c2c(c(n(c(=O)n2C)C)=O)n(C)c1
n1c2c(c(n(c(=O)n2C)C)=O)n(c1)C
n1c2c(c(n(c(n2C)=O)C)=O)n(C)c1
n1c2c(c(n(c(n2C)=O)C)=O)n(c1)C
n1c2c(c(n(C)c(=O)n2C)=O)n(C)c1
n1c2c(c(n(C)c(=O)n2C)=O)n(c1)C
n1c2c(c(n(C)c(n2C)=O)=O)n(C)c1
n1c2c(c(n(C)c(n2C)=O)=O)n(c1)C
n1c2n(c(n(c(c2n(C)c1)=O)C)=O)C
n1c2n(c(n(c(c2n(c1)C)=O)C)=O)C
n1c2n(c(n(c(=O)c2n(C)c1)C)=O)C
n1c2n(c(n(c(=O)c2n(c1)C)C)=O)C
n1c2n(c(n(C)c(c2n(C)c1)=O)=O)C
n1c2n(c(n(C)c(c2n(c1)C)=O)=O)C
n1c2n(c(n(C)c(=O)c2n(C)c1)=O)C
n1c2n(c(n(C)c(=O)c2n(c1)C)=O)C
n1c2n(c(=O)n(c(c2n(C)c1)=O)C)C
n1c2n(c(=O)n(c(c2n(c1)C)=O)C)C
n1c2n(c(=O)n(c(=O)c2n(C)c1)C)C
n1c2n(c(=O)n(c(=O)c2n(c1)C)C)C
n1c2n(c(=O)n(C)c(c2n(C)c1)=O)C
n1c2n(c(=O)n(C)c(c2n(c1)C)=O)C
n1c2n(c(=O)n(C)c(=O)c2n(C)c1)C
n1c2n(c(=O)n(C)c(=O)c2n(c1)C)C
n1c2n(C)c(n(c(c2n(C)c1)=O)C)=O
n1c2n(C)c(n(c(c2n(c1)C)=O)C)=O
n1c2n(C)c(n(c(=O)c2n(C)c1)C)=O
n1c2n(C)c(n(c(=O)c2n(c1)C)C)=O
n1c2n(C)c(n(C)c(c2n(C)c1)=O)=O
n1c2n(C)c(n(C)c(c2n(c1)C)=O)=O
n1c2n(C)c(n(C)c(=O)c2n(C)c1)=O
n1c2n(C)c(n(C)c(=O)c2n(c1)C)=O
n1c2n(C)c(=O)n(c(c2n(C)c1)=O)C
n1c2n(C)c(=O)n(c(c2n(c1)C)=O)C
n1c2n(C)c(=O)n(c(=O)c2n(C)c1)C
n1c2n(C)c(=O)n(c(=O)c2n(c1)C)C
n1c2n(C)c(=O)n(C)c(c2n(C)c1)=O
n1c2n(C)c(=O)n(C)c(c2n(c1)C)=O
n1c2n(C)c(=O)n(C)c(=O)c2n(C)c1
n1c2n(C)c(=O)n(C)c(=O)c2n(c1)C
n1c(n2C)c(n(C)c1)c(=O)n(c2=O)C
n1c(n2C)c(n(C)c1)c(=O)n(C)c2=O
n1c(n2C)c(n(C)c1)c(n(c2=O)C)=O
n1c(n2C)c(n(C)c1)c(n(C)c2=O)=O
n1c(n2C)c(n(c1)C)c(=O)n(c2=O)C
n1c(n2C)c(n(c1)C)c(=O)n(C)c2=O
n1c(n2C)c(n(c1)C)c(n(c2=O)C)=O
n1c(n2C)c(n(c1)C)c(n(C)c2=O)=O
n1c(n2C)c(c(=O)n(c2=O)C)n(C)c1
n1c(n2C)c(c(=O)n(c2=O)C)n(c1)C
n1c(n2C)c(c(=O)n(C)c2=O)n(C)c1
n1c(n2C)c(c(=O)n(C)c2=O)n(c1)C
n1c(n2C)c(c(n(c2=O)C)=O)n(C)c1
n1c(n2C)c(c(n(c2=O)C)=O)n(c1)C
n1c(n2C)c(c(n(C)c2=O)=O)n(C)c1
n1c(n2C)c(c(n(C)c2=O)=O)n(c1)C
n1c(n(c2=O)C)c(n(C)c1)c(=O)n2C
n1c(n(c2=O)C)c(n(C)c1)c(n2C)=O
n1c(n(c2=O)C)c(n(c1)C)c(=O)n2C
n1c(n(c2=O)C)c(n(c1)C)c(n2C)=O
n1c(n(c2=O)C)c(c(=O)n2C)n(C)c1
n1c(n(c2=O)C)c(c(=O)n2C)n(c1)C
n1c(n(c2=O)C)c(c(n2C)=O)n(C)c1
n1c(n(c2=O)C)c(c(n2C)=O)n(c1)C
n1c(n(c(n2C)=O)C)c(n(C)c1)c2=O
n1c(n(c(n2C)=O)C)c(n(c1)C)c2=O
n1c(n(c(n2C)=O)C)c(c2=O)n(C)c1
n1c(n(c(n2C)=O)C)c(c2=O)n(c1)C
n1c(n(c(n(c2=O)C)=O)C)c2n(C)c1
n1c(n(c(n(c2=O)C)=O)C)c2n(c1)C
n1c(n(c(n(C)c2=O)=O)C)c2n(C)c1
n1c(n(c(n(C)c2=O)=O)C)c2n(c1)C
n1c(n(c(=O)n2C)C)c(n(C)c1)c2=O
n1c(n(c(=O)n2C)C)c(n(c1)C)c2=O
n1c(n(c(=O)n2C)C)c(c2=O)n(C)c1
n1c(n(c(=O)n2C)C)c(c2=O)n(c1)C
n1c(n(c(=O)n(c2=O)C)C)c2n(C)c1
n1c(n(c(=O)n(c2=O)C)C)c2n(c1)C
n1c(n(c(=O)n(C)c2=O)C)c2n(C)c1
n1c(n(c(=O)n(C)c2=O)C)c2n(c1)C
n1c(n(C)c2=O)c(n(C)c1)c(=O)n2C
n1c(n(C)c2=O)c(n(C)c1)c(n2C)=O
n1c(n(C)c2=O)c(n(c1)C)c(=O)n2C
n1c(n(C)c2=O)c(n(c1)C)c(n2C)=O
n1c(n(C)c2=O)c(c(=O)n2C)n(C)c1
n1c(n(C)c2=O)c(c(=O)n2C)n(c1)C
n1c(n(C)c2=O)c(c(n2C)=O)n(C)c1
n1c(n(C)c2=O)c(c(n2C)=O)n(c1)C
n1c(n(C)c(n2C)=O)c(n(C)c1)c2=O
n1c(n(C)c(n2C)=O)c(n(c1)C)c2=O
n1c(n(C)c(n2C)=O)c(c2=O)n(C)c1
n1c(n(C)c(n2C)=O)c(c2=O)n(c1)C
n1c(n(C)c(n(c2=O)C)=O)c2n(C)c1
n1c(n(C)c(n(c2=O)C)=O)c2n(c1)C
n1c(n(C)c(n(C)c2=O)=O)c2n(C)c1
n1c(n(C)c(n(C)c2=O)=O)c2n(c1)C
n1c(n(C)c(=O)n2C)c(n(C)c1)c2=O
n1c(n(C)c(=O)n2C)c(n(c1)C)c2=O
n1c(n(C)c(=O)n2C)c(c2=O)n(C)c1
n1c(n(C)c(=O)n2C)c(c2=O)n(c1)C
n1c(n(C)c(=O)n(c2=O)C)c2n(C)c1
n1c(n(C)c(=O)n(c2=O)C)c2n(c1)C
n1c(n(C)c(=O)n(C)c2=O)c2n(C)c1
n1c(n(C)c(=O)n(C)c2=O)c2n(c1)C
n1c(c2n(C)c1)n(c(n(c2=O)C)=O)C
n1c(c2n(C)c1)n(c(n(C)c2=O)=O)C
n1c(c2n(C)c1)n(c(=O)n(c2=O)C)C
n1c(c2n(C)c1)n(c(=O)n(C)c2=O)C
n1c(c2n(C)c1)n(C)c(n(c2=O)C)=O
n1c(c2n(C)c1)n(C)c(n(C)c2=O)=O
n1c(c2n(C)c1)n(C)c(=O)n(c2=O)C
n1c(c2n(C)c1)n(C)c(=O)n(C)c2=O
n1c(c2n(c1)C)n(c(n(c2=O)C)=O)C
n1c(c2n(c1)C)n(c(n(C)c2=O)=O)C
n1c(c2n(c1)C)n(c(=O)n(c2=O)C)C
n1c(c2n(c1)C)n(c(=O)n(C)c2=O)C
n1c(c2n(c1)C)n(C)c(n(c2=O)C)=O
n1c(c2n(c1)C)n(C)c(n(C)c2=O)=O
n1c(c2n(c1)C)n(C)c(=O)n(c2=O)C
n1c(c2n(c1)C)n(C)c(=O)n(C)c2=O
n1c(c(n(C)c1)c2=O)n(c(n2C)=O)C
n1c(c(n(C)c1)c2=O)n(c(=O)n2C)C
n1c(c(n(C)c1)c2=O)n(C)c(n2C)=O
n1c(c(n(C)c1)c2=O)n(C)c(=O)n2C
n1c(c(n(C)c1)c(=O)n2C)n(c2=O)C
n1c(c(n(C)c1)c(=O)n2C)n(C)c2=O
n1c(c(n(C)c1)c(=O)n(c2=O)C)n2C
n1c(c(n(C)c1)c(=O)n(C)c2=O)n2C
n1c(c(n(C)c1)c(n2C)=O)n(c2=O)C
n1c(c(n(C)c1)c(n2C)=O)n(C)c2=O
n1c(c(n(C)c1)c(n(c2=O)C)=O)n2C
n1c(c(n(C)c1)c(n(C)c2=O)=O)n2C
n1c(c(n(c1)C)c2=O)n(c(n2C)=O)C
n1c(c(n(c1)C)c2=O)n(c(=O)n2C)C
n1c(c(n(c1)C)c2=O)n(C)c(n2C)=O
n1c(c(n(c1)C)c2=O)n(C)c(=O)n2C
n1c(c(n(c1)C)c(=O)n2C)n(c2=O)C
n1c(c(n(c1)C)c(=O)n2C)n(C)c2=O
n1c(c(n(c1)C)c(=O)n(c2=O)C)n2C
n1c(c(n(c1)C)c(=O)n(C)c2=O)n2C
n1c(c(n(c1)C)c(n2C)=O)n(c2=O)C
n1c(c(n(c1)C)c(n2C)=O)n(C)c2=O
n1c(c(n(c1)C)c(n(c2=O)C)=O)n2C
n1c(c(n(c1)C)c(n(C)c2=O)=O)n2C
n1c(c(c2=O)n(C)c1)n(c(n2C)=O)C
n1c(c(c2=O)n(C)c1)n(c(=O)n2C)C
n1c(c(c2=O)n(C)c1)n(C)c(n2C)=O
n1c(c(c2=O)n(C)c1)n(C)c(=O)n2C
n1c(c(c2=O)n(c1)C)n(c(n2C)=O)C
n1c(c(c2=O)n(c1)C)n(c(=O)n2C)C
n1c(c(c2=O)n(c1)C)n(C)c(n2C)=O
n1c(c(c2=O)n(c1)C)n(C)c(=O)n2C
n1c(c(c(=O)n2C)n(C)c1)n(c2=O)C
n1c(c(c(=O)n2C)n(C)c1)n(C)c2=O
n1c(c(c(=O)n2C)n(c1)C)n(c2=O)C
n1c(c(c(=O)n2C)n(c1)C)n(C)c2=O
n1c(c(c(=O)n(c2=O)C)n(C)c1)n2C
n1c(c(c(=O)n(c2=O)C)n(c1)C)n2C
n1c(c(c(=O)n(C)c2=O)n(C)c1)n2C
n1c(c(c(=O)n(C)c2=O)n(c1)C)n2C
n1c(c(c(n2C)=O)n(C)c1)n(c2=O)C
n1c(c(c(n2C)=O)n(C)c1)n(C)c2=O
n1c(c(c(n2C)=O)n(c1)C)n(c2=O)C
n1c(c(c(n2C)=O)n(c1)C)n(C)c2=O
n1c(c(c(n(c2=O)C)=O)n(C)c1)n2C
n1c(c(c(n(c2=O)C)=O)n(c1)C)n2C
n1c(c(c(n(C)c2=O)=O)n(C)c1)n2C
n1c(c(c(n(C)c2=O)=O)n(c1)C)n2C
n1cn(C)c2c(=O)n(c(=O)n(c12)C)C
n1cn(C)c2c(=O)n(c(=O)n(c21)C)C
n1cn(C)c2c(=O)n(c(=O)n(C)c12)C
n1cn(C)c2c(=O)n(c(=O)n(C)c21)C
n1cn(C)c2c(=O)n(c(n(c12)C)=O)C
n1cn(C)c2c(=O)n(c(n(c21)C)=O)C
n1cn(C)c2c(=O)n(c(n(C)c12)=O)C
n1cn(C)c2c(=O)n(c(n(C)c21)=O)C
n1cn(C)c2c(=O)n(C)c(=O)n(c12)C
n1cn(C)c2c(=O)n(C)c(=O)n(c21)C
n1cn(C)c2c(=O)n(C)c(=O)n(C)c12
n1cn(C)c2c(=O)n(C)c(=O)n(C)c21
n1cn(C)c2c(=O)n(C)c(n(c12)C)=O
n1cn(C)c2c(=O)n(C)c(n(c21)C)=O
n1cn(C)c2c(=O)n(C)c(n(C)c12)=O
n1cn(C)c2c(=O)n(C)c(n(C)c21)=O
n1cn(C)c2c(n(c(=O)n(c12)C)C)=O
n1cn(C)c2c(n(c(=O)n(c21)C)C)=O
n1cn(C)c2c(n(c(=O)n(C)c12)C)=O
n1cn(C)c2c(n(c(=O)n(C)c21)C)=O
n1cn(C)c2c(n(c(n(c12)C)=O)C)=O
n1cn(C)c2c(n(c(n(c21)C)=O)C)=O
n1cn(C)c2c(n(c(n(C)c12)=O)C)=O
n1cn(C)c2c(n(c(n(C)c21)=O)C)=O
n1cn(C)c2c(n(C)c(=O)n(c12)C)=O
n1cn(C)c2c(n(C)c(=O)n(c21)C)=O
n1cn(C)c2c(n(C)c(=O)n(C)c12)=O
n1cn(C)c2c(n(C)c(=O)n(C)c21)=O
n1cn(C)c2c(n(C)c(n(c12)C)=O)=O
n1cn(C)c2c(n(C)c(n(c21)C)=O)=O
n1cn(C)c2c(n(C)c(n(C)c12)=O)=O
n1cn(C)c2c(n(C)c(n(C)c21)=O)=O
n1cn(C)c2c1n(c(n(c2=O)C)=O)C
n1cn(C)c2c1n(c(n(C)c2=O)=O)C
n1cn(C)c2c1n(c(=O)n(c2=O)C)C
n1cn(C)c2c1n(c(=O)n(C)c2=O)C
n1cn(C)c2c1n(C)c(n(c2=O)C)=O
n1cn(C)c2c1n(C)c(n(C)c2=O)=O
n1cn(C)c2c1n(C)c(=O)n(c2=O)C
n1cn(C)c2c1n(C)c(=O)n(C)c2=O
n1cn(C)c(c1n2C)c(=O)n(c2=O)C
n1cn(C)c(c1n2C)c(=O)n(C)c2=O
n1cn(C)c(c1n2C)c(n(c2=O)C)=O
n1cn(C)c(c1n2C)c(n(C)c2=O)=O
n1cn(C)c(c1n(c2=O)C)c(=O)n2C
n1cn(C)c(c1n(c2=O)C)c(n2C)=O
n1cn(C)c(c1n(c(n2C)=O)C)c2=O
n1cn(C)c(c1n(c(=O)n2C)C)c2=O
n1cn(C)c(c1n(C)c2=O)c(=O)n2C
n1cn(C)c(c1n(C)c2=O)c(n2C)=O
n1cn(C)c(c1n(C)c(n2C)=O)c2=O
n1cn(C)c(c1n(C)c(=O)n2C)c2=O
n1cn(C)c(c2=O)c1n(c(n2C)=O)C
n1cn(C)c(c2=O)c1n(c(=O)n2C)C
n1cn(C)c(c2=O)c1n(C)c(n2C)=O
n1cn(C)c(c2=O)c1n(C)c(=O)n2C
n1cn(C)c(c(=O)n2C)c1n(c2=O)C
n1cn(C)c(c(=O)n2C)c1n(C)c2=O
n1cn(C)c(c(=O)n(c2=O)C)c1n2C
n1cn(C)c(c(=O)n(c(=O)n2C)C)c12
n1cn(C)c(c(=O)n(c(=O)n2C)C)c21
n1cn(C)c(c(=O)n(c(n2C)=O)C)c12
n1cn(C)c(c(=O)n(c(n2C)=O)C)c21
n1cn(C)c(c(=O)n(C)c2=O)c1n2C
n1cn(C)c(c(=O)n(C)c(=O)n2C)c12
n1cn(C)c(c(=O)n(C)c(=O)n2C)c21
n1cn(C)c(c(=O)n(C)c(n2C)=O)c12
n1cn(C)c(c(=O)n(C)c(n2C)=O)c21
n1cn(C)c(c(n2C)=O)c1n(c2=O)C
n1cn(C)c(c(n2C)=O)c1n(C)c2=O
n1cn(C)c(c(n(c2=O)C)=O)c1n2C
n1cn(C)c(c(n(c(=O)n2C)C)=O)c12
n1cn(C)c(c(n(c(=O)n2C)C)=O)c21
n1cn(C)c(c(n(c(n2C)=O)C)=O)c12
n1cn(C)c(c(n(c(n2C)=O)C)=O)c21
n1cn(C)c(c(n(C)c2=O)=O)c1n2C
n1cn(C)c(c(n(C)c(=O)n2C)=O)c12
n1cn(C)c(c(n(C)c(=O)n2C)=O)c21
n1cn(C)c(c(n(C)c(n2C)=O)=O)c12
n1cn(C)c(c(n(C)c(n2C)=O)=O)c21
n1cn(c2c(=O)n(c(=O)n(c12)C)C)C
n1cn(c2c(=O)n(c(=O)n(c21)C)C)C
n1cn(c2c(=O)n(c(=O)n(C)c12)C)C
n1cn(c2c(=O)n(c(=O)n(C)c21)C)C
n1cn(c2c(=O)n(c(n(c12)C)=O)C)C
n1cn(c2c(=O)n(c(n(c21)C)=O)C)C
n1cn(c2c(=O)n(c(n(C)c12)=O)C)C
n1cn(c2c(=O)n(c(n(C)c21)=O)C)C
n1cn(c2c(=O)n(C)c(=O)n(c12)C)C
n1cn(c2c(=O)n(C)c(=O)n(c21)C)C
n1cn(c2c(=O)n(C)c(=O)n(C)c12)C
n1cn(c2c(=O)n(C)c(=O)n(C)c21)C
n1cn(c2c(=O)n(C)c(n(c12)C)=O)C
n1cn(c2c(=O)n(C)c(n(c21)C)=O)C
n1cn(c2c(=O)n(C)c(n(C)c12)=O)C
n1cn(c2c(=O)n(C)c(n(C)c21)=O)C
n1cn(c2c(n(c(=O)n(c12)C)C)=O)C
n1cn(c2c(n(c(=O)n(c21)C)C)=O)C
n1cn(c2c(n(c(=O)n(C)c12)C)=O)C
n1cn(c2c(n(c(=O)n(C)c21)C)=O)C
n1cn(c2c(n(c(n(c12)C)=O)C)=O)C
n1cn(c2c(n(c(n(c21)C)=O)C)=O)C
n1cn(c2c(n(c(n(C)c12)=O)C)=O)C
n1cn(c2c(n(c(n(C)c21)=O)C)=O)C
n1cn(c2c(n(C)c(=O)n(c12)C)=O)C
n1cn(c2c(n(C)c(=O)n(c21)C)=O)C
n1cn(c2c(n(C)c(=O)n(C)c12)=O)C
n1cn(c2c(n(C)c(=O)n(C)c21)=O)C
n1cn(c2c(n(C)c(n(c12)C)=O)=O)C
n1cn(c2c(n(C)c(n(c21)C)=O)=O)C
n1cn(c2c(n(C)c(n(C)c12)=O)=O)C
n1cn(c2c(n(C)c(n(C)c21)=O)=O)C
n1cn(c2c1n(c(n(c2=O)C)=O)C)C
n1cn(c2c1n(c(n(C)c2=O)=O)C)C
n1cn(c2c1n(c(=O)n(c2=O)C)C)C
n1cn(c2c1n(c(=O)n(C)c2=O)C)C
n1cn(c2c1n(C)c(n(c2=O)C)=O)C
n1cn(c2c1n(C)c(n(C)c2=O)=O)C
n1cn(c2c1n(C)c(=O)n(c2=O)C)C
n1cn(c2c1n(C)c(=O)n(C)c2=O)C
n1cn(c(c1n2C)c(=O)n(c2=O)C)C
n1cn(c(c1n2C)c(=O)n(C)c2=O)C
n1cn(c(c1n2C)c(n(c2=O)C)=O)C
n1cn(c(c1n2C)c(n(C)c2=O)=O)C
n1cn(c(c1n(c2=O)C)c(=O)n2C)C
n1cn(c(c1n(c2=O)C)c(n2C)=O)C
n1cn(c(c1n(c(n2C)=O)C)c2=O)C
n1cn(c(c1n(c(=O)n2C)C)c2=O)C
n1cn(c(c1n(C)c2=O)c(=O)n2C)C
n1cn(c(c1n(C)c2=O)c(n2C)=O)C
n1cn(c(c1n(C)c(n2C)=O)c2=O)C
n1cn(c(c1n(C)c(=O)n2C)c2=O)C
n1cn(c(c2=O)c1n(c(n2C)=O)C)C
n1cn(c(c2=O)c1n(c(=O)n2C)C)C
n1cn(c(c2=O)c1n(C)c(n2C)=O)C
n1cn(c(c2=O)c1n(C)c(=O)n2C)C
n1cn(c(c(=O)n2C)c1n(c2=O)C)C
n1cn(c(c(=O)n2C)c1n(C)c2=O)C
n1cn(c(c(=O)n(c2=O)C)c1n2C)C
n1cn(c(c(=O)n(c(=O)n2C)C)c12)C
n1cn(c(c(=O)n(c(=O)n2C)C)c21)C
n1cn(c(c(=O)n(c(n2C)=O)C)c12)C
n1cn(c(c(=O)n(c(n2C)=O)C)c21)C
n1cn(c(c(=O)n(C)c2=O)c1n2C)C
n1cn(c(c(=O)n(C)c(=O)n2C)c12)C
n1cn(c(c(=O)n(C)c(=O)n2C)c21)C
n1cn(c(c(=O)n(C)c(n2C)=O)c12)C
n1cn(c(c(=O)n(C)c(n2C)=O)c21)C
n1cn(c(c(n2C)=O)c1n(c2=O)C)C
n1cn(c(c(n2C)=O)c1n(C)c2=O)C
n1cn(c(c(n(c2=O)C)=O)c1n2C)C
n1cn(c(c(n(c(=O)n2C)C)=O)c12)C
n1cn(c(c(n(c(=O)n2C)C)=O)c21)C
n1cn(c(c(n(c(n2C)=O)C)=O)c12)C
n1cn(c(c(n(c(n2C)=O)C)=O)c21)C
n1cn(c(c(n(C)c2=O)=O)c1n2C)C
n1cn(c(c(n(C)c(=O)n2C)=O)c12)C
n1cn(c(c(n(C)c(=O)n2C)=O)c21)C
n1cn(c(c(n(C)c(n2C)=O)=O)c12)C
n1cn(c(c(n(C)c(n2C)=O)=O)c21)C
n(cn1C)c2c1c(=O)n(c(=O)n2C)C
n(cn1C)c2c1c(=O)n(c(n2C)=O)C
n(cn1C)c2c1c(=O)n(C)c(=O)n2C
n(cn1C)c2c1c(=O)n(C)c(n2C)=O
n(cn1C)c2c1c(n(c(=O)n2C)C)=O
n(cn1C)c2c1c(n(c(n2C)=O)C)=O
n(cn1C)c2c1c(n(C)c(=O)n2C)=O
n(cn1C)c2c1c(n(C)c(n2C)=O)=O
n(cn1C)c2n(c(n(c(c12)=O)C)=O)C
n(cn1C)c2n(c(n(c(c21)=O)C)=O)C
n(cn1C)c2n(c(n(c(=O)c12)C)=O)C
n(cn1C)c2n(c(n(c(=O)c21)C)=O)C
n(cn1C)c2n(c(n(C)c(c12)=O)=O)C
n(cn1C)c2n(c(n(C)c(c21)=O)=O)C
n(cn1C)c2n(c(n(C)c(=O)c12)=O)C
n(cn1C)c2n(c(n(C)c(=O)c21)=O)C
n(cn1C)c2n(c(=O)n(c(c12)=O)C)C
n(cn1C)c2n(c(=O)n(c(c21)=O)C)C
n(cn1C)c2n(c(=O)n(c(=O)c12)C)C
n(cn1C)c2n(c(=O)n(c(=O)c21)C)C
n(cn1C)c2n(c(=O)n(C)c(c12)=O)C
n(cn1C)c2n(c(=O)n(C)c(c21)=O)C
n(cn1C)c2n(c(=O)n(C)c(=O)c12)C
n(cn1C)c2n(c(=O)n(C)c(=O)c21)C
n(cn1C)c2n(C)c(n(c(c12)=O)C)=O
n(cn1C)c2n(C)c(n(c(c21)=O)C)=O
n(cn1C)c2n(C)c(n(c(=O)c12)C)=O
n(cn1C)c2n(C)c(n(c(=O)c21)C)=O
n(cn1C)c2n(C)c(n(C)c(c12)=O)=O
n(cn1C)c2n(C)c(n(C)c(c21)=O)=O
n(cn1C)c2n(C)c(n(C)c(=O)c12)=O
n(cn1C)c2n(C)c(n(C)c(=O)c21)=O
n(cn1C)c2n(C)c(=O)n(c(c12)=O)C
n(cn1C)c2n(C)c(=O)n(c(c21)=O)C
n(cn1C)c2n(C)c(=O)n(c(=O)c12)C
n(cn1C)c2n(C)c(=O)n(c(=O)c21)C
n(cn1C)c2n(C)c(=O)n(C)c(c12)=O
n(cn1C)c2n(C)c(=O)n(C)c(c21)=O
n(cn1C)c2n(C)c(=O)n(C)c(=O)c12
n(cn1C)c2n(C)c(=O)n(C)c(=O)c21
n(cn1C)c(n2C)c1c(=O)n(c2=O)C
n(cn1C)c(n2C)c1c(=O)n(C)c2=O
n(cn1C)c(n2C)c1c(n(c2=O)C)=O
n(cn1C)c(n2C)c1c(n(C)c2=O)=O
n(cn1C)c(n(c2=O)C)c1c(=O)n2C
n(cn1C)c(n(c2=O)C)c1c(n2C)=O
n(cn1C)c(n(c(n2C)=O)C)c1c2=O
n(cn1C)c(n(c(n(c2=O)C)=O)C)c12
n(cn1C)c(n(c(n(c2=O)C)=O)C)c21
n(cn1C)c(n(c(n(C)c2=O)=O)C)c12
n(cn1C)c(n(c(n(C)c2=O)=O)C)c21
n(cn1C)c(n(c(=O)n2C)C)c1c2=O
n(cn1C)c(n(c(=O)n(c2=O)C)C)c12
n(cn1C)c(n(c(=O)n(c2=O)C)C)c21
n(cn1C)c(n(c(=O)n(C)c2=O)C)c12
n(cn1C)c(n(c(=O)n(C)c2=O)C)c21
n(cn1C)c(n(C)c2=O)c1c(=O)n2C
n(cn1C)c(n(C)c2=O)c1c(n2C)=O
n(cn1C)c(n(C)c(n2C)=O)c1c2=O
n(cn1C)c(n(C)c(n(c2=O)C)=O)c12
n(cn1C)c(n(C)c(n(c2=O)C)=O)c21
n(cn1C)c(n(C)c(n(C)c2=O)=O)c12
n(cn1C)c(n(C)c(n(C)c2=O)=O)c21
n(cn1C)c(n(C)c(=O)n2C)c1c2=O
n(cn1C)c(n(C)c(=O)n(c2=O)C)c12
n(cn1C)c(n(C)c(=O)n(c2=O)C)c21
n(cn1C)c(n(C)c(=O)n(C)c2=O)c12
n(cn1C)c(n(C)c(=O)n(C)c2=O)c21
n(cn1C)c(c1c2=O)n(c(n2C)=O)C
n(cn1C)c(c1c2=O)n(c(=O)n2C)C
n(cn1C)c(c1c2=O)n(C)c(n2C)=O
n(cn1C)c(c1c2=O)n(C)c(=O)n2C
n(cn1C)c(c1c(=O)n2C)n(c2=O)C
n(cn1C)c(c1c(=O)n2C)n(C)c2=O
n(cn1C)c(c1c(=O)n(c2=O)C)n2C
n(cn1C)c(c1c(=O)n(C)c2=O)n2C
n(cn1C)c(c1c(n2C)=O)n(c2=O)C
n(cn1C)c(c1c(n2C)=O)n(C)c2=O
n(cn1C)c(c1c(n(c2=O)C)=O)n2C
n(cn1C)c(c1c(n(C)c2=O)=O)n2C
n(cn(C)c1c2=O)c1n(c(n2C)=O)C
n(cn(C)c1c2=O)c1n(c(=O)n2C)C
n(cn(C)c1c2=O)c1n(C)c(n2C)=O
n(cn(C)c1c2=O)c1n(C)c(=O)n2C
n(cn(C)c1c(=O)n2C)c1n(c2=O)C
n(cn(C)c1c(=O)n2C)c1n(C)c2=O
n(cn(C)c1c(=O)n(c2=O)C)c1n2C
n(cn(C)c1c(=O)n(c(=O)n2C)C)c21
n(cn(C)c1c(=O)n(c(=O)n2C)C)c12
n(cn(C)c1c(=O)n(c(n2C)=O)C)c21
n(cn(C)c1c(=O)n(c(n2C)=O)C)c12
n(cn(C)c1c(=O)n(C)c2=O)c1n2C
n(cn(C)c1c(=O)n(C)c(=O)n2C)c21
n(cn(C)c1c(=O)n(C)c(=O)n2C)c12
n(cn(C)c1c(=O)n(C)c(n2C)=O)c21
n(cn(C)c1c(=O)n(C)c(n2C)=O)c12
n(cn(C)c1c(n2C)=O)c1n(c2=O)C
n(cn(C)c1c(n2C)=O)c1n(C)c2=O
n(cn(C)c1c(n(c2=O)C)=O)c1n2C
n(cn(C)c1c(n(c(=O)n2C)C)=O)c21
n(cn(C)c1c(n(c(=O)n2C)C)=O)c12
n(cn(C)c1c(n(c(n2C)=O)C)=O)c21
n(cn(C)c1c(n(c(n2C)=O)C)=O)c12
n(cn(C)c1c(n(C)c2=O)=O)c1n2C
n(cn(C)c1c(n(C)c(=O)n2C)=O)c21
n(cn(C)c1c(n(C)c(=O)n2C)=O)c12
n(cn(C)c1c(n(C)c(n2C)=O)=O)c21
n(cn(C)c1c(n(C)c(n2C)=O)=O)c12
n(cn(c1c2=O)C)c1n(c(n2C)=O)C
n(cn(c1c2=O)C)c1n(c(=O)n2C)C
n(cn(c1c2=O)C)c1n(C)c(n2C)=O
n(cn(c1c2=O)C)c1n(C)c(=O)n2C
n(cn(c1c(=O)n2C)C)c1n(c2=O)C
n(cn(c1c(=O)n2C)C)c1n(C)c2=O
n(cn(c1c(=O)n(c2=O)C)C)c1n2C
n(cn(c1c(=O)n(c(=O)n2C)C)C)c21
n(cn(c1c(=O)n(c(=O)n2C)C)C)c12
n(cn(c1c(=O)n(c(n2C)=O)C)C)c21
n(cn(c1c(=O)n(c(n2C)=O)C)C)c12
n(cn(c1c(=O)n(C)c2=O)C)c1n2C
n(cn(c1c(=O)n(C)c(=O)n2C)C)c21
n(cn(c1c(=O)n(C)c(=O)n2C)C)c12
n(cn(c1c(=O)n(C)c(n2C)=O)C)c21
n(cn(c1c(=O)n(C)c(n2C)=O)C)c12
n(cn(c1c(n2C)=O)C)c1n(c2=O)C
n(cn(c1c(n2C)=O)C)c1n(C)c2=O
n(cn(c1c(n(c2=O)C)=O)C)c1n2C
n(cn(c1c(n(c(=O)n2C)C)=O)C)c21
n(cn(c1c(n(c(=O)n2C)C)=O)C)c12
n(cn(c1c(n(c(n2C)=O)C)=O)C)c21
n(cn(c1c(n(c(n2C)=O)C)=O)C)c12
n(cn(c1c(n(C)c2=O)=O)C)c1n2C
n(cn(c1c(n(C)c(=O)n2C)=O)C)c21
n(cn(c1c(n(C)c(=O)n2C)=O)C)c12
n(cn(c1c(n(C)c(n2C)=O)=O)C)c21
n(cn(c1c(n(C)c(n2C)=O)=O)C)c12
n(c1c2c(=O)n(c(=O)n1C)C)cn2C
n(c1c2c(=O)n(c(n1C)=O)C)cn2C
n(c1c2c(=O)n(C)c(=O)n1C)cn2C
n(c1c2c(=O)n(C)c(n1C)=O)cn2C
n(c1c2c(n(c(=O)n1C)C)=O)cn2C
n(c1c2c(n(c(n1C)=O)C)=O)cn2C
n(c1c2c(n(C)c(=O)n1C)=O)cn2C
n(c1c2c(n(C)c(n1C)=O)=O)cn2C
n(c1c(n2C)c(=O)n(c(=O)n1C)C)c2
n(c1c(n2C)c(=O)n(c(n1C)=O)C)c2
n(c1c(n2C)c(=O)n(C)c(=O)n1C)c2
n(c1c(n2C)c(=O)n(C)c(n1C)=O)c2
n(c1c(n2C)c(n(c(=O)n1C)C)=O)c2
n(c1c(n2C)c(n(c(n1C)=O)C)=O)c2
n(c1c(n2C)c(n(C)c(=O)n1C)=O)c2
n(c1c(n2C)c(n(C)c(n1C)=O)=O)c2
n(c1c(c(=O)n(c(=O)n1C)C)n2C)c2
n(c1c(c(=O)n(c(n1C)=O)C)n2C)c2
n(c1c(c(=O)n(C)c(=O)n1C)n2C)c2
n(c1c(c(=O)n(C)c(n1C)=O)n2C)c2
n(c1c(c(n(c(=O)n1C)C)=O)n2C)c2
n(c1c(c(n(c(n1C)=O)C)=O)n2C)c2
n(c1c(c(n(C)c(=O)n1C)=O)n2C)c2
n(c1c(c(n(C)c(n1C)=O)=O)n2C)c2
n(c1n2C)cn(C)c1c(=O)n(c2=O)C
n(c1n2C)cn(C)c1c(=O)n(C)c2=O
n(c1n2C)cn(C)c1c(n(c2=O)C)=O
n(c1n2C)cn(C)c1c(n(C)c2=O)=O
n(c1n2C)cn(c1c(=O)n(c2=O)C)C
n(c1n2C)cn(c1c(=O)n(C)c2=O)C
n(c1n2C)cn(c1c(n(c2=O)C)=O)C
n(c1n2C)cn(c1c(n(C)c2=O)=O)C
n(c1n(c2=O)C)cn(C)c1c(=O)n2C
n(c1n(c2=O)C)cn(C)c1c(n2C)=O
n(c1n(c2=O)C)cn(c1c(=O)n2C)C
n(c1n(c2=O)C)cn(c1c(n2C)=O)C
n(c1n(c(n2C)=O)C)cn(C)c1c2=O
n(c1n(c(n2C)=O)C)cn(c1c2=O)C
n(c1n(c(n(c2=O)C)=O)C)cn(C)c12
n(c1n(c(n(c2=O)C)=O)C)cn(C)c21
n(c1n(c(n(c2=O)C)=O)C)cn(c12)C
n(c1n(c(n(c2=O)C)=O)C)cn(c21)C
n(c1n(c(n(c(c1n2C)=O)C)=O)C)c2
n(c1n(c(n(c(=O)c1n2C)C)=O)C)c2
n(c1n(c(n(C)c2=O)=O)C)cn(C)c12
n(c1n(c(n(C)c2=O)=O)C)cn(C)c21
n(c1n(c(n(C)c2=O)=O)C)cn(c12)C
n(c1n(c(n(C)c2=O)=O)C)cn(c21)C
n(c1n(c(n(C)c(c1n2C)=O)=O)C)c2
n(c1n(c(n(C)c(=O)c1n2C)=O)C)c2
n(c1n(c(=O)n2C)C)cn(C)c1c2=O
n(c1n(c(=O)n2C)C)cn(c1c2=O)C
n(c1n(c(=O)n(c2=O)C)C)cn(C)c12
n(c1n(c(=O)n(c2=O)C)C)cn(C)c21
n(c1n(c(=O)n(c2=O)C)C)cn(c12)C
n(c1n(c(=O)n(c2=O)C)C)cn(c21)C
n(c1n(c(=O)n(c(c1n2C)=O)C)C)c2
n(c1n(c(=O)n(c(=O)c1n2C)C)C)c2
n(c1n(c(=O)n(C)c2=O)C)cn(C)c12
n(c1n(c(=O)n(C)c2=O)C)cn(C)c21
n(c1n(c(=O)n(C)c2=O)C)cn(c12)C
n(c1n(c(=O)n(C)c2=O)C)cn(c21)C
n(c1n(c(=O)n(C)c(c1n2C)=O)C)c2
n(c1n(c(=O)n(C)c(=O)c1n2C)C)c2
n(c1n(C)c2=O)cn(C)c1c(=O)n2C
n(c1n(C)c2=O)cn(C)c1c(n2C)=O
n(c1n(C)c2=O)cn(c1c(=O)n2C)C
n(c1n(C)c2=O)cn(c1c(n2C)=O)C
n(c1n(C)c(n2C)=O)cn(C)c1c2=O
n(c1n(C)c(n2C)=O)cn(c1c2=O)C
n(c1n(C)c(n(c2=O)C)=O)cn(C)c12
n(c1n(C)c(n(c2=O)C)=O)cn(C)c21
n(c1n(C)c(n(c2=O)C)=O)cn(c12)C
n(c1n(C)c(n(c2=O)C)=O)cn(c21)C
n(c1n(C)c(n(c(c1n2C)=O)C)=O)c2
n(c1n(C)c(n(c(=O)c1n2C)C)=O)c2
n(c1n(C)c(n(C)c2=O)=O)cn(C)c12
n(c1n(C)c(n(C)c2=O)=O)cn(C)c21
n(c1n(C)c(n(C)c2=O)=O)cn(c12)C
n(c1n(C)c(n(C)c2=O)=O)cn(c21)C
n(c1n(C)c(n(C)c(c1n2C)=O)=O)c2
n(c1n(C)c(n(C)c(=O)c1n2C)=O)c2
n(c1n(C)c(=O)n2C)cn(C)c1c2=O
n(c1n(C)c(=O)n2C)cn(c1c2=O)C
n(c1n(C)c(=O)n(c2=O)C)cn(C)c12
n(c1n(C)c(=O)n(c2=O)C)cn(C)c21
n(c1n(C)c(=O)n(c2=O)C)cn(c12)C
n(c1n(C)c(=O)n(c2=O)C)cn(c21)C
n(c1n(C)c(=O)n(c(c1n2C)=O)C)c2
n(c1n(C)c(=O)n(c(=O)c1n2C)C)c2
n(c1n(C)c(=O)n(C)c2=O)cn(C)c12
n(c1n(C)c(=O)n(C)c2=O)cn(C)c21
n(c1n(C)c(=O)n(C)c2=O)cn(c12)C
n(c1n(C)c(=O)n(C)c2=O)cn(c21)C
n(c1n(C)c(=O)n(C)c(c1n2C)=O)c2
n(c1n(C)c(=O)n(C)c(=O)c1n2C)c2
n(c(n1C)c2c(=O)n(c1=O)C)cn2C
n(c(n1C)c2c(=O)n(C)c1=O)cn2C
n(c(n1C)c2c(n(c1=O)C)=O)cn2C
n(c(n1C)c2c(n(C)c1=O)=O)cn2C
n(c(n1C)c(n2C)c(=O)n(c1=O)C)c2
n(c(n1C)c(n2C)c(=O)n(C)c1=O)c2
n(c(n1C)c(n2C)c(n(c1=O)C)=O)c2
n(c(n1C)c(n2C)c(n(C)c1=O)=O)c2
n(c(n1C)c(c(=O)n(c1=O)C)n2C)c2
n(c(n1C)c(c(=O)n(C)c1=O)n2C)c2
n(c(n1C)c(c(n(c1=O)C)=O)n2C)c2
n(c(n1C)c(c(n(C)c1=O)=O)n2C)c2
n(c(n(c1=O)C)c2c(=O)n1C)cn2C
n(c(n(c1=O)C)c2c(n1C)=O)cn2C
n(c(n(c1=O)C)c(n2C)c(=O)n1C)c2
n(c(n(c1=O)C)c(n2C)c(n1C)=O)c2
n(c(n(c1=O)C)c(c(=O)n1C)n2C)c2
n(c(n(c1=O)C)c(c(n1C)=O)n2C)c2
n(c(n(c(n1C)=O)C)c2c1=O)cn2C
n(c(n(c(n1C)=O)C)c(n2C)c1=O)c2
n(c(n(c(n1C)=O)C)c(c1=O)n2C)c2
n(c(n(c(n(c1=O)C)=O)C)c1n2C)c2
n(c(n(c(n(C)c1=O)=O)C)c1n2C)c2
n(c(n(c(=O)n1C)C)c2c1=O)cn2C
n(c(n(c(=O)n1C)C)c(n2C)c1=O)c2
n(c(n(c(=O)n1C)C)c(c1=O)n2C)c2
n(c(n(c(=O)n(c1=O)C)C)c1n2C)c2
n(c(n(c(=O)n(C)c1=O)C)c1n2C)c2
n(c(n(C)c1=O)c2c(=O)n1C)cn2C
n(c(n(C)c1=O)c2c(n1C)=O)cn2C
n(c(n(C)c1=O)c(n2C)c(=O)n1C)c2
n(c(n(C)c1=O)c(n2C)c(n1C)=O)c2
n(c(n(C)c1=O)c(c(=O)n1C)n2C)c2
n(c(n(C)c1=O)c(c(n1C)=O)n2C)c2
n(c(n(C)c(n1C)=O)c2c1=O)cn2C
n(c(n(C)c(n1C)=O)c(n2C)c1=O)c2
n(c(n(C)c(n1C)=O)c(c1=O)n2C)c2
n(c(n(C)c(n(c1=O)C)=O)c1n2C)c2
n(c(n(C)c(n(C)c1=O)=O)c1n2C)c2
n(c(n(C)c(=O)n1C)c2c1=O)cn2C
n(c(n(C)c(=O)n1C)c(n2C)c1=O)c2
n(c(n(C)c(=O)n1C)c(c1=O)n2C)c2
n(c(n(C)c(=O)n(c1=O)C)c1n2C)c2
n(c(n(C)c(=O)n(C)c1=O)c1n2C)c2
n(c(c1c2=O)n(c(n2C)=O)C)cn1C
n(c(c1c2=O)n(c(=O)n2C)C)cn1C
n(c(c1c2=O)n(C)c(n2C)=O)cn1C
n(c(c1c2=O)n(C)c(=O)n2C)cn1C
n(c(c1c(=O)n2C)n(c2=O)C)cn1C
n(c(c1c(=O)n2C)n(C)c2=O)cn1C
n(c(c1c(=O)n(c2=O)C)n2C)cn1C
n(c(c1c(=O)n(C)c2=O)n2C)cn1C
n(c(c1c(n2C)=O)n(c2=O)C)cn1C
n(c(c1c(n2C)=O)n(C)c2=O)cn1C
n(c(c1c(n(c2=O)C)=O)n2C)cn1C
n(c(c1c(n(C)c2=O)=O)n2C)cn1C
n(c(c1n2C)n(c(n(c1=O)C)=O)C)c2
n(c(c1n2C)n(c(n(C)c1=O)=O)C)c2
n(c(c1n2C)n(c(=O)n(c1=O)C)C)c2
n(c(c1n2C)n(c(=O)n(C)c1=O)C)c2
n(c(c1n2C)n(C)c(n(c1=O)C)=O)c2
n(c(c1n2C)n(C)c(n(C)c1=O)=O)c2
n(c(c1n2C)n(C)c(=O)n(c1=O)C)c2
n(c(c1n2C)n(C)c(=O)n(C)c1=O)c2
n(c(c(n1C)c2=O)n(c(n2C)=O)C)c1
n(c(c(n1C)c2=O)n(c(=O)n2C)C)c1
n(c(c(n1C)c2=O)n(C)c(n2C)=O)c1
n(c(c(n1C)c2=O)n(C)c(=O)n2C)c1
n(c(c(n1C)c(=O)n2C)n(c2=O)C)c1
n(c(c(n1C)c(=O)n2C)n(C)c2=O)c1
n(c(c(n1C)c(=O)n(c2=O)C)n2C)c1
n(c(c(n1C)c(=O)n(C)c2=O)n2C)c1
n(c(c(n1C)c(n2C)=O)n(c2=O)C)c1
n(c(c(n1C)c(n2C)=O)n(C)c2=O)c1
n(c(c(n1C)c(n(c2=O)C)=O)n2C)c1
n(c(c(n1C)c(n(C)c2=O)=O)n2C)c1
n(c(c(c1=O)n2C)n(c(n1C)=O)C)c2
n(c(c(c1=O)n2C)n(c(=O)n1C)C)c2
n(c(c(c1=O)n2C)n(C)c(n1C)=O)c2
n(c(c(c1=O)n2C)n(C)c(=O)n1C)c2
n(c(c(c(=O)n1C)n2C)n(c1=O)C)c2
n(c(c(c(=O)n1C)n2C)n(C)c1=O)c2
n(c(c(c(=O)n(c1=O)C)n2C)n1C)c2
n(c(c(c(=O)n(C)c1=O)n2C)n1C)c2
n(c(c(c(n1C)=O)n2C)n(c1=O)C)c2
n(c(c(c(n1C)=O)n2C)n(C)c1=O)c2
n(c(c(c(n(c1=O)C)=O)n2C)n1C)c2
n(c(c(c(n(C)c1=O)=O)n2C)n1C)c2
c12c(n(C)cn1)c(=O)n(c(=O)n2C)C
c12c(n(C)cn1)c(=O)n(c(n2C)=O)C
c12c(n(C)cn1)c(=O)n(C)c(=O)n2C
c12c(n(C)cn1)c(=O)n(C)c(n2C)=O
c12c(n(C)cn1)c(n(c(=O)n2C)C)=O
c12c(n(C)cn1)c(n(c(n2C)=O)C)=O
c12c(n(C)cn1)c(n(C)c(=O)n2C)=O
c12c(n(C)cn1)c(n(C)c(n2C)=O)=O
c12c(n(cn1)C)c(=O)n(c(=O)n2C)C
c12c(n(cn1)C)c(=O)n(c(n2C)=O)C
c12c(n(cn1)C)c(=O)n(C)c(=O)n2C
c12c(n(cn1)C)c(=O)n(C)c(n2C)=O
c12c(n(cn1)C)c(n(c(=O)n2C)C)=O
c12c(n(cn1)C)c(n(c(n2C)=O)C)=O
c12c(n(cn1)C)c(n(C)c(=O)n2C)=O
c12c(n(cn1)C)c(n(C)c(n2C)=O)=O
c12c(c(=O)n(c(=O)n2C)C)n(C)cn1
c12c(c(=O)n(c(=O)n2C)C)n(cn1)C
c12c(c(=O)n(c(n2C)=O)C)n(C)cn1
c12c(c(=O)n(c(n2C)=O)C)n(cn1)C
c12c(c(=O)n(C)c(=O)n2C)n(C)cn1
c12c(c(=O)n(C)c(=O)n2C)n(cn1)C
c12c(c(=O)n(C)c(n2C)=O)n(C)cn1
c12c(c(=O)n(C)c(n2C)=O)n(cn1)C
c12c(c(n(c(=O)n2C)C)=O)n(C)cn1
c12c(c(n(c(=O)n2C)C)=O)n(cn1)C
c12c(c(n(c(n2C)=O)C)=O)n(C)cn1
c12c(c(n(c(n2C)=O)C)=O)n(cn1)C
c12c(c(n(C)c(=O)n2C)=O)n(C)cn1
c12c(c(n(C)c(=O)n2C)=O)n(cn1)C
c12c(c(n(C)c(n2C)=O)=O)n(C)cn1
c12c(c(n(C)c(n2C)=O)=O)n(cn1)C
c12n(c(n(c(c2n(C)cn1)=O)C)=O)C
c12n(c(n(c(c2n(cn1)C)=O)C)=O)C
c12n(c(n(c(=O)c2n(C)cn1)C)=O)C
c12n(c(n(c(=O)c2n(cn1)C)C)=O)C
c12n(c(n(C)c(c2n(C)cn1)=O)=O)C
c12n(c(n(C)c(c2n(cn1)C)=O)=O)C
c12n(c(n(C)c(=O)c2n(C)cn1)=O)C
c12n(c(n(C)c(=O)c2n(cn1)C)=O)C
c12n(c(=O)n(c(c2n(C)cn1)=O)C)C
c12n(c(=O)n(c(c2n(cn1)C)=O)C)C
c12n(c(=O)n(c(=O)c2n(C)cn1)C)C
c12n(c(=O)n(c(=O)c2n(cn1)C)C)C
c12n(c(=O)n(C)c(c2n(C)cn1)=O)C
c12n(c(=O)n(C)c(c2n(cn1)C)=O)C
c12n(c(=O)n(C)c(=O)c2n(C)cn1)C
c12n(c(=O)n(C)c(=O)c2n(cn1)C)C
c12n(C)c(n(c(c2n(C)cn1)=O)C)=O
c12n(C)c(n(c(c2n(cn1)C)=O)C)=O
c12n(C)c(n(c(=O)c2n(C)cn1)C)=O
c12n(C)c(n(c(=O)c2n(cn1)C)C)=O
c12n(C)c(n(C)c(c2n(C)cn1)=O)=O
c12n(C)c(n(C)c(c2n(cn1)C)=O)=O
c12n(C)c(n(C)c(=O)c2n(C)cn1)=O
c12n(C)c(n(C)c(=O)c2n(cn1)C)=O
c12n(C)c(=O)n(c(c2n(C)cn1)=O)C
c12n(C)c(=O)n(c(c2n(cn1)C)=O)C
c12n(C)c(=O)n(c(=O)c2n(C)cn1)C
c12n(C)c(=O)n(c(=O)c2n(cn1)C)C
c12n(C)c(=O)n(C)c(c2n(C)cn1)=O
c12n(C)c(=O)n(C)c(c2n(cn1)C)=O
c12n(C)c(=O)n(C)c(=O)c2n(C)cn1
c12n(C)c(=O)n(C)c(=O)c2n(cn1)C
c1(n2C)c(n(C)cn1)c(=O)n(c2=O)C
c1(n2C)c(n(C)cn1)c(=O)n(C)c2=O
c1(n2C)c(n(C)cn1)c(n(c2=O)C)=O
c1(n2C)c(n(C)cn1)c(n(C)c2=O)=O
c1(n2C)c(n(cn1)C)c(=O)n(c2=O)C
c1(n2C)c(n(cn1)C)c(=O)n(C)c2=O
c1(n2C)c(n(cn1)C)c(n(c2=O)C)=O
c1(n2C)c(n(cn1)C)c(n(C)c2=O)=O
c1(n2C)c(c(=O)n(c2=O)C)n(C)cn1
c1(n2C)c(c(=O)n(c2=O)C)n(cn1)C
c1(n2C)c(c(=O)n(C)c2=O)n(C)cn1
c1(n2C)c(c(=O)n(C)c2=O)n(cn1)C
c1(n2C)c(c(n(c2=O)C)=O)n(C)cn1
c1(n2C)c(c(n(c2=O)C)=O)n(cn1)C
c1(n2C)c(c(n(C)c2=O)=O)n(C)cn1
c1(n2C)c(c(n(C)c2=O)=O)n(cn1)C
c1(n(c2=O)C)c(n(C)cn1)c(=O)n2C
c1(n(c2=O)C)c(n(C)cn1)c(n2C)=O
c1(n(c2=O)C)c(n(cn1)C)c(=O)n2C
c1(n(c2=O)C)c(n(cn1)C)c(n2C)=O
c1(n(c2=O)C)c(c(=O)n2C)n(C)cn1
c1(n(c2=O)C)c(c(=O)n2C)n(cn1)C
c1(n(c2=O)C)c(c(n2C)=O)n(C)cn1
c1(n(c2=O)C)c(c(n2C)=O)n(cn1)C
c1(n(c(n2C)=O)C)c(n(C)cn1)c2=O
c1(n(c(n2C)=O)C)c(n(cn1)C)c2=O
c1(n(c(n2C)=O)C)c(c2=O)n(C)cn1
c1(n(c(n2C)=O)C)c(c2=O)n(cn1)C
c1(n(c(n(c2=O)C)=O)C)c2n(C)cn1
c1(n(c(n(c2=O)C)=O)C)c2n(cn1)C
c1(n(c(n(C)c2=O)=O)C)c2n(C)cn1
c1(n(c(n(C)c2=O)=O)C)c2n(cn1)C
c1(n(c(=O)n2C)C)c(n(C)cn1)c2=O
c1(n(c(=O)n2C)C)c(n(cn1)C)c2=O
c1(n(c(=O)n2C)C)c(c2=O)n(C)cn1
c1(n(c(=O)n2C)C)c(c2=O)n(cn1)C
c1(n(c(=O)n(c2=O)C)C)c2n(C)cn1
c1(n(c(=O)n(c2=O)C)C)c2n(cn1)C
c1(n(c(=O)n(C)c2=O)C)c2n(C)cn1
c1(n(c(=O)n(C)c2=O)C)c2n(cn1)C
c1(n(C)c2=O)c(n(C)cn1)c(=O)n2C
c1(n(C)c2=O)c(n(C)cn1)c(n2C)=O
c1(n(C)c2=O)c(n(cn1)C)c(=O)n2C
c1(n(C)c2=O)c(n(cn1)C)c(n2C)=O
c1(n(C)c2=O)c(c(=O)n2C)n(C)cn1
c1(n(C)c2=O)c(c(=O)n2C)n(cn1)C
c1(n(C)c2=O)c(c(n2C)=O)n(C)cn1
c1(n(C)c2=O)c(c(n2C)=O)n(cn1)C
c1(n(C)c(n2C)=O)c(n(C)cn1)c2=O
c1(n(C)c(n2C)=O)c(n(cn1)C)c2=O
c1(n(C)c(n2C)=O)c(c2=O)n(C)cn1
c1(n(C)c(n2C)=O)c(c2=O)n(cn1)C
c1(n(C)c(n(c2=O)C)=O)c2n(C)cn1
c1(n(C)c(n(c2=O)C)=O)c2n(cn1)C
c1(n(C)c(n(C)c2=O)=O)c2n(C)cn1
c1(n(C)c(n(C)c2=O)=O)c2n(cn1)C
c1(n(C)c(=O)n2C)c(n(C)cn1)c2=O
c1(n(C)c(=O)n2C)c(n(cn1)C)c2=O
c1(n(C)c(=O)n2C)c(c2=O)n(C)cn1
c1(n(C)c(=O)n2C)c(c2=O)n(cn1)C
c1(n(C)c(=O)n(c2=O)C)c2n(C)cn1
c1(n(C)c(=O)n(c2=O)C)c2n(cn1)C
c1(n(C)c(=O)n(C)c2=O)c2n(C)cn1
c1(n(C)c(=O)n(C)c2=O)c2n(cn1)C
c1(c2n(C)cn1)n(c(n(c2=O)C)=O)C
c1(c2n(C)cn1)n(c(n(C)c2=O)=O)C
c1(c2n(C)cn1)n(c(=O)n(c2=O)C)C
c1(c2n(C)cn1)n(c(=O)n(C)c2=O)C
c1(c2n(C)cn1)n(C)c(n(c2=O)C)=O
c1(c2n(C)cn1)n(C)c(n(C)c2=O)=O
c1(c2n(C)cn1)n(C)c(=O)n(c2=O)C
c1(c2n(C)cn1)n(C)c(=O)n(C)c2=O
c1(c2n(cn1)C)n(c(n(c2=O)C)=O)C
c1(c2n(cn1)C)n(c(n(C)c2=O)=O)C
c1(c2n(cn1)C)n(c(=O)n(c2=O)C)C
c1(c2n(cn1)C)n(c(=O)n(C)c2=O)C
c1(c2n(cn1)C)n(C)c(n(c2=O)C)=O
c1(c2n(cn1)C)n(C)c(n(C)c2=O)=O
c1(c2n(cn1)C)n(C)c(=O)n(c2=O)C
c1(c2n(cn1)C)n(C)c(=O)n(C)c2=O
c1(c(n(C)cn1)c2=O)n(c(n2C)=O)C
c1(c(n(C)cn1)c2=O)n(c(=O)n2C)C
c1(c(n(C)cn1)c2=O)n(C)c(n2C)=O
c1(c(n(C)cn1)c2=O)n(C)c(=O)n2C
c1(c(n(C)cn1)c(=O)n2C)n(c2=O)C
c1(c(n(C)cn1)c(=O)n2C)n(C)c2=O
c1(c(n(C)cn1)c(=O)n(c2=O)C)n2C
c1(c(n(C)cn1)c(=O)n(C)c2=O)n2C
c1(c(n(C)cn1)c(n2C)=O)n(c2=O)C
c1(c(n(C)cn1)c(n2C)=O)n(C)c2=O
c1(c(n(C)cn1)c(n(c2=O)C)=O)n2C
c1(c(n(C)cn1)c(n(C)c2=O)=O)n2C
c1(c(n(cn1)C)c2=O)n(c(n2C)=O)C
c1(c(n(cn1)C)c2=O)n(c(=O)n2C)C
c1(c(n(cn1)C)c2=O)n(C)c(n2C)=O
c1(c(n(cn1)C)c2=O)n(C)c(=O)n2C
c1(c(n(cn1)C)c(=O)n2C)n(c2=O)C
c1(c(n(cn1)C)c(=O)n2C)n(C)c2=O
c1(c(n(cn1)C)c(=O)n(c2=O)C)n2C
c1(c(n(cn1)C)c(=O)n(C)c2=O)n2C
c1(c(n(cn1)C)c(n2C)=O)n(c2=O)C
c1(c(n(cn1)C)c(n2C)=O)n(C)c2=O
c1(c(n(cn1)C)c(n(c2=O)C)=O)n2C
c1(c(n(cn1)C)c(n(C)c2=O)=O)n2C
c1(c(c2=O)n(C)cn1)n(c(n2C)=O)C
c1(c(c2=O)n(C)cn1)n(c(=O)n2C)C
c1(c(c2=O)n(C)cn1)n(C)c(n2C)=O
c1(c(c2=O)n(C)cn1)n(C)c(=O)n2C
c1(c(c2=O)n(cn1)C)n(c(n2C)=O)C
c1(c(c2=O)n(cn1)C)n(c(=O)n2C)C
c1(c(c2=O)n(cn1)C)n(C)c(n2C)=O
c1(c(c2=O)n(cn1)C)n(C)c(=O)n2C
c1(c(c(=O)n2C)n(C)cn1)n(c2=O)C
c1(c(c(=O)n2C)n(C)cn1)n(C)c2=O
c1(c(c(=O)n2C)n(cn1)C)n(c2=O)C
c1(c(c(=O)n2C)n(cn1)C)n(C)c2=O
c1(c(c(=O)n(c2=O)C)n(C)cn1)n2C
c1(c(c(=O)n(c2=O)C)n(cn1)C)n2C
c1(c(c(=O)n(C)c2=O)n(C)cn1)n2C
c1(c(c(=O)n(C)c2=O)n(cn1)C)n2C
c1(c(c(n2C)=O)n(C)cn1)n(c2=O)C
c1(c(c(n2C)=O)n(C)cn1)n(C)c2=O
c1(c(c(n2C)=O)n(cn1)C)n(c2=O)C
c1(c(c(n2C)=O)n(cn1)C)n(C)c2=O
c1(c(c(n(c2=O)C)=O)n(C)cn1)n2C
c1(c(c(n(c2=O)C)=O)n(cn1)C)n2C
c1(c(c(n(C)c2=O)=O)n(C)cn1)n2C
c1(c(c(n(C)c2=O)=O)n(cn1)C)n2C
c12c(n(C)cn2)c(=O)n(c(=O)n1C)C
c12c(n(C)cn2)c(=O)n(c(n1C)=O)C
c12c(n(C)cn2)c(=O)n(C)c(=O)n1C
c12c(n(C)cn2)c(=O)n(C)c(n1C)=O
c12c(n(C)cn2)c(n(c(=O)n1C)C)=O
c12c(n(C)cn2)c(n(c(n1C)=O)C)=O
c12c(n(C)cn2)c(n(C)c(=O)n1C)=O
c12c(n(C)cn2)c(n(C)c(n1C)=O)=O
c12c(n(cn2)C)c(=O)n(c(=O)n1C)C
c12c(n(cn2)C)c(=O)n(c(n1C)=O)C
c12c(n(cn2)C)c(=O)n(C)c(=O)n1C
c12c(n(cn2)C)c(=O)n(C)c(n1C)=O
c12c(n(cn2)C)c(n(c(=O)n1C)C)=O
c12c(n(cn2)C)c(n(c(n1C)=O)C)=O
c12c(n(cn2)C)c(n(C)c(=O)n1C)=O
c12c(n(cn2)C)c(n(C)c(n1C)=O)=O
c12c(c(=O)n(c(=O)n1C)C)n(C)cn2
c12c(c(=O)n(c(=O)n1C)C)n(cn2)C
c12c(c(=O)n(c(n1C)=O)C)n(C)cn2
c12c(c(=O)n(c(n1C)=O)C)n(cn2)C
c12c(c(=O)n(C)c(=O)n1C)n(C)cn2
c12c(c(=O)n(C)c(=O)n1C)n(cn2)C
c12c(c(=O)n(C)c(n1C)=O)n(C)cn2
c12c(c(=O)n(C)c(n1C)=O)n(cn2)C
c12c(c(n(c(=O)n1C)C)=O)n(C)cn2
c12c(c(n(c(=O)n1C)C)=O)n(cn2)C
c12c(c(n(c(n1C)=O)C)=O)n(C)cn2
c12c(c(n(c(n1C)=O)C)=O)n(cn2)C
c12c(c(n(C)c(=O)n1C)=O)n(C)cn2
c12c(c(n(C)c(=O)n1C)=O)n(cn2)C
c12c(c(n(C)c(n1C)=O)=O)n(C)cn2
c12c(c(n(C)c(n1C)=O)=O)n(cn2)C
c12ncn(C)c2c(=O)n(c(=O)n1C)C
c12ncn(C)c2c(=O)n(c(n1C)=O)C
c12ncn(C)c2c(=O)n(C)c(=O)n1C
c12ncn(C)c2c(=O)n(C)c(n1C)=O
c12ncn(C)c2c(n(c(=O)n1C)C)=O
c12ncn(C)c2c(n(c(n1C)=O)C)=O
c12ncn(C)c2c(n(C)c(=O)n1C)=O
c12ncn(C)c2c(n(C)c(n1C)=O)=O
c12ncn(c2c(=O)n(c(=O)n1C)C)C
c12ncn(c2c(=O)n(c(n1C)=O)C)C
c12ncn(c2c(=O)n(C)c(=O)n1C)C
c12ncn(c2c(=O)n(C)c(n1C)=O)C
c12ncn(c2c(n(c(=O)n1C)C)=O)C
c12ncn(c2c(n(c(n1C)=O)C)=O)C
c12ncn(c2c(n(C)c(=O)n1C)=O)C
c12ncn(c2c(n(C)c(n1C)=O)=O)C
c1(ncn2C)c2c(=O)n(c(=O)n1C)C
c1(ncn2C)c2c(=O)n(c(n1C)=O)C
c1(ncn2C)c2c(=O)n(C)c(=O)n1C
c1(ncn2C)c2c(=O)n(C)c(n1C)=O
c1(ncn2C)c2c(n(c(=O)n1C)C)=O
c1(ncn2C)c2c(n(c(n1C)=O)C)=O
c1(ncn2C)c2c(n(C)c(=O)n1C)=O
c1(ncn2C)c2c(n(C)c(n1C)=O)=O
c1(c2c(=O)n(c(=O)n1C)C)ncn2C
c1(c2c(=O)n(c(n1C)=O)C)ncn2C
c1(c2c(=O)n(C)c(=O)n1C)ncn2C
c1(c2c(=O)n(C)c(n1C)=O)ncn2C
c1(c2c(n(c(=O)n1C)C)=O)ncn2C
c1(c2c(n(c(n1C)=O)C)=O)ncn2C
c1(c2c(n(C)c(=O)n1C)=O)ncn2C
c1(c2c(n(C)c(n1C)=O)=O)ncn2C
c1(c(n2C)c(=O)n(c(=O)n1C)C)nc2
c1(c(n2C)c(=O)n(c(n1C)=O)C)nc2
c1(c(n2C)c(=O)n(C)c(=O)n1C)nc2
c1(c(n2C)c(=O)n(C)c(n1C)=O)nc2
c1(c(n2C)c(n(c(=O)n1C)C)=O)nc2
c1(c(n2C)c(n(c(n1C)=O)C)=O)nc2
c1(c(n2C)c(n(C)c(=O)n1C)=O)nc2
c1(c(n2C)c(n(C)c(n1C)=O)=O)nc2
c1(c(c(=O)n(c(=O)n1C)C)n2C)nc2
c1(c(c(=O)n(c(n1C)=O)C)n2C)nc2
c1(c(c(=O)n(C)c(=O)n1C)n2C)nc2
c1(c(c(=O)n(C)c(n1C)=O)n2C)nc2
c1(c(c(n(c(=O)n1C)C)=O)n2C)nc2
c1(c(c(n(c(n1C)=O)C)=O)n2C)nc2
c1(c(c(n(C)c(=O)n1C)=O)n2C)nc2
c1(c(c(n(C)c(n1C)=O)=O)n2C)nc2
c12n(c(n(c(c1n(C)cn2)=O)C)=O)C
c12n(c(n(c(c1n(cn2)C)=O)C)=O)C
c12n(c(n(c(=O)c1n(C)cn2)C)=O)C
c12n(c(n(c(=O)c1n(cn2)C)C)=O)C
c12n(c(n(C)c(c1n(C)cn2)=O)=O)C
c12n(c(n(C)c(c1n(cn2)C)=O)=O)C
c12n(c(n(C)c(=O)c1n(C)cn2)=O)C
c12n(c(n(C)c(=O)c1n(cn2)C)=O)C
c12n(c(=O)n(c(c1n(C)cn2)=O)C)C
c12n(c(=O)n(c(c1n(cn2)C)=O)C)C
c12n(c(=O)n(c(=O)c1n(C)cn2)C)C
c12n(c(=O)n(c(=O)c1n(cn2)C)C)C
c12n(c(=O)n(C)c(c1n(C)cn2)=O)C
c12n(c(=O)n(C)c(c1n(cn2)C)=O)C
c12n(c(=O)n(C)c(=O)c1n(C)cn2)C
c12n(c(=O)n(C)c(=O)c1n(cn2)C)C
c12n(C)c(n(c(c1n(C)cn2)=O)C)=O
c12n(C)c(n(c(c1n(cn2)C)=O)C)=O
c12n(C)c(n(c(=O)c1n(C)cn2)C)=O
c12n(C)c(n(c(=O)c1n(cn2)C)C)=O
c12n(C)c(n(C)c(c1n(C)cn2)=O)=O
c12n(C)c(n(C)c(c1n(cn2)C)=O)=O
c12n(C)c(n(C)c(=O)c1n(C)cn2)=O
c12n(C)c(n(C)c(=O)c1n(cn2)C)=O
c12n(C)c(=O)n(c(c1n(C)cn2)=O)C
c12n(C)c(=O)n(c(c1n(cn2)C)=O)C
c12n(C)c(=O)n(c(=O)c1n(C)cn2)C
c12n(C)c(=O)n(c(=O)c1n(cn2)C)C
c12n(C)c(=O)n(C)c(c1n(C)cn2)=O
c12n(C)c(=O)n(C)c(c1n(cn2)C)=O
c12n(C)c(=O)n(C)c(=O)c1n(C)cn2
c12n(C)c(=O)n(C)c(=O)c1n(cn2)C
c12ncn(C)c1c(=O)n(c(=O)n2C)C
c12ncn(C)c1c(=O)n(c(n2C)=O)C
c12ncn(C)c1c(=O)n(C)c(=O)n2C
c12ncn(C)c1c(=O)n(C)c(n2C)=O
c12ncn(C)c1c(n(c(=O)n2C)C)=O
c12ncn(C)c1c(n(c(n2C)=O)C)=O
c12ncn(C)c1c(n(C)c(=O)n2C)=O
c12ncn(C)c1c(n(C)c(n2C)=O)=O
c12ncn(c1c(=O)n(c(=O)n2C)C)C
c12ncn(c1c(=O)n(c(n2C)=O)C)C
c12ncn(c1c(=O)n(C)c(=O)n2C)C
c12ncn(c1c(=O)n(C)c(n2C)=O)C
c12ncn(c1c(n(c(=O)n2C)C)=O)C
c12ncn(c1c(n(c(n2C)=O)C)=O)C
c12ncn(c1c(n(C)c(=O)n2C)=O)C
c12ncn(c1c(n(C)c(n2C)=O)=O)C
c1(ncn2C)n(c(n(c(c21)=O)C)=O)C
c1(ncn2C)n(c(n(c(c12)=O)C)=O)C
c1(ncn2C)n(c(n(c(=O)c21)C)=O)C
c1(ncn2C)n(c(n(c(=O)c12)C)=O)C
c1(ncn2C)n(c(n(C)c(c21)=O)=O)C
c1(ncn2C)n(c(n(C)c(c12)=O)=O)C
c1(ncn2C)n(c(n(C)c(=O)c21)=O)C
c1(ncn2C)n(c(n(C)c(=O)c12)=O)C
c1(ncn2C)n(c(=O)n(c(c21)=O)C)C
c1(ncn2C)n(c(=O)n(c(c12)=O)C)C
c1(ncn2C)n(c(=O)n(c(=O)c21)C)C
c1(ncn2C)n(c(=O)n(c(=O)c12)C)C
c1(ncn2C)n(c(=O)n(C)c(c21)=O)C
c1(ncn2C)n(c(=O)n(C)c(c12)=O)C
c1(ncn2C)n(c(=O)n(C)c(=O)c21)C
c1(ncn2C)n(c(=O)n(C)c(=O)c12)C
c1(ncn2C)n(C)c(n(c(c21)=O)C)=O
c1(ncn2C)n(C)c(n(c(c12)=O)C)=O
c1(ncn2C)n(C)c(n(c(=O)c21)C)=O
c1(ncn2C)n(C)c(n(c(=O)c12)C)=O
c1(ncn2C)n(C)c(n(C)c(c21)=O)=O
c1(ncn2C)n(C)c(n(C)c(c12)=O)=O
c1(ncn2C)n(C)c(n(C)c(=O)c21)=O
c1(ncn2C)n(C)c(n(C)c(=O)c12)=O
c1(ncn2C)n(C)c(=O)n(c(c21)=O)C
c1(ncn2C)n(C)c(=O)n(c(c12)=O)C
c1(ncn2C)n(C)c(=O)n(c(=O)c21)C
c1(ncn2C)n(C)c(=O)n(c(=O)c12)C
c1(ncn2C)n(C)c(=O)n(C)c(c21)=O
c1(ncn2C)n(C)c(=O)n(C)c(c12)=O
c1(ncn2C)n(C)c(=O)n(C)c(=O)c21
c1(ncn2C)n(C)c(=O)n(C)c(=O)c12
c1(ncn(C)c1c2=O)n(c(n2C)=O)C
c1(ncn(C)c1c2=O)n(c(=O)n2C)C
c1(ncn(C)c1c2=O)n(C)c(n2C)=O
c1(ncn(C)c1c2=O)n(C)c(=O)n2C
c1(ncn(C)c1c(=O)n2C)n(c2=O)C
c1(ncn(C)c1c(=O)n2C)n(C)c2=O
c1(ncn(C)c1c(=O)n(c2=O)C)n2C
c1(ncn(C)c1c(=O)n(C)c2=O)n2C
c1(ncn(C)c1c(n2C)=O)n(c2=O)C
c1(ncn(C)c1c(n2C)=O)n(C)c2=O
c1(ncn(C)c1c(n(c2=O)C)=O)n2C
c1(ncn(C)c1c(n(C)c2=O)=O)n2C
c1(ncn(c1c2=O)C)n(c(n2C)=O)C
c1(ncn(c1c2=O)C)n(c(=O)n2C)C
c1(ncn(c1c2=O)C)n(C)c(n2C)=O
c1(ncn(c1c2=O)C)n(C)c(=O)n2C
c1(ncn(c1c(=O)n2C)C)n(c2=O)C
c1(ncn(c1c(=O)n2C)C)n(C)c2=O
c1(ncn(c1c(=O)n(c2=O)C)C)n2C
c1(ncn(c1c(=O)n(C)c2=O)C)n2C
c1(ncn(c1c(n2C)=O)C)n(c2=O)C
c1(ncn(c1c(n2C)=O)C)n(C)c2=O
c1(ncn(c1c(n(c2=O)C)=O)C)n2C
c1(ncn(c1c(n(C)c2=O)=O)C)n2C
c1(n2C)ncn(C)c1c(=O)n(c2=O)C
c1(n2C)ncn(C)c1c(=O)n(C)c2=O
c1(n2C)ncn(C)c1c(n(c2=O)C)=O
c1(n2C)ncn(C)c1c(n(C)c2=O)=O
c1(n2C)ncn(c1c(=O)n(c2=O)C)C
c1(n2C)ncn(c1c(=O)n(C)c2=O)C
c1(n2C)ncn(c1c(n(c2=O)C)=O)C
c1(n2C)ncn(c1c(n(C)c2=O)=O)C
c1(n(c2=O)C)ncn(C)c1c(=O)n2C
c1(n(c2=O)C)ncn(C)c1c(n2C)=O
c1(n(c2=O)C)ncn(c1c(=O)n2C)C
c1(n(c2=O)C)ncn(c1c(n2C)=O)C
c1(n(c(n2C)=O)C)ncn(C)c1c2=O
c1(n(c(n2C)=O)C)ncn(c1c2=O)C
c1(n(c(n(c2=O)C)=O)C)ncn(C)c12
c1(n(c(n(c2=O)C)=O)C)ncn(C)c21
c1(n(c(n(c2=O)C)=O)C)ncn(c12)C
c1(n(c(n(c2=O)C)=O)C)ncn(c21)C
c1(n(c(n(c(c1n2C)=O)C)=O)C)nc2
c1(n(c(n(c(=O)c1n2C)C)=O)C)nc2
c1(n(c(n(C)c2=O)=O)C)ncn(C)c12
c1(n(c(n(C)c2=O)=O)C)ncn(C)c21
c1(n(c(n(C)c2=O)=O)C)ncn(c12)C
c1(n(c(n(C)c2=O)=O)C)ncn(c21)C
c1(n(c(n(C)c(c1n2C)=O)=O)C)nc2
c1(n(c(n(C)c(=O)c1n2C)=O)C)nc2
c1(n(c(=O)n2C)C)ncn(C)c1c2=O
c1(n(c(=O)n2C)C)ncn(c1c2=O)C
c1(n(c(=O)n(c2=O)C)C)ncn(C)c12
c1(n(c(=O)n(c2=O)C)C)ncn(C)c21
c1(n(c(=O)n(c2=O)C)C)ncn(c12)C
c1(n(c(=O)n(c2=O)C)C)ncn(c21)C
c1(n(c(=O)n(c(c1n2C)=O)C)C)nc2
c1(n(c(=O)n(c(=O)c1n2C)C)C)nc2
c1(n(c(=O)n(C)c2=O)C)ncn(C)c12
c1(n(c(=O)n(C)c2=O)C)ncn(C)c21
c1(n(c(=O)n(C)c2=O)C)ncn(c12)C
c1(n(c(=O)n(C)c2=O)C)ncn(c21)C
c1(n(c(=O)n(C)c(c1n2C)=O)C)nc2
c1(n(c(=O)n(C)c(=O)c1n2C)C)nc2
c1(n(C)c2=O)ncn(C)c1c(=O)n2C
c1(n(C)c2=O)ncn(C)c1c(n2C)=O
c1(n(C)c2=O)ncn(c1c(=O)n2C)C
c1(n(C)c2=O)ncn(c1c(n2C)=O)C
c1(n(C)c(n2C)=O)ncn(C)c1c2=O
c1(n(C)c(n2C)=O)ncn(c1c2=O)C
c1(n(C)c(n(c2=O)C)=O)ncn(C)c12
c1(n(C)c(n(c2=O)C)=O)ncn(C)c21
c1(n(C)c(n(c2=O)C)=O)ncn(c12)C
c1(n(C)c(n(c2=O)C)=O)ncn(c21)C
c1(n(C)c(n(c(c1n2C)=O)C)=O)nc2
c1(n(C)c(n(c(=O)c1n2C)C)=O)nc2
c1(n(C)c(n(C)c2=O)=O)ncn(C)c12
c1(n(C)c(n(C)c2=O)=O)ncn(C)c21
c1(n(C)c(n(C)c2=O)=O)ncn(c12)C
c1(n(C)c(n(C)c2=O)=O)ncn(c21)C
c1(n(C)c(n(C)c(c1n2C)=O)=O)nc2
c1(n(C)c(n(C)c(=O)c1n2C)=O)nc2
c1(n(C)c(=O)n2C)ncn(C)c1c2=O
c1(n(C)c(=O)n2C)ncn(c1c2=O)C
c1(n(C)c(=O)n(c2=O)C)ncn(C)c12
c1(n(C)c(=O)n(c2=O)C)ncn(C)c21
c1(n(C)c(=O)n(c2=O)C)ncn(c12)C
c1(n(C)c(=O)n(c2=O)C)ncn(c21)C
c1(n(C)c(=O)n(c(c1n2C)=O)C)nc2
c1(n(C)c(=O)n(c(=O)c1n2C)C)nc2
c1(n(C)c(=O)n(C)c2=O)ncn(C)c12
c1(n(C)c(=O)n(C)c2=O)ncn(C)c21
c1(n(C)c(=O)n(C)c2=O)ncn(c12)C
c1(n(C)c(=O)n(C)c2=O)ncn(c21)C
c1(n(C)c(=O)n(C)c(c1n2C)=O)nc2
c1(n(C)c(=O)n(C)c(=O)c1n2C)nc2
c12c(=O)n(c(=O)n(c2ncn1C)C)C
c12c(=O)n(c(=O)n(C)c2ncn1C)C
c12c(=O)n(c(n(c2ncn1C)C)=O)C
c12c(=O)n(c(n(C)c2ncn1C)=O)C
c12c(=O)n(C)c(=O)n(c2ncn1C)C
c12c(=O)n(C)c(=O)n(C)c2ncn1C
c12c(=O)n(C)c(n(c2ncn1C)C)=O
c12c(=O)n(C)c(n(C)c2ncn1C)=O
c12c(n(c(=O)n(c2ncn1C)C)C)=O
c12c(n(c(=O)n(C)c2ncn1C)C)=O
c12c(n(c(n(c2ncn1C)C)=O)C)=O
c12c(n(c(n(C)c2ncn1C)=O)C)=O
c12c(n(C)c(=O)n(c2ncn1C)C)=O
c12c(n(C)c(=O)n(C)c2ncn1C)=O
c12c(n(C)c(n(c2ncn1C)C)=O)=O
c12c(n(C)c(n(C)c2ncn1C)=O)=O
c12c(ncn1C)n(c(n(c2=O)C)=O)C
c12c(ncn1C)n(c(n(C)c2=O)=O)C
c12c(ncn1C)n(c(=O)n(c2=O)C)C
c12c(ncn1C)n(c(=O)n(C)c2=O)C
c12c(ncn1C)n(C)c(n(c2=O)C)=O
c12c(ncn1C)n(C)c(n(C)c2=O)=O
c12c(ncn1C)n(C)c(=O)n(c2=O)C
c12c(ncn1C)n(C)c(=O)n(C)c2=O
c12c(n(c(n(c2=O)C)=O)C)ncn1C
c12c(n(c(n(C)c2=O)=O)C)ncn1C
c12c(n(c(=O)n(c2=O)C)C)ncn1C
c12c(n(c(=O)n(C)c2=O)C)ncn1C
c12c(n(C)c(n(c2=O)C)=O)ncn1C
c12c(n(C)c(n(C)c2=O)=O)ncn1C
c12c(n(C)c(=O)n(c2=O)C)ncn1C
c12c(n(C)c(=O)n(C)c2=O)ncn1C
c1(c2ncn1C)c(=O)n(c(=O)n2C)C
c1(c2ncn1C)c(=O)n(c(n2C)=O)C
c1(c2ncn1C)c(=O)n(C)c(=O)n2C
c1(c2ncn1C)c(=O)n(C)c(n2C)=O
c1(c2ncn1C)c(n(c(=O)n2C)C)=O
c1(c2ncn1C)c(n(c(n2C)=O)C)=O
c1(c2ncn1C)c(n(C)c(=O)n2C)=O
c1(c2ncn1C)c(n(C)c(n2C)=O)=O
c1(c(ncn1C)n2C)c(=O)n(c2=O)C
c1(c(ncn1C)n2C)c(=O)n(C)c2=O
c1(c(ncn1C)n2C)c(n(c2=O)C)=O
c1(c(ncn1C)n2C)c(n(C)c2=O)=O
c1(c(ncn1C)n(c2=O)C)c(=O)n2C
c1(c(ncn1C)n(c2=O)C)c(n2C)=O
c1(c(ncn1C)n(c(n2C)=O)C)c2=O
c1(c(ncn1C)n(c(=O)n2C)C)c2=O
c1(c(ncn1C)n(C)c2=O)c(=O)n2C
c1(c(ncn1C)n(C)c2=O)c(n2C)=O
c1(c(ncn1C)n(C)c(n2C)=O)c2=O
c1(c(ncn1C)n(C)c(=O)n2C)c2=O
c1(c(n2C)ncn1C)c(=O)n(c2=O)C
c1(c(n2C)ncn1C)c(=O)n(C)c2=O
c1(c(n2C)ncn1C)c(n(c2=O)C)=O
c1(c(n2C)ncn1C)c(n(C)c2=O)=O
c1(c(n(c2=O)C)ncn1C)c(=O)n2C
c1(c(n(c2=O)C)ncn1C)c(n2C)=O
c1(c(n(c(n2C)=O)C)ncn1C)c2=O
c1(c(n(c(=O)n2C)C)ncn1C)c2=O
c1(c(n(C)c2=O)ncn1C)c(=O)n2C
c1(c(n(C)c2=O)ncn1C)c(n2C)=O
c1(c(n(C)c(n2C)=O)ncn1C)c2=O
c1(c(n(C)c(=O)n2C)ncn1C)c2=O
c1(c2=O)c(ncn1C)n(c(n2C)=O)C
c1(c2=O)c(ncn1C)n(c(=O)n2C)C
c1(c2=O)c(ncn1C)n(C)c(n2C)=O
c1(c2=O)c(ncn1C)n(C)c(=O)n2C
c1(c2=O)c(n(c(n2C)=O)C)ncn1C
c1(c2=O)c(n(c(=O)n2C)C)ncn1C
c1(c2=O)c(n(C)c(n2C)=O)ncn1C
c1(c2=O)c(n(C)c(=O)n2C)ncn1C
c1(c(=O)n2C)c(ncn1C)n(c2=O)C
c1(c(=O)n2C)c(ncn1C)n(C)c2=O
c1(c(=O)n2C)c(n(c2=O)C)ncn1C
c1(c(=O)n2C)c(n(C)c2=O)ncn1C
c1(c(=O)n(c2=O)C)c(ncn1C)n2C
c1(c(=O)n(c2=O)C)c(n2C)ncn1C
c1(c(=O)n(c(=O)n2C)C)c2ncn1C
c1(c(=O)n(c(n2C)=O)C)c2ncn1C
c1(c(=O)n(C)c2=O)c(ncn1C)n2C
c1(c(=O)n(C)c2=O)c(n2C)ncn1C
c1(c(=O)n(C)c(=O)n2C)c2ncn1C
c1(c(=O)n(C)c(n2C)=O)c2ncn1C
c1(c(n2C)=O)c(ncn1C)n(c2=O)C
c1(c(n2C)=O)c(ncn1C)n(C)c2=O
c1(c(n2C)=O)c(n(c2=O)C)ncn1C
c1(c(n2C)=O)c(n(C)c2=O)ncn1C
c1(c(n(c2=O)C)=O)c(ncn1C)n2C
c1(c(n(c2=O)C)=O)c(n2C)ncn1C
c1(c(n(c(=O)n2C)C)=O)c2ncn1C
c1(c(n(c(n2C)=O)C)=O)c2ncn1C
c1(c(n(C)c2=O)=O)c(ncn1C)n2C
c1(c(n(C)c2=O)=O)c(n2C)ncn1C
c1(c(n(C)c(=O)n2C)=O)c2ncn1C
c1(c(n(C)c(n2C)=O)=O)c2ncn1C
c12c(=O)n(c(=O)n(c1ncn2C)C)C
c12c(=O)n(c(=O)n(C)c1ncn2C)C
c12c(=O)n(c(n(c1ncn2C)C)=O)C
c12c(=O)n(c(n(C)c1ncn2C)=O)C
c12c(=O)n(C)c(=O)n(c1ncn2C)C
c12c(=O)n(C)c(=O)n(C)c1ncn2C
c12c(=O)n(C)c(n(c1ncn2C)C)=O
c12c(=O)n(C)c(n(C)c1ncn2C)=O
c12c(n(c(=O)n(c1ncn2C)C)C)=O
c12c(n(c(=O)n(C)c1ncn2C)C)=O
c12c(n(c(n(c1ncn2C)C)=O)C)=O
c12c(n(c(n(C)c1ncn2C)=O)C)=O
c12c(n(C)c(=O)n(c1ncn2C)C)=O
c12c(n(C)c(=O)n(C)c1ncn2C)=O
c12c(n(C)c(n(c1ncn2C)C)=O)=O
c12c(n(C)c(n(C)c1ncn2C)=O)=O
c12n(C)cnc1n(c(n(c2=O)C)=O)C
c12n(C)cnc1n(c(n(C)c2=O)=O)C
c12n(C)cnc1n(c(=O)n(c2=O)C)C
c12n(C)cnc1n(c(=O)n(C)c2=O)C
c12n(C)cnc1n(C)c(n(c2=O)C)=O
c12n(C)cnc1n(C)c(n(C)c2=O)=O
c12n(C)cnc1n(C)c(=O)n(c2=O)C
c12n(C)cnc1n(C)c(=O)n(C)c2=O
c12n(cnc1n(c(n(c2=O)C)=O)C)C
c12n(cnc1n(c(n(C)c2=O)=O)C)C
c12n(cnc1n(c(=O)n(c2=O)C)C)C
c12n(cnc1n(c(=O)n(C)c2=O)C)C
c12n(cnc1n(C)c(n(c2=O)C)=O)C
c12n(cnc1n(C)c(n(C)c2=O)=O)C
c12n(cnc1n(C)c(=O)n(c2=O)C)C
c12n(cnc1n(C)c(=O)n(C)c2=O)C
c1(n2C)c(=O)n(c(=O)n(c1nc2)C)C
c1(n2C)c(=O)n(c(=O)n(C)c1nc2)C
c1(n2C)c(=O)n(c(n(c1nc2)C)=O)C
c1(n2C)c(=O)n(c(n(C)c1nc2)=O)C
c1(n2C)c(=O)n(C)c(=O)n(c1nc2)C
c1(n2C)c(=O)n(C)c(=O)n(C)c1nc2
c1(n2C)c(=O)n(C)c(n(c1nc2)C)=O
c1(n2C)c(=O)n(C)c(n(C)c1nc2)=O
c1(n2C)c(n(c(=O)n(c1nc2)C)C)=O
c1(n2C)c(n(c(=O)n(C)c1nc2)C)=O
c1(n2C)c(n(c(n(c1nc2)C)=O)C)=O
c1(n2C)c(n(c(n(C)c1nc2)=O)C)=O
c1(n2C)c(n(C)c(=O)n(c1nc2)C)=O
c1(n2C)c(n(C)c(=O)n(C)c1nc2)=O
c1(n2C)c(n(C)c(n(c1nc2)C)=O)=O
c1(n2C)c(n(C)c(n(C)c1nc2)=O)=O
c1(n(C)cnc1n2C)c(=O)n(c2=O)C
c1(n(C)cnc1n2C)c(=O)n(C)c2=O
c1(n(C)cnc1n2C)c(n(c2=O)C)=O
c1(n(C)cnc1n2C)c(n(C)c2=O)=O
c1(n(C)cnc1n(c2=O)C)c(=O)n2C
c1(n(C)cnc1n(c2=O)C)c(n2C)=O
c1(n(C)cnc1n(c(n2C)=O)C)c2=O
c1(n(C)cnc1n(c(=O)n2C)C)c2=O
c1(n(C)cnc1n(C)c2=O)c(=O)n2C
c1(n(C)cnc1n(C)c2=O)c(n2C)=O
c1(n(C)cnc1n(C)c(n2C)=O)c2=O
c1(n(C)cnc1n(C)c(=O)n2C)c2=O
c1(n(cnc1n2C)C)c(=O)n(c2=O)C
c1(n(cnc1n2C)C)c(=O)n(C)c2=O
c1(n(cnc1n2C)C)c(n(c2=O)C)=O
c1(n(cnc1n2C)C)c(n(C)c2=O)=O
c1(n(cnc1n(c2=O)C)C)c(=O)n2C
c1(n(cnc1n(c2=O)C)C)c(n2C)=O
c1(n(cnc1n(c(n2C)=O)C)C)c2=O
c1(n(cnc1n(c(=O)n2C)C)C)c2=O
c1(n(cnc1n(C)c2=O)C)c(=O)n2C
c1(n(cnc1n(C)c2=O)C)c(n2C)=O
c1(n(cnc1n(C)c(n2C)=O)C)c2=O
c1(n(cnc1n(C)c(=O)n2C)C)c2=O
c1(c2=O)n(C)cnc1n(c(n2C)=O)C
c1(c2=O)n(C)cnc1n(c(=O)n2C)C
c1(c2=O)n(C)cnc1n(C)c(n2C)=O
c1(c2=O)n(C)cnc1n(C)c(=O)n2C
c1(c2=O)n(cnc1n(c(n2C)=O)C)C
c1(c2=O)n(cnc1n(c(=O)n2C)C)C
c1(c2=O)n(cnc1n(C)c(n2C)=O)C
c1(c2=O)n(cnc1n(C)c(=O)n2C)C
c1(c(=O)n2C)n(C)cnc1n(c2=O)C
c1(c(=O)n2C)n(C)cnc1n(C)c2=O
c1(c(=O)n2C)n(cnc1n(c2=O)C)C
c1(c(=O)n2C)n(cnc1n(C)c2=O)C
c1(c(=O)n(c2=O)C)n(C)cnc1n2C
c1(c(=O)n(c2=O)C)n(cnc1n2C)C
c1(c(=O)n(c(=O)n2C)C)n(C)cnc21
c1(c(=O)n(c(=O)n2C)C)n(C)cnc12
c1(c(=O)n(c(=O)n2C)C)n(cnc21)C
c1(c(=O)n(c(=O)n2C)C)n(cnc12)C
c1(c(=O)n(c(n2C)=O)C)n(C)cnc21
c1(c(=O)n(c(n2C)=O)C)n(C)cnc12
c1(c(=O)n(c(n2C)=O)C)n(cnc21)C
c1(c(=O)n(c(n2C)=O)C)n(cnc12)C
c1(c(=O)n(C)c2=O)n(C)cnc1n2C
c1(c(=O)n(C)c2=O)n(cnc1n2C)C
c1(c(=O)n(C)c(=O)n2C)n(C)cnc21
c1(c(=O)n(C)c(=O)n2C)n(C)cnc12
c1(c(=O)n(C)c(=O)n2C)n(cnc21)C
c1(c(=O)n(C)c(=O)n2C)n(cnc12)C
c1(c(=O)n(C)c(n2C)=O)n(C)cnc21
c1(c(=O)n(C)c(n2C)=O)n(C)cnc12
c1(c(=O)n(C)c(n2C)=O)n(cnc21)C
c1(c(=O)n(C)c(n2C)=O)n(cnc12)C
c1(c(n2C)=O)n(C)cnc1n(c2=O)C
c1(c(n2C)=O)n(C)cnc1n(C)c2=O
c1(c(n2C)=O)n(cnc1n(c2=O)C)C
c1(c(n2C)=O)n(cnc1n(C)c2=O)C
c1(c(n(c2=O)C)=O)n(C)cnc1n2C
c1(c(n(c2=O)C)=O)n(cnc1n2C)C
c1(c(n(c(=O)n2C)C)=O)n(C)cnc21
c1(c(n(c(=O)n2C)C)=O)n(C)cnc12
c1(c(n(c(=O)n2C)C)=O)n(cnc21)C
c1(c(n(c(=O)n2C)C)=O)n(cnc12)C
c1(c(n(c(n2C)=O)C)=O)n(C)cnc21
c1(c(n(c(n2C)=O)C)=O)n(C)cnc12
c1(c(n(c(n2C)=O)C)=O)n(cnc21)C
c1(c(n(c(n2C)=O)C)=O)n(cnc12)C
c1(c(n(C)c2=O)=O)n(C)cnc1n2C
c1(c(n(C)c2=O)=O)n(cnc1n2C)C
c1(c(n(C)c(=O)n2C)=O)n(C)cnc21
c1(c(n(C)c(=O)n2C)=O)n(C)cnc12
c1(c(n(C)c(=O)n2C)=O)n(cnc21)C
c1(c(n(C)c(=O)n2C)=O)n(cnc12)C
c1(c(n(C)c(n2C)=O)=O)n(C)cnc21
c1(c(n(C)c(n2C)=O)=O)n(C)cnc12
c1(c(n(C)c(n2C)=O)=O)n(cnc21)C
c1(c(n(C)c(n2C)=O)=O)n(cnc12)C
c12c(ncn2C)n(c(n(c1=O)C)=O)C
c12c(ncn2C)n(c(n(C)c1=O)=O)C
c12c(ncn2C)n(c(=O)n(c1=O)C)C
c12c(ncn2C)n(c(=O)n(C)c1=O)C
c12c(ncn2C)n(C)c(n(c1=O)C)=O
c12c(ncn2C)n(C)c(n(C)c1=O)=O
c12c(ncn2C)n(C)c(=O)n(c1=O)C
c12c(ncn2C)n(C)c(=O)n(C)c1=O
c12c(n(c(n(c1=O)C)=O)C)ncn2C
c12c(n(c(n(C)c1=O)=O)C)ncn2C
c12c(n(c(=O)n(c1=O)C)C)ncn2C
c12c(n(c(=O)n(C)c1=O)C)ncn2C
c12c(n(C)c(n(c1=O)C)=O)ncn2C
c12c(n(C)c(n(C)c1=O)=O)ncn2C
c12c(n(C)c(=O)n(c1=O)C)ncn2C
c12c(n(C)c(=O)n(C)c1=O)ncn2C
c12n(C)cnc2n(c(n(c1=O)C)=O)C
c12n(C)cnc2n(c(n(C)c1=O)=O)C
c12n(C)cnc2n(c(=O)n(c1=O)C)C
c12n(C)cnc2n(c(=O)n(C)c1=O)C
c12n(C)cnc2n(C)c(n(c1=O)C)=O
c12n(C)cnc2n(C)c(n(C)c1=O)=O
c12n(C)cnc2n(C)c(=O)n(c1=O)C
c12n(C)cnc2n(C)c(=O)n(C)c1=O
c12n(cnc2n(c(n(c1=O)C)=O)C)C
c12n(cnc2n(c(n(C)c1=O)=O)C)C
c12n(cnc2n(c(=O)n(c1=O)C)C)C
c12n(cnc2n(c(=O)n(C)c1=O)C)C
c12n(cnc2n(C)c(n(c1=O)C)=O)C
c12n(cnc2n(C)c(n(C)c1=O)=O)C
c12n(cnc2n(C)c(=O)n(c1=O)C)C
c12n(cnc2n(C)c(=O)n(C)c1=O)C
c1(n2C)c(nc2)n(c(n(c1=O)C)=O)C
c1(n2C)c(nc2)n(c(n(C)c1=O)=O)C
c1(n2C)c(nc2)n(c(=O)n(c1=O)C)C
c1(n2C)c(nc2)n(c(=O)n(C)c1=O)C
c1(n2C)c(nc2)n(C)c(n(c1=O)C)=O
c1(n2C)c(nc2)n(C)c(n(C)c1=O)=O
c1(n2C)c(nc2)n(C)c(=O)n(c1=O)C
c1(n2C)c(nc2)n(C)c(=O)n(C)c1=O
c1(n2C)c(n(c(n(c1=O)C)=O)C)nc2
c1(n2C)c(n(c(n(C)c1=O)=O)C)nc2
c1(n2C)c(n(c(=O)n(c1=O)C)C)nc2
c1(n2C)c(n(c(=O)n(C)c1=O)C)nc2
c1(n2C)c(n(C)c(n(c1=O)C)=O)nc2
c1(n2C)c(n(C)c(n(C)c1=O)=O)nc2
c1(n2C)c(n(C)c(=O)n(c1=O)C)nc2
c1(n2C)c(n(C)c(=O)n(C)c1=O)nc2
c1(c2n(c(n(c1=O)C)=O)C)n(C)cn2
c1(c2n(c(n(c1=O)C)=O)C)n(cn2)C
c1(c2n(c(n(C)c1=O)=O)C)n(C)cn2
c1(c2n(c(n(C)c1=O)=O)C)n(cn2)C
c1(c2n(c(=O)n(c1=O)C)C)n(C)cn2
c1(c2n(c(=O)n(c1=O)C)C)n(cn2)C
c1(c2n(c(=O)n(C)c1=O)C)n(C)cn2
c1(c2n(c(=O)n(C)c1=O)C)n(cn2)C
c1(c2n(C)c(n(c1=O)C)=O)n(C)cn2
c1(c2n(C)c(n(c1=O)C)=O)n(cn2)C
c1(c2n(C)c(n(C)c1=O)=O)n(C)cn2
c1(c2n(C)c(n(C)c1=O)=O)n(cn2)C
c1(c2n(C)c(=O)n(c1=O)C)n(C)cn2
c1(c2n(C)c(=O)n(c1=O)C)n(cn2)C
c1(c2n(C)c(=O)n(C)c1=O)n(C)cn2
c1(c2n(C)c(=O)n(C)c1=O)n(cn2)C
c1(=O)n(c(=O)n(c2c1n(C)cn2)C)C
c1(=O)n(c(=O)n(c2c1n(cn2)C)C)C
c1(=O)n(c(=O)n(c2ncn(C)c21)C)C
c1(=O)n(c(=O)n(c2ncn(C)c12)C)C
c1(=O)n(c(=O)n(c2ncn(c21)C)C)C
c1(=O)n(c(=O)n(c2ncn(c12)C)C)C
c1(=O)n(c(=O)n(c(ncn2C)c21)C)C
c1(=O)n(c(=O)n(c(ncn2C)c12)C)C
c1(=O)n(c(=O)n(c(c1n2C)nc2)C)C
c1(=O)n(c(=O)n(C)c2c1n(C)cn2)C
c1(=O)n(c(=O)n(C)c2c1n(cn2)C)C
c1(=O)n(c(=O)n(C)c2ncn(C)c21)C
c1(=O)n(c(=O)n(C)c2ncn(C)c12)C
c1(=O)n(c(=O)n(C)c2ncn(c21)C)C
c1(=O)n(c(=O)n(C)c2ncn(c12)C)C
c1(=O)n(c(=O)n(C)c(ncn2C)c21)C
c1(=O)n(c(=O)n(C)c(ncn2C)c12)C
c1(=O)n(c(=O)n(C)c(c1n2C)nc2)C
c1(=O)n(c(n(c2c1n(C)cn2)C)=O)C
c1(=O)n(c(n(c2c1n(cn2)C)C)=O)C
c1(=O)n(c(n(c2ncn(C)c21)C)=O)C
c1(=O)n(c(n(c2ncn(C)c12)C)=O)C
c1(=O)n(c(n(c2ncn(c21)C)C)=O)C
c1(=O)n(c(n(c2ncn(c12)C)C)=O)C
c1(=O)n(c(n(c(ncn2C)c21)C)=O)C
c1(=O)n(c(n(c(ncn2C)c12)C)=O)C
c1(=O)n(c(n(c(c1n2C)nc2)C)=O)C
c1(=O)n(c(n(C)c2c1n(C)cn2)=O)C
c1(=O)n(c(n(C)c2c1n(cn2)C)=O)C
c1(=O)n(c(n(C)c2ncn(C)c21)=O)C
c1(=O)n(c(n(C)c2ncn(C)c12)=O)C
c1(=O)n(c(n(C)c2ncn(c21)C)=O)C
c1(=O)n(c(n(C)c2ncn(c12)C)=O)C
c1(=O)n(c(n(C)c(ncn2C)c21)=O)C
c1(=O)n(c(n(C)c(ncn2C)c12)=O)C
c1(=O)n(c(n(C)c(c1n2C)nc2)=O)C
c1(=O)n(C)c(=O)n(c2c1n(C)cn2)C
c1(=O)n(C)c(=O)n(c2c1n(cn2)C)C
c1(=O)n(C)c(=O)n(c2ncn(C)c21)C
c1(=O)n(C)c(=O)n(c2ncn(C)c12)C
c1(=O)n(C)c(=O)n(c2ncn(c21)C)C
c1(=O)n(C)c(=O)n(c2ncn(c12)C)C
c1(=O)n(C)c(=O)n(c(ncn2C)c21)C
c1(=O)n(C)c(=O)n(c(ncn2C)c12)C
c1(=O)n(C)c(=O)n(c(c1n2C)nc2)C
c1(=O)n(C)c(=O)n(C)c2c1n(C)cn2
c1(=O)n(C)c(=O)n(C)c2c1n(cn2)C
c1(=O)n(C)c(=O)n(C)c2ncn(C)c21
c1(=O)n(C)c(=O)n(C)c2ncn(C)c12
c1(=O)n(C)c(=O)n(C)c2ncn(c21)C
c1(=O)n(C)c(=O)n(C)c2ncn(c12)C
c1(=O)n(C)c(=O)n(C)c(ncn2C)c21
c1(=O)n(C)c(=O)n(C)c(ncn2C)c12
c1(=O)n(C)c(=O)n(C)c(c1n2C)nc2
c1(=O)n(C)c(n(c2c1n(C)cn2)C)=O
c1(=O)n(C)c(n(c2c1n(cn2)C)C)=O
c1(=O)n(C)c(n(c2ncn(C)c21)C)=O
c1(=O)n(C)c(n(c2ncn(C)c12)C)=O
c1(=O)n(C)c(n(c2ncn(c21)C)C)=O
c1(=O)n(C)c(n(c2ncn(c12)C)C)=O
c1(=O)n(C)c(n(c(ncn2C)c21)C)=O
c1(=O)n(C)c(n(c(ncn2C)c12)C)=O
c1(=O)n(C)c(n(c(c1n2C)nc2)C)=O
c1(=O)n(C)c(n(C)c2c1n(C)cn2)=O
c1(=O)n(C)c(n(C)c2c1n(cn2)C)=O
c1(=O)n(C)c(n(C)c2ncn(C)c21)=O
c1(=O)n(C)c(n(C)c2ncn(C)c12)=O
c1(=O)n(C)c(n(C)c2ncn(c21)C)=O
c1(=O)n(C)c(n(C)c2ncn(c12)C)=O
c1(=O)n(C)c(n(C)c(ncn2C)c21)=O
c1(=O)n(C)c(n(C)c(ncn2C)c12)=O
c1(=O)n(C)c(n(C)c(c1n2C)nc2)=O
c1(n(c(=O)n(c2c1n(C)cn2)C)C)=O
c1(n(c(=O)n(c2c1n(cn2)C)C)C)=O
c1(n(c(=O)n(c2ncn(C)c21)C)C)=O
c1(n(c(=O)n(c2ncn(C)c12)C)C)=O
c1(n(c(=O)n(c2ncn(c21)C)C)C)=O
c1(n(c(=O)n(c2ncn(c12)C)C)C)=O
c1(n(c(=O)n(c(ncn2C)c21)C)C)=O
c1(n(c(=O)n(c(ncn2C)c12)C)C)=O
c1(n(c(=O)n(c(c1n2C)nc2)C)C)=O
c1(n(c(=O)n(C)c2c1n(C)cn2)C)=O
c1(n(c(=O)n(C)c2c1n(cn2)C)C)=O
c1(n(c(=O)n(C)c2ncn(C)c21)C)=O
c1(n(c(=O)n(C)c2ncn(C)c12)C)=O
c1(n(c(=O)n(C)c2ncn(c21)C)C)=O
c1(n(c(=O)n(C)c2ncn(c12)C)C)=O
c1(n(c(=O)n(C)c(ncn2C)c21)C)=O
c1(n(c(=O)n(C)c(ncn2C)c12)C)=O
c1(n(c(=O)n(C)c(c1n2C)nc2)C)=O
c1(n(c(n(c2c1n(C)cn2)C)=O)C)=O
c1(n(c(n(c2c1n(cn2)C)C)=O)C)=O
c1(n(c(n(c2ncn(C)c21)C)=O)C)=O
c1(n(c(n(c2ncn(C)c12)C)=O)C)=O
c1(n(c(n(c2ncn(c21)C)C)=O)C)=O
c1(n(c(n(c2ncn(c12)C)C)=O)C)=O
c1(n(c(n(c(ncn2C)c21)C)=O)C)=O
c1(n(c(n(c(ncn2C)c12)C)=O)C)=O
c1(n(c(n(c(c1n2C)nc2)C)=O)C)=O
c1(n(c(n(C)c2c1n(C)cn2)=O)C)=O
c1(n(c(n(C)c2c1n(cn2)C)=O)C)=O
c1(n(c(n(C)c2ncn(C)c21)=O)C)=O
c1(n(c(n(C)c2ncn(C)c12)=O)C)=O
c1(n(c(n(C)c2ncn(c21)C)=O)C)=O
c1(n(c(n(C)c2ncn(c12)C)=O)C)=O
c1(n(c(n(C)c(ncn2C)c21)=O)C)=O
c1(n(c(n(C)c(ncn2C)c12)=O)C)=O
c1(n(c(n(C)c(c1n2C)nc2)=O)C)=O
c1(n(C)c(=O)n(c2c1n(C)cn2)C)=O
c1(n(C)c(=O)n(c2c1n(cn2)C)C)=O
c1(n(C)c(=O)n(c2ncn(C)c21)C)=O
c1(n(C)c(=O)n(c2ncn(C)c12)C)=O
c1(n(C)c(=O)n(c2ncn(c21)C)C)=O
c1(n(C)c(=O)n(c2ncn(c12)C)C)=O
c1(n(C)c(=O)n(c(ncn2C)c21)C)=O
c1(n(C)c(=O)n(c(ncn2C)c12)C)=O
c1(n(C)c(=O)n(c(c1n2C)nc2)C)=O
c1(n(C)c(=O)n(C)c2c1n(C)cn2)=O
c1(n(C)c(=O)n(C)c2c1n(cn2)C)=O
c1(n(C)c(=O)n(C)c2ncn(C)c21)=O
c1(n(C)c(=O)n(C)c2ncn(C)c12)=O
c1(n(C)c(=O)n(C)c2ncn(c21)C)=O
c1(n(C)c(=O)n(C)c2ncn(c12)C)=O
c1(n(C)c(=O)n(C)c(ncn2C)c21)=O
c1(n(C)c(=O)n(C)c(ncn2C)c12)=O
c1(n(C)c(=O)n(C)c(c1n2C)nc2)=O
c1(n(C)c(n(c2c1n(C)cn2)C)=O)=O
c1(n(C)c(n(c2c1n(cn2)C)C)=O)=O
c1(n(C)c(n(c2ncn(C)c21)C)=O)=O
c1(n(C)c(n(c2ncn(C)c12)C)=O)=O
c1(n(C)c(n(c2ncn(c21)C)C)=O)=O
c1(n(C)c(n(c2ncn(c12)C)C)=O)=O
c1(n(C)c(n(c(ncn2C)c21)C)=O)=O
c1(n(C)c(n(c(ncn2C)c12)C)=O)=O
c1(n(C)c(n(c(c1n2C)nc2)C)=O)=O
c1(n(C)c(n(C)c2c1n(C)cn2)=O)=O
c1(n(C)c(n(C)c2c1n(cn2)C)=O)=O
c1(n(C)c(n(C)c2ncn(C)c21)=O)=O
c1(n(C)c(n(C)c2ncn(C)c12)=O)=O
c1(n(C)c(n(C)c2ncn(c21)C)=O)=O
c1(n(C)c(n(C)c2ncn(c12)C)=O)=O
c1(n(C)c(n(C)c(ncn2C)c21)=O)=O
c1(n(C)c(n(C)c(ncn2C)c12)=O)=O
c1(n(C)c(n(C)c(c1n2C)nc2)=O)=O
c1(c2c(ncn2C)n(c(n1C)=O)C)=O
c1(c2c(ncn2C)n(c(=O)n1C)C)=O
c1(c2c(ncn2C)n(C)c(n1C)=O)=O
c1(c2c(ncn2C)n(C)c(=O)n1C)=O
c1(c2c(n(c(n1C)=O)C)ncn2C)=O
c1(c2c(n(c(=O)n1C)C)ncn2C)=O
c1(c2c(n(C)c(n1C)=O)ncn2C)=O
c1(c2c(n(C)c(=O)n1C)ncn2C)=O
c1(c2n(C)cnc2n(c(n1C)=O)C)=O
c1(c2n(C)cnc2n(c(=O)n1C)C)=O
c1(c2n(C)cnc2n(C)c(n1C)=O)=O
c1(c2n(C)cnc2n(C)c(=O)n1C)=O
c1(c2n(cnc2n(c(n1C)=O)C)C)=O
c1(c2n(cnc2n(c(=O)n1C)C)C)=O
c1(c2n(cnc2n(C)c(n1C)=O)C)=O
c1(c2n(cnc2n(C)c(=O)n1C)C)=O
c1(c(n2C)c(nc2)n(c(n1C)=O)C)=O
c1(c(n2C)c(nc2)n(c(=O)n1C)C)=O
c1(c(n2C)c(nc2)n(C)c(n1C)=O)=O
c1(c(n2C)c(nc2)n(C)c(=O)n1C)=O
c1(c(n2C)c(n(c(n1C)=O)C)nc2)=O
c1(c(n2C)c(n(c(=O)n1C)C)nc2)=O
c1(c(n2C)c(n(C)c(n1C)=O)nc2)=O
c1(c(n2C)c(n(C)c(=O)n1C)nc2)=O
c1(c(c2n(c(n1C)=O)C)n(C)cn2)=O
c1(c(c2n(c(n1C)=O)C)n(cn2)C)=O
c1(c(c2n(c(=O)n1C)C)n(C)cn2)=O
c1(c(c2n(c(=O)n1C)C)n(cn2)C)=O
c1(c(c2n(C)c(n1C)=O)n(C)cn2)=O
c1(c(c2n(C)c(n1C)=O)n(cn2)C)=O
c1(c(c2n(C)c(=O)n1C)n(C)cn2)=O
c1(c(c2n(C)c(=O)n1C)n(cn2)C)=O
c1(=O)c2c(ncn2C)n(c(n1C)=O)C
c1(=O)c2c(ncn2C)n(c(=O)n1C)C
c1(=O)c2c(ncn2C)n(C)c(n1C)=O
c1(=O)c2c(ncn2C)n(C)c(=O)n1C
c1(=O)c2c(n(c(n1C)=O)C)ncn2C
c1(=O)c2c(n(c(=O)n1C)C)ncn2C
c1(=O)c2c(n(C)c(n1C)=O)ncn2C
c1(=O)c2c(n(C)c(=O)n1C)ncn2C
c1(=O)c2n(C)cnc2n(c(n1C)=O)C
c1(=O)c2n(C)cnc2n(c(=O)n1C)C
c1(=O)c2n(C)cnc2n(C)c(n1C)=O
c1(=O)c2n(C)cnc2n(C)c(=O)n1C
c1(=O)c2n(cnc2n(c(n1C)=O)C)C
c1(=O)c2n(cnc2n(c(=O)n1C)C)C
c1(=O)c2n(cnc2n(C)c(n1C)=O)C
c1(=O)c2n(cnc2n(C)c(=O)n1C)C
c1(=O)c(n2C)c(nc2)n(c(n1C)=O)C
c1(=O)c(n2C)c(nc2)n(c(=O)n1C)C
c1(=O)c(n2C)c(nc2)n(C)c(n1C)=O
c1(=O)c(n2C)c(nc2)n(C)c(=O)n1C
c1(=O)c(n2C)c(n(c(n1C)=O)C)nc2
c1(=O)c(n2C)c(n(c(=O)n1C)C)nc2
c1(=O)c(n2C)c(n(C)c(n1C)=O)nc2
c1(=O)c(n2C)c(n(C)c(=O)n1C)nc2
c1(=O)c(c2n(c(n1C)=O)C)n(C)cn2
c1(=O)c(c2n(c(n1C)=O)C)n(cn2)C
c1(=O)c(c2n(c(=O)n1C)C)n(C)cn2
c1(=O)c(c2n(c(=O)n1C)C)n(cn2)C
c1(=O)c(c2n(C)c(n1C)=O)n(C)cn2
c1(=O)c(c2n(C)c(n1C)=O)n(cn2)C
c1(=O)c(c2n(C)c(=O)n1C)n(C)cn2
c1(=O)c(c2n(C)c(=O)n1C)n(cn2)C
O=c1n(c(=O)n(c2c1n(C)cn2)C)C
O=c1n(c(=O)n(c2c1n(cn2)C)C)C
O=c1n(c(=O)n(c2ncn(C)c21)C)C
O=c1n(c(=O)n(c2ncn(C)c12)C)C
O=c1n(c(=O)n(c2ncn(c21)C)C)C
O=c1n(c(=O)n(c2ncn(c12)C)C)C
O=c1n(c(=O)n(c(ncn2C)c21)C)C
O=c1n(c(=O)n(c(ncn2C)c12)C)C
O=c1n(c(=O)n(c(c1n2C)nc2)C)C
O=c1n(c(=O)n(C)c2c1n(C)cn2)C
O=c1n(c(=O)n(C)c2c1n(cn2)C)C
O=c1n(c(=O)n(C)c2ncn(C)c21)C
O=c1n(c(=O)n(C)c2ncn(C)c12)C
O=c1n(c(=O)n(C)c2ncn(c21)C)C
O=c1n(c(=O)n(C)c2ncn(c12)C)C
O=c1n(c(=O)n(C)c(ncn2C)c21)C
O=c1n(c(=O)n(C)c(ncn2C)c12)C
O=c1n(c(=O)n(C)c(c1n2C)nc2)C
O=c1n(c(n(c2c1n(C)cn2)C)=O)C
O=c1n(c(n(c2c1n(cn2)C)C)=O)C
O=c1n(c(n(c2ncn(C)c21)C)=O)C
O=c1n(c(n(c2ncn(C)c12)C)=O)C
O=c1n(c(n(c2ncn(c21)C)C)=O)C
O=c1n(c(n(c2ncn(c12)C)C)=O)C
O=c1n(c(n(c(ncn2C)c21)C)=O)C
O=c1n(c(n(c(ncn2C)c12)C)=O)C
O=c1n(c(n(c(c1n2C)nc2)C)=O)C
O=c1n(c(n(C)c2c1n(C)cn2)=O)C
O=c1n(c(n(C)c2c1n(cn2)C)=O)C
O=c1n(c(n(C)c2ncn(C)c21)=O)C
O=c1n(c(n(C)c2ncn(C)c12)=O)C
O=c1n(c(n(C)c2ncn(c21)C)=O)C
O=c1n(c(n(C)c2ncn(c12)C)=O)C
O=c1n(c(n(C)c(ncn2C)c21)=O)C
O=c1n(c(n(C)c(ncn2C)c12)=O)C
O=c1n(c(n(C)c(c1n2C)nc2)=O)C
O=c1n(C)c(=O)n(c2c1n(C)cn2)C
O=c1n(C)c(=O)n(c2c1n(cn2)C)C
O=c1n(C)c(=O)n(c2ncn(C)c21)C
O=c1n(C)c(=O)n(c2ncn(C)c12)C
O=c1n(C)c(=O)n(c2ncn(c21)C)C
O=c1n(C)c(=O)n(c2ncn(c12)C)C
O=c1n(C)c(=O)n(c(ncn2C)c21)C
O=c1n(C)c(=O)n(c(ncn2C)c12)C
O=c1n(C)c(=O)n(c(c1n2C)nc2)C
O=c1n(C)c(=O)n(C)c2c1n(C)cn2
O=c1n(C)c(=O)n(C)c2c1n(cn2)C
O=c1n(C)c(=O)n(C)c2ncn(C)c21
O=c1n(C)c(=O)n(C)c2ncn(C)c12
O=c1n(C)c(=O)n(C)c2ncn(c21)C
O=c1n(C)c(=O)n(C)c2ncn(c12)C
O=c1n(C)c(=O)n(C)c(ncn2C)c21
O=c1n(C)c(=O)n(C)c(ncn2C)c12
O=c1n(C)c(=O)n(C)c(c1n2C)nc2
O=c1n(C)c(n(c2c1n(C)cn2)C)=O
O=c1n(C)c(n(c2c1n(cn2)C)C)=O
O=c1n(C)c(n(c2ncn(C)c21)C)=O
O=c1n(C)c(n(c2ncn(C)c12)C)=O
O=c1n(C)c(n(c2ncn(c21)C)C)=O
O=c1n(C)c(n(c2ncn(c12)C)C)=O
O=c1n(C)c(n(c(ncn2C)c21)C)=O
O=c1n(C)c(n(c(ncn2C)c12)C)=O
O=c1n(C)c(n(c(c1n2C)nc2)C)=O
O=c1n(C)c(n(C)c2c1n(C)cn2)=O
O=c1n(C)c(n(C)c2c1n(cn2)C)=O
O=c1n(C)c(n(C)c2ncn(C)c21)=O
O=c1n(C)c(n(C)c2ncn(C)c12)=O
O=c1n(C)c(n(C)c2ncn(c21)C)=O
O=c1n(C)c(n(C)c2ncn(c12)C)=O
O=c1n(C)c(n(C)c(ncn2C)c21)=O
O=c1n(C)c(n(C)c(ncn2C)c12)=O
O=c1n(C)c(n(C)c(c1n2C)nc2)=O
O=c1c2c(ncn2C)n(c(n1C)=O)C
O=c1c2c(ncn2C)n(c(=O)n1C)C
O=c1c2c(ncn2C)n(C)c(n1C)=O
O=c1c2c(ncn2C)n(C)c(=O)n1C
O=c1c2c(n(c(n1C)=O)C)ncn2C
O=c1c2c(n(c(=O)n1C)C)ncn2C
O=c1c2c(n(C)c(n1C)=O)ncn2C
O=c1c2c(n(C)c(=O)n1C)ncn2C
O=c1c2n(C)cnc2n(c(n1C)=O)C
O=c1c2n(C)cnc2n(c(=O)n1C)C
O=c1c2n(C)cnc2n(C)c(n1C)=O
O=c1c2n(C)cnc2n(C)c(=O)n1C
O=c1c2n(cnc2n(c(n1C)=O)C)C
O=c1c2n(cnc2n(c(=O)n1C)C)C
O=c1c2n(cnc2n(C)c(n1C)=O)C
O=c1c2n(cnc2n(C)c(=O)n1C)C
O=c1c(n2C)c(nc2)n(c(n1C)=O)C
O=c1c(n2C)c(nc2)n(c(=O)n1C)C
O=c1c(n2C)c(nc2)n(C)c(n1C)=O
O=c1c(n2C)c(nc2)n(C)c(=O)n1C
O=c1c(n2C)c(n(c(n1C)=O)C)nc2
O=c1c(n2C)c(n(c(=O)n1C)C)nc2
O=c1c(n2C)c(n(C)c(n1C)=O)nc2
O=c1c(n2C)c(n(C)c(=O)n1C)nc2
O=c1c(c2n(c(n1C)=O)C)n(C)cn2
O=c1c(c2n(c(n1C)=O)C)n(cn2)C
O=c1c(c2n(c(=O)n1C)C)n(C)cn2
O=c1c(c2n(c(=O)n1C)C)n(cn2)C
O=c1c(c2n(C)c(n1C)=O)n(C)cn2
O=c1c(c2n(C)c(n1C)=O)n(cn2)C
O=c1c(c2n(C)c(=O)n1C)n(C)cn2
O=c1c(c2n(C)c(=O)n1C)n(cn2)C
O=c(c1c2ncn1C)n(c(=O)n2C)C
O=c(c1c2ncn1C)n(c(n2C)=O)C
O=c(c1c2ncn1C)n(C)c(=O)n2C
O=c(c1c2ncn1C)n(C)c(n2C)=O
O=c(c1c(ncn1C)n2C)n(c2=O)C
O=c(c1c(ncn1C)n2C)n(C)c2=O
O=c(c1c(ncn1C)n(c2=O)C)n2C
O=c(c1c(ncn1C)n(C)c2=O)n2C
O=c(c1c(n2C)ncn1C)n(c2=O)C
O=c(c1c(n2C)ncn1C)n(C)c2=O
O=c(c1c(n(c2=O)C)ncn1C)n2C
O=c(c1c(n(C)c2=O)ncn1C)n2C
O=c(c1n2C)n(c(=O)n(c1nc2)C)C
O=c(c1n2C)n(c(=O)n(C)c1nc2)C
O=c(c1n2C)n(c(n(c1nc2)C)=O)C
O=c(c1n2C)n(c(n(C)c1nc2)=O)C
O=c(c1n2C)n(C)c(=O)n(c1nc2)C
O=c(c1n2C)n(C)c(=O)n(C)c1nc2
O=c(c1n2C)n(C)c(n(c1nc2)C)=O
O=c(c1n2C)n(C)c(n(C)c1nc2)=O
O=c(c1n(C)cnc1n2C)n(c2=O)C
O=c(c1n(C)cnc1n2C)n(C)c2=O
O=c(c1n(C)cnc1n(c2=O)C)n2C
O=c(c1n(C)cnc1n(C)c2=O)n2C
O=c(c1n(cnc1n2C)C)n(c2=O)C
O=c(c1n(cnc1n2C)C)n(C)c2=O
O=c(c1n(cnc1n(c2=O)C)C)n2C
O=c(c1n(cnc1n(C)c2=O)C)n2C
O=c(c(n1C)c2nc1)n(c(=O)n2C)C
O=c(c(n1C)c2nc1)n(c(n2C)=O)C
O=c(c(n1C)c2nc1)n(C)c(=O)n2C
O=c(c(n1C)c2nc1)n(C)c(n2C)=O
O=c(c(n1C)c(nc1)n2C)n(c2=O)C
O=c(c(n1C)c(nc1)n2C)n(C)c2=O
O=c(c(n1C)c(nc1)n(c2=O)C)n2C
O=c(c(n1C)c(nc1)n(C)c2=O)n2C
O=c(c(n1C)c(n2C)nc1)n(c2=O)C
O=c(c(n1C)c(n2C)nc1)n(C)c2=O
O=c(c(n1C)c(n(c2=O)C)nc1)n2C
O=c(c(n1C)c(n(C)c2=O)nc1)n2C
O=c(c(c1n2C)n(C)cn1)n(c2=O)C
O=c(c(c1n2C)n(C)cn1)n(C)c2=O
O=c(c(c1n2C)n(cn1)C)n(c2=O)C
O=c(c(c1n2C)n(cn1)C)n(C)c2=O
O=c(c(c1n(c2=O)C)n(C)cn1)n2C
O=c(c(c1n(c2=O)C)n(cn1)C)n2C
O=c(c(c1n(C)c2=O)n(C)cn1)n2C
O=c(c(c1n(C)c2=O)n(cn1)C)n2C
O=c(n1C)c2c(ncn2C)n(c1=O)C
O=c(n1C)c2c(ncn2C)n(C)c1=O
O=c(n1C)c2c(n(c1=O)C)ncn2C
O=c(n1C)c2c(n(C)c1=O)ncn2C
O=c(n1C)c2n(C)cnc2n(c1=O)C
O=c(n1C)c2n(C)cnc2n(C)c1=O
O=c(n1C)c2n(cnc2n(c1=O)C)C
O=c(n1C)c2n(cnc2n(C)c1=O)C
O=c(n1C)c(n2C)c(nc2)n(c1=O)C
O=c(n1C)c(n2C)c(nc2)n(C)c1=O
O=c(n1C)c(n2C)c(n(c1=O)C)nc2
O=c(n1C)c(n2C)c(n(C)c1=O)nc2
O=c(n1C)c(c2n(c1=O)C)n(C)cn2
O=c(n1C)c(c2n(c1=O)C)n(cn2)C
O=c(n1C)c(c2n(C)c1=O)n(C)cn2
O=c(n1C)c(c2n(C)c1=O)n(cn2)C
O=c(n(c1=O)C)c2c(ncn2C)n1C
O=c(n(c1=O)C)c2c(n1C)ncn2C
O=c(n(c1=O)C)c2n(C)cnc2n1C
O=c(n(c1=O)C)c2n(cnc2n1C)C
O=c(n(c1=O)C)c(n2C)c(nc2)n1C
O=c(n(c1=O)C)c(n2C)c(n1C)nc2
O=c(n(c1=O)C)c(c2n1C)n(C)cn2
O=c(n(c1=O)C)c(c2n1C)n(cn2)C
O=c(n(c(=O)n1C)C)c2c1ncn2C
O=c(n(c(=O)n1C)C)c2n(C)cnc12
O=c(n(c(=O)n1C)C)c2n(C)cnc21
O=c(n(c(=O)n1C)C)c2n(cnc12)C
O=c(n(c(=O)n1C)C)c2n(cnc21)C
O=c(n(c(=O)n1C)C)c(n2C)c1nc2
O=c(n(c(=O)n(c1ncn2C)C)C)c21
O=c(n(c(=O)n(c1ncn2C)C)C)c12
O=c(n(c(=O)n(C)c1ncn2C)C)c21
O=c(n(c(=O)n(C)c1ncn2C)C)c12
O=c(n(c(n1C)=O)C)c2c1ncn2C
O=c(n(c(n1C)=O)C)c2n(C)cnc12
O=c(n(c(n1C)=O)C)c2n(C)cnc21
O=c(n(c(n1C)=O)C)c2n(cnc12)C
O=c(n(c(n1C)=O)C)c2n(cnc21)C
O=c(n(c(n1C)=O)C)c(n2C)c1nc2
O=c(n(c(n(c1ncn2C)C)=O)C)c21
O=c(n(c(n(c1ncn2C)C)=O)C)c12
O=c(n(c(n(C)c1ncn2C)=O)C)c21
O=c(n(c(n(C)c1ncn2C)=O)C)c12
O=c(n(C)c1=O)c2c(ncn2C)n1C
O=c(n(C)c1=O)c2c(n1C)ncn2C
O=c(n(C)c1=O)c2n(C)cnc2n1C
O=c(n(C)c1=O)c2n(cnc2n1C)C
O=c(n(C)c1=O)c(n2C)c(nc2)n1C
O=c(n(C)c1=O)c(n2C)c(n1C)nc2
O=c(n(C)c1=O)c(c2n1C)n(C)cn2
O=c(n(C)c1=O)c(c2n1C)n(cn2)C
O=c(n(C)c(=O)n1C)c2c1ncn2C
O=c(n(C)c(=O)n1C)c2n(C)cnc12
O=c(n(C)c(=O)n1C)c2n(C)cnc21
O=c(n(C)c(=O)n1C)c2n(cnc12)C
O=c(n(C)c(=O)n1C)c2n(cnc21)C
O=c(n(C)c(=O)n1C)c(n2C)c1nc2
O=c(n(C)c(=O)n(c1ncn2C)C)c21
O=c(n(C)c(=O)n(c1ncn2C)C)c12
O=c(n(C)c(=O)n(C)c1ncn2C)c21
O=c(n(C)c(=O)n(C)c1ncn2C)c12
O=c(n(C)c(n1C)=O)c2c1ncn2C
O=c(n(C)c(n1C)=O)c2n(C)cnc12
O=c(n(C)c(n1C)=O)c2n(C)cnc21
O=c(n(C)c(n1C)=O)c2n(cnc12)C
O=c(n(C)c(n1C)=O)c2n(cnc21)C
O=c(n(C)c(n1C)=O)c(n2C)c1nc2
O=c(n(C)c(n(c1ncn2C)C)=O)c21
O=c(n(C)c(n(c1ncn2C)C)=O)c12
O=c(n(C)c(n(C)c1ncn2C)=O)c21
O=c(n(C)c(n(C)c1ncn2C)=O)c12
n1(c(=O)n(c2c(n(C)cn2)c1=O)C)C
n1(c(=O)n(c2c(n(cn2)C)c1=O)C)C
n1(c(=O)n(c2c(c1=O)n(C)cn2)C)C
n1(c(=O)n(c2c(c1=O)n(cn2)C)C)C
n1(c(=O)n(c2ncn(C)c2c1=O)C)C
n1(c(=O)n(c2ncn(c2c1=O)C)C)C
n1(c(=O)n(c(ncn2C)c2c1=O)C)C
n1(c(=O)n(c(c2c1=O)ncn2C)C)C
n1(c(=O)n(c(c(n2C)c1=O)nc2)C)C
n1(c(=O)n(c(c(c1=O)n2C)nc2)C)C
n1(c(=O)n(C)c2c(n(C)cn2)c1=O)C
n1(c(=O)n(C)c2c(n(cn2)C)c1=O)C
n1(c(=O)n(C)c2c(c1=O)n(C)cn2)C
n1(c(=O)n(C)c2c(c1=O)n(cn2)C)C
n1(c(=O)n(C)c2ncn(C)c2c1=O)C
n1(c(=O)n(C)c2ncn(c2c1=O)C)C
n1(c(=O)n(C)c(ncn2C)c2c1=O)C
n1(c(=O)n(C)c(c2c1=O)ncn2C)C
n1(c(=O)n(C)c(c(n2C)c1=O)nc2)C
n1(c(=O)n(C)c(c(c1=O)n2C)nc2)C
n1(c(n(c2c(n(C)cn2)c1=O)C)=O)C
n1(c(n(c2c(n(cn2)C)c1=O)C)=O)C
n1(c(n(c2c(c1=O)n(C)cn2)C)=O)C
n1(c(n(c2c(c1=O)n(cn2)C)C)=O)C
n1(c(n(c2ncn(C)c2c1=O)C)=O)C
n1(c(n(c2ncn(c2c1=O)C)C)=O)C
n1(c(n(c(ncn2C)c2c1=O)C)=O)C
n1(c(n(c(c2c1=O)ncn2C)C)=O)C
n1(c(n(c(c(n2C)c1=O)nc2)C)=O)C
n1(c(n(c(c(c1=O)n2C)nc2)C)=O)C
n1(c(n(C)c2c(n(C)cn2)c1=O)=O)C
n1(c(n(C)c2c(n(cn2)C)c1=O)=O)C
n1(c(n(C)c2c(c1=O)n(C)cn2)=O)C
n1(c(n(C)c2c(c1=O)n(cn2)C)=O)C
n1(c(n(C)c2ncn(C)c2c1=O)=O)C
n1(c(n(C)c2ncn(c2c1=O)C)=O)C
n1(c(n(C)c(ncn2C)c2c1=O)=O)C
n1(c(n(C)c(c2c1=O)ncn2C)=O)C
n1(c(n(C)c(c(n2C)c1=O)nc2)=O)C
n1(c(n(C)c(c(c1=O)n2C)nc2)=O)C
n1(C)c(=O)n(c2c(n(C)cn2)c1=O)C
n1(C)c(=O)n(c2c(n(cn2)C)c1=O)C
n1(C)c(=O)n(c2c(c1=O)n(C)cn2)C
n1(C)c(=O)n(c2c(c1=O)n(cn2)C)C
n1(C)c(=O)n(c2ncn(C)c2c1=O)C
n1(C)c(=O)n(c2ncn(c2c1=O)C)C
n1(C)c(=O)n(c(ncn2C)c2c1=O)C
n1(C)c(=O)n(c(c2c1=O)ncn2C)C
n1(C)c(=O)n(c(c(n2C)c1=O)nc2)C
n1(C)c(=O)n(c(c(c1=O)n2C)nc2)C
n1(C)c(=O)n(C)c2c(n(C)cn2)c1=O
n1(C)c(=O)n(C)c2c(n(cn2)C)c1=O
n1(C)c(=O)n(C)c2c(c1=O)n(C)cn2
n1(C)c(=O)n(C)c2c(c1=O)n(cn2)C
n1(C)c(=O)n(C)c2ncn(C)c2c1=O
n1(C)c(=O)n(C)c2ncn(c2c1=O)C
n1(C)c(=O)n(C)c(ncn2C)c2c1=O
n1(C)c(=O)n(C)c(c2c1=O)ncn2C
n1(C)c(=O)n(C)c(c(n2C)c1=O)nc2
n1(C)c(=O)n(C)c(c(c1=O)n2C)nc2
n1(C)c(n(c2c(n(C)cn2)c1=O)C)=O
n1(C)c(n(c2c(n(cn2)C)c1=O)C)=O
n1(C)c(n(c2c(c1=O)n(C)cn2)C)=O
n1(C)c(n(c2c(c1=O)n(cn2)C)C)=O
n1(C)c(n(c2ncn(C)c2c1=O)C)=O
n1(C)c(n(c2ncn(c2c1=O)C)C)=O
n1(C)c(n(c(ncn2C)c2c1=O)C)=O
n1(C)c(n(c(c2c1=O)ncn2C)C)=O
n1(C)c(n(c(c(n2C)c1=O)nc2)C)=O
n1(C)c(n(c(c(c1=O)n2C)nc2)C)=O
n1(C)c(n(C)c2c(n(C)cn2)c1=O)=O
n1(C)c(n(C)c2c(n(cn2)C)c1=O)=O
n1(C)c(n(C)c2c(c1=O)n(C)cn2)=O
n1(C)c(n(C)c2c(c1=O)n(cn2)C)=O
n1(C)c(n(C)c2ncn(C)c2c1=O)=O
n1(C)c(n(C)c2ncn(c2c1=O)C)=O
n1(C)c(n(C)c(ncn2C)c2c1=O)=O
n1(C)c(n(C)c(c2c1=O)ncn2C)=O
n1(C)c(n(C)c(c(n2C)c1=O)nc2)=O
n1(C)c(n(C)c(c(c1=O)n2C)nc2)=O
n1(c(c2c(ncn2C)n(c1=O)C)=O)C
n1(c(c2c(ncn2C)n(C)c1=O)=O)C
n1(c(c2c(n(c1=O)C)ncn2C)=O)C
n1(c(c2c(n(C)c1=O)ncn2C)=O)C
n1(c(c2n(C)cnc2n(c1=O)C)=O)C
n1(c(c2n(C)cnc2n(C)c1=O)=O)C
n1(c(c2n(cnc2n(c1=O)C)C)=O)C
n1(c(c2n(cnc2n(C)c1=O)C)=O)C
n1(c(c(n2C)c(nc2)n(c1=O)C)=O)C
n1(c(c(n2C)c(nc2)n(C)c1=O)=O)C
n1(c(c(n2C)c(n(c1=O)C)nc2)=O)C
n1(c(c(n2C)c(n(C)c1=O)nc2)=O)C
n1(c(c(c2n(c1=O)C)n(C)cn2)=O)C
n1(c(c(c2n(c1=O)C)n(cn2)C)=O)C
n1(c(c(c2n(C)c1=O)n(C)cn2)=O)C
n1(c(c(c2n(C)c1=O)n(cn2)C)=O)C
n1(c(=O)c2c(ncn2C)n(c1=O)C)C
n1(c(=O)c2c(ncn2C)n(C)c1=O)C
n1(c(=O)c2c(n(c1=O)C)ncn2C)C
n1(c(=O)c2c(n(C)c1=O)ncn2C)C
n1(c(=O)c2n(C)cnc2n(c1=O)C)C
n1(c(=O)c2n(C)cnc2n(C)c1=O)C
n1(c(=O)c2n(cnc2n(c1=O)C)C)C
n1(c(=O)c2n(cnc2n(C)c1=O)C)C
n1(c(=O)c(n2C)c(nc2)n(c1=O)C)C
n1(c(=O)c(n2C)c(nc2)n(C)c1=O)C
n1(c(=O)c(n2C)c(n(c1=O)C)nc2)C
n1(c(=O)c(n2C)c(n(C)c1=O)nc2)C
n1(c(=O)c(c2n(c1=O)C)n(C)cn2)C
n1(c(=O)c(c2n(c1=O)C)n(cn2)C)C
n1(c(=O)c(c2n(C)c1=O)n(C)cn2)C
n1(c(=O)c(c2n(C)c1=O)n(cn2)C)C
n1(C)c(c2c(ncn2C)n(c1=O)C)=O
n1(C)c(c2c(ncn2C)n(C)c1=O)=O
n1(C)c(c2c(n(c1=O)C)ncn2C)=O
n1(C)c(c2c(n(C)c1=O)ncn2C)=O
n1(C)c(c2n(C)cnc2n(c1=O)C)=O
n1(C)c(c2n(C)cnc2n(C)c1=O)=O
n1(C)c(c2n(cnc2n(c1=O)C)C)=O
n1(C)c(c2n(cnc2n(C)c1=O)C)=O
n1(C)c(c(n2C)c(nc2)n(c1=O)C)=O
n1(C)c(c(n2C)c(nc2)n(C)c1=O)=O
n1(C)c(c(n2C)c(n(c1=O)C)nc2)=O
n1(C)c(c(n2C)c(n(C)c1=O)nc2)=O
n1(C)c(c(c2n(c1=O)C)n(C)cn2)=O
n1(C)c(c(c2n(c1=O)C)n(cn2)C)=O
n1(C)c(c(c2n(C)c1=O)n(C)cn2)=O
n1(C)c(c(c2n(C)c1=O)n(cn2)C)=O
n1(C)c(=O)c2c(ncn2C)n(c1=O)C
n1(C)c(=O)c2c(ncn2C)n(C)c1=O
n1(C)c(=O)c2c(n(c1=O)C)ncn2C
n1(C)c(=O)c2c(n(C)c1=O)ncn2C
n1(C)c(=O)c2n(C)cnc2n(c1=O)C
n1(C)c(=O)c2n(C)cnc2n(C)c1=O
n1(C)c(=O)c2n(cnc2n(c1=O)C)C
n1(C)c(=O)c2n(cnc2n(C)c1=O)C
n1(C)c(=O)c(n2C)c(nc2)n(c1=O)C
n1(C)c(=O)c(n2C)c(nc2)n(C)c1=O
n1(C)c(=O)c(n2C)c(n(c1=O)C)nc2
n1(C)c(=O)c(n2C)c(n(C)c1=O)nc2
n1(C)c(=O)c(c2n(c1=O)C)n(C)cn2
n1(C)c(=O)c(c2n(c1=O)C)n(cn2)C
n1(C)c(=O)c(c2n(C)c1=O)n(C)cn2
n1(C)c(=O)c(c2n(C)c1=O)n(cn2)C
c1(=O)n(c2c(n(C)cn2)c(=O)n1C)C
c1(=O)n(c2c(n(C)cn2)c(n1C)=O)C
c1(=O)n(c2c(n(cn2)C)c(=O)n1C)C
c1(=O)n(c2c(n(cn2)C)c(n1C)=O)C
c1(=O)n(c2c(c(=O)n1C)n(C)cn2)C
c1(=O)n(c2c(c(=O)n1C)n(cn2)C)C
c1(=O)n(c2c(c(n1C)=O)n(C)cn2)C
c1(=O)n(c2c(c(n1C)=O)n(cn2)C)C
c1(=O)n(c2ncn(C)c2c(=O)n1C)C
c1(=O)n(c2ncn(C)c2c(n1C)=O)C
c1(=O)n(c2ncn(c2c(=O)n1C)C)C
c1(=O)n(c2ncn(c2c(n1C)=O)C)C
c1(=O)n(c(ncn2C)c2c(=O)n1C)C
c1(=O)n(c(ncn2C)c2c(n1C)=O)C
c1(=O)n(c(c2c(=O)n1C)ncn2C)C
c1(=O)n(c(c2c(n1C)=O)ncn2C)C
c1(=O)n(c(c(n2C)c(=O)n1C)nc2)C
c1(=O)n(c(c(n2C)c(n1C)=O)nc2)C
c1(=O)n(c(c(c(=O)n1C)n2C)nc2)C
c1(=O)n(c(c(c(n1C)=O)n2C)nc2)C
c1(=O)n(C)c2c(n(C)cn2)c(=O)n1C
c1(=O)n(C)c2c(n(C)cn2)c(n1C)=O
c1(=O)n(C)c2c(n(cn2)C)c(=O)n1C
c1(=O)n(C)c2c(n(cn2)C)c(n1C)=O
c1(=O)n(C)c2c(c(=O)n1C)n(C)cn2
c1(=O)n(C)c2c(c(=O)n1C)n(cn2)C
c1(=O)n(C)c2c(c(n1C)=O)n(C)cn2
c1(=O)n(C)c2c(c(n1C)=O)n(cn2)C
c1(=O)n(C)c2ncn(C)c2c(=O)n1C
c1(=O)n(C)c2ncn(C)c2c(n1C)=O
c1(=O)n(C)c2ncn(c2c(=O)n1C)C
c1(=O)n(C)c2ncn(c2c(n1C)=O)C
c1(=O)n(C)c(ncn2C)c2c(=O)n1C
c1(=O)n(C)c(ncn2C)c2c(n1C)=O
c1(=O)n(C)c(c2c(=O)n1C)ncn2C
c1(=O)n(C)c(c2c(n1C)=O)ncn2C
c1(=O)n(C)c(c(n2C)c(=O)n1C)nc2
c1(=O)n(C)c(c(n2C)c(n1C)=O)nc2
c1(=O)n(C)c(c(c(=O)n1C)n2C)nc2
c1(=O)n(C)c(c(c(n1C)=O)n2C)nc2
c1(n(c2c(n(C)cn2)c(=O)n1C)C)=O
c1(n(c2c(n(C)cn2)c(n1C)=O)C)=O
c1(n(c2c(n(cn2)C)c(=O)n1C)C)=O
c1(n(c2c(n(cn2)C)c(n1C)=O)C)=O
c1(n(c2c(c(=O)n1C)n(C)cn2)C)=O
c1(n(c2c(c(=O)n1C)n(cn2)C)C)=O
c1(n(c2c(c(n1C)=O)n(C)cn2)C)=O
c1(n(c2c(c(n1C)=O)n(cn2)C)C)=O
c1(n(c2ncn(C)c2c(=O)n1C)C)=O
c1(n(c2ncn(C)c2c(n1C)=O)C)=O
c1(n(c2ncn(c2c(=O)n1C)C)C)=O
c1(n(c2ncn(c2c(n1C)=O)C)C)=O
c1(n(c(ncn2C)c2c(=O)n1C)C)=O
c1(n(c(ncn2C)c2c(n1C)=O)C)=O
c1(n(c(c2c(=O)n1C)ncn2C)C)=O
c1(n(c(c2c(n1C)=O)ncn2C)C)=O
c1(n(c(c(n2C)c(=O)n1C)nc2)C)=O
c1(n(c(c(n2C)c(n1C)=O)nc2)C)=O
c1(n(c(c(c(=O)n1C)n2C)nc2)C)=O
c1(n(c(c(c(n1C)=O)n2C)nc2)C)=O
c1(n(C)c2c(n(C)cn2)c(=O)n1C)=O
c1(n(C)c2c(n(C)cn2)c(n1C)=O)=O
c1(n(C)c2c(n(cn2)C)c(=O)n1C)=O
c1(n(C)c2c(n(cn2)C)c(n1C)=O)=O
c1(n(C)c2c(c(=O)n1C)n(C)cn2)=O
c1(n(C)c2c(c(=O)n1C)n(cn2)C)=O
c1(n(C)c2c(c(n1C)=O)n(C)cn2)=O
c1(n(C)c2c(c(n1C)=O)n(cn2)C)=O
c1(n(C)c2ncn(C)c2c(=O)n1C)=O
c1(n(C)c2ncn(C)c2c(n1C)=O)=O
c1(n(C)c2ncn(c2c(=O)n1C)C)=O
c1(n(C)c2ncn(c2c(n1C)=O)C)=O
c1(n(C)c(ncn2C)c2c(=O)n1C)=O
c1(n(C)c(ncn2C)c2c(n1C)=O)=O
c1(n(C)c(c2c(=O)n1C)ncn2C)=O
c1(n(C)c(c2c(n1C)=O)ncn2C)=O
c1(n(C)c(c(n2C)c(=O)n1C)nc2)=O
c1(n(C)c(c(n2C)c(n1C)=O)nc2)=O
c1(n(C)c(c(c(=O)n1C)n2C)nc2)=O
c1(n(C)c(c(c(n1C)=O)n2C)nc2)=O
c1(n(c(c2c(ncn2C)n1C)=O)C)=O
c1(n(c(c2c(n1C)ncn2C)=O)C)=O
c1(n(c(c2n(C)cnc2n1C)=O)C)=O
c1(n(c(c2n(cnc2n1C)C)=O)C)=O
c1(n(c(c(n2C)c(nc2)n1C)=O)C)=O
c1(n(c(c(n2C)c(n1C)nc2)=O)C)=O
c1(n(c(c(c2n1C)n(C)cn2)=O)C)=O
c1(n(c(c(c2n1C)n(cn2)C)=O)C)=O
c1(n(c(=O)c2c(ncn2C)n1C)C)=O
c1(n(c(=O)c2c(n1C)ncn2C)C)=O
c1(n(c(=O)c2n(C)cnc2n1C)C)=O
c1(n(c(=O)c2n(cnc2n1C)C)C)=O
c1(n(c(=O)c(n2C)c(nc2)n1C)C)=O
c1(n(c(=O)c(n2C)c(n1C)nc2)C)=O
c1(n(c(=O)c(c2n1C)n(C)cn2)C)=O
c1(n(c(=O)c(c2n1C)n(cn2)C)C)=O
c1(n(C)c(c2c(ncn2C)n1C)=O)=O
c1(n(C)c(c2c(n1C)ncn2C)=O)=O
c1(n(C)c(c2n(C)cnc2n1C)=O)=O
c1(n(C)c(c2n(cnc2n1C)C)=O)=O
c1(n(C)c(c(n2C)c(nc2)n1C)=O)=O
c1(n(C)c(c(n2C)c(n1C)nc2)=O)=O
c1(n(C)c(c(c2n1C)n(C)cn2)=O)=O
c1(n(C)c(c(c2n1C)n(cn2)C)=O)=O
c1(n(C)c(=O)c2c(ncn2C)n1C)=O
c1(n(C)c(=O)c2c(n1C)ncn2C)=O
c1(n(C)c(=O)c2n(C)cnc2n1C)=O
c1(n(C)c(=O)c2n(cnc2n1C)C)=O
c1(n(C)c(=O)c(n2C)c(nc2)n1C)=O
c1(n(C)c(=O)c(n2C)c(n1C)nc2)=O
c1(n(C)c(=O)c(c2n1C)n(C)cn2)=O
c1(n(C)c(=O)c(c2n1C)n(cn2)C)=O
c1(=O)n(c(c2c(ncn2C)n1C)=O)C
c1(=O)n(c(c2c(n1C)ncn2C)=O)C
c1(=O)n(c(c2n(C)cnc2n1C)=O)C
c1(=O)n(c(c2n(cnc2n1C)C)=O)C
c1(=O)n(c(c(n2C)c(nc2)n1C)=O)C
c1(=O)n(c(c(n2C)c(n1C)nc2)=O)C
c1(=O)n(c(c(c2n1C)n(C)cn2)=O)C
c1(=O)n(c(c(c2n1C)n(cn2)C)=O)C
c1(=O)n(c(=O)c2c(ncn2C)n1C)C
c1(=O)n(c(=O)c2c(n1C)ncn2C)C
c1(=O)n(c(=O)c2n(C)cnc2n1C)C
c1(=O)n(c(=O)c2n(cnc2n1C)C)C
c1(=O)n(c(=O)c(n2C)c(nc2)n1C)C
c1(=O)n(c(=O)c(n2C)c(n1C)nc2)C
c1(=O)n(c(=O)c(c2n1C)n(C)cn2)C
c1(=O)n(c(=O)c(c2n1C)n(cn2)C)C
c1(=O)n(C)c(c2c(ncn2C)n1C)=O
c1(=O)n(C)c(c2c(n1C)ncn2C)=O
c1(=O)n(C)c(c2n(C)cnc2n1C)=O
c1(=O)n(C)c(c2n(cnc2n1C)C)=O
c1(=O)n(C)c(c(n2C)c(nc2)n1C)=O
c1(=O)n(C)c(c(n2C)c(n1C)nc2)=O
c1(=O)n(C)c(c(c2n1C)n(C)cn2)=O
c1(=O)n(C)c(c(c2n1C)n(cn2)C)=O
c1(=O)n(C)c(=O)c2c(ncn2C)n1C
c1(=O)n(C)c(=O)c2c(n1C)ncn2C
c1(=O)n(C)c(=O)c2n(C)cnc2n1C
c1(=O)n(C)c(=O)c2n(cnc2n1C)C
c1(=O)n(C)c(=O)c(n2C)c(nc2)n1C
c1(=O)n(C)c(=O)c(n2C)c(n1C)nc2
c1(=O)n(C)c(=O)c(c2n1C)n(C)cn2
c1(=O)n(C)c(=O)c(c2n1C)n(cn2)C
O=c1n(c2c(n(C)cn2)c(=O)n1C)C
O=c1n(c2c(n(C)cn2)c(n1C)=O)C
O=c1n(c2c(n(cn2)C)c(=O)n1C)C
O=c1n(c2c(n(cn2)C)c(n1C)=O)C
O=c1n(c2c(c(=O)n1C)n(C)cn2)C
O=c1n(c2c(c(=O)n1C)n(cn2)C)C
O=c1n(c2c(c(n1C)=O)n(C)cn2)C
O=c1n(c2c(c(n1C)=O)n(cn2)C)C
O=c1n(c2ncn(C)c2c(=O)n1C)C
O=c1n(c2ncn(C)c2c(n1C)=O)C
O=c1n(c2ncn(c2c(=O)n1C)C)C
O=c1n(c2ncn(c2c(n1C)=O)C)C
O=c1n(c(ncn2C)c2c(=O)n1C)C
O=c1n(c(ncn2C)c2c(n1C)=O)C
O=c1n(c(c2c(=O)n1C)ncn2C)C
O=c1n(c(c2c(n1C)=O)ncn2C)C
O=c1n(c(c(n2C)c(=O)n1C)nc2)C
O=c1n(c(c(n2C)c(n1C)=O)nc2)C
O=c1n(c(c(c(=O)n1C)n2C)nc2)C
O=c1n(c(c(c(n1C)=O)n2C)nc2)C
O=c1n(C)c2c(n(C)cn2)c(=O)n1C
O=c1n(C)c2c(n(C)cn2)c(n1C)=O
O=c1n(C)c2c(n(cn2)C)c(=O)n1C
O=c1n(C)c2c(n(cn2)C)c(n1C)=O
O=c1n(C)c2c(c(=O)n1C)n(C)cn2
O=c1n(C)c2c(c(=O)n1C)n(cn2)C
O=c1n(C)c2c(c(n1C)=O)n(C)cn2
O=c1n(C)c2c(c(n1C)=O)n(cn2)C
O=c1n(C)c2ncn(C)c2c(=O)n1C
O=c1n(C)c2ncn(C)c2c(n1C)=O
O=c1n(C)c2ncn(c2c(=O)n1C)C
O=c1n(C)c2ncn(c2c(n1C)=O)C
O=c1n(C)c(ncn2C)c2c(=O)n1C
O=c1n(C)c(ncn2C)c2c(n1C)=O
O=c1n(C)c(c2c(=O)n1C)ncn2C
O=c1n(C)c(c2c(n1C)=O)ncn2C
O=c1n(C)c(c(n2C)c(=O)n1C)nc2
O=c1n(C)c(c(n2C)c(n1C)=O)nc2
O=c1n(C)c(c(c(=O)n1C)n2C)nc2
O=c1n(C)c(c(c(n1C)=O)n2C)nc2
O=c1n(c(c2c(ncn2C)n1C)=O)C
O=c1n(c(c2c(n1C)ncn2C)=O)C
O=c1n(c(c2n(C)cnc2n1C)=O)C
O=c1n(c(c2n(cnc2n1C)C)=O)C
O=c1n(c(c(n2C)c(nc2)n1C)=O)C
O=c1n(c(c(n2C)c(n1C)nc2)=O)C
O=c1n(c(c(c2n1C)n(C)cn2)=O)C
O=c1n(c(c(c2n1C)n(cn2)C)=O)C
O=c1n(c(=O)c2c(ncn2C)n1C)C
O=c1n(c(=O)c2c(n1C)ncn2C)C
O=c1n(c(=O)c2n(C)cnc2n1C)C
O=c1n(c(=O)c2n(cnc2n1C)C)C
O=c1n(c(=O)c(n2C)c(nc2)n1C)C
O=c1n(c(=O)c(n2C)c(n1C)nc2)C
O=c1n(c(=O)c(c2n1C)n(C)cn2)C
O=c1n(c(=O)c(c2n1C)n(cn2)C)C
O=c1n(C)c(c2c(ncn2C)n1C)=O
O=c1n(C)c(c2c(n1C)ncn2C)=O
O=c1n(C)c(c2n(C)cnc2n1C)=O
O=c1n(C)c(c2n(cnc2n1C)C)=O
O=c1n(C)c(c(n2C)c(nc2)n1C)=O
O=c1n(C)c(c(n2C)c(n1C)nc2)=O
O=c1n(C)c(c(c2n1C)n(C)cn2)=O
O=c1n(C)c(c(c2n1C)n(cn2)C)=O
O=c1n(C)c(=O)c2c(ncn2C)n1C
O=c1n(C)c(=O)c2c(n1C)ncn2C
O=c1n(C)c(=O)c2n(C)cnc2n1C
O=c1n(C)c(=O)c2n(cnc2n1C)C
O=c1n(C)c(=O)c(n2C)c(nc2)n1C
O=c1n(C)c(=O)c(n2C)c(n1C)nc2
O=c1n(C)c(=O)c(c2n1C)n(C)cn2
O=c1n(C)c(=O)c(c2n1C)n(cn2)C
O=c(n1C)n(c2c(n(C)cn2)c1=O)C
O=c(n1C)n(c2c(n(cn2)C)c1=O)C
O=c(n1C)n(c2c(c1=O)n(C)cn2)C
O=c(n1C)n(c2c(c1=O)n(cn2)C)C
O=c(n1C)n(c2ncn(C)c2c1=O)C
O=c(n1C)n(c2ncn(c2c1=O)C)C
O=c(n1C)n(c(ncn2C)c2c1=O)C
O=c(n1C)n(c(c2c1=O)ncn2C)C
O=c(n1C)n(c(c(n2C)c1=O)nc2)C
O=c(n1C)n(c(c(c1=O)n2C)nc2)C
O=c(n1C)n(C)c2c(n(C)cn2)c1=O
O=c(n1C)n(C)c2c(n(cn2)C)c1=O
O=c(n1C)n(C)c2c(c1=O)n(C)cn2
O=c(n1C)n(C)c2c(c1=O)n(cn2)C
O=c(n1C)n(C)c2ncn(C)c2c1=O
O=c(n1C)n(C)c2ncn(c2c1=O)C
O=c(n1C)n(C)c(ncn2C)c2c1=O
O=c(n1C)n(C)c(c2c1=O)ncn2C
O=c(n1C)n(C)c(c(n2C)c1=O)nc2
O=c(n1C)n(C)c(c(c1=O)n2C)nc2
O=c(n(c1=O)C)n(c2c1n(C)cn2)C
O=c(n(c1=O)C)n(c2c1n(cn2)C)C
O=c(n(c1=O)C)n(c2ncn(C)c21)C
O=c(n(c1=O)C)n(c2ncn(C)c12)C
O=c(n(c1=O)C)n(c2ncn(c21)C)C
O=c(n(c1=O)C)n(c2ncn(c12)C)C
O=c(n(c1=O)C)n(c(ncn2C)c21)C
O=c(n(c1=O)C)n(c(ncn2C)c12)C
O=c(n(c1=O)C)n(c(c1n2C)nc2)C
O=c(n(c1=O)C)n(C)c2c1n(C)cn2
O=c(n(c1=O)C)n(C)c2c1n(cn2)C
O=c(n(c1=O)C)n(C)c2ncn(C)c21
O=c(n(c1=O)C)n(C)c2ncn(C)c12
O=c(n(c1=O)C)n(C)c2ncn(c21)C
O=c(n(c1=O)C)n(C)c2ncn(c12)C
O=c(n(c1=O)C)n(C)c(ncn2C)c21
O=c(n(c1=O)C)n(C)c(ncn2C)c12
O=c(n(c1=O)C)n(C)c(c1n2C)nc2
O=c(n(c(c1c2ncn1C)=O)C)n2C
O=c(n(c(c1n2C)=O)C)n(c1nc2)C
O=c(n(c(c1n2C)=O)C)n(C)c1nc2
O=c(n(c(c(n1C)c2nc1)=O)C)n2C
O=c(n(c(=O)c1c2ncn1C)C)n2C
O=c(n(c(=O)c1n2C)C)n(c1nc2)C
O=c(n(c(=O)c1n2C)C)n(C)c1nc2
O=c(n(c(=O)c(n1C)c2nc1)C)n2C
O=c(n(C)c1=O)n(c2c1n(C)cn2)C
O=c(n(C)c1=O)n(c2c1n(cn2)C)C
O=c(n(C)c1=O)n(c2ncn(C)c21)C
O=c(n(C)c1=O)n(c2ncn(C)c12)C
O=c(n(C)c1=O)n(c2ncn(c21)C)C
O=c(n(C)c1=O)n(c2ncn(c12)C)C
O=c(n(C)c1=O)n(c(ncn2C)c21)C
O=c(n(C)c1=O)n(c(ncn2C)c12)C
O=c(n(C)c1=O)n(c(c1n2C)nc2)C
O=c(n(C)c1=O)n(C)c2c1n(C)cn2
O=c(n(C)c1=O)n(C)c2c1n(cn2)C
O=c(n(C)c1=O)n(C)c2ncn(C)c21
O=c(n(C)c1=O)n(C)c2ncn(C)c12
O=c(n(C)c1=O)n(C)c2ncn(c21)C
O=c(n(C)c1=O)n(C)c2ncn(c12)C
O=c(n(C)c1=O)n(C)c(ncn2C)c21
O=c(n(C)c1=O)n(C)c(ncn2C)c12
O=c(n(C)c1=O)n(C)c(c1n2C)nc2
O=c(n(C)c(c1c2ncn1C)=O)n2C
O=c(n(C)c(c1n2C)=O)n(c1nc2)C
O=c(n(C)c(c1n2C)=O)n(C)c1nc2
O=c(n(C)c(c(n1C)c2nc1)=O)n2C
O=c(n(C)c(=O)c1c2ncn1C)n2C
O=c(n(C)c(=O)c1n2C)n(c1nc2)C
O=c(n(C)c(=O)c1n2C)n(C)c1nc2
O=c(n(C)c(=O)c(n1C)c2nc1)n2C
O=c(n1C)n(c(c2c1ncn2C)=O)C
O=c(n1C)n(c(c2n(C)cnc12)=O)C
O=c(n1C)n(c(c2n(C)cnc21)=O)C
O=c(n1C)n(c(c2n(cnc12)C)=O)C
O=c(n1C)n(c(c2n(cnc21)C)=O)C
O=c(n1C)n(c(c(n2C)c1nc2)=O)C
O=c(n1C)n(c(=O)c2c1ncn2C)C
O=c(n1C)n(c(=O)c2n(C)cnc12)C
O=c(n1C)n(c(=O)c2n(C)cnc21)C
O=c(n1C)n(c(=O)c2n(cnc12)C)C
O=c(n1C)n(c(=O)c2n(cnc21)C)C
O=c(n1C)n(c(=O)c(n2C)c1nc2)C
O=c(n1C)n(C)c(c2c1ncn2C)=O
O=c(n1C)n(C)c(c2n(C)cnc12)=O
O=c(n1C)n(C)c(c2n(C)cnc21)=O
O=c(n1C)n(C)c(c2n(cnc12)C)=O
O=c(n1C)n(C)c(c2n(cnc21)C)=O
O=c(n1C)n(C)c(c(n2C)c1nc2)=O
O=c(n1C)n(C)c(=O)c2c1ncn2C
O=c(n1C)n(C)c(=O)c2n(C)cnc12
O=c(n1C)n(C)c(=O)c2n(C)cnc21
O=c(n1C)n(C)c(=O)c2n(cnc12)C
O=c(n1C)n(C)c(=O)c2n(cnc21)C
O=c(n1C)n(C)c(=O)c(n2C)c1nc2
O=c(n(c1c2n(C)cn1)C)n(c2=O)C
O=c(n(c1c2n(C)cn1)C)n(C)c2=O
O=c(n(c1c2n(cn1)C)C)n(c2=O)C
O=c(n(c1c2n(cn1)C)C)n(C)c2=O
O=c(n(c1c(n(C)cn1)c2=O)C)n2C
O=c(n(c1c(n(cn1)C)c2=O)C)n2C
O=c(n(c1c(c2=O)n(C)cn1)C)n2C
O=c(n(c1c(c2=O)n(cn1)C)C)n2C
O=c(n(c1ncn2C)C)n(c(c21)=O)C
O=c(n(c1ncn2C)C)n(c(c12)=O)C
O=c(n(c1ncn2C)C)n(c(=O)c21)C
O=c(n(c1ncn2C)C)n(c(=O)c12)C
O=c(n(c1ncn2C)C)n(C)c(c21)=O
O=c(n(c1ncn2C)C)n(C)c(c12)=O
O=c(n(c1ncn2C)C)n(C)c(=O)c21
O=c(n(c1ncn2C)C)n(C)c(=O)c12
O=c(n(c1ncn(C)c1c2=O)C)n2C
O=c(n(c1ncn(c1c2=O)C)C)n2C
O=c(n(c(ncn1C)c1c2=O)C)n2C
O=c(n(c(c1c2=O)ncn1C)C)n2C
O=c(n(c(c1n2C)nc2)C)n(c1=O)C
O=c(n(c(c1n2C)nc2)C)n(C)c1=O
O=c(n(c(c(n1C)c2=O)nc1)C)n2C
O=c(n(c(c(c1=O)n2C)nc2)C)n1C
O=c(n(C)c1c2n(C)cn1)n(c2=O)C
O=c(n(C)c1c2n(C)cn1)n(C)c2=O
O=c(n(C)c1c2n(cn1)C)n(c2=O)C
O=c(n(C)c1c2n(cn1)C)n(C)c2=O
O=c(n(C)c1c(n(C)cn1)c2=O)n2C
O=c(n(C)c1c(n(cn1)C)c2=O)n2C
O=c(n(C)c1c(c2=O)n(C)cn1)n2C
O=c(n(C)c1c(c2=O)n(cn1)C)n2C
O=c(n(C)c1ncn2C)n(c(c21)=O)C
O=c(n(C)c1ncn2C)n(c(c12)=O)C
O=c(n(C)c1ncn2C)n(c(=O)c21)C
O=c(n(C)c1ncn2C)n(c(=O)c12)C
O=c(n(C)c1ncn2C)n(C)c(c21)=O
O=c(n(C)c1ncn2C)n(C)c(c12)=O
O=c(n(C)c1ncn2C)n(C)c(=O)c21
O=c(n(C)c1ncn2C)n(C)c(=O)c12
O=c(n(C)c1ncn(C)c1c2=O)n2C
O=c(n(C)c1ncn(c1c2=O)C)n2C
O=c(n(C)c(ncn1C)c1c2=O)n2C
O=c(n(C)c(c1c2=O)ncn1C)n2C
O=c(n(C)c(c1n2C)nc2)n(c1=O)C
O=c(n(C)c(c1n2C)nc2)n(C)c1=O
O=c(n(C)c(c(n1C)c2=O)nc1)n2C
O=c(n(C)c(c(c1=O)n2C)nc2)n1C
n1(c(n(c(c2c1ncn2C)=O)C)=O)C
n1(c(n(c(c2n(C)cnc12)=O)C)=O)C
n1(c(n(c(c2n(C)cnc21)=O)C)=O)C
n1(c(n(c(c2n(cnc12)C)=O)C)=O)C
n1(c(n(c(c2n(cnc21)C)=O)C)=O)C
n1(c(n(c(c(n2C)c1nc2)=O)C)=O)C
n1(c(n(c(=O)c2c1ncn2C)C)=O)C
n1(c(n(c(=O)c2n(C)cnc12)C)=O)C
n1(c(n(c(=O)c2n(C)cnc21)C)=O)C
n1(c(n(c(=O)c2n(cnc12)C)C)=O)C
n1(c(n(c(=O)c2n(cnc21)C)C)=O)C
n1(c(n(c(=O)c(n2C)c1nc2)C)=O)C
n1(c(n(C)c(c2c1ncn2C)=O)=O)C
n1(c(n(C)c(c2n(C)cnc12)=O)=O)C
n1(c(n(C)c(c2n(C)cnc21)=O)=O)C
n1(c(n(C)c(c2n(cnc12)C)=O)=O)C
n1(c(n(C)c(c2n(cnc21)C)=O)=O)C
n1(c(n(C)c(c(n2C)c1nc2)=O)=O)C
n1(c(n(C)c(=O)c2c1ncn2C)=O)C
n1(c(n(C)c(=O)c2n(C)cnc12)=O)C
n1(c(n(C)c(=O)c2n(C)cnc21)=O)C
n1(c(n(C)c(=O)c2n(cnc12)C)=O)C
n1(c(n(C)c(=O)c2n(cnc21)C)=O)C
n1(c(n(C)c(=O)c(n2C)c1nc2)=O)C
n1(c(=O)n(c(c2c1ncn2C)=O)C)C
n1(c(=O)n(c(c2n(C)cnc12)=O)C)C
n1(c(=O)n(c(c2n(C)cnc21)=O)C)C
n1(c(=O)n(c(c2n(cnc12)C)=O)C)C
n1(c(=O)n(c(c2n(cnc21)C)=O)C)C
n1(c(=O)n(c(c(n2C)c1nc2)=O)C)C
n1(c(=O)n(c(=O)c2c1ncn2C)C)C
n1(c(=O)n(c(=O)c2n(C)cnc12)C)C
n1(c(=O)n(c(=O)c2n(C)cnc21)C)C
n1(c(=O)n(c(=O)c2n(cnc12)C)C)C
n1(c(=O)n(c(=O)c2n(cnc21)C)C)C
n1(c(=O)n(c(=O)c(n2C)c1nc2)C)C
n1(c(=O)n(C)c(c2c1ncn2C)=O)C
n1(c(=O)n(C)c(c2n(C)cnc12)=O)C
n1(c(=O)n(C)c(c2n(C)cnc21)=O)C
n1(c(=O)n(C)c(c2n(cnc12)C)=O)C
n1(c(=O)n(C)c(c2n(cnc21)C)=O)C
n1(c(=O)n(C)c(c(n2C)c1nc2)=O)C
n1(c(=O)n(C)c(=O)c2c1ncn2C)C
n1(c(=O)n(C)c(=O)c2n(C)cnc12)C
n1(c(=O)n(C)c(=O)c2n(C)cnc21)C
n1(c(=O)n(C)c(=O)c2n(cnc12)C)C
n1(c(=O)n(C)c(=O)c2n(cnc21)C)C
n1(c(=O)n(C)c(=O)c(n2C)c1nc2)C
n1(C)c(n(c(c2c1ncn2C)=O)C)=O
n1(C)c(n(c(c2n(C)cnc12)=O)C)=O
n1(C)c(n(c(c2n(C)cnc21)=O)C)=O
n1(C)c(n(c(c2n(cnc12)C)=O)C)=O
n1(C)c(n(c(c2n(cnc21)C)=O)C)=O
n1(C)c(n(c(c(n2C)c1nc2)=O)C)=O
n1(C)c(n(c(=O)c2c1ncn2C)C)=O
n1(C)c(n(c(=O)c2n(C)cnc12)C)=O
n1(C)c(n(c(=O)c2n(C)cnc21)C)=O
n1(C)c(n(c(=O)c2n(cnc12)C)C)=O
n1(C)c(n(c(=O)c2n(cnc21)C)C)=O
n1(C)c(n(c(=O)c(n2C)c1nc2)C)=O
n1(C)c(n(C)c(c2c1ncn2C)=O)=O
n1(C)c(n(C)c(c2n(C)cnc12)=O)=O
n1(C)c(n(C)c(c2n(C)cnc21)=O)=O
n1(C)c(n(C)c(c2n(cnc12)C)=O)=O
n1(C)c(n(C)c(c2n(cnc21)C)=O)=O
n1(C)c(n(C)c(c(n2C)c1nc2)=O)=O
n1(C)c(n(C)c(=O)c2c1ncn2C)=O
n1(C)c(n(C)c(=O)c2n(C)cnc12)=O
n1(C)c(n(C)c(=O)c2n(C)cnc21)=O
n1(C)c(n(C)c(=O)c2n(cnc12)C)=O
n1(C)c(n(C)c(=O)c2n(cnc21)C)=O
n1(C)c(n(C)c(=O)c(n2C)c1nc2)=O
n1(C)c(=O)n(c(c2c1ncn2C)=O)C
n1(C)c(=O)n(c(c2n(C)cnc12)=O)C
n1(C)c(=O)n(c(c2n(C)cnc21)=O)C
n1(C)c(=O)n(c(c2n(cnc12)C)=O)C
n1(C)c(=O)n(c(c2n(cnc21)C)=O)C
n1(C)c(=O)n(c(c(n2C)c1nc2)=O)C
n1(C)c(=O)n(c(=O)c2c1ncn2C)C
n1(C)c(=O)n(c(=O)c2n(C)cnc12)C
n1(C)c(=O)n(c(=O)c2n(C)cnc21)C
n1(C)c(=O)n(c(=O)c2n(cnc12)C)C
n1(C)c(=O)n(c(=O)c2n(cnc21)C)C
n1(C)c(=O)n(c(=O)c(n2C)c1nc2)C
n1(C)c(=O)n(C)c(c2c1ncn2C)=O
n1(C)c(=O)n(C)c(c2n(C)cnc12)=O
n1(C)c(=O)n(C)c(c2n(C)cnc21)=O
n1(C)c(=O)n(C)c(c2n(cnc12)C)=O
n1(C)c(=O)n(C)c(c2n(cnc21)C)=O
n1(C)c(=O)n(C)c(c(n2C)c1nc2)=O
n1(C)c(=O)n(C)c(=O)c2c1ncn2C
n1(C)c(=O)n(C)c(=O)c2n(C)cnc12
n1(C)c(=O)n(C)c(=O)c2n(C)cnc21
n1(C)c(=O)n(C)c(=O)c2n(cnc12)C
n1(C)c(=O)n(C)c(=O)c2n(cnc21)C
n1(C)c(=O)n(C)c(=O)c(n2C)c1nc2
n1(c2c(n(C)cn2)c(=O)n(c1=O)C)C
n1(c2c(n(C)cn2)c(=O)n(C)c1=O)C
n1(c2c(n(C)cn2)c(n(c1=O)C)=O)C
n1(c2c(n(C)cn2)c(n(C)c1=O)=O)C
n1(c2c(n(cn2)C)c(=O)n(c1=O)C)C
n1(c2c(n(cn2)C)c(=O)n(C)c1=O)C
n1(c2c(n(cn2)C)c(n(c1=O)C)=O)C
n1(c2c(n(cn2)C)c(n(C)c1=O)=O)C
n1(c2c(c(=O)n(c1=O)C)n(C)cn2)C
n1(c2c(c(=O)n(c1=O)C)n(cn2)C)C
n1(c2c(c(=O)n(C)c1=O)n(C)cn2)C
n1(c2c(c(=O)n(C)c1=O)n(cn2)C)C
n1(c2c(c(n(c1=O)C)=O)n(C)cn2)C
n1(c2c(c(n(c1=O)C)=O)n(cn2)C)C
n1(c2c(c(n(C)c1=O)=O)n(C)cn2)C
n1(c2c(c(n(C)c1=O)=O)n(cn2)C)C
n1(c2ncn(C)c2c(=O)n(c1=O)C)C
n1(c2ncn(C)c2c(=O)n(C)c1=O)C
n1(c2ncn(C)c2c(n(c1=O)C)=O)C
n1(c2ncn(C)c2c(n(C)c1=O)=O)C
n1(c2ncn(c2c(=O)n(c1=O)C)C)C
n1(c2ncn(c2c(=O)n(C)c1=O)C)C
n1(c2ncn(c2c(n(c1=O)C)=O)C)C
n1(c2ncn(c2c(n(C)c1=O)=O)C)C
n1(c(ncn2C)c2c(=O)n(c1=O)C)C
n1(c(ncn2C)c2c(=O)n(C)c1=O)C
n1(c(ncn2C)c2c(n(c1=O)C)=O)C
n1(c(ncn2C)c2c(n(C)c1=O)=O)C
n1(c(c2c(=O)n(c1=O)C)ncn2C)C
n1(c(c2c(=O)n(C)c1=O)ncn2C)C
n1(c(c2c(n(c1=O)C)=O)ncn2C)C
n1(c(c2c(n(C)c1=O)=O)ncn2C)C
n1(c(c(n2C)c(=O)n(c1=O)C)nc2)C
n1(c(c(n2C)c(=O)n(C)c1=O)nc2)C
n1(c(c(n2C)c(n(c1=O)C)=O)nc2)C
n1(c(c(n2C)c(n(C)c1=O)=O)nc2)C
n1(c(c(c(=O)n(c1=O)C)n2C)nc2)C
n1(c(c(c(=O)n(C)c1=O)n2C)nc2)C
n1(c(c(c(n(c1=O)C)=O)n2C)nc2)C
n1(c(c(c(n(C)c1=O)=O)n2C)nc2)C
n1(C)c2c(n(C)cn2)c(=O)n(c1=O)C
n1(C)c2c(n(C)cn2)c(=O)n(C)c1=O
n1(C)c2c(n(C)cn2)c(n(c1=O)C)=O
n1(C)c2c(n(C)cn2)c(n(C)c1=O)=O
n1(C)c2c(n(cn2)C)c(=O)n(c1=O)C
n1(C)c2c(n(cn2)C)c(=O)n(C)c1=O
n1(C)c2c(n(cn2)C)c(n(c1=O)C)=O
n1(C)c2c(n(cn2)C)c(n(C)c1=O)=O
n1(C)c2c(c(=O)n(c1=O)C)n(C)cn2
n1(C)c2c(c(=O)n(c1=O)C)n(cn2)C
n1(C)c2c(c(=O)n(C)c1=O)n(C)cn2
n1(C)c2c(c(=O)n(C)c1=O)n(cn2)C
n1(C)c2c(c(n(c1=O)C)=O)n(C)cn2
n1(C)c2c(c(n(c1=O)C)=O)n(cn2)C
n1(C)c2c(c(n(C)c1=O)=O)n(C)cn2
n1(C)c2c(c(n(C)c1=O)=O)n(cn2)C
n1(C)c2ncn(C)c2c(=O)n(c1=O)C
n1(C)c2ncn(C)c2c(=O)n(C)c1=O
n1(C)c2ncn(C)c2c(n(c1=O)C)=O
n1(C)c2ncn(C)c2c(n(C)c1=O)=O
n1(C)c2ncn(c2c(=O)n(c1=O)C)C
n1(C)c2ncn(c2c(=O)n(C)c1=O)C
n1(C)c2ncn(c2c(n(c1=O)C)=O)C
n1(C)c2ncn(c2c(n(C)c1=O)=O)C
n1(C)c(ncn2C)c2c(=O)n(c1=O)C
n1(C)c(ncn2C)c2c(=O)n(C)c1=O
n1(C)c(ncn2C)c2c(n(c1=O)C)=O
n1(C)c(ncn2C)c2c(n(C)c1=O)=O
n1(C)c(c2c(=O)n(c1=O)C)ncn2C
n1(C)c(c2c(=O)n(C)c1=O)ncn2C
n1(C)c(c2c(n(c1=O)C)=O)ncn2C
n1(C)c(c2c(n(C)c1=O)=O)ncn2C
n1(C)c(c(n2C)c(=O)n(c1=O)C)nc2
n1(C)c(c(n2C)c(=O)n(C)c1=O)nc2
n1(C)c(c(n2C)c(n(c1=O)C)=O)nc2
n1(C)c(c(n2C)c(n(C)c1=O)=O)nc2
n1(C)c(c(c(=O)n(c1=O)C)n2C)nc2
n1(C)c(c(c(=O)n(C)c1=O)n2C)nc2
n1(C)c(c(c(n(c1=O)C)=O)n2C)nc2
n1(C)c(c(c(n(C)c1=O)=O)n2C)nc2
Cn1c(n(c(c2c1ncn2C)=O)C)=O
Cn1c(n(c(c2n(C)cnc12)=O)C)=O
Cn1c(n(c(c2n(C)cnc21)=O)C)=O
Cn1c(n(c(c2n(cnc12)C)=O)C)=O
Cn1c(n(c(c2n(cnc21)C)=O)C)=O
Cn1c(n(c(c(n2C)c1nc2)=O)C)=O
Cn1c(n(c(=O)c2c1ncn2C)C)=O
Cn1c(n(c(=O)c2n(C)cnc12)C)=O
Cn1c(n(c(=O)c2n(C)cnc21)C)=O
Cn1c(n(c(=O)c2n(cnc12)C)C)=O
Cn1c(n(c(=O)c2n(cnc21)C)C)=O
Cn1c(n(c(=O)c(n2C)c1nc2)C)=O
Cn1c(n(C)c(c2c1ncn2C)=O)=O
Cn1c(n(C)c(c2n(C)cnc12)=O)=O
Cn1c(n(C)c(c2n(C)cnc21)=O)=O
Cn1c(n(C)c(c2n(cnc12)C)=O)=O
Cn1c(n(C)c(c2n(cnc21)C)=O)=O
Cn1c(n(C)c(c(n2C)c1nc2)=O)=O
Cn1c(n(C)c(=O)c2c1ncn2C)=O
Cn1c(n(C)c(=O)c2n(C)cnc12)=O
Cn1c(n(C)c(=O)c2n(C)cnc21)=O
Cn1c(n(C)c(=O)c2n(cnc12)C)=O
Cn1c(n(C)c(=O)c2n(cnc21)C)=O
Cn1c(n(C)c(=O)c(n2C)c1nc2)=O
Cn1c(=O)n(c(c2c1ncn2C)=O)C
Cn1c(=O)n(c(c2n(C)cnc12)=O)C
Cn1c(=O)n(c(c2n(C)cnc21)=O)C
Cn1c(=O)n(c(c2n(cnc12)C)=O)C
Cn1c(=O)n(c(c2n(cnc21)C)=O)C
Cn1c(=O)n(c(c(n2C)c1nc2)=O)C
Cn1c(=O)n(c(=O)c2c1ncn2C)C
Cn1c(=O)n(c(=O)c2n(C)cnc12)C
Cn1c(=O)n(c(=O)c2n(C)cnc21)C
Cn1c(=O)n(c(=O)c2n(cnc12)C)C
Cn1c(=O)n(c(=O)c2n(cnc21)C)C
Cn1c(=O)n(c(=O)c(n2C)c1nc2)C
Cn1c(=O)n(C)c(c2c1ncn2C)=O
Cn1c(=O)n(C)c(c2n(C)cnc12)=O
Cn1c(=O)n(C)c(c2n(C)cnc21)=O
Cn1c(=O)n(C)c(c2n(cnc12)C)=O
Cn1c(=O)n(C)c(c2n(cnc21)C)=O
Cn1c(=O)n(C)c(c(n2C)c1nc2)=O
Cn1c(=O)n(C)c(=O)c2c1ncn2C
Cn1c(=O)n(C)c(=O)c2n(C)cnc12
Cn1c(=O)n(C)c(=O)c2n(C)cnc21
Cn1c(=O)n(C)c(=O)c2n(cnc12)C
Cn1c(=O)n(C)c(=O)c2n(cnc21)C
Cn1c(=O)n(C)c(=O)c(n2C)c1nc2
Cn1c2c(n(C)cn2)c(=O)n(c1=O)C
Cn1c2c(n(C)cn2)c(=O)n(C)c1=O
Cn1c2c(n(C)cn2)c(n(c1=O)C)=O
Cn1c2c(n(C)cn2)c(n(C)c1=O)=O
Cn1c2c(n(cn2)C)c(=O)n(c1=O)C
Cn1c2c(n(cn2)C)c(=O)n(C)c1=O
Cn1c2c(n(cn2)C)c(n(c1=O)C)=O
Cn1c2c(n(cn2)C)c(n(C)c1=O)=O
Cn1c2c(c(=O)n(c1=O)C)n(C)cn2
Cn1c2c(c(=O)n(c1=O)C)n(cn2)C
Cn1c2c(c(=O)n(C)c1=O)n(C)cn2
Cn1c2c(c(=O)n(C)c1=O)n(cn2)C
Cn1c2c(c(n(c1=O)C)=O)n(C)cn2
Cn1c2c(c(n(c1=O)C)=O)n(cn2)C
Cn1c2c(c(n(C)c1=O)=O)n(C)cn2
Cn1c2c(c(n(C)c1=O)=O)n(cn2)C
Cn1c2ncn(C)c2c(=O)n(c1=O)C
Cn1c2ncn(C)c2c(=O)n(C)c1=O
Cn1c2ncn(C)c2c(n(c1=O)C)=O
Cn1c2ncn(C)c2c(n(C)c1=O)=O
Cn1c2ncn(c2c(=O)n(c1=O)C)C
Cn1c2ncn(c2c(=O)n(C)c1=O)C
Cn1c2ncn(c2c(n(c1=O)C)=O)C
Cn1c2ncn(c2c(n(C)c1=O)=O)C
Cn1c(ncn2C)c2c(=O)n(c1=O)C
Cn1c(ncn2C)c2c(=O)n(C)c1=O
Cn1c(ncn2C)c2c(n(c1=O)C)=O
Cn1c(ncn2C)c2c(n(C)c1=O)=O
Cn1c(c2c(=O)n(c1=O)C)ncn2C
Cn1c(c2c(=O)n(C)c1=O)ncn2C
Cn1c(c2c(n(c1=O)C)=O)ncn2C
Cn1c(c2c(n(C)c1=O)=O)ncn2C
Cn1c(c(n2C)c(=O)n(c1=O)C)nc2
Cn1c(c(n2C)c(=O)n(C)c1=O)nc2
Cn1c(c(n2C)c(n(c1=O)C)=O)nc2
Cn1c(c(n2C)c(n(C)c1=O)=O)nc2
Cn1c(c(c(=O)n(c1=O)C)n2C)nc2
Cn1c(c(c(=O)n(C)c1=O)n2C)nc2
Cn1c(c(c(n(c1=O)C)=O)n2C)nc2
Cn1c(c(c(n(C)c1=O)=O)n2C)nc2
Cn(c1c2n(C)cn1)c(n(c2=O)C)=O
Cn(c1c2n(C)cn1)c(n(C)c2=O)=O
Cn(c1c2n(C)cn1)c(=O)n(c2=O)C
Cn(c1c2n(C)cn1)c(=O)n(C)c2=O
Cn(c1c2n(cn1)C)c(n(c2=O)C)=O
Cn(c1c2n(cn1)C)c(n(C)c2=O)=O
Cn(c1c2n(cn1)C)c(=O)n(c2=O)C
Cn(c1c2n(cn1)C)c(=O)n(C)c2=O
Cn(c1c(n(C)cn1)c2=O)c(n2C)=O
Cn(c1c(n(C)cn1)c2=O)c(=O)n2C
Cn(c1c(n(C)cn1)c(=O)n2C)c2=O
Cn(c1c(n(C)cn1)c(n2C)=O)c2=O
Cn(c1c(n(cn1)C)c2=O)c(n2C)=O
Cn(c1c(n(cn1)C)c2=O)c(=O)n2C
Cn(c1c(n(cn1)C)c(=O)n2C)c2=O
Cn(c1c(n(cn1)C)c(n2C)=O)c2=O
Cn(c1c(c2=O)n(C)cn1)c(n2C)=O
Cn(c1c(c2=O)n(C)cn1)c(=O)n2C
Cn(c1c(c2=O)n(cn1)C)c(n2C)=O
Cn(c1c(c2=O)n(cn1)C)c(=O)n2C
Cn(c1c(c(=O)n2C)n(C)cn1)c2=O
Cn(c1c(c(=O)n2C)n(cn1)C)c2=O
Cn(c1c(c(n2C)=O)n(C)cn1)c2=O
Cn(c1c(c(n2C)=O)n(cn1)C)c2=O
Cn(c1ncn2C)c(n(c(c21)=O)C)=O
Cn(c1ncn2C)c(n(c(c12)=O)C)=O
Cn(c1ncn2C)c(n(c(=O)c21)C)=O
Cn(c1ncn2C)c(n(c(=O)c12)C)=O
Cn(c1ncn2C)c(n(C)c(c21)=O)=O
Cn(c1ncn2C)c(n(C)c(c12)=O)=O
Cn(c1ncn2C)c(n(C)c(=O)c21)=O
Cn(c1ncn2C)c(n(C)c(=O)c12)=O
Cn(c1ncn2C)c(=O)n(c(c21)=O)C
Cn(c1ncn2C)c(=O)n(c(c12)=O)C
Cn(c1ncn2C)c(=O)n(c(=O)c21)C
Cn(c1ncn2C)c(=O)n(c(=O)c12)C
Cn(c1ncn2C)c(=O)n(C)c(c21)=O
Cn(c1ncn2C)c(=O)n(C)c(c12)=O
Cn(c1ncn2C)c(=O)n(C)c(=O)c21
Cn(c1ncn2C)c(=O)n(C)c(=O)c12
Cn(c1ncn(C)c1c2=O)c(n2C)=O
Cn(c1ncn(C)c1c2=O)c(=O)n2C
Cn(c1ncn(C)c1c(=O)n2C)c2=O
Cn(c1ncn(C)c1c(n2C)=O)c2=O
Cn(c1ncn(c1c2=O)C)c(n2C)=O
Cn(c1ncn(c1c2=O)C)c(=O)n2C
Cn(c1ncn(c1c(=O)n2C)C)c2=O
Cn(c1ncn(c1c(n2C)=O)C)c2=O
Cn(c(ncn1C)c1c2=O)c(n2C)=O
Cn(c(ncn1C)c1c2=O)c(=O)n2C
Cn(c(ncn1C)c1c(=O)n2C)c2=O
Cn(c(ncn1C)c1c(n2C)=O)c2=O
Cn(c(c1c2=O)ncn1C)c(n2C)=O
Cn(c(c1c2=O)ncn1C)c(=O)n2C
Cn(c(c1c(=O)n2C)ncn1C)c2=O
Cn(c(c1c(n2C)=O)ncn1C)c2=O
Cn(c(c1n2C)nc2)c(n(c1=O)C)=O
Cn(c(c1n2C)nc2)c(n(C)c1=O)=O
Cn(c(c1n2C)nc2)c(=O)n(c1=O)C
Cn(c(c1n2C)nc2)c(=O)n(C)c1=O
Cn(c(c(n1C)c2=O)nc1)c(n2C)=O
Cn(c(c(n1C)c2=O)nc1)c(=O)n2C
Cn(c(c(n1C)c(=O)n2C)nc1)c2=O
Cn(c(c(n1C)c(n2C)=O)nc1)c2=O
Cn(c(c(c1=O)n2C)nc2)c(n1C)=O
Cn(c(c(c1=O)n2C)nc2)c(=O)n1C
Cn(c(c(c(=O)n1C)n2C)nc2)c1=O
Cn(c(c(c(n1C)=O)n2C)nc2)c1=O
Cn(c1=O)c2c(n(C)cn2)c(=O)n1C
Cn(c1=O)c2c(n(C)cn2)c(n1C)=O
Cn(c1=O)c2c(n(cn2)C)c(=O)n1C
Cn(c1=O)c2c(n(cn2)C)c(n1C)=O
Cn(c1=O)c2c(c(=O)n1C)n(C)cn2
Cn(c1=O)c2c(c(=O)n1C)n(cn2)C
Cn(c1=O)c2c(c(n1C)=O)n(C)cn2
Cn(c1=O)c2c(c(n1C)=O)n(cn2)C
Cn(c1=O)c2ncn(C)c2c(=O)n1C
Cn(c1=O)c2ncn(C)c2c(n1C)=O
Cn(c1=O)c2ncn(c2c(=O)n1C)C
Cn(c1=O)c2ncn(c2c(n1C)=O)C
Cn(c1=O)c(ncn2C)c2c(=O)n1C
Cn(c1=O)c(ncn2C)c2c(n1C)=O
Cn(c1=O)c(c2c(=O)n1C)ncn2C
Cn(c1=O)c(c2c(n1C)=O)ncn2C
Cn(c1=O)c(c(n2C)c(=O)n1C)nc2
Cn(c1=O)c(c(n2C)c(n1C)=O)nc2
Cn(c1=O)c(c(c(=O)n1C)n2C)nc2
Cn(c1=O)c(c(c(n1C)=O)n2C)nc2
Cn(c(n1C)=O)c2c(n(C)cn2)c1=O
Cn(c(n1C)=O)c2c(n(cn2)C)c1=O
Cn(c(n1C)=O)c2c(c1=O)n(C)cn2
Cn(c(n1C)=O)c2c(c1=O)n(cn2)C
Cn(c(n1C)=O)c2ncn(C)c2c1=O
Cn(c(n1C)=O)c2ncn(c2c1=O)C
Cn(c(n1C)=O)c(ncn2C)c2c1=O
Cn(c(n1C)=O)c(c2c1=O)ncn2C
Cn(c(n1C)=O)c(c(n2C)c1=O)nc2
Cn(c(n1C)=O)c(c(c1=O)n2C)nc2
Cn(c(n(c1=O)C)=O)c2c1n(C)cn2
Cn(c(n(c1=O)C)=O)c2c1n(cn2)C
Cn(c(n(c1=O)C)=O)c2ncn(C)c21
Cn(c(n(c1=O)C)=O)c2ncn(C)c12
Cn(c(n(c1=O)C)=O)c2ncn(c21)C
Cn(c(n(c1=O)C)=O)c2ncn(c12)C
Cn(c(n(c1=O)C)=O)c(ncn2C)c21
Cn(c(n(c1=O)C)=O)c(ncn2C)c12
Cn(c(n(c1=O)C)=O)c(c1n2C)nc2
Cn(c(n(c(c1n2C)=O)C)=O)c1nc2
Cn(c(n(c(=O)c1n2C)C)=O)c1nc2
Cn(c(n(C)c1=O)=O)c2c1n(C)cn2
Cn(c(n(C)c1=O)=O)c2c1n(cn2)C
Cn(c(n(C)c1=O)=O)c2ncn(C)c21
Cn(c(n(C)c1=O)=O)c2ncn(C)c12
Cn(c(n(C)c1=O)=O)c2ncn(c21)C
Cn(c(n(C)c1=O)=O)c2ncn(c12)C
Cn(c(n(C)c1=O)=O)c(ncn2C)c21
Cn(c(n(C)c1=O)=O)c(ncn2C)c12
Cn(c(n(C)c1=O)=O)c(c1n2C)nc2
Cn(c(n(C)c(c1n2C)=O)=O)c1nc2
Cn(c(n(C)c(=O)c1n2C)=O)c1nc2
Cn(c(=O)n1C)c2c(n(C)cn2)c1=O
Cn(c(=O)n1C)c2c(n(cn2)C)c1=O
Cn(c(=O)n1C)c2c(c1=O)n(C)cn2
Cn(c(=O)n1C)c2c(c1=O)n(cn2)C
Cn(c(=O)n1C)c2ncn(C)c2c1=O
Cn(c(=O)n1C)c2ncn(c2c1=O)C
Cn(c(=O)n1C)c(ncn2C)c2c1=O
Cn(c(=O)n1C)c(c2c1=O)ncn2C
Cn(c(=O)n1C)c(c(n2C)c1=O)nc2
Cn(c(=O)n1C)c(c(c1=O)n2C)nc2
Cn(c(=O)n(c1=O)C)c2c1n(C)cn2
Cn(c(=O)n(c1=O)C)c2c1n(cn2)C
Cn(c(=O)n(c1=O)C)c2ncn(C)c21
Cn(c(=O)n(c1=O)C)c2ncn(C)c12
Cn(c(=O)n(c1=O)C)c2ncn(c21)C
Cn(c(=O)n(c1=O)C)c2ncn(c12)C
Cn(c(=O)n(c1=O)C)c(ncn2C)c21
Cn(c(=O)n(c1=O)C)c(ncn2C)c12
Cn(c(=O)n(c1=O)C)c(c1n2C)nc2
Cn(c(=O)n(c(c1n2C)=O)C)c1nc2
Cn(c(=O)n(c(=O)c1n2C)C)c1nc2
Cn(c(=O)n(C)c1=O)c2c1n(C)cn2
Cn(c(=O)n(C)c1=O)c2c1n(cn2)C
Cn(c(=O)n(C)c1=O)c2ncn(C)c21
Cn(c(=O)n(C)c1=O)c2ncn(C)c12
Cn(c(=O)n(C)c1=O)c2ncn(c21)C
Cn(c(=O)n(C)c1=O)c2ncn(c12)C
Cn(c(=O)n(C)c1=O)c(ncn2C)c21
Cn(c(=O)n(C)c1=O)c(ncn2C)c12
Cn(c(=O)n(C)c1=O)c(c1n2C)nc2
Cn(c(=O)n(C)c(c1n2C)=O)c1nc2
Cn(c(=O)n(C)c(=O)c1n2C)c1nc2
Cn1c(=O)n(c2c(n(C)cn2)c1=O)C
Cn1c(=O)n(c2c(n(cn2)C)c1=O)C
Cn1c(=O)n(c2c(c1=O)n(C)cn2)C
Cn1c(=O)n(c2c(c1=O)n(cn2)C)C
Cn1c(=O)n(c2ncn(C)c2c1=O)C
Cn1c(=O)n(c2ncn(c2c1=O)C)C
Cn1c(=O)n(c(ncn2C)c2c1=O)C
Cn1c(=O)n(c(c2c1=O)ncn2C)C
Cn1c(=O)n(c(c(n2C)c1=O)nc2)C
Cn1c(=O)n(c(c(c1=O)n2C)nc2)C
Cn1c(=O)n(C)c2c(n(C)cn2)c1=O
Cn1c(=O)n(C)c2c(n(cn2)C)c1=O
Cn1c(=O)n(C)c2c(c1=O)n(C)cn2
Cn1c(=O)n(C)c2c(c1=O)n(cn2)C
Cn1c(=O)n(C)c2ncn(C)c2c1=O
Cn1c(=O)n(C)c2ncn(c2c1=O)C
Cn1c(=O)n(C)c(ncn2C)c2c1=O
Cn1c(=O)n(C)c(c2c1=O)ncn2C
Cn1c(=O)n(C)c(c(n2C)c1=O)nc2
Cn1c(=O)n(C)c(c(c1=O)n2C)nc2
Cn1c(n(c2c(n(C)cn2)c1=O)C)=O
Cn1c(n(c2c(n(cn2)C)c1=O)C)=O
Cn1c(n(c2c(c1=O)n(C)cn2)C)=O
Cn1c(n(c2c(c1=O)n(cn2)C)C)=O
Cn1c(n(c2ncn(C)c2c1=O)C)=O
Cn1c(n(c2ncn(c2c1=O)C)C)=O
Cn1c(n(c(ncn2C)c2c1=O)C)=O
Cn1c(n(c(c2c1=O)ncn2C)C)=O
Cn1c(n(c(c(n2C)c1=O)nc2)C)=O
Cn1c(n(c(c(c1=O)n2C)nc2)C)=O
Cn1c(n(C)c2c(n(C)cn2)c1=O)=O
Cn1c(n(C)c2c(n(cn2)C)c1=O)=O
Cn1c(n(C)c2c(c1=O)n(C)cn2)=O
Cn1c(n(C)c2c(c1=O)n(cn2)C)=O
Cn1c(n(C)c2ncn(C)c2c1=O)=O
Cn1c(n(C)c2ncn(c2c1=O)C)=O
Cn1c(n(C)c(ncn2C)c2c1=O)=O
Cn1c(n(C)c(c2c1=O)ncn2C)=O
Cn1c(n(C)c(c(n2C)c1=O)nc2)=O
Cn1c(n(C)c(c(c1=O)n2C)nc2)=O
Cn1c(c2c(ncn2C)n(c1=O)C)=O
Cn1c(c2c(ncn2C)n(C)c1=O)=O
Cn1c(c2c(n(c1=O)C)ncn2C)=O
Cn1c(c2c(n(C)c1=O)ncn2C)=O
Cn1c(c2n(C)cnc2n(c1=O)C)=O
Cn1c(c2n(C)cnc2n(C)c1=O)=O
Cn1c(c2n(cnc2n(c1=O)C)C)=O
Cn1c(c2n(cnc2n(C)c1=O)C)=O
Cn1c(c(n2C)c(nc2)n(c1=O)C)=O
Cn1c(c(n2C)c(nc2)n(C)c1=O)=O
Cn1c(c(n2C)c(n(c1=O)C)nc2)=O
Cn1c(c(n2C)c(n(C)c1=O)nc2)=O
Cn1c(c(c2n(c1=O)C)n(C)cn2)=O
Cn1c(c(c2n(c1=O)C)n(cn2)C)=O
Cn1c(c(c2n(C)c1=O)n(C)cn2)=O
Cn1c(c(c2n(C)c1=O)n(cn2)C)=O
Cn1c(=O)c2c(ncn2C)n(c1=O)C
Cn1c(=O)c2c(ncn2C)n(C)c1=O
Cn1c(=O)c2c(n(c1=O)C)ncn2C
Cn1c(=O)c2c(n(C)c1=O)ncn2C
Cn1c(=O)c2n(C)cnc2n(c1=O)C
Cn1c(=O)c2n(C)cnc2n(C)c1=O
Cn1c(=O)c2n(cnc2n(c1=O)C)C
Cn1c(=O)c2n(cnc2n(C)c1=O)C
Cn1c(=O)c(n2C)c(nc2)n(c1=O)C
Cn1c(=O)c(n2C)c(nc2)n(C)c1=O
Cn1c(=O)c(n2C)c(n(c1=O)C)nc2
Cn1c(=O)c(n2C)c(n(C)c1=O)nc2
Cn1c(=O)c(c2n(c1=O)C)n(C)cn2
Cn1c(=O)c(c2n(c1=O)C)n(cn2)C
Cn1c(=O)c(c2n(C)c1=O)n(C)cn2
Cn1c(=O)c(c2n(C)c1=O)n(cn2)C
Cn(c1=O)c(=O)n(c2c1n(C)cn2)C
Cn(c1=O)c(=O)n(c2c1n(cn2)C)C
Cn(c1=O)c(=O)n(c2ncn(C)c21)C
Cn(c1=O)c(=O)n(c2ncn(C)c12)C
Cn(c1=O)c(=O)n(c2ncn(c21)C)C
Cn(c1=O)c(=O)n(c2ncn(c12)C)C
Cn(c1=O)c(=O)n(c(ncn2C)c21)C
Cn(c1=O)c(=O)n(c(ncn2C)c12)C
Cn(c1=O)c(=O)n(c(c1n2C)nc2)C
Cn(c1=O)c(=O)n(C)c2c1n(C)cn2
Cn(c1=O)c(=O)n(C)c2c1n(cn2)C
Cn(c1=O)c(=O)n(C)c2ncn(C)c21
Cn(c1=O)c(=O)n(C)c2ncn(C)c12
Cn(c1=O)c(=O)n(C)c2ncn(c21)C
Cn(c1=O)c(=O)n(C)c2ncn(c12)C
Cn(c1=O)c(=O)n(C)c(ncn2C)c21
Cn(c1=O)c(=O)n(C)c(ncn2C)c12
Cn(c1=O)c(=O)n(C)c(c1n2C)nc2
Cn(c1=O)c(n(c2c1n(C)cn2)C)=O
Cn(c1=O)c(n(c2c1n(cn2)C)C)=O
Cn(c1=O)c(n(c2ncn(C)c21)C)=O
Cn(c1=O)c(n(c2ncn(C)c12)C)=O
Cn(c1=O)c(n(c2ncn(c21)C)C)=O
Cn(c1=O)c(n(c2ncn(c12)C)C)=O
Cn(c1=O)c(n(c(ncn2C)c21)C)=O
Cn(c1=O)c(n(c(ncn2C)c12)C)=O
Cn(c1=O)c(n(c(c1n2C)nc2)C)=O
Cn(c1=O)c(n(C)c2c1n(C)cn2)=O
Cn(c1=O)c(n(C)c2c1n(cn2)C)=O
Cn(c1=O)c(n(C)c2ncn(C)c21)=O
Cn(c1=O)c(n(C)c2ncn(C)c12)=O
Cn(c1=O)c(n(C)c2ncn(c21)C)=O
Cn(c1=O)c(n(C)c2ncn(c12)C)=O
Cn(c1=O)c(n(C)c(ncn2C)c21)=O
Cn(c1=O)c(n(C)c(ncn2C)c12)=O
Cn(c1=O)c(n(C)c(c1n2C)nc2)=O
Cn(c(c1c2ncn1C)=O)c(=O)n2C
Cn(c(c1c2ncn1C)=O)c(n2C)=O
Cn(c(c1c(ncn1C)n2C)=O)c2=O
Cn(c(c1c(n2C)ncn1C)=O)c2=O
Cn(c(c1n2C)=O)c(=O)n(c1nc2)C
Cn(c(c1n2C)=O)c(=O)n(C)c1nc2
Cn(c(c1n2C)=O)c(n(c1nc2)C)=O
Cn(c(c1n2C)=O)c(n(C)c1nc2)=O
Cn(c(c1n(C)cnc1n2C)=O)c2=O
Cn(c(c1n(cnc1n2C)C)=O)c2=O
Cn(c(c(n1C)c2nc1)=O)c(=O)n2C
Cn(c(c(n1C)c2nc1)=O)c(n2C)=O
Cn(c(c(n1C)c(nc1)n2C)=O)c2=O
Cn(c(c(n1C)c(n2C)nc1)=O)c2=O
Cn(c(c(c1n2C)n(C)cn1)=O)c2=O
Cn(c(c(c1n2C)n(cn1)C)=O)c2=O
Cn(c(=O)c1c2ncn1C)c(=O)n2C
Cn(c(=O)c1c2ncn1C)c(n2C)=O
Cn(c(=O)c1c(ncn1C)n2C)c2=O
Cn(c(=O)c1c(n2C)ncn1C)c2=O
Cn(c(=O)c1n2C)c(=O)n(c1nc2)C
Cn(c(=O)c1n2C)c(=O)n(C)c1nc2
Cn(c(=O)c1n2C)c(n(c1nc2)C)=O
Cn(c(=O)c1n2C)c(n(C)c1nc2)=O
Cn(c(=O)c1n(C)cnc1n2C)c2=O
Cn(c(=O)c1n(cnc1n2C)C)c2=O
Cn(c(=O)c(n1C)c2nc1)c(=O)n2C
Cn(c(=O)c(n1C)c2nc1)c(n2C)=O
Cn(c(=O)c(n1C)c(nc1)n2C)c2=O
Cn(c(=O)c(n1C)c(n2C)nc1)c2=O
Cn(c(=O)c(c1n2C)n(C)cn1)c2=O
Cn(c(=O)c(c1n2C)n(cn1)C)c2=O
Cn(c1=O)c(c2c(ncn2C)n1C)=O
Cn(c1=O)c(c2c(n1C)ncn2C)=O
Cn(c1=O)c(c2n(C)cnc2n1C)=O
Cn(c1=O)c(c2n(cnc2n1C)C)=O
Cn(c1=O)c(c(n2C)c(nc2)n1C)=O
Cn(c1=O)c(c(n2C)c(n1C)nc2)=O
Cn(c1=O)c(c(c2n1C)n(C)cn2)=O
Cn(c1=O)c(c(c2n1C)n(cn2)C)=O
Cn(c1=O)c(=O)c2c(ncn2C)n1C
Cn(c1=O)c(=O)c2c(n1C)ncn2C
Cn(c1=O)c(=O)c2n(C)cnc2n1C
Cn(c1=O)c(=O)c2n(cnc2n1C)C
Cn(c1=O)c(=O)c(n2C)c(nc2)n1C
Cn(c1=O)c(=O)c(n2C)c(n1C)nc2
Cn(c1=O)c(=O)c(c2n1C)n(C)cn2
Cn(c1=O)c(=O)c(c2n1C)n(cn2)C
Cn(c(=O)n1C)c(c2c1ncn2C)=O
Cn(c(=O)n1C)c(c2n(C)cnc12)=O
Cn(c(=O)n1C)c(c2n(C)cnc21)=O
Cn(c(=O)n1C)c(c2n(cnc12)C)=O
Cn(c(=O)n1C)c(c2n(cnc21)C)=O
Cn(c(=O)n1C)c(c(n2C)c1nc2)=O
Cn(c(=O)n1C)c(=O)c2c1ncn2C
Cn(c(=O)n1C)c(=O)c2n(C)cnc12
Cn(c(=O)n1C)c(=O)c2n(C)cnc21
Cn(c(=O)n1C)c(=O)c2n(cnc12)C
Cn(c(=O)n1C)c(=O)c2n(cnc21)C
Cn(c(=O)n1C)c(=O)c(n2C)c1nc2
Cn(c(=O)n(c1c2n(C)cn1)C)c2=O
Cn(c(=O)n(c1c2n(cn1)C)C)c2=O
Cn(c(=O)n(c1ncn2C)C)c(c21)=O
Cn(c(=O)n(c1ncn2C)C)c(c12)=O
Cn(c(=O)n(c1ncn2C)C)c(=O)c21
Cn(c(=O)n(c1ncn2C)C)c(=O)c12
Cn(c(=O)n(c(c1n2C)nc2)C)c1=O
Cn(c(=O)n(C)c1c2n(C)cn1)c2=O
Cn(c(=O)n(C)c1c2n(cn1)C)c2=O
Cn(c(=O)n(C)c1ncn2C)c(c21)=O
Cn(c(=O)n(C)c1ncn2C)c(c12)=O
Cn(c(=O)n(C)c1ncn2C)c(=O)c21
Cn(c(=O)n(C)c1ncn2C)c(=O)c12
Cn(c(=O)n(C)c(c1n2C)nc2)c1=O
Cn(c(n1C)=O)c(c2c1ncn2C)=O
Cn(c(n1C)=O)c(c2n(C)cnc12)=O
Cn(c(n1C)=O)c(c2n(C)cnc21)=O
Cn(c(n1C)=O)c(c2n(cnc12)C)=O
Cn(c(n1C)=O)c(c2n(cnc21)C)=O
Cn(c(n1C)=O)c(c(n2C)c1nc2)=O
Cn(c(n1C)=O)c(=O)c2c1ncn2C
Cn(c(n1C)=O)c(=O)c2n(C)cnc12
Cn(c(n1C)=O)c(=O)c2n(C)cnc21
Cn(c(n1C)=O)c(=O)c2n(cnc12)C
Cn(c(n1C)=O)c(=O)c2n(cnc21)C
Cn(c(n1C)=O)c(=O)c(n2C)c1nc2
Cn(c(n(c1c2n(C)cn1)C)=O)c2=O
Cn(c(n(c1c2n(cn1)C)C)=O)c2=O
Cn(c(n(c1ncn2C)C)=O)c(c21)=O
Cn(c(n(c1ncn2C)C)=O)c(c12)=O
Cn(c(n(c1ncn2C)C)=O)c(=O)c21
Cn(c(n(c1ncn2C)C)=O)c(=O)c12
Cn(c(n(c(c1n2C)nc2)C)=O)c1=O
Cn(c(n(C)c1c2n(C)cn1)=O)c2=O
Cn(c(n(C)c1c2n(cn1)C)=O)c2=O
Cn(c(n(C)c1ncn2C)=O)c(c21)=O
Cn(c(n(C)c1ncn2C)=O)c(c12)=O
Cn(c(n(C)c1ncn2C)=O)c(=O)c21
Cn(c(n(C)c1ncn2C)=O)c(=O)c12
Cn(c(n(C)c(c1n2C)nc2)=O)c1=O

Compared to connection tables, such as MDL Mol files, this permutation count is actually quite limited.  A molecule with n atoms and m bonds typically has n!m!2m possible connection tables.  For Caffeine, with 14 heavy atoms and 15 bonds between them, this is over 3.735×1027 equivalent connection tables.

However, the 4160 permuted SMILES orderings above are just the tip of the iceberg of the true potential number of valid SMILES representations that have the exact same Caffeine InChI.

As Roger Rabbit aptly said in the film ‘Who Framed Roger Rabbit?’, “Let me count the ways… One one-thousand…”

Next, we can consider the possible of lexical forms of each atom.  Rather than the single character atoms used in Cn1cnc2c1c(=O)n(c(=O)n2C)C, we can instead (optionally and independently) use bracketed forms for each atom such as:

Cn1[cH]nc2c1c(=O)n(c(=O)n2C)C
C[n]1cnc2c1c(=O)[n](c(=O)[n]2C)C
[CH3][n]1[cH][n][c]2[c]1[c](=[O])[n]([c](=[O])[n]2[CH3])[CH3]

This alone leads to 16384 variants for each of the 4160 permutations above.

Next, we can consider the effects of aromaticity, as each aromatic ring may be represented as either aromatic or explicitly in each of its conjugated Kekule forms.  Four Caffeine case study, examples include:

Cn1cnc2c1c(=O)n(c(=O)n2C)C
Cn1cnc2c1C(=O)N(C(=O)N2C)C
CN1C=NC2=C1C(=O)N(C(=O)N2C)C

Next, we can consider the use of explicit vs. implicit hydrogen atoms. Zero, some or all of the hydrogen atoms on each heavy atom may be denoted explicitly. With three methyl groups and hydrogen bearing aromatic carbon, this leads us to 4*4*4*2=128 explicit hydrogen variants, including:

[H]C([H])([H])n1c([H])nc2c1c(=O)n(c(=O)n2C([H])([H])[H])C([H])([H])[H]
[H]Cn1c([H])nc2c1c(=O)n(c(=O)n2C[H])C[H]
[H]Cn1cnc2c1c(=O)n(c(=O)n2C[H])C[H]
Cn1c([H])nc2c1c(=O)n(c(=O)n2C)C

Alas, there are no polar hydrogen atoms in Caffeine, so alternate tautomeric forms, potentially one of the richest sources of SMILES with the same InChI, aren’t applicable in this example.

However, even more mind-bending than tautomerism are the multiple potential mesomeric forms of molecule, created by shuffling formal charges around a molecule whilst respecting the valency rules at each atom. Zwitterionic forms of Caffeine include:

C[n+]1c[n-]c2c1c(=O)n(c(=O)n2C)C

Cn1cnc2c1c([O-])[n+](c(=O)n2C)C
Cn1cnc2c1c(=O)[n+](c([O-])n2C)C
Cn1cnc2c1c(=O)n(c([O-])[n+]2C)C
Cn1cnc2c1c([O-])n(c(=O)[n+]2C)C

C[n+]1c[n-]c2c1c([O-])[n+](c(=O)n2C)C
C[n+]1c[n-]c2c1c(=O)[n+](c([O-])n2C)C
C[n+]1c[n-]c2c1c(=O)n(c([O-])[n+]2C)C
C[n+]1c[n-]c2c1c2c1c([O-])n(c(=O)[n+]2C)C

Cn1cnc2c1c([O-])[n+](c([O-])[n+]2C)C
C[n+]1c[n-]c2c1c([O-])[n+](c([O-])[n+]2C)C

C[n+]1c[n-]c2c1c([O-])[n+](c([O-])[n+]2C)C

All of the above zwitterions are “traditional”, only placing formal charges on polar atoms, but continuing the madness even further considers all the following to be mesomeric forms of Caffeine:

Cn1cnc2c1[c+]([O-])n(c(=O)n2C)C
Cn1cnc2c1c(=O)n([c+]([O-])n2C)C
Cn1cnc2c1[c+]([O-])n([c+]([O-])n2C)C

Finally, ylid-like mesomerism may often be used to eliminate bond orders from connection tables, producing one of my favourite representations of Caffeine, one without any double bonds:

Cn1[cH+][n-][c+]2[c-]1[c+]([O-])n([c+]([O-])n2C)C

This, along with all of the millions of Caffeine SMILES variants outlined above, has the exact same InChI:

InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

That all of these SMILES are represented by the same unique InChI is very useful in many applications. However, that any of these SMILES may potentially be presented to the user as a legitimate example/depiction of that InChI can also be a liability. Whoops – I said no discussion of InChI versus SMILES. 🙂

Image credit: oswaldo on Twitter.

Validity checking antibody sequence data

NextMove Software’s Sugar & Splice product is a toolkit for handling biopolymers, including oligopeptides, oliogonucleotides and oligosaccharides (and combinations thereof). Amongst its many possible applications is the ability to rapidly identify possible errors in the sequences of antibodies (during registration). Therapeutic antibodies are increasingly important to the pharmaceutical industry, with about 8 out of the top 20 selling drugs being monoclonal antibody therapeutics. Antibodies are large covalently bound molecules, formed of four protein chains cross-linked by disulfide bonds. These polypeptide chains consist of two longer “heavy” chains and two shorter “light” chains. Almost always (with the exception of synthetic bispecific antibodies), the sequences of the two heavy chains in each antibody are identical, and the sequences of the two light chains are identical.

The most defining characteristic of these heavy and light chains, as implied by their names, are their lengths. Heavy chains are almost always between 432 and 456 amino acids long, and light chains are almost always 204 to 220 amino acids long. This very naturally suggests an incredibly simple sanity check (during antibody sequence registration); namely that the light and heavy chains are within their correct length ranges respectively. A major benefit of therapeutic antibodies over arbitrary peptide and protein therapeutics relies on their not being recognized as “foreign” by the patient’s immune system, and thereby avoiding the side-effects associated with an immune response. To achieve this an antibody drug must look very much like a native human antibody which places tight constraints on the length and composition of its constituent protein chains. This remarkably simple check is in practice effective at finding real problems in trusted data sources, as described by the three example failures below.

[1] Canakinumab light chain
Novartis’ canakinumab (sold under the tradename Ilaris) is a human antibody against IL-1β for the treatment of cryopyrin-associated periodic syndrome (CAPS). The sequence of the light chain in both DrugBank (DB06168) and ChEMBL (CHEMBL1201834) is 394 amino acids long, much longer than a typical light chain. Inspection of the drug bank FASTA records reveals the source of the error and the correction.

>8836_H|canakinumab|Homo sapiens||H-GAMMA-1 (VH(1-118)+CH1(119-216)+HINGE-REGION(217-231)+CH2(232-341)+CH3(342-448))|||||||448||||MW 49253.6|MW 49253.6|
QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYY
ADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGL
YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPS
VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNST
YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMT
KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ
GNVFSCSVMHEALHNHYTQKSLSLSPGK
>8836_L|canakinumab|Homo sapiens||L-KAPPA (V-KAPPA(1-107)+C-KAPPA(108-214))|||||||214||||MW 23357.9|MW 23357.9|
QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYY
ADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGL
EIVLTQSPDFQSVTPKEKVTITCRASQSIGSSLHWYQQKPDQSPKLLIKYASQSFSGVPS
RFSGSGSGTDFTLTINSLEAEDAAAYYCHQSSSLPFTFGPGTKVDIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Notice that the first three lines of the light chain entry (8836_L) match identically the first three lines of the heavy chain entry (8836_H), probably due to a cut’n’paste error. The correct sequence for the light chain starts with the sequence “EIVL”, and indeed this is confirmed as the resulting sequence is 214 amino acids long, which both the length specified in the DrugBank FASTA header line and falls within our allowed length range.

[2] Adalimumab heavy chain
Abbott Laboratories’ (now AbbVie’s) Adalimumab, sold under the tradename Humira, is a human antibody against TNF-α for autoimmune disorders. Here the ChEMBL entry (CHEMBL1201580) lacks any sequence annotation for either chain, and DrugBank’s entry (DB00051) contains a heavy chain sequence of only 224 amino acids, too short to be the full sequence. This partial sequence fragment is actually just the Fab (antigen binding) domain of Adalimumab’s heavy chain. Searching online reveals a presentation from Jeremy Fry in 2012 that repeats this Fab fragment sequence (on slide 7) together with text “Full sequence information for Humira is not in the public domain”.

Fortunately, this is no longer the case as the full sequence of the heavy chain has now been published, found in a bitmap image (figure 8) in a PDF whitepaper from Thermo Fisher Scientific who use Adalimumab’s heavy chain as an example case study for intact antibody sequencing with the Orbitrap mass spectrometry hardware.

Here (possibly for the first time in machine-readable form) is the full sequence of Adalimumab’s heavy chain.

>Adalimumab_H
EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDY
ADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVS
SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQS
SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG
GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNVYVDGVEVHNAKTKPREEQY
NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD
ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR
WQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

[3] Cixutumumab heavy chain
ImClone Systems’ Cixutumumab is a human antibody against IGF-1R. The ChEMBL entry (CHEMBL1743001) provides a heavy chain sequence that is 460 amino acids long. Whilst not much longer than the permissible range, it does flag this sequence as suspicious. This is confirmed by sequence alignment, for example to the heavy chain of rafivirumab shown on the lower lines in the sequence alignment below.

SNSAlign (Needleman-Wunsch sequence alignment) version 0.9beta14
Copyright (C) 2014 NextMove Software Limited

Sequence 1 Length: 460
Sequence 2 Length: 456
Alignment Type: 1
Gap penalty:    -10
Extend penalty: -2
Alignment score: 1542
Identity:    78.73% (359/456)
Similarity:  81.58% (372/456)

    EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANY 60
    |||||||||||||||||||||||||||||: | ::|||||||||||||||||||||||||
    EVQLVQSGAEVKKPGSSVKVSCKASGGTFNRYTVNWVRQAPGQGLEWMGGIIPIFGTANY 60

    LRFLEWSTQDGTAALGCLVKVPSSSLGTQTPSVFLFPPKPKTKPREEQYNKAKGQPREPQ 120
                                                                
    ------------------------------------------------------------ 60

    ENNYKTTPPVQKSLSLSPGKAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR-- 178
                        ||:||||:|||||:||||||||||||||:|||||:|||  
    --------------------AQRFQGRLTITADESTSTAYMELSSLRSDDTAVYFCAREN 100

    ----APHYYYY-YMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSG----------DYF 223
          :||:  : | ||:|| |||||||||||||||||||||||||          |||
    LDNSGTYYYFSGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 160

    PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVV----------TYICNVNHKPSNTK 273
    ||||||||||||||||||||||||||||||||||||          ||||||||||||||
    PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK 220

    VDKKVEPKSCDKTHTCPPCPAPELLGG----------KDTLMISRTPEVTCVVVDVSHED 323
    |||:|||||||||||||||||||||||          |||||||||||||||||||||||
    VDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 280

    PEVKFNWYVDGVEVHNA----------STYRVVSVLTVLHQDWLNGKEYKCKVSNKALPA 373
    |||||||||||||||||          |||||||||||||||||||||||||||||||||
    PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPA 340

    PIEKTIS----------VYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQP--- 420
    |||||||          ||||||||||||||||||||||||||||||||||||||||   
    PIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENN 400

    -------LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYT--------- 460
           ||||||||||||||||||||||||||||||||||||||||         
    YKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 456

Alas this mysterious pattern of gaps doesn’t indicate the discovery of a novel human immunoglobulin transposon by the ChEMBL team in Hinxton, but another cut’n’paste error. In UNIPROT sequence file format, and often in patent filings, protein sequences are written in blocks of ten amino acids. The tell tale alignment above (which looks very pretty as a dotplot) indicates that one of the columns of this sequence file has been shuffled. If one looks closely, many of the missing 10-mers from the later lines, appear consecutively in the anomalous large insertion close to the start.

As demonstrated by the above examples, antibody sequence databases appear to contain a number of serious errors that can be caught/flagged by even simple quality checks. Fortunately, advanced antibody validation algorithms are able to identify far more subtle problems in large biologics registration systems, sometimes containing millions of entries. Hopefully, corrections for the above issues will shortly be seen in DrugBank, ChEMBL and IUPHAR databases.

Name to Structure, not just for systematic names

While advanced software now exists for converting systematic chemical names to structures, the humble chemical line formula has for the most part avoided the limelight. For a long time LeadMine has been able to recognize chemical line formulae but we are now adding the ability to interpret them.

A simple example would be CHF3 which is CHF3

Line formulae are interpreted from left-to-right, but in such a way that valency rules are respected e.g. the fluorine in the above example bonds to the C not the H.

More complicated examples include:

bondOrders

 

CF2=CF-O-CF2CF(CF3)O-CF2CF2-CH2OH [has an explicit double bond] {from US20020002258A1}

Formula with abbreviation

 

HO2C-CH2CH(NHFmoc)-CONH-(CH2)10CH3 [contains an abbreviated prefix: Fmoc] {from US20010038824A1}

Complicated line formula

(NH2NHCOCH2CH2)2N(CH2)11CONHNH2 [has a repeated substituent, repeated infix and implicit double bonds for the carbonyls] {from US20050081961A1}

This is useful for pulling out reagents of chemical reactions and where the described compound is important in its own right.

A small corner of SmallWorld

SmallWorld is a graph database where the nodes are molecules or molecular fragments and where the edges are directed and point to substructures. While frequently stated in the literature that calculation of the MCS through enumerating all possible substructures is impossible, really what they mean is that the time/space tradeoff is quite high. SmallWorld is the proof that with enough disk space, the time reduces quite a lot.

While finding the MCS is still an NP-complete problem, by precomputing canonical substructures of molecules, the NP-complete part is already factored out so that implementing algorithms just involves traversing the tree. For example, substructure searching means going up the graph from a single node, while finding a multi-molecule MCS means simultaneously going down the graph from several nodes.

To mark the growth of SmallWorld to 4 billion molecular substructures, I thought it’d be interesting to take an in-depth look at a small corner, all those acyclic structures with 8 bonds (in the molecular skeleton). There are 35. Here they are arranged by the number of subgraphs each has. (Notice anything about the order?)B8R0Some of these structures occur more often than others. Here is their frequency in ChEMBL molecules (only including acyclic molecules with up to 20 bonds).B8R0_2What is the smallest ChEMBL molecule that is a superstructure of as many of these as possible? The following molecule, CHEMBL1992288, is a superstructure of all but one.CHEMBL1992288These are just toy examples of the sorts of analyses possible. As part of a current collaboration, we are assessing how well SmallWorld compares to other methods for similarity searching. It’ll be interesting to find out.

ChemSpider and CaffeineFix

CaffeineFix Chemspider IntegrationIn collaboration with ChemSpider, CaffeineFix technology is now being used to make suggestions whenever a ChemSpider user’s query doesn’t match a synonym in ChemSpider.

CaffeineFix enables the correction of text to match entries in a dictionary or those expressed by a grammar/regular expression.

The system considers 4 correction operations: insertions, deletions, substitutions and transpositions. To improve the ability to distinguish likely from unlikely errors, the cost of these operations is parameterised by the context they are found in.

For example pyrole is one edit away from both pyrrole and pyrone but the correction to pyrrole is used as it is far more likely.

Peptide informatics at Bio-IT World

Congratulations to the Pistoia Alliance for winning this year’s Bio-IT World Best Practices Award for Informatics for the development of HELM, the Hierarchical Editing Language for Macromolecules. As NextMove’s Sugar & Splice was cited in the submission as supporting HELM, we can claim a small part in helping them achieve this recognition.

Handling and interconverting peptide representations was also the topic of Lisa Sach-Peltason’s talk, “Peptide Informatics – Bridging the gap between small-molecule and large-molecule systems“. She described the peptide registration system that Roche have developed, in which Sugar & Splice has played a major role. One of the many challenges is that although non-standard amino acids make up 7% by frequency of amino acids used by Roche, over 88% of their peptides contain at least one non-standard amino acid.


And finally Roger presented a poster around the same topic, on the challenges of handling peptide line notations for biologics registration and patent filings:

Qualitative structure-activity at UK-QSAR

I’ve been wondering whether my Matched Series work falls under QSAR, as it does not use a numerical model nor does it make absolute activity predictions. Everything it does is based on relative activity/property orders. So perhaps this is not a Quantitative Structure-Activity Relationship, but rather a Qualitative Structure-Activity Relationship (let’s call it QualSAR for short). Is this a useful distinction? Are there additional areas of cheminformatics that would fall under this (MMPA springs to mind)?

But until the whole QualSAR field takes off as a separate discipline, I guess I’m going to continue to file my work under QSAR. Earlier this year, I was invited to contribute a brief description of the algorithm to the current UK-QSAR newsletter (direct link here).

And last week I presented the Matsy algorithm at UK-QSAR, hosted by Eli Lilly. Here’s the poster I presented, which summarises the recent paper and also has some additional examples of the sort of predictions generated (better quality PDF available here).